Beta-blockers: mankhwala mndandanda, zikuonetsa ntchito

Mankhwala ndi zotsatira kwambiri achire ankagwiritsa ntchito ndi akatswiri. Iwo ntchito zochizira matenda mtima, amene ali pafupipafupi kwambiri pakati pathologies ena. matenda amenewa m'posavuta kuyambitsa imfa ya odwala. Mankhwala kuti akufunika zochizira matenda amenewa, ndi beta-blockers. List gulu la mankhwala, wopangidwa mwa zigawo 4 ndipo gulu awo anapereka m'munsimu.

Gulu la beta-blockers

Kapangidwe ka kalasi mankhwala si yunifolomu ku zotsatirapo matenda mankhwala ali paokha. Zofunika kwambiri kuonetsetsa yeniyeni ndi lilime makamaka ndi kuyandikana kwa iye. The apamwamba a kulunjika kwa beta-1 zolandilira, zotsatira ochepa mbali ya mankhwala. Pa nkhani imeneyi, mndandanda wa mankhwala beta-blocker kuperekedwa monga rationally.

M'badwo woyamba wa mankhwala:

• sanali kusankha beta-cholandilira 1 ndi mtundu 2, "Propranolol" ndi "Sotalol", "timolol" ndi "oxprenolol", "nadolol," "Penbutamol".

M'badwo wachiwiri:

• kusankha beta cholandilira mtundu 1, "bisoprolol" ndi "Metoprolol", "acebutolol" ndi "Atenolol", "Esmolol."

mbadwo wachitatu:

• Kusankha beta 1 blockers ndi katundu zina pharmacological: "Nebivolol" ndi "Betaksalol", "talinolol" ndi "celiprolol".
• Nelektivnye beta-1 ndi beta-2 blockers ndi katundu zina pharmacological: "Carvedilol" ndi "carteolol," "Labetalol" ndi "bucindolol".

Izi beta-blockers (onani mndandanda wa mankhwala. Pamwamba) pa nthawi anali osiyana gulu lalikulu la mankhwala zagwiritsidwa ntchito ndipo tsopano ntchito matenda a mitsempha ya magazi ndi mtima. Ambiri a iwo, makamaka akuluakulu a mibadwo wachiwiri ndi wachitatu, ntchito lero. Chifukwa zotsatira zawo pharmacological kusamalira kulamulira kugunda kwa mtima ndi kugwira ectopic mungoli kuti ventricles, kuti achepetse pafupipafupi kuukira angina a angina.

Chinsinsi gulu

The mankhwala oyambirira ali mamembala a m'badwo woyamba, ndiko kuti, si kusankha beta-blockers. A mndandanda wa mankhwala ndi kukonzekera zapatsidwa pamwambazi. Mankhwalawa angathe kutsekereza zolandilira wa 1 ndi 2 mtundu, kupereka onse obwera achire ndi mbali, amene anasonyeza bronchospasm. Chifukwa iwo ali contraindicated odwala ndi COPD, bronchial mphumu. The lofunika kwambiri la mankhwala m'badwo woyamba ndi "Propranolol", "Sotalol", "timolol".

Mwa oimira m'badwo wachiwiri wa mndandanda wa mankhwala beta-blockers, limagwirira cha zochita za amene amagwirizana ndi chachikulu kutsekereza zolandilira yoyamba. Iwo yodziwika ndi kuyandikana ofooka kwa mtundu cholandilira 2, chifukwa kawirikawiri chifukwa bronchospasm odwala ndi mphumu COPD. Kukonzekera zofunika kwambiri m'badwo 2 ndi "bisoprolol" ndi "Metoprolol", "Atenolol".

A m'badwo wachitatu beta-blockers

Oyimira a mbadwo wachitatu - ndi blockers atsopano beta. Mndandanda wa mankhwala zikuphatikizapo "Nebivolol", "carvedilol", "Labetalol", "bucindolol", "celiprolol" ndipo ena (onani. Pamwamba). Zofunika kwambiri kwa mfundo matenda a maganizo ndi izi: "Nebivolol" ndi "Carvedilol". Origin advantageously oletsedwa beta-1 zolandilira ndipo zimachititsa kuti amasulidwe NO. Izi zimachitika chifukwa cha kukula kwa mitsempha ndi kuchepetsa chiopsezo mipukutuyi atherosclerotic.

Akukhulupirira kuti beta-blockers - mankhwala oopsa ndi matenda a mtima, pamene "Nebivolol" - ndi generic mankhwala ndi loyenereradi zolinga onse. Komabe, mtengo wake ndi pang'ono kuposa mtengo wa ena. Similar katundu koma pang'ono zodula, ndi "Carvedilol". Chili katundu wa beta-1 ndi alpha-blocker kuti kumathandiza kuchepetsa pafupipafupi ndi mphamvu contractions mtima, komanso kukuza periphery ziwiya.

Zimenezi amakulolani kuugwira aakulu kulephera mtima ndi matenda oopsa. Ndipo pa nkhani ya matenda a mtima, "Carvedilol" - mankhwala a kusankha, chifukwa adakali antioxidant. Chifukwa chida chindiletsa aggravation ya mipukutuyi atherosclerotic.

Zikuonetsa gulu mankhwala

zizindikiro zonse ntchito beta-blockers zimadalira katundu zenizeni za gulu makamaka mankhwala. Mu blockers sanali kusankha zizindikiro ndi kuchepera, koma kusankha abwino ndi ingagwiritsidwe kwambiri ambiri. Nthawi zambiri, zikuoneka wamba, ngakhale iwo okha ndi ndikosatheka ntchito mankhwala odwala ena. Kuti mankhwala si kusankha izi zikuonetsa:

• m'mnyewa wamtima infarction mu zonse nthawi angina, zina, wosakhazikika angina ;
• Matenda fibrillation normoforma ndi tahiforma;
• nkusani tachyarrhythmia ndi kumapitiriza kapena popanda iye ventricles;
• mtima kulephera (aakulu);
• oopsa ;
• hyperthyroidism, hyperthyroidism, kapena popanda vuto la izo;
• pheochromocytoma kuchokera vuto la mankhwala maziko kapena matenda preoperatively;
• migraine;
• Kugaŵa kung'ambika aneurysm;
• mankhwala kapena matenda mowa achire.

Chifukwa chitetezo cha magulu ambiri a mankhwala, makamaka lachiwiri ndi lachitatu m'badwo, mndandanda wa mankhwala beta-blockers, umatchulidwatchulidwa mbiri ya mankhwala a mtima ndi matenda mtima. Malinga pafupipafupi ntchito, iwo ali pafupifupi ofanana ndi zoletsa Ace, amene ntchito zochizira matenda a mtima ndi matenda oopsa ndi matenda kagayidwe kachakudya ndipo popanda izo. Pamodzi ndi okodzetsa, magulu awiriwa mankhwala akhoza kuonjezera moyo amayembekezeka kulephera aakulu mtima.

contraindications

Beta-blockers, komanso mankhwala ena, ndi ena contraindications. Ndipo chifukwa mankhwala zinthu pa zolandilira, iwo ndi abwinopo kusiyana Ace zoletsa. contraindications General:

• mphumu, COPD;
• bradyarrhythmia, odwala nkusani syndrome;
• atrioventricular chipika II digiri;
• symptomatic hypotension;
• mimba, mwana;
• decompensated mtima kulephera - mtima kulephera II B-III.

Komanso amachita ngati contra matupi awo sagwirizana anachita poyankha kulandira blocker. Ngati aliyense ziwengo mankhwala akufotokozera, m'malo mankhwala kwa wina kusiya zochimwazo kumathetsa mavuto.

Zotsatira za ntchito yachipatala mankhwala

Pamene mankhwala angina kuchepetsa pafupipafupi kuukira angina mphamvu zawo, asapatsidwe zochitika pachimake inatsekeratu. Mu CHF mankhwala ndi beta-blockers ndi Ace zoletsa ndi okodzetsa ukuwonjezeka awiri moyo zaka zambiri. Mankhwala oyenera kulamulira tachyarrhythmias ndi akamenyane pafupipafupi kumenyedwa ectopic mu ventricle lapansi. Okwana ndalama kuchepetsa zizindikiro zilizonse za matenda a mtima.

Mawuwo za beta-blockers

"Carvedilol" ndi "Nebivolol" - Ngwabwino beta-blockers. Mndandanda wa mankhwala kuti aonetse ntchito mokondera a beta-zolandilira, likugwirizana mndandanda wa mankhwala waukulu therapeutically zofunika. Chifukwa kuchita matenda ayenera kugwiritsidwa ntchito kapena ndi mbadwo wachitatu, kutanthauza "Carvedilol" kapena "Nebivolol" kapena ambiri kusankha kwa beta-1 mankhwala cholandilira, "bisoprolol", "metoprolol". Ngakhale lero, ntchito yawo limakupatsani kulamulira matenda oopsa ndi kuchiza matenda mtima.