"Celecoxib": malangizo ntchito, ndemanga. analogues mankhwala

Chithandizo cha matenda kugwirizana ndi kuwononga dongosolo minofu ndi mafupa, zofuna ku msika mankhwala kulenga mankhwala atsopano sakhala ndi zovuta zambiri ndi dzuwa kwambiri. Asayansi atulukira ndipo apanga mbadwo watsopano wa sanali steroidal mankhwala odana ndi yotupa pamaziko a celecoxib. Mankhwalawa chepetse kawopsedwe ndi bwino analekerera ndi thupi.

Kufotokozera za "Celecoxib" mankhwala

Mankhwala celecoxib ali wotumbululuka chikasu ndipo amatanthauza coxibs gulu lomwe kuonetsa kusankha chopinga wa mtundu cyclooxygenase chachiwiri. Medicaments zochokera mankhwala pano Adzalandira kutchulidwa katundu odana ndi yotupa ndi analgesic. Mankhwala choyambirira pa maziko a celecoxib imatengedwa kuti anayamba ndi kampani American "Pfizer" mankhwala "Celebrex". zinali anaphunzira ndipo ankafufuza makhalidwe pharmacodynamic cha kawopsedwe ndi thupi la munthu.

The medicaments zina munali yogwira mankhwala celecoxib ndi generic, kuphatikizapo mankhwala "celecoxib".

mitundu mlingo

Mukhozanso mankhwala makapisozi molimba gelatin pa mlingo wa yogwira pophika, 100 mg ndi 200 mg. Mosiyana sanali-steroid wothandizila ena odana ndi yotupa, alibe maonekedwe mlingo monga mafuta ndi, gel osakaniza, njira injectable kapena suspensions. Ndi odwala ena molakwika anaitana mtundu kumasulidwa "Celecoxib" mankhwala - mapiritsi, ngakhale tikulankhula makapisozi a.

kapangidwe

Chofunika yogwira ndi celecoxib thunthu mu kuchuluka kwa 100 mg ndi 200 mg. The zikuchokera makapisozi monga zigawo wothandiza kuti kupereka danga kudzazidwa, ndi flowability ndi mtendere wa osakaniza granulated. Zikuphatikizapo lactose, ndi sodium lauryl sulphate polyvinylpyrrolidone (K30), sodium croscarmellose, magnesium stearate.

Mayina a Buku mankhwala "celecoxib" malangizo limapangidwa kapangidwe ndi khalidwe maonekedwe a chipolopolo gelatin kapisozi. Malinga ndi kufotokoza, zikuwoneka kuzimiririka, pakupezeka loyera ndipo limadziwika ndi zizindikiro "100" kapena "200", yomwe ili pa gulu buluu kapena wachikasu, motero. Zimenezi zimathandiza kusiyanitsa makapisozi ndi Mlingo osiyana. Zikuchokera inks chikasu ndi buluu amagwiritsidwa utoto mwatsatanetsatane kusonyeza utoto vuto lililonse kwa chamoyo.

mankhwala ofanana

Mankhwala mankhwala "Celecoxib", analogues umene ulinso ndi yogwira mankhwala celecoxib, akhoza kuonetsa yemweyo achire zotsatira pa nyamakazi a mafupa a anthu.

Mankhwala pachiyambi "Celebrex" ndiponso generic "Celecoxib", "Artoksib", "Zitsel", "Revmoksib", "Ranseleks" amaonedwa mankhwala mosinthana. Komabe, mtengo choyambirira gulu ndalama dongosolo la udzakwaniritsidwa okwera mtengo kusiyana ndi anzawo.

Pokonzekera "Celebrex" lili celecoxib pa mlingo 100 ndi 200 mg monga medicament "celecoxib". Wothandiza zigawo za kapisozi ndi envelopu ake amasiyana onse Mkhalidwe ndi kachulukidwe zikuchokera kuti sikumangotikhudza katundu wawo. Ponena za mtundu wa amasulidwe generic "Celecoxib" analogues mankhwala amatuluka okha makapisozi gelatin mwakhama ntchito mkati.

Pali sanali steroidal odana ndi yotupa wothandizira, cyclooxygenase mofanana ntchito mtundu wachiwiri koma kukhala kusiyana zikuchokera mbali yogwira, ndi pharmacokinetic ndi makhalidwe pharmacodynamic. Zikuphatikizapo sulfonamide pawiri nimesulide imene mlingo tsiku la 200 mg bwino amachitira zizindikiro za nyamakazi ndi nyamakazi. Formulations potengera zotsatira zake odana ndi yotupa ndi analgesic ndi inhibiting ndi cyclooxygenase chachiwiri ndi Pamlingo wamng'ono - a mtundu woyamba, bwanji zosiyanasiyana amkhalapakati a ululu ndi kutupa.

Monga nimesulide, celecoxib ndi limaimira sulfonamide zinthu, komanso mlingo tsiku la 200 mg kumatha zizindikiro za nyamakazi. Zilibe ziletsa cyclooxygenase woyamba mtundu ndi zochita pa ochepa amkhalapakati a ululu ndi kutupa.

An zina mankhwala coxibs makonzedwe m'kamwa mitundu jekeseni wa NSAIDs. Mmodzi mwa ubwino waukulu "Celecoxib" mankhwala - mtengo. Majekeseni (ampoules jekeseni) sanali steroidal odana ndi yotupa mankhwala ena ndalama zodula, koma jekeseni Mwachangu amaposa zotsatira kugwiritsa ntchito mankhwala m'njira olimba.

limagwirira kanthu

Mankhwala "Celecoxib" - mankhwala akuimira mbadwo watsopano wa nonsteroidal wothandizila odana ndi yotupa, odana ndi yotupa, analgesic, ntchito antipyretic. njira yake ya kanthu amagwirizana ndi kutsekereza mapangidwe prostaglandins yotupa ndi kuchepetsa ntchito ya Cox-2.

zochita yotupa hule kupatsidwa ulemu wa mtundu cyclooxygenase chachiwiri, nayenso Iyamba kudzikundikira prostaglandin kaphatikizidwe ndi zinthu kumapangitsanso kutupa. State akufotokozera kutupa ndi ululu.

Cyclooxygenase yoyamba si bwanji achire mlingo "celecoxib" kukonzekera. Malangizo ntchito limafotokoza inertia mankhwala ndi kulemekeza enzyme ichi kugwirizana ndi zochitika zawo za ndondomeko zokhudza thupi kunachitika maselo a m'mimba thirakiti kupatsidwa zinthu za m'mwazi nyumba.

Komanso, malangizo anapatsidwa deta pa zotsatira za mankhwala pa impso. Mu zochita za celecoxib ndi zosakwana kuwonetsedwa mkodzo zikuchokera prostaglandin E2 ndi F1 6-keto-prostaglandin, koma sasintha Kugawilidwa kwanthaka wa B2 11 dehydro-thromboxane, lomwe limasonyeza kusankha zotsatira mankhwala.

Ntchito mankhwala "Celecoxib" sichichititsa kuchepa mlingo kusefera mu glomeruli impso okalamba ndi odwala ndi insufficiency aimpso.

Zikuonetsa ntchito

Malinga makhalidwe pharmacodynamic tsiku lokonzekera "celecoxib" ntchito zidzakhala ochiza matenda a rheumatoid ndi psoriatic nyamakazi, aakulu kutupa ndi ululu wa msana ndi sacroiliac zimfundo ndi nyamakazi.

Chifukwa katundu analgesic ntchito chikhalidwe opweteka ululu minofu ndi mafupa pambuyo opaleshoni chithandizo, dysmenorrhea, amene anatsagana ndi kusamba chopweteka. Odana ndi yotupa zotsatira za mankhwala umalimbana kuchepetsa outgrowths ndi tizilombo ting'onoting'ono mu m'matumbo rectum ku matenda a "adenomatous polyposis".

Kodi kutenga

Makhwalawa "Celecoxib" malangizo ntchito mkati amalimbikitsa osati kulumikiza ndi kumwa chakudya. makapisozi chiyani sanatsegule ndipo si fodya ameneyu amatafunidwa, ndi kumeza lonse pakumwa madzi ambiri.

The pazipita kuchuluka kwa celecoxib, amene akhoza kumwedwa pa tsiku 0.4 ga kukonzekera Izi ntchito owonjezera okha nthawi zina.

zosokonezeka mtima zingachititse mlingo waukulu ndi mankhwala yaitali ndi mankhwala "Celecoxib". Guide kakunena pa Mlingo yaing'ono zochizira symptomatic aliyense kuwerenga. Amapereka malangizo pa ntchito yochepa.

Kuthetsa zizindikiro kugwirizana ndi nyamakazi, ndi ankylosing spondylitis, tsiku kutenga nthawi imodzi kapena awiri ndi mg wa 200 ya mankhwala.

Kuthetsa zizindikiro za nyamakazi ntchito mlingo tsiku la 200 kapena 400 mg, umene unatenga kawiri.

Ululu ndi dysmenorrhea chachikulu amaliona pa tsiku loyamba mlingo mkulu wa 400 mg, ndi phwando mwina zina 200 mg, patsiku ntchito 200 mg nthawi 2 tsiku.

Achikulire ndi anthu odwala ndi digiri wofatsa osakwanira chiwindi kapena wofatsa chowongolera insufficiency aimpso, palibe recalculation a mlingo ikuchitika.

Low kulemera (osachepera 50 makilogalamu), ambiri azikhala kulephera chiwindi - siyana deta odwala mankhwala mlingo wochepa wa mankhwala akuchipatala.

Childs, zochizira njira yotupa mu mafupa ntchito machitidwe chithandizo zochokera ntchito mankhwala angapo mu zosiyanasiyana mlingo. Phatikizani "celecoxib" kapisozi, mafuta, kapena gel osakaniza-mtundu kwanyengo "Apizatrona" kapena "finalgon. ntchito apakhungu amayambitsa zotsatira osakhalitsa, kotero iwo ntchito limodzi ndi mankhwala phwando m'nyumba.

Izi loletsa kugwiritsa ntchito

Si odwala onse ndi matenda a mafupa, inu mukhoza kutenga mankhwala "Celecoxib". Malangizo ntchito lili ndi mndandanda wa matenda ndi zinthu zimene chida adzakhala kwambiri kuvulaza kuposa zabwino. Njirazi ndi monga:

• ming'oma, mphumu, matupi awo sagwirizana chikhalidwe ndi zochita za aspirin ndi nonsteroidal odana ndi yotupa mankhwala ena;
• kuchira ntchito kugwirizana ndi inatsekeratu mtsempha wamagazi kulambalala kumezetsanitsa ;
• exacerbation wa chironda chachikulu;
• m'mimba ndipo magazi matumbo;
• kutupa kwa mucosa mu matumbo;
• mtima kulephera;
• matenda ischemic a minofu mtima;
• imfa ya mitsempha zotumphukira ndi ziwiya oziziritsa ndi mkhutu magazi oziziritsa;
• kwa chiwindi nedostatochnosttyazheloy mawonekedwe;
• aakulu aimpso kulephera;
• wobereka;
• Kuyamwitsa mwana;
• pansi zaka khumi ndi zisanu ndi zitatu;
• hypersensitivity kuti excipients;
• kuchuluka chiwopsezo ku chigawo sulfonamide.

Ndi kugwiritsira ntchito bwino mankhwala "Celecoxib" ayenera kukhala anthu ndi matenda a thirakiti m'mimba kugwirizana ndi chironda chachikulu magazi m'mbuyomu, matenda a mabakiteriya mucous ya mtundu Helicobacter pylori.

madzi posungira mu thupi ndi zimakhala zofewa edema, matenda a chiwindi siteji, mtima ndi mtima matenda sekondale, mu thupi, mmene kuwonjezeka mlingo mafuta mu madzi a m'magazi anati zamadzimadzi kagayidwe, matenda a shuga, shuga, matenda somatic mu kwambiri ndi ndife chifukwa pazipita kugwiritsa ntchito bwino mankhwala "celecoxib" kuyang'aniridwa ndi dokotala.

zotsatira zoyipazi

Ngakhale zomwe nzeru polenga mbadwo watsopano wa coxibs, izi mankhwala ozunguza bongo zochokera iwo sali wopanda mavuto.

M'munsili mankhwala "Celecoxib" malangizo ntchito, pamene umboni uperekedwa mtima ndi akatswiri - zinthu zimenezi zili ndi mfundo za chingachitike chokhwima kuti angagwe ziwalo zofunika kwambiri.

The zotheka zoipa yaikulu dongosolo m'mimba yodziwika ndi NSAID-gastropathy, kupweteka pamimba, nseru, kusanza, kutentha, kuchepa kufunika kudya chakudya ndi kutsekula m'mimba. Yaitali ntchito mlingo waukulu zingachititse ulceration ndi magazi mu Kakhungu mucous ya m'mimba ndipo matumbo, magazi m'kamwa, amaika kutsegula kwa transferase chiwindi.

matenda mantha ndi kuwonetseredwa chisangalalo, mutu, chizungulire, somnolence tulo, mayiko a maganizo.

Mphamvu pa dongosolo mtima chifukwa kuthamanga mu mitsempha, ndi tachycardia.

Kukonzekera "celecoxib" kumachepetsa kukaniza matenda opatsirana a dongosolo kupuma, zomwe tingasonyezere kukula kwa sinusitis, rhinitis, pharyngitis, kupweteka kwa mphuno komanso pakhosi, chifuwa, dyspnea, bronchospasm.

Zotsatira za mankhwala pa mphamvu amachititsa kuchepetsa maganizo Makutu ndi maonekedwe a tinnitus.

Pa dongosolo mkodzo zimakhudza mankhwala "Celecoxib" kotero kuti mukalandire kulephera aimpso ndi chitukuko cha matenda edema.

Pankhani ziwalo magazi kupanga, mankhwala zingachititse chiwonetsero cha agranulocytosis, kuchepa magazi, leucopenia, thrombocytopenia.

Totupa kumachitika ndi maonekedwe a matupi awo sagwirizana pruritus, urticaria, photosensitivity, angioedema mu nkhope dera, m'makona, maliseche.

Features phwando

Mankhwala "Celecoxib" chibadidwe sangathe kugwirizana ndi chiopsezo cha mavuto pa dongosolo mtima zikubweretsa thrombosis, infarction cha m'mnyewa wamtima zidzasintha minofu ndi sitiroko. Makamaka atsikana pachiopsezo pa makonzedwe aakulu mankhwala ndi odwala amene ali ndi matenda a mtima.

Kuchepetsa chiopsezo cha mavuto amenewa odwala kumwa mankhwala "Celecoxib" mankhwala mlingo wotsikitsitsa ambiri yochepa chithandizo. Wodwala ayenera kukambirana ndi dokotala wanu zizindikiro zotheka matenda ndi kulandira malangizo kuyankha akapezeka.

ntchito osakaniza asidi acetylsalicylic pa mlingo kochepa kwa mankhwala "celecoxib" Pofuna kuchepetsa zizindikiro mtima. Reviews madokotala amasonyeza antiplatelet zotsatira za aspirin woonda magazi pamene mukumwa coxibs, amene alibe katundu odana thrombotic. Childs, monga osakaniza zikusonyezedwa odwala achikulire matenda a dongosolo minofu ndi mafupa ndi dongosolo mtima, m'mimba kawopsedwe ndi chinawonjezeka pamene sanali kusankha sanali steroidal odana ndi yotupa mankhwala. Koma ntchito mankhwala celecoxib ndi NSAIDs ena ali osavomerezeka.

Kwa odwala matenda a kuthamanga magazi, chounikira apitirize chizindikiro ichi pamene kulandira "Celecoxib" mankhwala.

chidwi ayenera kuyan'anila mkhalidwe wa chamoyo osakaniza ndi anticoagulant (warfarin) ndi zinthu antiplatelet (asidi acetylsalicylic, clopidogrel) ntchito zoletsa kusankha (citalopram, sertraline), inhibiting serotonin reuptake zoletsa wa CYP2C9 isozyme, mitundu piritsi glucocorticosteroids.

Mankhwala "celecoxib" amalimbikitsa yopanga prostaglandin zinthu, zomwe achigonjetse madzi m'thupi ndiponso kulimbikitsa chitukuko cha edema. Makamaka kusamala mankhwala mankhwala ayenera kukhala anthu amene amadwala matenda a mtima minofu ndi kuthamanga kwa magazi. ayenera kusiya kumwa "Celecoxib" mankhwala ngati pali zizindikiro za kutupa kwa zimakhala.

Odwala coxibs matenda a impso chithandizo ayenera limodzi ndi kuwayang'anira nthaŵi zonse zizindikiro zawo kiyi.

Pamene madzi m'thupi kutenga mankhwala n'chotheka pambuyo zakumwa zobwezeretsa Inde zakumwa zobwezeretsa.

Phwando "celecoxib" antipyretic mankhwala chifukwa kanthu kumabweretsa vuto la index matenda monga kutentha okwera pa chitukuko cha zinthu opatsirana.

Zochita za mankhwala akhoza kupundula mu ntchito chiwindi, makamaka anthu amene analipo matenda a chiwindi. matenda kugwirizana ndi chiwindi fulminant, chiwindi nekrozomtkaney. zinthu zimenezi zimachitika nthawi yomweyo, koma masiku pokhapokha 30 pambuyo ntchito "celecoxib" kukonzekera. Ndiye mukufuna kuwunika ntchito pa matenda a chiwindi malo ichi, ndi vuto la kulephera katundu muyenera mwamsanga adzafafaniza kusankhidwa.

Reviews zochizira "Celecoxib"

Nonsteroidal mankhwala odana ndi yotupa ikuchitika yekha mankhwala. The zotsatira za ntchito ya "Celecoxib" ndemanga mankhwala a kanthu zake losanganikirana. mankhwala umodzi amathandiza kulimbana ndi njira yotupa mu malo, ena ndi osathandiza ndipo amachititsa zambiri zomwe zinachitika chowawa.

Monga odwala kwambiri kuunikira mankhwala "Celecoxib"? Reviews akusonyeza nambala ya mavuto: kupweteka m'mimba, impso, matenda kusamba. Chotero odwala dokotala amakhala Kulipira medicament ndipo anapereka chithandizo zina.

Potengera maganizo a odwala pa zotsatira za mankhwala pa mfundo chofuna, Ndizachidziwikire kuti zothandiza polimbana ndi nyamakazi. Kuthetsa zizindikiro zowawa, kutupa zimakhala mu zinkakhala m'dera zachilengedwe aakulu, odwala ali mu yophukira ndi mlingo kasupe wa mankhwala "Celecoxib". Izo ntchito ndi othamanga mu zoopsa ndi mafupa.

Makamaka medicament amachita bwino osakaniza n'kumawotha mafuta ndi angakhale angelo kuti ntchito apakhungu. Komabe, malinga ndi malangizo opezeka malangizo ntchito anapatsidwa NSAID ntchito nthawi yochepa, pofuna kupewa mavuto impso, chiwindi, mtima ndi m'mimba. Apo ayi si kupewa zolephera mu ntchito ya matupi awa.