Monocytic ehrlichiosis munthu: matenda ndi mankhwala

Monocytic ehrlichiosis munthu - ichi ndi chosowa nthenda oyamba ndi bakiteriya a banja Ehrlich. Kudwala angasonyeze kuwonjezeka lakuthwa kutentha thupi, mutu, kupweteka kwa minofu (myalgia), kuzizira, osadziŵika kutopa, kufooka. Symptomatology zimawonedwa mu masabata angapo pambuyo matenda koyamba. Komanso, nthawi zambiri chifukwa cha mayesero zasayansi anaulula kuchepetsa chiwerengero cha othandiza magazi kuundana mu kufalitsidwa magazi (thrombocytopenia) pamodzi ndi kuchepa woyera achiyesa maselo a magazi (leucopenia), ndi kuwonjezeka nthenda mu kuchuluka kwa zina michere chiwindi (kwa chiwindi transaminase). Nthawi zina, zizindikiro patsogolo ndipo anasonyeza mwa nseru, kusanza, kutsekula m'mimba, kuwonda, imfa lathu mu mlengalenga. Ngati wodwala wapezeka anthu monocytic ehrlichiosis, mankhwala ayenera kutsatira yomweyo pambuyo matenda, chifukwa pakalibe ndi matenda mokwanira mankhwala kumabweretsa mavuto oopsa monga kulephera aimpso kapena kupuma. Onyamula matenda ndi nthata.

Zizindikiro

Monocytic ehrlichiosis munthu, zizindikiro zimene n'zosavuta kusokonezedwa ndi zizindikiro za matenda ena opatsirana, ndipo anapezeka n'zochepa posachedwapa ankafufuza. Childs, kudwala akuwonetseredwa pafupifupi milungu itatu pambuyo Mafunso Chongani kuluma - Ehrlich mabakiteriya chonyamulira banja. Poyamba, odwala matenda zizindikiro mmene matenda, kuphatikizapo kuwonjezeka lakuthwa kutentha thupi ndi zofooka ambiri. Nthawi zina, zotupa pa khungu ndi anawonjezera kuti zizindikiro zimenezi. Mu matenda akulu wodwala wotaya kudya, kuonda kudya ndipo ali pangozi ya matenda a anorexia matenda. Nthawi zina, pali zizindikiro za ehrlichiosis n'kukhala - monga chifuwa, kutsegula m'mimba, zilonda zapakhosi (pharyngitis), ndipo ululu m'mimba.

Nthawi zambiri, pamene anthu monocytic ehrlichiosis ndi achifwamba, matenda kumafuna MAGAZI. The zotsatira za mayeso izi (Kulumikizana leuko- ndi thrombocytopenia pamodzi ndi okwera nthenda ya michere chiwindi) kulola mtima kuika matenda zolondola. Nthawi zina, wodwalayo komanso amadwala kutupa chiwindi (a chiwindi).

Popeza mankhwala okwanira kukhala aakulu monocytic ehrlichiosis munthu. Zizindikiro za matendawa pa siteji amasiyana mawonetseredwe muyezo kachilombo ndi lofotokozeredwa m'njira zochitika zotsatirazi ndipo umati:

• kufupika kwa mpweya (dyspnea, dyspnea);
• mavuto ndi clotting magazi (coagulopathy) zimene zingachititse kuti magazi kapepala kakuti m'mimba;
• matenda a ubongo chifukwa matenda oziziritsa ndi msana (chapakati mantha dongosolo).

Ngati matenda kusesa chapakati mantha dongosolo, wodwala ndi matenda a "anthu monocytic ehrlichiosis" wapezeka nthenda minofu (chotupa) ku ubongo. Komanso, nthawi zina anayamba meninjaitisi - kutupa atetezeke Kakhungu nembanemba a ubongo ndi msana. madzimadzi Cerebrospinal Angagwiritsidwenso anakhudzidwa ndi matenda.

mawonetseredwe minyewa

Zizindikiro ubongo wa matenda monga:

• disorientation;
• nthenda kudziwa kuwala (photophobia);
• stiffness mu khosi;
• Makanema a ntchito kusalankhula magetsi mu ubongo (kukomoka);
• chikomokere.
• Nthawi zina, pali:
• mwauchidakwa kwambiri zochita reflex (hyperreflexia);
• incoordination kayendedwe zaufulu (ataxia);
• tsankho imfa ya luso galimoto minofu nkhope chifukwa kuwonongeka kwa wina (kapena kuposa) la awiriawiri khumi ndi awiri a misempha kugwirizana ndi ubongo (palsies cranial mitsempha).

Monocytic ehrlichiosis ndi anthu granulocytic anaplasmosis pakalibe kuchipatala cha matenda ndi moyo pachiswe.

zifukwa

Mitundu yonse ya kudwala kusanthula oyamba ndi bakiteriya a m'banja la Ehrlich. Tizilomboto monocytic ehrlichiosis munthu imatengedwa galamu-negative.

Akukhulupirira kuti chifukwa chachikulu cha matenda - bango kuluma. Ena mwa tizilombo awa ali ndi tizilombo toyambitsa matenda.

Kamodzi mu thupi kupyolera mu magazi, Ehrlichia kufalitsa mwa mwazi ndi ziwiya lymphatic. Lymph - a thupi madzimadzi onyamula maselo cholinga kulimbana ndi matenda opatsirana. mabakiteriya kukhazikika ena maselo (monocytes ndi macrophages), lomwe mbali kwambiri kukhalabe chamoyo khola la chitetezo cha m'thupi. Maselo amenewa chidzakantha mabakiteriya ndi kukonzedwa (ndondomeko amatchedwa phagocytosis), monga mabakiteriya ndi zinthu zina yachilendo. Komabe, Ehrlichia angatithandize kudzifufuza zachilengedwe chitetezo cha m'thupi akuyamba kukula mu vacuoles - mphako, atazungulira Kakhungu. matendawa amakhudza osati monocytes ndi macrophages mu magazi, komanso mitundu ina ya zimakhala thupi (kuphatikizapo mafupa, lymph mfundo, chiwindi, ndulu, impso, m'mapapo ndi madzimadzi msana).

Differentsiatsialnaya matenda: granulocytic anaplasmosis

Zizindikiro za matenda izi zikhoza kusokonezedwa ndi zizindikiro za pathologies ena. Nthawi zambiri masiyanidwe matenda kukhala monocytic ehrlichiosis ndi anthu granulocytic anaplasmosis.

Mosiyana Mach, granulocytic anaplasmosis oyamba ndi bakiteriya ndi dzina labwino Anaplasma. Bakiteriya adatengedwa ndi nkhupakupa, zimakhudza ena granular maselo magazi woyera - neutrophilic granulocytes. Maselo amenewa zedi mu ndondomeko ya phagocytosis ndipo amakhala amachititsa chiwonongeko cha tizilombo ting'onoting'ono zoipa. Pamene kachilombo Anaplasma zizindikiro lililonse zambiri akuwonetseredwa mu sabata pambuyo Mafunso Chongani kuluma - mabakiteriya transporter. Pafupifupi nthawi zonse, wodwala akudwala malungo, kuzizira, kupweteka kwa minofu (myalgia), kufooka ambiri, kutopa, kupweteka kwa mutu. Nthawi zina palinso chifuwa, kusanza ndi / kapena disorientation. Komanso, granulocytic anaplasmosis ofanana ndi matenda monga anthu monocytic ehrlichiosis, chifukwa chakuti zotsatira za mayesero magazi anapeza kuwonjezeka chomwecho zina michere chiwindi (kwa chiwindi transaminase). Nthawi zambiri undiagnosed ndi magazi m'thupi anachititsa ndi kuchepa nthenda mu mlingo wa maselo ofiira mu magazi kufalitsidwa. Popeza mankhwalawa limapezeka pa chiopsezo amayamba kulephera aimpso. Mu US, milandu ya anthu granulocytic anaplasmosis kaŵirikaŵiri olembedwa limati kumpoto chakum'mawa ndi kumadzulo.

malungo sennetsu

Monocytic ehrlichiosis munthu (Mach) kulekanitsidwa komanso malungo sennetsu - kwambiri bwino kudziwika ndi chosowa kwambiri matenda a subtype wa ehrlichiosis anthu oyamba ndi bakiteriya ndiponso moyenera dzina - Ehrlichia sennetsu. A masabata angapo pambuyo matenda koyamba kukhala ndi zizindikiro zofanana ndi zizindikiro wamba Mach: kuwonjezeka lakuthwa kutentha thupi, mutu, kupweteka kwa minofu (myalgia). Odwala ena ndi nseru, kusanza kapena kusowa chilakolako mpaka matenda a anorexia. Komanso, zotsatira za MAGAZI Tingaone kuchepetsa mlingo wa woyera achiyesa maselo a magazi (leucopenia) ndiponso kuchuluka pathological mu buku la michere chiwindi. Chonyamulira (kapena chonyamulira) malungo sennetsu akadali osati ndendende anakhazikitsa; asayansi ena amanena kuti kungakhale nkhupakupa, pamene ofufuza ena amanena kuti matenda akhoza kukhala ndi kachilombo atatha kudya nsomba zosaphika. Pa nthawi, matenda anali kokha mu kum'mawa kwa Japan ndi Malaysia.

Lyme borreliosis

Lyme borreliosis - matenda oyamba ndi bakiteriya, spirochetes wa banja Borrelia. Onyamula vredosnosnyh tizilomboto ali Ixodes scapularis. Nthawi zambiri, matenda makamaka owonetseredwa maonekedwe a chotupa wofiira pa khungu, amene amaoneka woyamba ngati anakweza zozungulira malo a kukula yaing'ono (papules). Papule akuyamba kukula mofulumira ndipo kenako ukufika masentimita osachepera asanu awiri. Pambuyo kuti pali symptomatology, amakhala ndi monocytic ehrlichiosis munthu. Mwina wa matenda a Lyme borreliosis kwambiri m'munsi kuposa ngozi kugwira Mach, koma masiyanidwe matenda akhala n'kofunika kudziwa matenda. Odwala Lyme borreliosis komanso Kawirikawiri malungo (osati monga lakuthwa ndi oopsa, monga Mach), kuzizira, myalgia, mutu, kufooka, kutopa ndi kupweteka kapena stiffness mu mfundo zikuluzikulu (opatsirana nyamakazi), kawirikawiri mu mawondo. The symptomatology akhoza kutenga maonekedwe a m'zinthu kobwereza. Zikavuta, ngati sanalandire chithandizo ananena matenda a ubongo ndi matenda a minofu mtima. Malinga ndi kafukufuku, ambiri a Lyme borreliosis zimapezeka kumpoto chakum'mawa kwa United States. Komabe, pali milandu kachilombo ndi m'mayiko ena, kuphatikizapo China, Japan, Australia ndi mayiko ena a ku Ulaya.

piroplasmosis munthu

Monocytic ehrlichiosis munthu, mpata matenda tingati ndi apamwamba kuposa kutenga matenda ndi tizilombo ena, si yekha zikanavulaza nthenda adatengedwa ndi nkhupakupa. Piroplasmosis munthu (mu mawu ena - babesiosis) - matenda chifukwa cha yaying'ono-zamoyo zokhala ndi selo imodzi pa banja la Babesia. Nthawi zambiri matenda amakhudza nyama, koma nthawi zina pali milandu ya anthu omwe ali ndi. Makamaka, akukhulupirira kuti nkhupakupa ali ndi Babesia kuti akhoza parasitize thupi. Piroplasmosis ngati monocytic zizindikiro woyamba ehrlichiosis munthu: odwala amadandaula malungo, kuzizira, kupweteka ululu minofu, nseru, kusanza. Komanso, pali zochitika ngati nthenda kuwonongedwa msanga ndi maselo ofiira a magazi (hemolytic magazi m'thupi), nthenda kuchepa chiwerengero chawo (thrombocytopenia), kuchepa mu okwana achiyesa selo woyera magazi (leucopenia), ndi kukulitsa malire a ndulu (splenomegaly). Anthu ndi zizindikiro zosonyeza zogwira mtima thanzi zingasiyane softness kapena kwina palimodzi. Zikavuta wa piroplasmosis munthu asunga odwala amene kale opaleshoni ndulu (splenectomy) kapena ndi chitetezo ofooka. Nthawi zambiri anapezeka babesiosis anthu kumpoto wa United States, koma pali milandu kudziwika m'mayiko a ku Ulaya.

American mudzichonga Nthenda yofanana ndi tayifodi

Monocytic ehrlichiosis munthu ayenera kuwasiyanitsa ku American mudzichonga ricketsiosis - ochepa chabe nthenda oyamba ndi bakiteriya a banja Rickettsia. Vekitala kulamulira ndi tizilombo yemweyo amene angathe kuwononga anthu monocytic ehrlichiosis. Pamene Nthenda yofanana ndi tayifodi anaona mutu kwambiri ndi zopweteka minofu, malungo, kuzizira, imfa lathu mu mlengalenga. Nthawi zambiri, pambuyo awiri - masiku asanu ndi limodzi pambuyo Mafunso Chongani kuluma pali zotupa pa khungu, makamaka kuphimba zikhatho, woimbayo mapazi, akakolo ndi mkono wonse wakumanja. Kenako, zidzolo afalikira mpaka kumaso, torso ndi mwendo m'munsi. Nthawi zina pali nseru, kusanza, kupweteka m'mimba. Nthawi zina, pamene matenda si matenda mu nthawi, kapena sitili pa mankhwala okwanira, zizindikiro za bango ofalitsidwa ricketsiosis US akhale moyo pachiswe. Kubuka matenda zalembedwa mu madera osiyana a US.

diagnostics

Oterewa anthu monocytic ehrlichiosis, matenda okhoza chifukwa zizindikiro oopsa muyenera kugwiritsa ntchito mokwanira Kupenda mankhwala, kusanthula ndi mayesero lopanda matenda ndi zasayansi apadera. MAGAZI zambiri amasonyeza mawonetseredwe ankaikira anthu monocytic ehrlichiosis: kuchepa wofiira achiyesa maselo a magazi (thrombocytopenia), kuchepetsa ena woyera achiyesa maselo (leucopenia), ndi munthawi yomweyo kuwonjezeka mlingo wa chiwindi michere yeniyeni (mwachitsanzo, seramu aspartate aminotransferase ndi alanine aminotransferase). Nthawi zina, chifukwa cha mayesero zasayansi anapeza pathological cerebrospinal madzimadzi. Komanso, chifuwa X-ray akhoza kuona kusintha nthenda mu mapapo (mwachitsanzo m'mapapo mwanga infiltrates kapena owonjezera madzimadzi kudzikundikira).

Research magazi kuipitsa mbiri ya pansi zinthu zosiyanasiyana za mtengo maso amatha kudziwa kudzikundikira mabakiteriya mu vacuoles maselo ena (makamaka monocytes), koma magawo oyambirira matenda masango zimenezi si nthawi zonse kuwoneka. Nthawi zina, zina mayesero apadera zasayansi kudziwa mtundu wa matenda ndi kutsimikiza matenda.

Chotero mayesero apadera monga Mwachitsanzo, mosadziwika immunofluorescence njira kupeza pathologies, imene imakhudza kuphunzira seramu opangidwa pamaziko a magazi wodwalayo. Chitetezo - mapuloteni opangidwa ndi zina maselo oyera - athandize kulimbisa thupi nkhondo poizoni ndi tizilombo zoipa. Pamene ntchito mozungulira immunofluorescence kudetsa wa chitetezo yeniyeni anthu zimalembedwa utoto fulorosenti, seramu anaika cheza ultraviolet ndi tichiphunzire pansi maso ndi kuzindikira reciprocal oteteza anachita tizilombo yeniyeni.

chithandizo

Ngati anatsimikizira matenda a "anthu monocytic ehrlichiosis," kuposa kuchiza matenda? Nthawi zambiri, madokotala mankhwala muyezo mlingo wa mankhwala tetracycline. Ngati mankhwala zina nthawi zina amagwiritsidwa ntchito pa maziko a doxycycline. Zikavuta, wodwalayo angafunike kuyang'aniridwa akatswiri kuchipatala. Kuwonjezera mankhwala, n'zotheka kutenga chilolezo mankhwala aliwonse dokotala kuti atsogolere zizindikiro mmene matenda.

kupewa

Ngati mukukhala dera linalake, amene anthu nkhupakupa zingakhale woopsawo, kuphatikizapo onyamula mabakiteriya banja Ehrlich, ndi zofunika kutenga njira yoyenera. Ngati inu akusiya dziko, kumbukirani kuti muli potero kulera angathe kutenga matenda oopsa monga monocytic ehrlichiosis munthu. Photo nthata ndi anatsimikizira onyamula mabakiteriya, adzakhalabe maso Komabe, kudziwa mdani kuthekera mu nkhope sikokwanira. Azivala mathalauza, malaya ndi T-malaya ndi zazitali manja. Nkofunika kuvala zipewa, zabwino - zotambalala zipewa, monga nthata ambiri amakhala mitengo. Sankhani zovala chowala, popeza Chophweka kuona tizilombo. Ntchito yapadera zida-kufumbwa ndipo onetsetsani onse khungu ndi zovala zambiri kuyendera. Ambiri Mafunso Chongani kulumidwa zimachitika mu scalp ndi khosi.