Immunoglobulin E ndi tanthauzo lake thupi

Immunoglobulin E ndi kufunika kwake thupi - mavuto amene amafuna kuganizira. Pakali pano, pali mitundu ingapo ya immunoglobulins (chitetezo). Pali mitundu ingapo ya chitetezo kuti amasiyana chikhalidwe cha kanthu ndi njira ya chitetezo chokwanira odana infective. Chitetezo imfayo mpweya ndi flocculation wa kusungunuka mankhwala bakiteriya, agglomeration ndi agglutination corpuscular antigens (spirochetes, mavairasi, mogwirizana ndi mabakiteriya). Pa selo nembanemba vibrios trypanosomes ndipo anakakonza spirochetes immunoglobulins maofesi yeniyeni ndi womuyenerera, kuchititsa kupatsidwa zinthu za m'mwazi kumamatira. Childs, izi wothandizila opatsirana asungidwa mu minofu lymphoid. The immunoglobulins magulu G ndi M pamodzi ndi womuyenerera akhoza hydrolyze spirochetes, trypanosomes, mabakiteriya ndi tizilombo tina.

Mmene chitetezo pa tizilomboto pa lili tikafika muchipindachi, ndipo si kulongosola Antigen padziko selo. Immunoglobulins zingalimbitse kapena kufooketsa kukana m'thupi la chamoyo. Antigen-oteteza zovuta imene muli Antigen muyeso, amachita wapaulendoyo, ndi zovuta ndi owonjezera chitetezo amachititsa azisiyana. Nthawi zambiri, ndi immunoglobulins ndi chifukwa mavuto autoimmune ndi matupi awo sagwirizana.

IgE ndi apanga makamaka maselo a nembanemba mucous ya m'mapapo thirakiti gastro-m'mimba, komanso mfundo dera lymph. Kwa nthawi yoyamba, monga gulu la osiyana immunoglobulin E anazindikiritsidwa mu 1966, ndipo mu 1968, omwe anazindikira monga palokha IgE kalasi ya immunoglobulins.

kalasi mapulotini anapeza anthu, anyani ndi nyama zina zasayansi. Ambiri mwa E immunoglobulin mamolekyulu zogwirizana maselo a khungu mlongoti ndi basophils. Kuyambira pansi yachibadwa woipa zinthu immunoglobulin E mu seramu mwazi wa nanograms zochepa milliliter, lingaliro yaikulu ya kapangidwe ka molekyulu izi zimapezeka kokha pa pophunzira mapulotini angapo myeloid. pamlingo wochepa kwambiri wa immunoglobulin E ku seramu mwachionekere ukapezeka chifukwa chakuti ndi chingathe "anakopeka" pamwamba pa maselo ndi zolimba kumumanga maselo mlongoti ndi basophils.

Akukhulupirira kuti Іg E ndi kalasi yaikulu ya immunoglobulins amene Maselo mlongoti ndi basophils nawo thupi lawo siligwirizana. Mlingo zomanga thupi ili ku seramu wa odwala ukuwonjezeka ziwengo ndi zambiri kuposa 350-800 U / mg. Total IgE ponseponse zake ana osakwana zaka miyezi 12 mpaka 15 U / ml. IgE amagwira ntchito yofunika kwambiri mu zochita za hypersensitivity yomweyo. Immunoglobulin E ponseponse akuluakulu osiyanasiyana monga 0 kuti 120 U / ml.

Malinga ndi mfundo ano, ntchito yaikulu ya immunoglobulin E ndi kuteteza thupi nembanemba mucous chifukwa kutsegula zinthu m'dera la madzi a m'magazi ndi maselo effector. Tizilombo toyambitsa matenda amatha anagumula mzere chitetezo zomwe zimapanga immunoglobulins a kalasi A. Kenako mavairasi kapena mabakiteriya padziko maselo mlongoti kumumanga kuti yeniyeni kalasi immunoglobulin E, monga Chifukwa maselo mogwirizana mlongoti kulandira chizindikiro kumasula a amines vasoactive ndi zinthu chemotactic, imene zimayambitsa kukhota inflow wa kufalitsidwa Ig kalasi G, womuyenerera, eosinophils ndi neutrophils. Eosinophilic chemotactic chinthu, amene anamasulidwa maselo Posakhalitsa, amalimbikitsa kudzikundikira eosinophils ndi chiwonongeko cha nyongolotsi. Akukhulupirira kuti IgE adsorbed padziko tiziromboti, ndi amakopeka macrophages kuyamika FC-maselo.