Creatinine - ponseponse mu magazi ndi mkodzo. Tanthauzo matenda a nyemba

Creatinine - muyezo wa umagwirira magazi ndi urinalysis. Mu umagwirira ntchito yachipatala amaonekera makamaka ndi kufufuza reabsorbtsionnoy kusefera ndi ntchito aimpso. Kwa dokotala, creatinine, mlingo wa kuwonjezeka pathological wake kapena limasonyeza. Koma poyamba tiyeni tione zimene mankhwala komanso mmene amapangidwa m'thupi.

Wa sayansi buku angapezeke kuti creatinine ndi imodzi mwa otchedwa mapeto umatuluka kagayidwe. Iwo aumbike kwa mapuloteni creatine kutumikira gwero mphamvu kwa minofu. Mu minofu creatine ndi pawiri wotchedwa phosphocreatine. Ndi kuchepetsa minofu creatine amapereka mphamvu zake, ndipo iye akuswa pansi kuti chomaliza mankhwala - sikelo creatinine, madzi ndi phosphorous. Choncho thupi limapezeka creatinine. ndende umadalira pa kuchuluka kwa minofu misa. Chifukwa cha ichi, magazi creatinine amuna, mlingo wa izo, nthawi zonse apamwamba kuposa akazi.

Mapeto mankhwala a ndondomeko kagayidwe mapuloteni excreted kudzera impso mu mkodzo. The glomerulus creatinine magazi ndi osasankhidwa ndi wadutsa mu tubules ndi aimpso. Pa ntchito yachibadwa ya impso kwathunthu kuchotsedwa m'thupi, ndiko kuti, ndi anachotsa magazi. Pa izi zachokera paradaiso ndi chimodzi mwa ziyeso chofunika kwambiri impso - kuyesa Rehberg. Ntchito anatsimikiza glomerular kusefera. Ndipo pa maziko a kudziwika GFR masamu aimpso reabsorption tubular. Koma tiyeni tikambirane zimenezi nthawi ina.

Creatinine amene ponseponse kwa anthu 0,044-0,106 mmol / l, ndi akazi - 0.44-0,88 mmol / L ukuwonjezeka makamaka matenda a impso. zingapo Laboratories zotsatira za kafukufuku ndi m'kukoma mayunitsi ena - mu micromoles. Kuika mu micromoles mmol kanjedza creatinine ayenera kuchulukitsa ndi 1000. Mwachitsanzo, mlingo kwa amuna - 44-106 mmol / l.

Kuchuluka creatinine - wina zizindikiro zazikulu kulephera impso. Ndi chifukwa chakuti kusefera mu glomeruli ndi aimpso amachepetsa kwambiri zotupa pamene aimpso.

Komabe, aimpso kudwala - osati chifukwa chokha kuenjezera chizindikiro ichi. Onse limati ndi matenda amene pali kusokonezeka mwamsanga phosphocreatine mu minofu, angathe kuonjezera creatinine mu magazi manambala mkulu. Izi zikhoza anatsindika ntchito akulu, hyperthyroidism, zakudya zokhala ndi zomanga thupi, madzi m'thupi, acromegaly.

Pamene zinthu zokhudza minofu minofu zotupa, creatinine kuchuluka, nayenso. Mwachitsanzo, yaikulu m'mnyewa wamtima infarction limodzi ndi kuchuluka creatinine. matenda poizoni amayaka, kugona tulo syndrome komanso chitani ndi kuchuluka kwake.

Mukumwa mankhwala kumawonjezera creatinine. wakudziko yake kuposa ngati wodwala alandira sulfonamides, barbiturates, mankhwala wa tetracycline ndi aminoglycoside zino.

The kuchepa creatinine poyerekeza yachibadwa alibe phindu matenda monga awonjezere. Izo zikhoza kukhala chifukwa wambiri kuchepa kwa zakudya zomanga thupi, njala, kutopa. Utachepa creatinine wachitatu woyamba wa mimba, edema, ascites. Amathandiza kuchepetsa creatinine yaitali ntchito corticosteroids.

Kulephera amaganiziridwa aimpso, monga kale, nthawi zambiri kutumikiridwa Reberga nyemba.

Pamene anatsimikiza mwa kuchititsa creatinine, mlingo umene mu magazi kulephera aimpso akhoza kwambiri kuposa ndi mkodzo creatinine. Mkodzo chitsanzo Rehberg iyenera kusonkhanitsidwa masana, limapereka zotsatira zolondola koposa ngati Akusonkhanitsa nthawi zochepa. M'pofunika molondola kuyeza buku ake. Laboratory laperekedwa kwa pang'ono tsiku buku mkodzo, onse alibe kubala. Pamene kusonkhanitsa mkodzo ayenera kupewa kuchita masewera olimbitsa thupi yovutayi ndiponso sankadya mapuloteni kwambiri. Magazi adzasala pa chopanda kanthu m'mimba m'mawa. The tsiku creatinine excretion mu mkodzo mu yachibadwa ofanana 4,4-17,7 mmol / tsiku.

Pambuyo kudziwa magazi ndi mkodzo creatinine, podziwa kuchuluka kwa mkodzo tsiku, kulemera kwa wodwalayo ndipo kutalika (yotsirizira likukhudza makamaka ana) mu wapadera zasayansi chilinganizo linaŵerengera ndi kusefera glomerular kenako - tubular reabsorption. Mfundo akuluakulu wazaka zapakati: glomerular kusefera kwa amuna - 82-140 ml ya / Mph, akazi - 81-128 ml ya / min. Norma tubular reabsorption - 95-99%. Ngati kuphwanya ntchito aimpso mfundo izi yafupika.