Vitrification wa oocytes: ndichiyani?

M'zaka zaposachedwapa, mu umuna m'galasi kusiyana mofulumira kwambiri. Ndondomeko sanalinso kukhala chinthu chosakhulupirika kunali anthu wamba. Lidzawagwiritsenso ikuchitika padziko lonse. Laboratories apadera ndiponso zipatala akupezeka mzinda zonse zazikulu. Chaka kukhala zatsopano, njira patsogolo kuti chonde. Kudzera chitukuko cha njira imeneyi, mabanja ambiri osabereka anatha kukhala makolo. Nthawi zambiri zosonkhanitsira zokhudza lidzawagwiritsenso, amai ndi mawu monga vitrification wa oocytes. Mawu amenewa amanena za ndondomeko watsopano kuti amalola kuti kuwongolera mazira.

Lingaliro la "oocyte vitrification" - ndichiyani?

Kumvetsa mmene ndondomeko vitrification, muyenera kukhala ndi maganizo a mu m'galasi umuna. njirayi kumafuna zochepa chabe pamalangizo maselo wamkazi nyongolosi (oocytes) ku thumba losunga mazira ndi. Ndiye pali kuyeretsa ndi umuna awo umuna mwiniwake kapena bwenzi (ngati mwamuna sangathe ndi ana). Patatha izi, gawo zygote aikidwa mu uterine patsekeke. Vitrification wa oocytes - njira zofanana ndi cryopreservation wa oocytes. Komabe, patsogolo kwambiri. Pansi vitrification anatanthauza yozizira koopsa wa mwana maselo nyongolosi. Chifukwa cha zimenezi, oocytes akhoza kusungidwa kwa nthawi yaitali. Ngakhale "mazira" boma, maselo Vitrified kukhala yotheka. njirayi akuti ndi yojambula yaikulu mankhwala, chifukwa kuyamika akazi ake amatha kukhala ndi mwana, ngakhale pakalibe Ziwalo zoberekera.

Kodi cholinga cha oocyte vitrification ikuchitika?

Ku Ulaya, mfundo monga cryopreservation, vitrification a mazira ndi oocytes, akhala kudziwika kwa nthawi yaitali. Tikhoza kuona pa kumadzulo filimu pa mankhwalawo. Mu mayiko a Soviet Union, nayenso, madokotala bwino mawu awa kwa zaka zambiri. Komabe, njira zakhala zilipo odwala posachedwapa. Nthawi zambiri, vitrification wa oocytes amapangidwa kuti mu m'galasi umuna. Pa yozizira koopsa maselo mwana m'njira mkazi ali ndi mwayi waukulu kwambiri lidzawagwiritsenso bwino. The mtanda loyamba oocytes osankhidwa n'kuwasanganiza sangathe zikhazikike. Mu izi kukonzanso zochepa chabe pamalangizo chuma safunika ngati pali maselo kale Vitrified. Komanso, pali milandu pamene awiri wosabala atam'pempha kuteteza oocytes kwa nthawi yaitali. nthawi zambiri zofunika pa zinthu zosiyanasiyana pathological imene mzimayi sangakhale ndi ana. Komanso, ndi pempho chotero amanena odwala kukonzekera opaleshoni kuti achotse ziwalo zoberekera.

Palibe pathologies amalangiza vitrification mazira?

Vitrification wa oocytes ndi mazira - ndondomeko analipira kupezeka kwa aliyense. zikuonetsa Special chifukwa iwo alibe Komabe, m'pofunika pokha pokha yeniyeni. Izi sizikutanthauza kuti akazi ena sangathe kupeza vitrified maselo awo. Komabe, pakalibe zifukwa yozizira koopsa wa oocytes mu N'chimodzimodzinso odwala amalangiza cryopreservation. Nthawi zambiri vitrification wochititsidwa pansi zinthu zotsatirazi:

1. Akukonzekera ovariectomy. Opaleshoni imeneyi ikuchitika khansa yamchiberekero ndi kukayikirana wa chitukuko. Pachifukwa ichi si ambiri kwambiri, chifukwa nthawi zambiri, matenda a khansa pathologies chikutha ndi chiberekero.
2. Kulephera kupeza umuna tsiku madyedwe a oocytes. Pachifukwa ichi, maselo ayenera atapanga malinga ngati mfundo umuna sati mopepuka.
3. Khansa ya kutanthauzira kulikonse. Kaya kumene ali ndi khansara amafuna radiotherapy ndi mankhwala mankhwala (cytostatic) mankhwala. Aliyense wa awa njira osafunika zotsatira mimba. Pambuyo mankhwala awa kuononga osati khansa, komanso maselo wathanzi, kuphatikizapo oocytes.
4. chilakolako mkazi ndi ana mu nthawi ya kutali, mwachitsanzo, pambuyo kusintha. Zikatero kawirikawiri cryopreservation imayenda chifukwa dzira kuzizira njira imeneyi yotheka kwa nthawi yaitali. Choncho, madokotala amati njira zina - vitrification wa oocytes.
5. Mobwerezabwereza lidzawagwiritsenso, ngati nthawi yoyamba dzira si anazolowera. Pankhaniyi, kupereka vitrification kuti ndisatenge nkhani katatu.

Vitrified oocytes mwiniwake - ndichiyani?

Mu zina, nthunzi wosabala sangathe pakati mwana, ngakhale mothandizidwa mu m'galasi umuna. Tikuyankhula zokhudza akazi ndi mkhutu ntchito ya gonads lapansi. Chifukwa chaichi, magombe othandizira ndalama oocytes anali olemera. Mwatsoka, iwo palibe m'mayiko onse. Onse maselo mwana nyongolosi ndi boma vitrified, kotero kuti iwo akhoza kusungidwa. Zikuonetsa kuti lidzawagwiritsenso ntchito oocytes mwiniwake ndi:

1. Chibadwa anatsimikiza kudwala - yamchiberekero kulephera syndrome.
2. Pakalibe oocytes chifukwa makhalidwe zaka cha ziwalo zoberekera (zaka 40 ndi kuposerapo).
3. Kulephera yotithandiza ovulation chifukwa zikunena opaleshoni pa thumba losunga mazira, mankhwala amphamvu kukhudzana.
4. Chiopsezo mwana matenda chibadwa.
5. Mobwerezabwereza lidzawagwiritsenso, amakhala yayenda bwino chifukwa cha "khalidwe osauka" mazira awo.

Amene akhoza kukhala oocytes mwiniwake vitrified: Zofunika

Njira Zakulera - ichi ndi nkhani yaikulu kwambiri, makamaka milandu pamene banjali amakakamizidwa ntchito maselo mwiniwake. Inu musanakafike oocytes ndi kugonjetsera iwo vitrification, dokotala ikuchitika Kafukufuku yambiri ya mayiyu ndi mabuku operekedwa. Chimodzi cha zinthu unakhazikitsidwa mu mtsinje wa umakakumana ndi mazira, ndi kudzibisa. Ndiko kuti, makolo samadziwa za mwiniwake, ndi mosemphanitsa. Amafuna kuti akazi amene asankha oocytes awo vitrified:

1. Age: zaka 20-35.
2. Chosowa matenda somatic ndi chibadwa.
3. Mofewa kutchulidwa fenotayipi.
4. Kupezeka kwa woperekayo mwana mmodzi wa awo.
5. Aminoni zachinsinsi.

Njira ya vitrification

Musanayambe kuti amaundana gametes wamkazi unachitika ovulation kukondoweza. M'pofunika kuti oocytes anali angapo, osati munthu. Pambuyo yakucha yachibadwa zidzachitika ovulation ndi follicle zokolola za linagwira chimodzi chokha. Kukondoweza imagwiridwa ndi mankhwala. Kenako imagwiridwa ultrasound m'chiuno. Mukaona kuti ovulation chimenechi chidza- ndi oocytes mu n'kuwasanganiza wambiri zokwanira, ndondomeko lidzawagwiritsenso ikupitirira. selo kukolola ikuchitika pogonekedwa ndi mankhwala ambiri. Kuti puncture singano kugunda icho pamenepo, pamene oocytes, ndondomeko yonse imagwiridwa pansi ultrasound malangizo. Akamaliza kuchita zinthu kuyamba gawo lina lotsatira - kuteteza oocytes mwana. Vitrification wa oocytes imagwiridwa mu dongosolo zachilengedwe chifukwa cha njira mofulumira yozizira koopsa. Ichi ndi chinthu chachikulu kwa njira kuteteza.

Ubwino vitrification wa oocytes

Popeza kuti vitrikatsii ndondomeko anayamba pang'onopang'ono m'malo njira zina kuteteza umakakumana ndi mazira, ndi bwino osati kwa madokotala komanso odwala. Njira Ubwino:

1. n'zotheka kusiya kaye mimba. Chifukwa chakuti oocytes ndi mazira kwa nthawi yaitali (malingana ndi chigamulo cha mkazi).
2. Luso kachiwiri lidzawagwiritsenso ndondomeko popanda kutenga nkhani za chachiwiri (kapena zambiri) nthawi.
3. Luso pakati opaleshoni pa zopangitsa maliseche, cheza ndi mankhwala amphamvu.

kunali kusiyana pakati pa vitrification ndi cryopreservation mazira chiyani?

Monga amadziwika, njira kriokenservatsii ndi vitrification wa oocytes ndi ofanana kwambiri. njira onse anapangidwa kuti kuzizira kwa oocytes ndi mazira kuti asunge viability awo. Komabe, pali kusiyana. Nthawi zambiri, mwana oocyte cryopreservation kuonongeka. Ichi ndi chifukwa chakuti njira imeneyi kumafuna pang'onopang'ono zinthu yozizira koopsa. Chifukwa cha zimenezi, cytoplasm madzi n'kukhala ndi timibulu ayezi. Kuti iwo kuwononga khoma selo. Njira yabwino Ya cryopreservation wa oocytes ndi vitrification. Kuchuluka defrost pamene tikugwira ake m'munsi, monga kuzirala mazira limapezeka nthawi yomweyo. Kuti pali kusiyana zazikulu cryopreservation amaonedwa umisiri kukhalabe oocytes yaitali mu mkhalidwe yotheka. Kuzengereza lingaliro kwa nthawi yaitali angakhoze kokha njira vitrification. Cryopreservation sasamalira chonchi mpaka kalekale.

Kodi lidzawagwiritsenso pambuyo vitrification wa oocytes?

Oocyte vitrification ikuchitika kulikonse. Yozizira wa gametes ndi mazira kwa nthawi yaitali chinkhoswe okha Laboratories apadera kwambiri. Pafupifupi chipatala ndi zida izi ali ndi banki ya oocytes mwiniwake vitrified. Kamodzi mkazi waganiza mukufuna pakati mwana, maselo ndi thawed. Ndiye ntchito njira ICSI imagwiridwa umuna. Ndisanaumbidwe chifukwa ali pansi culturing (masiku 3-5) ndipo anapatsa mu endometrium okonzeka. Maselo otsala akhoza ukala kachiwiri vitrified. Pamene pofuna likhazikike lidzawagwiritsenso ndondomeko akubwerezedwa.

Vitrification wa oocytes: ndemanga madokotala

Panopa vitrification ndi kusunga oocytes ndi mazira imagwiridwa m'mizinda yonse yaikulu ya mankhwala olemera. Kamodzi njira imeneyi wayesedwa ndipo lasonyeza, madokotala kulankhula za izo ndithu, kuona ubwino pa ena (kale) yosungirako mazira njira. Kukwanitsa amaundana oocytes awo akazi ambiri. Ndondomeko Ndipafupifupi 12 zikwi rubles. mtengo Izi ndi vitrification. Mtengo wa kusungiramo maselo achisanu ndi rubles 1000 pamwezi.