Mankhwala "Doxorubicin": malangizo Buku, ndemanga, photos, mawonekedwe kumasulidwa, mlingo yosungirako. "Doxorubicin-Lance": malangizo ntchito

The khansa ndi loopsa kwambiri kuti moyo wa munthu. Amakhala ndi zilonda ndi kusalankhula maselo proliferating, okhoza kulowa mu minofu ozungulira ndi metastasize ziwalo zina.

Kukula kwa mankhwala ndi chithandizo kwa matenda ndi yofunika kwambiri. Mwatsoka, kufikira tsopano palibe munthu mpaka mapeto ndipo Ine ndiribe anaganiza. Ngakhale pali mankhwala amachepetsa gulu la maselo chotupa. Mmodzi wa iwo amatchedwa mankhwala "Doxorubicin". Malangizo ntchito ndi chithunzi cha mankhwala lidzadzala m'nkhani ino. Mmenemo mungapeze mfundo za mmene anati njira imene kupanga lilipo zogulitsa, ndi zambiri.

Kenaka, zikuchokera, mawonekedwe ndi kufotokozera

Mu mawonekedwe zomwe chogulitsidwa "Doxorubicin"? Malangizo ntchito akusonyeza mitundu zotsatirazi mankhwala:

• Lyophilizate kwa yokonza njira yothetsera intravascular ndi intravesical jekeseni. Ndi red-chikasu porous misa ndipo lili ndi mankhwala yogwira monga doxorubicin hydrochloride. zosakaniza monga zina pogwiritsa ntchito mannitol. Mankhwala chogulitsidwa mabotolo, akachita mukatoni.
• Muzilimbikira yopangira yankho kwa intravascular ndi intravesical jekeseni. Ndi madzi ofiira ndi mandala muli doxorubicin hydrochloride ndipo amapezeka mu mabotolo ndi makatoni.

The mankhwala mankhwala

ndi mankhwalawa monga "Doxorubicin" n'chiyani? Malangizo (mawonekedwe amasulidwe mankhwala anali tanena) ntchito akusimba kuti ndi odana ndi chotupa anthracycline mankhwala, amene anali olekanitsidwa zikhalidwe za bowa Streptomyces peucetius. Iye akhoza kuchita khama zotsatira antimitotic ndi antiproliferative.

Zimavuta ndi DNA, ndi medicament kumabwezera mmbuyo RNA polymerase, DNA polymerase ndi topoisomerase mtundu 2, komanso imayendetsa yopanga ankafuna kusintha zinthu mopitirira ufulu ndi kumachita pa khoma selo. Chifukwa cha limakhudza kubweza DNA kugawanika ndi kwachilengedwenso mkati asidi kaphatikizidwe.

N'kosatheka kuona chakuti tiganizire njira ali mwachindunji cytotoxic kwenikweni. maselo kuonetsa tilinazo makamaka mankhwala mu G2-gawo ndi S-gawo la moyo wawo.

katundu kayendedwe

magawo Kodi kayendedwe chibadidwe mankhwala "Doxorubicin"? Malangizo ntchito limanena kuti pambuyo jekeseni mtsempha, chida nthawizonse anagawira multiphase. Pa tsiku loyamba Mphindi 5 medicament mofulumiracho. analanda minofu, ndi ndende zake magazi amachepetsa mofulumira. Nkhani yachiwiri, izo ikuchitika mamolekyulu mankhwala pang'onopang'ono kuchokera zimakhala ndi.

Limafotokoza yogwira mankhwala chiwindi, impso, ndulu, mapapo ndi myocardium. Komanso likulowerera latuluka ndipo excreted ndi mkaka wa m'mawere.

Anayankha mapuloteni plasma amapezeka ndi 75%. Kagayidwe wa mankhwala chiwindi, potero musayambe otumphukira yogwira monga doxorubicinol.

Pa kuchepetsa ankafuna kusintha zinthu mopitirira ufulu kaphatikizidwe enzyme zingakhudze chitukuko cha kawopsedwe mtima.

Theka moyo wa doxorubicin ndi doxorubicinol zofanana ndi za 20-48 maola.

Pafupifupi 40% ya mlingo wa mankhwala adzamasulidwa pamodzi ndi ya ndulu, ndi% 6-11 yekha wa doxorubicin ndi ena ofanana kwa masiku 5 zimapezeka mkodzo.

zikuonetsa

mankhwala "Doxorubicin" Akhozanso kusankha pa matenda?

Malangizo ntchito (khansa chikhodzodzo ndi chida ntchito zambiri) limati mankhwala amene akuchita bwino pamene:

• chithokomiro England khansa, sarcoma Kaposi ndi Ewing;
• Wilms 'chotupa m'mimba muzituluka khansa, ang'ono selo khansa ya m'mapapo;
• insulinoma, khansa ya m'mawere Mesothelioma;
• esophageal khansa, carcinoid, neuroblastoma;
• osteogenic sarcoma, chachikulu hepatocellular carcinoma, sanali Hodgkin a lymphoma ;
• Cancer ya prostate, khansa ya mutu ndi khosi, zilonda thymoma;
• khansa khomo lachiberekero, mitundu ina ya zotupa testicular;
• uterine sarcoma, endometrial khansa, matenda Hodgkin ndi;
• rhabdomyosarcoma, pachimake khansa;
• aakulu lymphocytic khansa, angapo myeloma.

contraindications

Kodi mmene wodwalayo mankhwala Musamletse mankhwala "Doxorubicin"? Malangizo ntchito, oncologists lenileni kuti chida likutsimikizira osati kwambiri mu:

• zina kuti doxorubicin kapena zinthu zina mankhwala, komanso oimira anthracyclines ndi anthracenediones;
• mankhwala isanafike, kapena anthu ena a anthracenediones anthracycline mu Kuchepetsa Mlingo, komanso kulephera chiwindi (aakulu), m'mnyewa wamtima infarction, arrhythmias, matenda pachimake tizilombo ndi matenda a mtima (pa makonzedwe mtsempha);
• zotupa zilonda, germinating mpanda wa chikhodzodzo, kwamikodzo thirakiti matenda cystitis (kwa intravesical).

Mosamala kwambiri, mankhwala ayenera kugwiritsidwa ntchito pa anthu amene tima Morning, komanso zinthu chiopsezo cha cardiotoxicity, kuphwanya chiwindi, mafupa kusalola maselo a khansa ndi kunenepa.

Komanso mosamala mankhwala Kwalamulidwa kwa ana ndi anthu okalamba, ndi mbali ya Mipikisano mitundu ndi multicomponent antitumor mankhwala.

Mankhwala "Doxorubicin": malangizo ntchito, mlingo

Malinga ndi malangizo amene ankaona mankhwala angathe kuperekedwa intraarterially, kudzera m'mitsempha intravesically. Iwo ayenera kukumbukira kuti chida adzakhala ntchito singly kapena limodzi ndi mankhwala ena cytostatic mu Mlingo osiyana.

Reconstituted mankhwala njira "Doxorubicin" ndi ntchito yomweyo pambuyo kupanga ake.

Mtsempha chiphunzitso jekeseni

Pa mlingo otero monotherapy "Doxorubicin" pa mkombero ndi 60-75 mg / sq. M milungu itatu iliyonse. Childs, mankhwala jekeseni kamodzi. Komabe, mankhwalawa akhoza kutumikiridwa ndi kubayidwa (mu kuchuluka kwa 25-30 mg / sq. M patsiku kwa masiku 3 kuzungulira).

Kuchepetsa zotsatira poizoni wa njira ntchito yoyang'anira mlungu ndi mlungu 10-20 mg / sq. mamita pa sabata.

Pamene pamodzi ndi atumiki anticancer yogwira medicament ndi kutumikiridwa mu mlingo mkombero mu kuchuluka kwa 30-60 mg / sq. M pa masabata 4.

maphunziro mobwerezabwereza mankhwala ikuchitika pambuyo pothetsa zizindikiro zonse kawopsedwe.

Mlingo okwana mankhwala sayenera oposa 550 mg / sq. m.

Kwapakati pa-wolumikizira utsogoleli wa m'mwamba

Kodi jekeseni kwapakati pa-wolumikizira "Doxorubicin" mankhwala? Atsogolereni limanena kuti kupereka sidetone anthu ndi hepatocellular carcinoma yogwira medicament zimene tikubweretsazi kwa mtsempha wamagazi wamba kwa chiwindi mu mlingo wa 35-150 mg / sq. m. Pa intervals nthawi yomweyo pakati m'zinthu ayenera kukhala wolingana kwa masabata 3 mpaka miyezi 3.

Mawu oyamba a mankhwala mu chikhodzodzo

Monga chikhodzodzo jekeseni mankhwala "Doxorubicin-Teva"? Malangizo ntchito inanena kuti mlingo izi zikutanthauza kuti makonzedwe intravesical ayenera kukhala 35-50 mg wa pa unsembe.

chamankhwala ziyenera kuperekedwa pa intervals wa masiku 7-28, malingana ndi cholinga (kupewa kapena chithandizo).

Ambiri njira mankhwala akhale 1 mg / 1 njira ml ya madzi kapena thupi.

Instillation imagwiridwa pasanathe maola 2. Kumapeto kwa wodwala ayenera tidzikhuthule chikhodzodzo.

zotsatira zoyipazi

Kukonzekera "Doxorubicin", limene malangizo tafotokozazi Chifukwa cha zochita zotsatirazi mbali:

• kusanza, kupweteka m'mimba, kunyansidwa, matenda a m'matumbo, stomatitis, kutsekula m'mimba, esophagitis, m'kamwa mucosa hyperpigmentation, anorexia, kuchuluka bilirubin ndende m'magazi, m'mimba magazi, kuchuluka transaminases kwa chiwindi;
• kumwa mankhwala amadalira kusintha leukopenia, thrombocytopenia, kuchepa magazi, leukopenia, neutropenia;
• nkusani tachycardia, atrioventricular chipika, tachyarrhythmia mawonekedwe congestive kulephera mtima, bradycardia, thrombophlebitis, nthambi chipika Wake mtolo, kuvutika pa ECG, yamitsempha yamagazi arrythmia, embolism m'mapapo mwanga, phlebitis, zosokonezeka thromboembolic;
• amenorrhea, oligospermia, hyperuricemia, mkodzo wofiira kudetsa, azoospermia;
• conjunctivitis, keratitis, lacrimation;
• zotumphukira neurotoxicity, khunyu, chikomokere;
• edema, kusintha alopecia, photosensitivity, khungu hyperpigmentation, zotupa, kuyabwa, kupweteka kwambiri, zotupa erythema, lonyowa khungu;
• dermatitis, zotupa bronchospasm, khungu ankatenthetsa, anaphylaxis;
• Local phlebitis, amalembedwa kutupa, fleboskleroz, thrombophlebitis, ululu wamba, minofu necrosis;
• polyuria, nocturia, dysuria, necrosis a chikhodzodzo zimagwira ntchito zosiyanasiyana, hematuria, kusapeza, kupweteka pokodza;
• erythematous striation pa malo jekeseni;
• kutopa, malaise, malungo, kuzizira, chitukuko cha lymphocytic kapena myelocytic khansa ya m'magazi (pachimake), hyperuricemia, mafunde, nephropathy;
• chilonda 12 mmatumbo / chapamimba, biliary sclerosis.

Zizindikiro cha mankhwala osokoneza bongo

Kodi zizindikiro cha mankhwala osokoneza bongo zimachitika pamene inu ntchito ambiri "Doxorubicin" mankhwala? Malangizo Ntchito ananena kuti ambiri osokoneza la ndalama kungachititse kuti zizindikiro poizoni ndi kuwonetseredwa mwa dongosolo m'mimba, komanso myelosuppression kwambiri. Komanso, mlingo waukulu wa mankhwala kungakhale N'zosavuta matenda pachimake mtima.

Mankhwala mankhwala "Doxorubicin" kulibe. Mu ambiri osokoneza bwanji kutumikiridwa mankhwala symptomatic. Komanso, iwo m'chipatala ndi asonyezedwa mankhwala antibacterial.

Mwanjira mankhwala

Kodi n'zotheka zimagwirizizirana ndi mankhwala ena mankhwala "Doxorubicin"? Malangizo ntchito zikuwonetsa kuti pamene inu ntchito chida ichi limodzi ndi mankhwala ena cytotoxic zambiri akuwonetseredwa zowonjezera awo kawopsedwe.

Pamene osakaniza mankhwala ndi mankhwala ena cytotoxic, amene cardiotoxicity (mwachitsanzo, "FU" kapena "Cyclophosphamide"), amafuna polojekiti mosamala mtima pa njira yonse ya mankhwala.

"Streptozocin" kumawonjezera theka moyo "Doxorubicin".

The mankhwala "Doxorubicin" wodwala akhoza kusonyeza zizindikiro za pachimake hemorrhagic cystitis mankhwala "cyclophosphamide", komanso kwambiri chodabwitsa cha kawopsedwe chiwindi mankhwala "mercaptopurine."

Ntchito "Paclitaxel" pamaso oyamba enieni a "Doxorubicin" imfayo kuwonjezeka mu ndende magazi a mtsogolo.

Kodi mankhwala akuletsedwa ntchito mankhwala "Doxorubicin"? Malangizo ntchito (nyama ndi sanagaŵiridwe) akusimba kuti chida ichi sayenera wothira mankhwala ena. Mwachitsanzo, ndi pharmaceutically yogwirizana ndi "heparin", "Dexamethasone", sodium succinate, "hydrocortisone", "cephalothin", "aminophylline", "FU" ndi mankhwala ena anticancer.

Pamene pamodzi ndi katemera moyo tizilombo ndi zotheka tizilombo kugawanika ndi kuchuluka zochita mbali ndi kuchepa oteteza kaphatikizidwe m'thupi wodwala poyankha ntchito katemera.

ayamikira enieni kugwiritsa ntchito mankhwala

Zimene muyenera kudziwa musanagwiritse ntchito "Doxorubicin-Lance"? Malangizo ntchito limasonyeza kuti njira ya mankhwala wothandizila antineoplastic zofunika kuchita polojekiti nthawi zonse ntchito chiwindi, chithunzi cha zotumphukira magazi, ECG ndi ultrasound za mtima.

malonda zinthu, njira yosungirako ndi alumali moyo

Kodi mankhwala "Doxorubicin-Lance"? Malangizo ntchito inanena kuti chida ichi iyenela wouma ndi mdima malo kutentha si upambana madigiri asanu.

medicament The adzamasulidwa ku pharmacies ndi mankhwala okha. alumali moyo wake ndi zaka ziwiri.

Price ndi analogues

Mtengo wa mankhwala imatengedwa 120-150 rubles mu 5 ml. Ngati kuli kofunikira akhoza m'malo mwa monga "Doxorubicin-Teva", "Lachema Doxorubicin", "Onkodoks 50", "10 Onkodoks", "Doxorubicin-Ebewe", "CRC-Doxorubicin" ndi ena.

ndemanga ogula la mankhwala

Tsopano inu mukudziwa momwe ntchito mankhwala "Doxorubicin". Malangizo ntchito ndi kusunga mankhwala anali kuperekedwa pamwamba.

Ndithu ambiri ndemanga ogula kugwirizana ndi zochita kwambiri chowawa komwe kumachitika nthawi chithandizo ndi mankhwala. Kuti zotsatira ali okhudzidwa mkati limba, okhalitsa kudwala, tsitsi imfa ndi mapangidwe zilonda malo jekeseni.

Pa uthenga abwino n'zochepa kwambiri. Ndipo zimenezi si zodabwitsa, popeza mphamvu ya anticancer mankhwala ayenera kuunikira yekha odziwa katswiri, zochokera ambiri zinthu zosiyanasiyana: mtundu wa monotherapy mankhwala osakaniza, khansara, alili, ndi zotsatira zina yaitali.