Kukonzekera "Proxium": malangizo ogwiritsira ntchito, ndemanga, zofanana

Kodi Proxiamu imagwiritsidwa ntchito motani? Malangizo ogwiritsira ntchito mankhwalawa akufotokozedwa mu zipangizo za nkhaniyi. Mmenemo mungapeze zambiri zokhudza mawonekedwe omwe mankhwalawa amapangidwa, kaya ali ndi mafananidwe, ndi cholinga chotani, ndi zina zotero.

Mafomu, ma CD, mawonekedwe a mankhwala

Kodi mankhwala monga Proxyium amapangidwa m'njira yotani? Malangizo ogwiritsira ntchito amasonyeza kuti mankhwalawa alipo ngati mapiritsi oyera mu makhadi a cardboard, komanso mu lyophilizate ndi solvent vial (10 ml).

Mtundu woyamba wa mankhwala uli ndi pantoprazole (40 mg), komanso zinthu zina zowonjezera. Pa botolo la lyophilizate, lili ndi 40 mg yogwiritsira ntchito + sodium hydroxide.

Mankhwala osokoneza bongo

Kodi ndi mankhwala ati a "Proxyum"? Malangizo ogwiritsiridwa ntchito akusonyeza kuti wothandizana ndi antiprocessor ndi antisecretory agent.

Mutatenga mankhwalawa mkati mwake, amaletsa kupanga hydrochloric acid. Izi zimachokera ku chiletso chachitetezo cha proton Nanos chomwe chili m'maselo achiberekero a mmimba.

Mankhwalawa amakhala othandiza kuchepetsa chiwombankhanga, kuphatikizapo mavitamini a pentagastrin, chakudya ndi insulini. Kuphatikiza apo, mankhwalawa amachititsa kuti moyo wa Helicobacter pylori mabakiteriya uwonongeke. Monga momwe zikudziwikiratu, zimakhala ndi kubereka kwake mwakhama kuti mapangidwe a zilonda zam'mimba ndi zowonongeka pamakoma a m'mimba zimagwirizanitsidwa.

Kuwonjezera pa zomwe tafotokozazi, mankhwalawa amachititsa kuti magulu ena amadzimadzi azitsulo azigwira bwino ntchito.

Pharmacokinetics ya mankhwala

Ndi mankhwala ati a pharmacokinetic omwe ali ndi mankhwala a "Proxyum"? Malangizo ogwiritsira ntchito amauza odwala kuti pambuyo pa mlingo woyamba zotsatira za mankhwala zikukula mofulumira kwambiri ndipo zimatha tsiku lonse.

Zambiri mwa mankhwalawa m'magazi a magazi amatha maola anayi mutatha kumwa mlingo wa 40 mg. Mlingo woyankhulana ndi mapuloteni ndi 98%. Miyezi iwiri ya mankhwalawa imatha maola awiri.

Mankhwala amachotsedwa mu impso ndi m'matumbo.

Pantoprazole imalowa m'matumbo aang'ono. Kupezeka kwa chilengedwe ichi ndi pafupifupi 75%.

Mitsemphali ya chida chogwiritsira ntchito mankhwala imapezeka m'chiwindi. Pankhani imeneyi, kugwiritsidwa ntchito, kukhudzana ndi okosijeni ndi machitidwe a dealkylation kumachitika ndi kutenga mwachindunji wa enzyme monga cytochrome P450.

Tiyeneranso kukumbukira kuti mankhwala omwe akugwiritsidwa ntchito mosavuta amapezetsa vuto la magazi. Kuonjezerapo, imatulutsidwa pamodzi ndi mkaka wa amayi.

Kwa okalamba, ndondomeko ya madzi a m'magazi komanso mankhwala omwe amapezeka ndi mankhwalawa ndi apamwamba kuposa odwala.

Pamaso pa chiwindi cha chiwindi, mankhwalawa akhoza kutulutsidwa mpaka maola 9.

Mukasankha?

Tsopano mukudziwa momwe mankhwala a "Proxyum" amagwirira ntchito. Malangizo ogwiritsira ntchito, ndemanga za mankhwala awa amasonyeza kuti zizindikiro zake zogwiritsira ntchito ndi matenda awa:

• Zilonda za m'mimba, komanso zilonda zam'mimba 12 (kuphatikizapo kuwonjezereka);
• Kuchiza kuchokera ku bakiteriya Helicobacter pylori (kutengedwa ngati gawo limodzi la mankhwala ovuta);
• Reflux-esophagitis ndi Zollinger-Alison matenda;
• Kuwonjezeka kwa kupanga madzi ammimba;
• Njira yosavuta ya reflux esophagitis.

Simungagwiritse ntchito

Kodi mankhwala awa, monga Proxyum (mapiritsi), ali ndi zotsutsana? Malangizo ogwiritsira ntchito amauza odwala kuti mankhwala awa sungathe kuuzidwa mwanjira iliyonse:

• Kulephera kokwanira mwachangu;
• Mimba;
• Matenda oopsa m'magulu a m'mimba;
• Kuyamwitsa;
• Kuwopsa kwa zigawo zothandizira mankhwala;
• Ana osapitirira zaka 14.

Ponena za njira yothetsera ampoules, sizowonjezeka kwa odwala omwe sagwirizana ndi Pantoprazole. Kuwonjezera apo, mtundu uwu wa mankhwala sayenera kuphatikizidwa ndi Atazanavir.

Mapepala "Proxium": malangizo othandizira

Mankhwala a mankhwala awa antiulcer adzafotokozedwa kumapeto kwa nkhaniyi. Mu gawo lomwelo, tidzakuuzani momwe mankhwalawa ayenera kutengedwa ndi matenda ena.

Pogwiritsira ntchito "Proxium" ya mankhwala, madokotala ambiri amapereka zofuna zawo pa pepala. Ngati wodwalayo ali ndi vuto ndi kumeza, ndiye kuti akuuzidwa yankho.

Mlingo wa mankhwalawa, komanso regimen ayenera kutsimikiziridwa ndi dokotala yemwe akupezekapo.

Ndiye mungatani kuti mutenge Proxium 40? Malangizo (mapiritsi a mankhwala awa amagulitsidwa m'ma pharmacies onse) akuti mlingo woyenera wa mankhwalawa ndi 40 mg patsiku. Mankhwala amatengedwa pakadutsa chakudya kapena pamapeto, ndi madzi ambiri.

Mukapeza kuti chilonda kapena kutentha kwa m'mimba, mlingo wa tsiku ndi tsiku umakula kufika 80 mg.

Pochiza zilonda za duodenum, mankhwala amatengedwa masiku 15-30. Pa reflux isophagitis ndi zilonda za m'mimba, njira yothandizira matenda otero ayenera kukhala osaposa miyezi iwiri.

Kuti athetse helicobacter pylori mabakiteriya, wodwalayo amalembedwa piritsi 1 kawiri pa tsiku. Kutalika kwa mankhwala otere ndi masabata awiri.

Odwala omwe ali ndi impso kulephera, komanso okalamba samapereka mlingo wa tsiku lililonse woposa 40 mg.

Polephera kuchepa kwa chiwindi ndi chiwindi cha chiwindi, mankhwalawa amaloledwa kutenga 1 piritsi imodzi tsiku ndi tsiku.

Solution Proxium: malangizo othandizira

Mu ampoules, mankhwalawa amalembedwa ngati kuyankhula kwakamwa sikutheka.

10 ml ya njira yothetsera thupi imatsanulidwira mu chiwindi cha lyophilizate. Akatswiri ena amalimbikitsa kuwonjezera kukonzekera ndi 100 ml ya 5% ya shuga.

Kulowetsa m'mimba kumakhala kwa mphindi ziwiri (makamaka ma ola ¼).

Njira yothetsera mankhwalayo iyenera kugwiritsidwa ntchito mwamsanga mutangolumikizana ndi zigawo zonse. Ngati izi sizikufunika, ndiye kuti mankhwalawa ayenera kuikidwa m'firiji ndikugwiritsa ntchito pasanathe maola 12.

Nthawi ya mankhwala ndi mankhwala otero ndi ofanana ndi mawonekedwe apiritsi. Nthawi yochuluka ya mankhwala ndi miyezi iwiri.

Ndi matendawa, monga reflux esophagitis, mankhwalawa amalembedwa mu botolo kamodzi patsiku.

Kuchiza magazi amene anachitika pachilonda cha duodenum ndi m'mimba, komanso kupewa kupewa, mankhwalawa amagwiritsidwa ntchito mu 80 ml mwachangu (bolus).

Utsogoleri wa mankhwalawa umasonyezedwa ndi infusomat pa 8 mg pa ora.

Ndi matenda a Zollinger-Ellison ndi hypersecretion, mankhwala amaperekedwa pa 80 mg. Ngati kuli kotheka, dokotala akhoza kuwonjezera mlingo kwa 160 mg. Pankhaniyi, iyenera kugawa magawo awiri.

Kuti mwamsanga kuchepetsa acidity wa chapamimba madzi, nthawi zambiri 80 mg ya mankhwala amagwiritsidwa ntchito kawiri pa tsiku.

Milandu yowonjezereka

Kodi ndizizindikiro ziti pamene mukudya kwambiri Proxium (40 mg)? Malangizo akuti panopa palibe malipoti a milandu yotereyi.

Pamene mankhwalawa amathandizidwa ndi intravenously (osapitirira 240 mg), amalekerera bwino ndi odwala. Ngati munagwiritsira ntchito mankhwala ambiri, muyenera kugwiritsa ntchito mankhwala othandizira komanso othandizira.

Akatswiri amanena kuti kuwonjezera pa mapiritsi a "Proxy" angapangitse kuwonjezereka kwa mphamvu ndi nthawi zambiri za zotsatira. Pachifukwa ichi, kutenga mapiritsi kumaletsedwa.

Zotsatira Zovuta

Kodi ndi zotsatira zovuta zotani zomwe zingachitike polemba Proxium 40? Malangizo akuti kugwiritsa ntchito chida ichi nthawi zambiri kumabweretsa:

• Kutsekemera, kupweteka kwa m'mimba, kutsegula m'mimba ndi flatulence;
• Cephalgia.

Nthawi zina odwala amayamba:

• Kuwunduka ndi kuphulika pakhungu;
• Kuthetsa;
• Arthralgia;
• Kuuma kwa nsalu za mucous;
• Kuwonjezeka kwa kudya;
• Kuwongolera;
• Angioedema;
• Kufooka ndi kugona;
• Chizungulire.

Milandu ya chitukuko cha zolakwika zotsatirazi adalembedwanso:

• Kusokonezeka maganizo, matenda a myalgia, Lyell's, urticaria, matenda a Stevens-Johnson;
• Ntchito yowonjezereka ya mavitamini a chiwindi, jaundice, kuwonongeka kwa hepatocytes, malungo, nephritis;
• Chisamaliro kuunika, thrombocytopenia, leukopenia;
• Thrombophlebitis (amatanthauza yankho, amapezeka pa malo opangira jekeseni);
• Kudandaula, mantha, kumva bwino ndi masomphenya;
• Mavalasi, alopecia, hyperglycemia.

Kuyanjana kwa Mankhwala

Kodi ndi mankhwala ati omwe mukufunikira kuti mudziwe wodwala musanayambe kutenga Proxyum? Malangizo a chida ichi akuwonetsa izi:

• Mankhwalawa akhoza kuphatikizidwa ndi Diclofenac, caffeine, Glibenclamide, ethanol, Phenytoin, Metoprolol, Diazepam, Nifedipine, Carbamazepine, Theophylline, Digoxin, komanso njira za kulera kwa mahomoni , "Naproxen" ndi "Digoxin".
• Ndizovuta kwambiri kumwa mankhwalawa ndi "Atazanavir".
• Anticoagulants oterewa monga Fenprokumon ndi Warfarin, pokhala ndi Proxyum, amatha kuchepa mu PTI.
• Kuphatikizana kwa mankhwala ndi "Metronidazole", "Amoxicillin" ndi "Clarithromycin" sikunali kudziwika.
• Pantoprazole imachepetsa kumwa mankhwala osokoneza bongo, zomwe zimagwiritsidwa ntchito mwachindunji zotsatiridwa ndi hydrogen index ya chapamimba madzi (mwachitsanzo, "Posaconazole", "Ketoconazole", "Itraconazole", "Atazanavir", "Erlotinib").
• Kuphatikiza kwa mankhwala omwe ali mu funso ndi "Methotrexate" nthawi zambiri kumapangitsa kuwonjezeka kwa poizoni wa wotsirizira.

Malangizo apadera

Kodi ndi mankhwala ati omwe adokotala ayenera kuwauza asanadziwe mankhwalawa ngati Proxyum (mapiritsi)? Malangizo, ophatikizidwa ndi mankhwalawa, ndi oyenera kuwerenga. Limanena kuti mankhwalawa ndiletsedwa kwa anthu omwe ali ndi mantha a dyspepsia.

Mukatenga mankhwalawa kwa miyezi itatu, wodwalayo akhoza kukhala ndi hypomagnesemia. Zizindikiro za matendawa ndi: kupsinjika, kutopa, tetany, delirium, ventricular arrhythmia ndi chizungulire. Ngati zizindikiro zoterezi, mankhwala ayenera kuchotsedwa ndipo nthawi yomweyo funsani dokotala.

Musanamwalire komanso mutatha mankhwala, gastroendoscopy ndi yodalirika kuti mudziwe momwe chikhalidwe cha m'mimba chimakhalira. Tiyenera kukumbukira kuti pantoprazole ikhoza kusokoneza zizindikiro za matenda osokoneza bongo.

Mankhwalawa amadziwika kwambiri pa tsiku la okalamba, komanso odwala omwe ali ndi vuto lopweteka kwambiri ndi 40 mg. Kwa odwala matenda a chiwindi, chiwerengero cha mankhwalawa chiyenera kuchepetsedwa ndi theka.

Mankhwala omwe amachitidwa ndi wothandizira nthawi zambiri amachititsa kuti pakhale chitukuko cha campylobacteriosis ndi salmonellosis.

Proton pump inhibitors amachititsa kuti anthu okalamba apulumuke pang'onopang'ono ndi 30 peresenti.

Mankhwala ndi zizindikiro za mankhwala

Tsopano mukudziwa chomwe chiri ndi momwe mungatengere mankhwala "Proxium". Malangizo ogwiritsa ntchito chida ichi afotokozedwa mwatsatanetsatane.

Ngati pazifukwa zilizonse mankhwalawa sali oyenera kwa inu, akhoza kutsatiridwa ndi mafananidwe ofanana monga "Barol", "Emanera", "Geerdine", "Esomeprazole", "Diaprazole", "Ortanol", "Nexium", " Rabeprazole, Veloz, Sunpras, Lansoprazole, Ezolong, Gassek, Ultop, Deksilant, Pariet, Zulbex, Omeprazol, Omelik, Ozol Losek, Omez, Epicurus, Omelox.

Komanso, mankhwalawa "Proxyum" amamasulira mawu akuti "Controller", "Pantaz", "Panzol", "Panum", "Nolpaz", "Penta", "Pantex", "Pulcet", "Ultera".

Ndemanga za mankhwala

Pafupifupi ndemanga zonse zokhudzana ndi mankhwala omwe ali mu funsoli ndi zabwino. Odwala amanena kuti mankhwala a "Proxyum" amathandiza kuti machiritso apitirize kuchiritsidwa komanso zilonda zam'mimba, komanso amalepheretsanso kuti pakhale kuyambiranso.

Pankhani za zotsatira, odwala omwe amawonekera kwambiri amakhala ndi vuto la mseru ndi mavuto.