"Montelukast": ndemanga, malangizo ndi analogues wa mankhwala

"Montelukast" - za ndemanga mankhwala mosavuta pa maonekedwe Intaneti ndi malo wodzipereka kwa vuto la mphumu - ndi antagonist tingachipeze powerenga za leukotriene D4-cholandilira. Mankhwala chimagwiritsidwa ntchito monga m'munsi pa mankhwala ndi kuteteza kuukira khalidwe la matenda. Kusamala zikuchokera amalola kugwiritsa ntchito mankhwala ndi zochizira odwala pafupifupi msinkhu uliwonse.

Fomu kumasulidwa

Zifukwa "montelukast" analandira makamaka ndemanga zabwino, kwambiri. Komabe, chinthu choyamba chimene zakusangalatsani - izi, ndithudi, ndi assortment miyala, wogulitsidwa malonda dzina la deta.

Pa nthawi ndondomeko chimakhala chogwidwa ndi atatu masanjidwewo. Ndi za mankhwala muyezo ndi envelopu zojambulazo (1 limakhala 10 mg wa mankhwala yogwira) ndi analogues awo kutafuna (4 mg wa ndi 5 mg ankalemekeza a reagent a). Base maziko milandu onse, amachita montelukast sodium, koma zikuchokera zigawo zosiyanasiyana wothandiza - Mannitol ndi aspartame alipo mu zitsanzo anafuna ingestion mwamsanga pa ntchito.

Mu ndemanga zambiri izo pops funsolo wa onyenga, amene tsopano kenako kuwonekera unyolo mankhwala. Kuchilango counterfeiting akhoza kukhala, ngati si yake amamvetsera maonekedwe a mankhwala pharmacological.

Makamaka, kutafuna mankhwala ndi mamiligalamu 4 wa yogwira pophika, ali mawonekedwe chowulungika ndi kum'chitira pinki (kulongosola limafanana mapiritsi kukoma chitumbuwa, ntchito flavorings ena kusiyana chovomerezeka), ndipo limadziwika ndi manambala "4" pa mbali imodzi. Analogs imene yaikulu yogwira pophika ndi 1 mg zambiri - wozungulira n'kumati ndi "zisanu". Mankhwala monga likule geometrically akufanana ndi rectangle; Iwo beige ndipo anawerengedwa "10" chiwerengero.

pharmacological amayanjana

"Montelukast" (maumboni kufotokoza zochitika komwe zovuta reagent chikwiyire chifuwa n'zochepa kwambiri) - uyu ndi nthumwi ankaikira gulu antibronhokonstriktornyh mankhwala. The aligorivimu amalola zochita zake kulankhula za "ubwenzi" ndi intermedianty / prostaglandins ndi thromboxanes.

Ntchito yaikulu ya mankhwala - kutsekereza cysteinyl leukotriene "masensa" a dongosolo kupuma. zolandilira amayesetsako ntchito yapamwamba mu chitukuko bronchial mphumu komanso Zimachititsa kaphatikizidwe secretions kenako amasonkhana ndi complicates ndi mucosa.

madyedwe zonse kumabweretsa kuchepetsa kwambiri popereka zizindikiro mu maziko a kuchepa ambiri chiwerengero cha anthu odwala matenda a mphumu (monga taonera ndi odwala ambiri, anasinthira kale anati m'masiku oyambirira mankhwala).

mbali kagayidwe kachakudya

"Montelukast" (ndemanga mankhwala amati kusankha chenicheni cha maimidwe-ins yochepa kuti ndondomeko mtengo wa opanga ie munthu mankhwala-ofanana matanthauzo, kunena kapangidwe kake zofanana-Structured mamolekyulu ndi chigawo chachikulu, pali kangapo mtengo kuposa yokonza anafotokoza), nalowa plasma ndi magazi, chimamanga mwangwiro ndi mapuloteni ake. Mu maphunziro ovutika chifukwa cha chinalembedwa pa 99, 37%. Pa nthawi yomweyo, bioavailability ake ndi zogwirizana mwachindunji kwa ndondomeko ya issuance. Mwachitsanzo, popanga mapiritsi 5-milligram amenable kuti mayamwidwe ndi 73%, koma analogues ndi zapamadzi Kakhungu limene pali nthawi 2 yogwira zinthu, - yekha ndi 64%.

Nkhani yofanana ndi theka moyo wa reagent kuti: Zigawo kutafuna mapilisi, inalandira kagayidwe, kusiya thupi pambuyo maola 2 pambuyo phwando, koma zinthu constituent miyala ochiritsira - pambuyo Mphindi 180-200. Mu chilolezo ichi plasma zimasiyanasiyana pakati 43-45 ml ya / miniti. Ndipo, chochititsa chidwi n'chakuti% 0.2 okha a mlingo imapezeka njira ya mkodzo. Intestine, poyerekezera, - oposa 85%.

Pa zimene akuluakulu wolemekezeka, ndizoonekeratu kuti ndondomeko pharmacokinetic mofanana bwino odwala a amuna ndi akazi, ndi kuti kusintha lalikulu ndi msinkhu kudwala aimpso mu mawerengedwe a servings tsiku la mankhwala chofunika. Koma kulephera kwa chiwindi, makamaka pankhani matenda aakulu, kuliganizira wapadera mu yokonza ndandanda achire.

zikuonetsa kuti

Pamene wolungama mwa ntchito za "montelukast" ndemanga mankhwala (ana mankhwala tikuyivomereza mu mawonekedwe a chingamu, mapiritsi, TACHIMATA Kakhungu chipolopolo, izo m'pofunika kuti aike akulu okha ndi achinyamata), anachoka pa maonekedwe, kumene, kutithandiza kumvetsa. Komabe, okha motsogozedwa ndi maganizo ena - ndi chibwana, chifukwa popanda kufunsa dokotala, "kudziwa" mtundu wa mphumu, ndipo ambiri Chofunika - kupeza zifukwa pakuwonekera kwake kuli kovuta.

Pankhani mawu boma bwalo pali zizindikiro, matenda ndiponso mavuto ena lagawidwa motere:

• spasms bronchial amayamba ndi kumwetsa katundu thupi;
• Nyengo / aakulu rhinitis, matupi awo sagwirizana chikhalidwe cha chiyambi;
• mphumu;
• kufunika zodzitetezera.

Mlingo akadakwanitsira

"Montelukast" (maganizo oipa ndi kovuta kupeza, chifukwa pophika achangu kale bwinobwino ntchito ngati pakati chigawo chimodzi ambiri mankhwala) chikuyendetsedwera pakamwa, kamodzi pa tsiku, popanda kuchita ndandanda "kadzutsa - nkhomaliro -. Chakudya"

Pakuti magome chewable, 4 mg wa ndi 5 mg wotere Mlingo malamulo:

• ana a zaka zapakati pa 2 ndi 5: 1 unit wa mankhwala (4 mg) tsiku, pogona, mpaka kukwaniritsa kulamulira zizindikiro ndi prolongation wa Inde mokakamizidwa kwa masabata 2-4 kukonza zotsatira chotsatira;
• odwala zaka 6 mpaka 14: akafuna chomwecho, koma mtengo umodzi nthawi - 5 mg.

Pakuti mankhwala ndi wrapper zojambulazo zogwirizana izi ayamikira:

• akulu ndi ana akale zaka 15, akudwala mphumu bronchial kapena aakulu rhinitis: 1 Unit (10 mg chuma) / tsiku madzulo;
• kuteteza omangana: mlingo chomwecho pa nthawi imeneyi masiku 14-28.

mbali zotsatira

"Montelukast" malangizo (ndemanga amati ngakhale kugwilizana zonse ndi utsogoleri boma mosiyanasiyana atypical kukhalapo kwa zosakaniza mapeto sangathe lilibe) ali pabwino monga mankhwala zingakhale otetezedwa, koma ndi proviso kuti si yeniyeni "Poyankha" pa gawo la thupi milandu munthu akadali zotheka.

Analola sewero:

• GI: m'mimba, pakamwa youma, kupweteka kwa matenda pamimba, nseru;
• mtima ndi magazi mizere: kuwonjezeka yofunika kwambiri mu mtima umagunda mofulumira;
• ziwengo, urticaria, hematoma kuderalo;
• dongosolo kupuma: chimfine mphuno ndi kukhosomola;
• CNS: chizungulire, kutopa, maganizo maganizo alternating ndi kumwetsa psychomotor mukubwadamuka;
• minofu ndi mafupa: myalgia ndi arthralgia (kuphatikizapo kupweteka.).
• Other: zizindikiro khalidwe la matenda pachimake kupuma ndi fuluwenza.

Zofooka ndi contraindications

"Montelukast" (malangizo ntchito ndi ndemanga kwambiri zabwino, ndipo mauthenga uli m'bukuli, mwa mawu a Kudziwa mafunso anthu a ku Forum ndi pafupifupi palibe) sadzakhala ntchito ngati:

• Iwo anapeza tilinazo kuchuluka kwa zikuchokera mankhwala (zambiri zoona kwa mitundu yonse ya mapiritsi);
• matenda tinatengera matenda osowa, kuphatikizapo anthu amene chamoyo si kuphunzira galactose kapena akukumana yovuta lactase akusowa (lamulo ili siligwira ntchito kwa kutafuna mapilisi);
• wodwalayo ali wolemedwa ndi phenylketonuria;
• wodwalayo sanabadwe anatembenuka zaka ziwiri (cha miyala lokutidwa "zaka malire" - zaka 15).

Ambiri osokoneza: Zizindikiro ndi Chithandizo

Kafukufuku wasonyeza, "Montelukast" 4 mg (maumboni za mawonekedwe malonda reagent ndi zoona, zofanana ndemanga kuti akupita kutafuna analogs munali 5 mg wa mankhwala yogwira) owonjezera mlingo tsiku mowa ali pa zotsatira mofanana 10 mg . Zizindikiro kwambiri kutchulidwa cha mankhwala osokoneza bongo Tingaone odwala gulu wamng'ono. Akulu, ngakhale pamene mukumwa 200 mg / tsiku kwa miyezi 5, ena zochita nthenda anali anaona.

The nkhani umodzi chizindikiro cha kuchuluka kwa mankhwala ndi:

• wosazima ludzu;
• kusinza;
• mmimba kupweteka m'dera;
• kusanza;

Chithandizo ikuchitika, zochokera chithunzi matenda anati. Information za mphamvu ya hemodialysis kwina.

Mwanjira mankhwala, ndi analogues otchuka

"Montelukast" 5 mg (ndemanga za kutafuna zitsanzo anatsala madokotala, wiritsani pansi zoti mankhwala, mosakayikira, woyenera chidwi cha makolo achinyamata), komanso njira zina leukotriene cholandilira antagonist, pamene ntchito mu kufanana ndi wothandizila zogwirizana imathandizira mphamvu zabwino : zizindikiro mphumu kumakhala kosavuta kwambiri, chiwerengero cha anthu odwala matenda utachepa. Komabe, kusiya mwadzidzidzi mankhwala ikuchitika pamaziko a corticosteroids Mpweya ali osavomerezeka.

Kusiyana kwambiri njira pharmacokinetic yokhudza theophylline ndi prednizola wapezeka. Koma mayamwidwe pa "mwa" phenobarbital amachepetsa ndi mochuluka momwe 40%.

Reagents kuti ziletsa kaphatikizidwe CYP3A4 isoenzyme, ayenera kugwiritsidwa ntchito moyang'aniridwa ndi achipatala.

Kandalama analogs kuti Kawirikawiri pa zogulitsa:

• "Monkasta".
• "Singlon".
• "Singulair".
• "Ektalust".
• "Singuleks".

"Singulair" kapena "montelukast": ndemanga madokotala ndi mankhwala

Malinga pharmacologists Katswiri, mtsutso zimene mankhwala ndi abwino ndi othandiza kwambiri, tanthauzo, popeza "Singulair" ndi "montelukast" ali m'modzi ndipo olingana mankhwala m'munsi. Wangomwalira woyamba mtundu dzina setifiketi kalembera, ndipo lachiwiri ndi mayiko. madokotala munthu ndi odwala, Koma zimatengera maganizo osiyana ndi kuganizira mankhwala anagawira pansi pa alendo yekha zolondola chisankho.