"Zanidip": malangizo ntchito, odwala weniweni ndi madokotala Anzawo. "Zanidip-Rekordati": zimatsogolera ndemanga, analogs

Malinga ndi ziwerengero za 26% ya akulu mu dziko akudwala BP zonse. Nthawi zambiri matenda kugwirizana ndi kutengera za kumtundu. Komabe, pali zifukwa zina pakuwonekera kwake. Zikuphatikizapo kunenepa, kusuta, kudya kwambiri a mchere, kusowa kufufuza zinthu ndi mavitamini m'thupi, uchidakwa, nkhawa, ntchito otsika thupi, ndi ena.

Iwo ayenera kukumbukira kuti chitukuko cha matenda oopsa zimadalira m'badwo munthu. Akulu iye, ndi apamwamba chiopsezo chotero boma pathological. Pa zaka 40, matenda ndi pafupifupi nthawi zonse chifukwa cha zotupa sclerotic mtima.

zambiri

Nthawi zambiri, madokotala kuika odwala awo matenda "zofunika oopsa". Ndi chiyani icho? Ndi matenda aakulu ndi mawonekedwe a matenda oopsa. matenda chizindikiro chachikulu amachita khama ndipo nthawi yaitali kukwezedwa kwa magazi.

Kusintha pa matenda amenewa angakhale osiyana. Komabe, iwo makamaka ikukhudzana bwanji ndi mitsempha ya magazi ndi mtima.

Kuti bwino mmene alili, madokotala amalangiza mankhwala monga "Zanidip". Reviews odwala pa mphamvu ya mankhwala ayankhidwa zipangizo za nkhaniyi. Komanso pali mudzapeza mudziwe mmene kulandira anati mankhwala, ngati iye anali analogues aliyense ndi zotsatira zake zoyipa.

Kufotokozera, zikuchokera, mawonekedwe ndi ma CD

The medicament "Zanidip" malangizo kusungidwa mu mtolo makatoni amachoka mu mawonekedwe a mapiritsi kuyatsa chikasu ndi kuzungulira ndi biconvex mitundu chizindikiro pa imodzi mwa mbali. Iwo filimu-lokutidwa ndi ndi kulocha chikasu pa kuswa.

The yogwira pophika mankhwala amachita lercanidipine hydrochloride. Komanso, kumaphatikizapo ndi mbali wothandiza, amene ankayimiridwa ngati povidone K30, lactose monohydrate, sodium carboxymethyl wowuma, microcrystalline mapadi ndi magnesium stearate.

Pankhani chiphunzitso filimu-❖ kuyanika, ndiye wapangidwa ndi zinthu monga Opadry Yellow, talc, hypromellose, titaniyamu dioxide, chitsulo okusayidi utoto wachikasu ndi macrogol 6000.

Gulani "Zanidip" mapilitsi mu mapaketi chithuza mwina, kuti anayikidwa mu mabokosi pepala.

Pharmacological makhalidwe a mankhwala

Kodi mukudziwa kuti ndi mankhwala "Zanidip"? Malangizo pa ntchito limasonyeza kuti kashiamu njira blocker pang'onopang'ono. pophika wake wamphamvu ndi osakaniza racemic wa stereoisomers dextro ndi levorotatory. Iwo ayenera kukumbukira kuti ndilochokera wa 1,4-dihydropyridine.

medicament Izi kusankha kutsekereza panopa ayoni kashiamu m'zipinda mtima, maselo mtima ndi minofu yosalala.

Mfundo chosunga zotsatira antihypertensive mankhwala ndi chifukwa mwachindunji anasiya kugwira ntchito pa maselo mtima yosalala minofu.

Malinga ndi malangizo atalandira zotsatira akangofika medicament ndi zimatheka pambuyo maola 5-7. Kutalika kwa n'loonadi ake anakhalabe tsiku lonse.

Chifukwa selectivity mkulu wa mankhwala kwa mtima maselo yosalala minofu, alibe oipa inotropic kwenikweni.

Nanga mankhwala "Zanidip-Rekordati"? Guide limanena kuti metabolically ndale mankhwala amene alibe chikoka kwambiri zomwe zili apolipoproteins ndi lipoproteins ku seramu magazi, komanso sasintha mbiri ya mafuta anthu ndi matenda oopsa.

The kinetics wa mankhwala

Kodi odzipereka mankhwala "Zanidip"? Malangizo ntchito akufotokozera ife atalandira miyala (10 kapena 20 mg) m'kati lercanidipine pafupifupi atamezedwa kotheratu kwa mundawo m'mimba. Patapita maola 1.5-3 pazipita ndende ya mankhwala mu madzi a m'magazi kufika mtengo wa 3.3 ng / ml ya kapena 7,66 ng / ml motero.

Kufalitsidwa kwa mankhwala mu zimakhala ndi ziwalo kumachitika mofulumira ndithu. Kulankhulana ndi mapuloteni plasma kuposa 98%. Mobwerezabwereza mapiritsi mlingo wa kudzikundikira awo zimawonedwa.

Kagayidwe mankhwala ikuchitika pa ziyambe kudutsa chiwindi. Izi zimachitika ndi biotransformation CYP3A4. Izi amalenga angapo metabolites amene alibe ntchito pharmacological.

Anasonyeza mankhwala "Zanidip", ndemanga za amene anapereka pang'ono m'munsi mwa matumbo ndi impso. Pali magawo awiri kuchotsa lercanidipine: oyambirira amene nthawi ndi maola 2-5 ndi chomaliza - maola 8-10.

Mankhwala zikutsatiridwa ali pafupifupi osati wapezeka mu ndowe ndi mkodzo.

Anthu ndi chiwindi kapena aimpso matenda mapuloteni zili plasma ali kwambiri yafupika. Pa nkhani imeneyi, mfulu timene mankhwala yogwira medicament mwina zayamba kuchuluka.

Zikuonetsa kuti alandire mankhwala othandiza

Cholinga chimene awerenge mankhwala "Zanidip"? Reviews madokotala inanena kuti nthumwi zimenezi bwino akusonyeza lokha oopsa zofunikira ndipo wofatsa chowongolera mwamphamvu.

Contraindications kulandira magomewo

Malinga ndi malangizo, mankhwala "Zanidip" sayenera kumwedwa pa zinthu zotsatirazi:

• aakulu ntchito chiwindi;
• aakulu mtima kulephera chikhalidwe (makamaka decompensation sitepe);
• chakhungu ntchito aimpso;
• wosakhazikika angina ;
• Mothandizana ndi zoletsa amphamvu isoenzyme CYP3A4 (mwachitsanzo, "ketoconazole", "erythromycins", "itraconazole") ndi "cyclosporin" ndi madzi manyumwa;
• pa mimba;
• kutsekeka ziwiya magazi amene anabwera kuchokera ventricle kumanzere kwa mtima;
• lactose tsankho, kusowa lactase ndi malabsorption syndrome galactose / shuga;
• nthawi yoyamwitsa;
• Posachedwapa ndi m'mnyewa wamtima infarction (m'nthawi ya mwezi umodzi);
• Akazi akafika msinkhu wobereka amene si ntchito njira zodalirika za kulera;
• osakwanitsa zaka (efficacy ndi chitetezo sizinachitike anakhazikitsa);
• hypersensitivity kuti lercanidipine ndi ena ofanana ena dihydropyridine kapena zigawo aliyense wa mankhwala.

Mosamala kumwa mankhwala

The medicament "Zanidip-Rekordati" kusamala bwino kutenga anthu ndi mkhutu chiwindi ntchito (zolimbitsa ndi wofatsa), aakulu mtima nedostatochnostyusindromom nkusani, kumanzere kulephera yamitsempha yamagazi ndi inatsekeratu matenda mtsempha wamagazi, ndi phwando munthawi yomweyo "Digoxin" beta-blockers.

Miyala "Zanidip": malangizo ntchito

Poona kuchuluka kwa zinthu chowawa ankaona mankhwala ayenera kuperekedwa ndi ogwira odziwa. Childs, mankhwala yogwira bwino kutenga ndalama ya 10 mg tsiku lililonse.

Mankhwala ayenera kuchitidwa m'mawa, kwa ¼ ora pamaso chakudya.

Malinga ndi zotsatira akangofika mlingo wa mankhwala, pansi pa kuganizira akhoza kawiri, i.e. pafupifupi 20 mg. Kuwonjezeka mlingo wa medicament lizisunga pang'onopang'ono. Ngati chofunika, ndi kuwonjezeka mu kuchuluka kwa medicament ikuchitika pambuyo masabata awiri ukatha mwambo wa mankhwala.

Kodi nditenge "Zanidip-Rekordati"? Musati kutafuna miyala. Nthawi zambiri kumeza ndi kusamba pansi ndi okwanira kuchuluka kwa madzi.

Okalamba No kusintha mlingo chofunika. Koma pamene kumwa mankhwala chikhalidwe chawo amafuna polojekiti zonse.

Mu kukhalapo kwa kwa chiwindi kapena aimpso kulephera kapena zolimbitsa kusalekerera mlingo kuwongolera safunikira. Mu masiku oyambirira angapo a mankhwala kutumikiridwa mu kuchuluka kwa 10 mg, ndiyeno mosamala akawawonjezere mlingo wa 20 mg wa pa tsiku.

Ngati zotsatira antihypertensive kwambiri umaonetseredwa, mwachindunji mlingo yafupika.

zotsatira zoyipazi

Zingachititse zosiyanasiyana osafunika "Zanidip-Rekordati"? Ogula ndemanga kudziŵitsa kuti zakudya izi zikutanthauza kuti nthawi zambiri ndimaoneka mavuto. Kodi kwenikweni, tikambirana pompano:

• chitetezo: Hypersensitivity.
• Mtima dongosolo: tachycardia, angina, palpitations, kukomoka, ankatenthetsa khungu nkhope, kupweteka m'chifuwa, amalembedwa kuchepetsa kuthamanga kwa magazi, matenda a mtima.
• mantha dongosolo: somnolence, mutu, chizungulire.
• M'mimba thirakiti: kusanza, dyspepsia, nseru, kusintha kuwonjezeka michere chiwindi, m'mimba ndiponso ululu m'mimba.
• Ziwengo.
• dongosolo minofu ndi mafupa: myalgia.
• Mkodzo: polyuria.
• Other: zotumphukira edema, kutopa, gingival hyperplasia, kutopa.

Zizindikiro cha mankhwala osokoneza bongo

Kodi zotsatira adzatsatira, ngati inu kutenga mlingo waukulu wa mankhwala "Zanidip"? Guide imalemba zizindikiro zotsatirazi cha mankhwala osokoneza bongo: m'mnyewa wamtima infarction, reflex tachycardia, vasodilation zotumphukira ndi Amowabu kuchepa magazi, kuchuluka kwa nthawi ndi pafupipafupi kuukira angina.

Kuthetsa limati ngati mankhwala symptomatic.

Mwanjira mankhwala

Kodi n'zotheka zimagwirizizirana ndi mankhwala ena mankhwala "Zanidip"? Malangizo ntchito akusonyeza kuti chida zoletsedwa kuphatikiza ndi zoletsa ngati CYP3A4 (cytochrome P450 chiwindi), monga "Itraconazole" "ketoconazole" ndi "mankhwalawa". Ichi ndi chifukwa chakuti mankhwala onsewa kuonjezera ndende ya lercanidipine mu magazi, komanso kutsogolera zotsatira antihypertensive.

Munthawi yomweyo phwando malipoti amatanthauza "cyclosporin" ali contraindicated, monga kungachititse ndi kuwonjezeka zili zinthu zonse mu magazi a wodwalayo.

Lercanidipine ndikoletsedwa ntchito pamodzi ndi madzi manyumwa. kuphatikiza zingatipangitse potentiation cha mphamvu antihypertensive wa lercanidipine ndi chopinga wa kagayidwe.

Iwo ayenera kusamala kwambiri pamene kulandira "Zanidipa" ndi mankhwala monga "Astemizole", "Terfenadine" ndi "quinidine", komanso antiarrhythmics a kalasi lachitatu (mwachitsanzo, "Amiodarone").

Kuphatikiza medicament ankaona ndi mankhwala anticonvulsant ( "phenytoin," Carbamazepine ") ndi" rifamycins "zingachititse kuchepetsa milingo magazi a lercanidipine, chifukwa mu kuchepa kwa zotsatira antihypertensive wa lercanidipine.

Pamene osakaniza mankhwala ndi "Digoxin" ayenera mosalekeza kuwunika zizindikiro za kuledzera.

Munthawi yomweyo chithandizo ndi medicament "midazolam" mu akula akhoza kuonjezera absorbability wa lercanidipine ndi kuchepetsa mlingo wake mayamwidwe.

Akatswiri amanena kuti "metoprolol" amatha kuchepetsa bioavailability wa lercanidipine 50%. Mu nkhani iyi, bioavailability wa "Metoprolol" ndi zikutsatiridwa. Amenewa ukapezeka ku kuchepa kwa chiwindi magazi chifukwa cha beta-blockers.

Kukonzekera "cimetidine" mu mlingo wa mg wa 800 pa tsiku zimabweretsa kusintha kwakukulu mu ndende magazi a lercanidipine. Koma pa phwando ake amafuna kusamala yapadera, kuyambira mlingo waukulu achuluke ndi bioavailability wa lercanidipine ndipo potsatira kuonjezera mphamvu zake antihypertensive.

Ndi kuphatikiza "Zanidipa" ndi "Simvastatin" mankhwala oyamba kumwedwa m'mawa, ndipo chachiwiri - madzulo.

The medicament "fluoxetine" alibe zotsatira pa kinetics wa lercanidipine.

Munthawi yomweyo phwando "Zanidipa" ndi "warfarin" sanali bwanji pharmacokinetics ya masika.

Ndalama akhoza pamodzi okodzetsa, beta-blockers ndi zoletsa Ace.

Tiyenera kuona Mowa kuti timapitiriza antihypertensive zotsatira lekarnidipina.

ayamikira yeniyeni

Mankhwala "Zanidip", analogues zimene zili m'munsimu, ayenera kukhala ndi kusamala kwambiri anthu ndi makutu impso ntchito ndi inatsekeratu matenda mtsempha wamagazi, monga mu nkhani iyi, pali chiopsezo chachikulu cha kuchuluka pafupipafupi kuukira angina.

Isanafike kulandira mankhwala ayenera nthawi zonse kulipidwa mtima kulephera chikhalidwe aakulu.

kusamala makamaka uyenera kuchitika pa chiyambi cha mankhwala, makamaka odwala ndi digiri zolimbitsa ndi wofatsa wa insufficiency kwa chiwindi.

Pa mankhwala, ndi zofunika kuti mosamalitsa kugwira ntchito yofuna mwapadera, kuphatikizapo anira msewu. Ichi ndi chifukwa chakuti pa chiyambi cha mankhwala ndi Mlingo owonjezera pali chiopsezo zosayembekezereka wa litsipa, kugona ndi chizungulire.

zinthu yosungirako, alumali moyo wa kukonzekera ndi zogulitsa

Ndingapite kugula mapiritsi "Zanidip-Rekordati"? Analogs ndalama yekha mankhwala amagulitsidwa ogulitsa mankhawala iliyonse. Komabe, iwo zikhoza kugulidwa pa mankhwala dokotala.

Pitirizani kupereka mankhwalawa asaawone zofunika ana kumene kutentha si upambana 30 madigiri.

Alumali moyo wa mankhwala pansi kulingalira ndi zaka zitatu. Itatha nthawi iyi, kumwa mankhwala ndikoletsedwa.

analogues mankhwala

Kodi mukudziwa zimene mukhoza m'malo mankhwala "Zanidip"? Analogues chida ndi kovuta kupeza. Akatswiri amanena kuti katundu zofanana ndi ntchito zinthuzi likhale "Lerkamen" ndi "Lercanidipine". Kumwa mankhwala awa ayenera kukhala kuchipatala.

Mankhwala "Zanidip": ndemanga za odwala ndiponso akatswiri

Ndi othandiza kwambiri antihypertensive wothandizira. Kuti view izi nawo madokotala ambiri. Tikugwirizana ndi iwo, ndipo pafupifupi onse odwala kumwa mankhwala "Zanidip". Iwo amati pambuyo kumwa mankhwalawa chikhalidwe chawo ndinasintha bwino. Zizindikiro za matenda oopsa kofunika ndi wofatsa ndi zolimbitsa kusalekerera kusiya pafupifupi pomwepo.

The drawback mankhwala okhawo izi kuti cholanda zambiri amayambitsa zotsatira zina zoyipa, makamaka pa mundawo m'mimba ndi dongosolo mtima.

Iwo ayenera kukumbukira kuti anthu ambiri amadandaula za mtengo wa mankhwala ndi okwera kwambiri. Izi mankhwala ndi kuchuluka kwa mapiritsi 28 zikhoza kugulidwa kwa 450-500 rubles. Tikumbukenso kuti analogues wa anati medicament mu mawonekedwe a "Lerkamena" ndi "lercanidipine" sanatero mtengo. Iwo akhoza kukopedwa pa mtengo womwewo.

Akatswiri amanena kuti mtengo wa "Zanidip" antihypertensive mankhwala complies kwathunthu ndi ubwino wake. Izo zikusonyeza pafupifupi lonse la nthawi yaitali mu ntchito.