Subleukemic myelosis - ndi chosaopsa zosinthika khansa aakulu

Subleukemic myelosis ndi limodzi la khansa pang'onopang'ono aakulu, kumene chifukwa cha matenda amakhala kusintha pathological maselo kalambulabwalo myelocyte. Imodzi ndi mkhutu kusasitsa maselo hematopoietic mu ndondomeko matenda anayamba zotakasika zotupa fibro-sclerotic mu mafupa a mafupa ndi psinjika concomitant za mafupa ndi kusintha proliferative mu ndulu ndi chiwindi. N'chifukwa chake subleukemic myelosis anatchula khansa monga myeloproliferative.

Zifukwa myelofibrosis ndi mitundu ya matenda

Nthawi zambiri, matenda kumachitika odwala amene ali zaka 50 ndi achikulire, kotero mtengo ena Ufumuyo wonongeka majini a nyukiliya maselo kholo zinthu tsinde, matenda autoimmune, matenda tizilombo. Morphological gawo lapansi amakhala mieloza kusintha onse atatu nyongolosi hematopoiesis - granulocytic, megakaryocytic ndi erythroid. Zili ndi choopsa mwa matenda amenewa ndi zimatengera matendawa ndi madokotala ananena zawo.

Nthawi zambiri subleukemic myelosis chimaposa m'malo chosaopsa, ndipo pali malumikizanidwe pakati pa zaka mtima pa nthawi ya isanayambike matenda ndi madokotala ananena zawo - wamng'ono wodwalayo, zimakhalanso zovuta myelofibrosis amapezeka. Mu siteji osachiritsika a matenda, amene angathe pambuyo 5-15, ndipo ngakhale zaka 20 pambuyo kudziwika zizindikiro woyamba, odwala akhoza kuphulitsa mavuto. Ndiye matenda amatenga pa mbali khansa pachimake: ambiri mabomba kuwonekera magazi zotumphukira. Zizindikiro za chotero chitukuko cha matenda ndi malungo, zizindikiro za kuledzera, akupereweredwa magazi hemorrhagic matenda. Nthawi kuchuluka ndulu ndi chiwindi. Odwala ena, mwina mofulumira Kukula kwa matendawa ndi maonekedwe oyambirira a matenda a magazi ndi anemizatsiey wodwalayo.

The matenda chithunzi subleukemic mieloza

Nthawi zambiri odwala nkhawa anasonyeza kufooka ambiri, kulemera m'mimba, amene kumawonjezera ndi gulu makamaka pambuyo chakudya (Chifukwa cha kuwonjezeka kwambiri mu ndulu ndi chiwindi). Pali kulira kwa mutu, kupweteka mafupa ndi msana. kawirikawiri, mu siteji osachiritsika a matenda, wodwalayo angathe aakulu chisokonezo imalandira. dokotala ayenera kukusalani Masitima achingwe am'mapiri myelosis - chikhalidwe pathological ya ubongo imene kumachitika pamene ena megaloblastic magazi m'thupi. chikhalidwe ichi nthawi zambiri amapezeka mu magazi, kumene kumachitika odwala ndi madyedwe osakwanira vitamini B12 mu thupi.

Komanso, thrombosis amayambira, amene akukhala chifukwa cha nambala kuchuluka kwa maselo othandiza magazi kuundana m'magazi zotumphukira ambiri, ndipo krovi.Poslednee matenda coagulation ingayambe ndi morphological chosakhwima ngakhale ambiri ndithu yaikulu ya maselo othandiza magazi kuundana. Pasanapite nthawi yaitali, thrombocytosis kumabweretsa chitukuko cha splenomegaly, koma ndulu ya ayamba kuphwanyaphwanya osati othandiza magazi kuundana komanso maselo ofiira a magazi, zomwe zimabweretsa chitukuko cha magazi m'thupi.

The mosamala pulogalamu ndi chithandizo chosiyanasiyana odwala

Matendawa "myelosis subleukemic" chiyenera kuikidwa osati pamaziko a mayesero matenda magazi, ndi zotsatira za puncture sternal kapena iliac trepanobiopsy. Kusintha magazi zimadalira si yeniyeni ndi kokha pa chizindikiritso cha kuchuluka kapena kuchepa kwa chiwerengero wa maselo a mwazi ndi kusintha chiwerengero sangathe apezeke "subleukemic myelosis".

Chithandizo cha matendawa alinso amadalira boma la m'mafupa ndi kupezeka kuvutika Mafupa. Nthawi zina, zokwanira zazikulu ananena wodwala, pamene myelofibrosis msanga patsogolo ayenera kukhala poika mankhwala mankhwala amphamvu.

Mu siteji osachiritsika a matenda zina, ayenera kukumana ndi cheza mankhwala chachikulu Kusankhidwa kwa chithandizo cha mankhwala pachimake myeloid pulogalamu ya m'magazi mankhwala, kuchotsa ndulu - koma pa nkhani iliyonse mankhwalawa matenda wodwala ayenera kusankha panthawiyi, dokotala oyenerera.