Carbonic anhydrase zoletsa: limagwirira cha zochita za m'maso kwa khungu

Carbonic anhydrase zoletsa ndi okodzetsa omwe si ntchito ngati okodzetsa kapena mochegonki. Chosonyeza kuti mankhwala awa ndi khungu. Tiyeni tione mwatsatanetsatane anthu otchuka.

Acetazolamide (Acetazolamide)

Iwo ali katundu diuretic. Mabasi carbonic anhydrase aimpso proximal tubules amachepetsa reabsorption a K, Na ndi madzi (diuresis amachititsa awonjezere), tidzapeza kuchepa mu Bcc ndi kagayidwe kachakudya acidosis. Carbonic anhydrase depresses ndi ciliary thupi ndipo akutitsogolera kuti kutsitsa kuthamanga intraocular, komanso amachepetsa katulutsidwe nthabwala amadzimadzi mu ubongo amachititsa ntchito antiepileptic. Iwo ali mayamwidwe wabwino kwa thirakiti m'mimba, Cmax m'magazi maola awiri. Zotsatira ukhoza maola 12. 40-60% Sachita IOP ndipo kumachepetsa ulimi wa madzimadzi intraocular.

Zikuonetsa & Mlingo

The zizindikiro zazikulu: ocular oopsa, khungu. Mu khungu, mkati kutenga 0.125-0.25 ga nthawi 1-3 tsiku, tsiku kwa masiku 5, kenako akusowa masiku awiri yopuma.

Zotsatira zoyipa za mankhwalawa: nseru, kusowa chilakolako cha kutsegula m'mimba, chifuwa, mkhutu tanthauzo la kukhudza paraesthesia, tinnitus, kusinza. Zonsezi zingakubweretsereni carbonic anhydrase zoletsa. Kukonzekera komanso ndi contraindications. Izi tilinazo kwambiri (ndi sulfonamides kuphatikizapo), matenda Addison ndi, mankhwala acidosis, matenda pachimake chiwindi ndi matenda a impso, mimba, shuga, uremia.

Kagwiritsidwe zoletsa: embolism m'mapapo mwanga, ndiko kumayambitsa m'mapapo mwanga (mwina kuwonjezeka acidosis).

Mankhwala: Mapale opangidwa ku Poland Polpharma "Diakarb" kuti 0,5 ga

Dorzolamide (dorzolamide)

Kumabwezera mmbuyo carbonic anhydrase isoenzyme II Ntchito (Imalankhula kusintha hydration zimene mpweya woipa ndi carbonic asidi madzi m'thupi) diso ciliary thupi. Katulutsidwe intraocular chinyezi yafupika ndi 50%, kubweza mapangidwe ayoni bicarbonate, ndi pang'ono amachepetsa mayendedwe a madzi ndi sodium wochuluka. Kuchepetsedwa ndi 38% ya ulimi wa madzimadzi intraocular kuti si bwanji outflow. Iwo likulowerera mu mwana wa m'diso la anthu ambiri kudzera nthambi, diso kapena sclera. Pang'ono odzipereka mu zokhudza zonse mtima kama wa Diso mucosal (ayenera kulankhula diuretic ndi zotsatira zina sulfonamides lililonse). Pambuyo thunthu ali mu magazi, mofulumira likulowerera ku maselo a magazi, amene ali yambiri carbonic anhydrase II. Dorzolamide 33% womangidwa kwa mapulotini plasma. The pazipita hypotensive zotsatira kuwawonetsera pambuyo instillation kudzera ora 2 ndi masitolo maola 12. Pamene backfilling nthawi 2 pa 9-21% pa tsiku amachepetsa intraocular kuthamanga pamene anaika monga 3 pa tsiku - mpaka 14-24%. Kuchepetsa kuthamanga intraocular pogwiritsa ntchito 2% njira akhoza kupanga pazipita 4,5-6,1 mamilimita Hg. A njira ya 3% adzakhala sakhala ogwira chifukwa mwamsanga kutsukidwa wa M'mimbamo conjunctival monga izo zimayambitsa amphamvu womwetula. Mogwirizana ndi kuikidwa timolol ali zina kutchulidwa zotsatira kuchokera 13 mpaka 21%. Kochepa zimakhudzanso magazi ndiponso kugunda kwa mtima ndi carbonic anhydrase zoletsa. Okodzetsa gulu ili si ntchito cholinga chake. Pa lino.

Zikuonetsa & Mlingo

Zikuonetsa: pulayimale ndi sekondale otsegula ngodya khungu, ocular oopsa. Mankhwala akusonyeza 1 dontho 2-3 pa tsiku.

Zotsatira zoyipa za mankhwalawa: paresthesia, kuwonda, maganizo, tizilonda ta pakhungu, aplasticheskayaanemiya, agranulocytosis, kutopa, kupweteka kwa mutu, poizoni epidermal necrolysis owawa kukoma pa kamwa, nseru, kuwonjezeka kwa makulidwe a diso la, iridocyclitis, blepharitis, keratitis, conjunctivitis, photophobia, amaona masomphenya, kuyabwa ndi kumva kulasalasa kumverera mu maso, kusapeza, Stevens - Johnson syndrome, moto, maso madzi.

The carbonic anhydrase woletsa (madontho diso) ali contraindications zotsatirazi: tilinazo kwambiri (ndi sulfonamides kuphatikizapo), mwana, matenda pachimake chiwindi ndi matenda a impso, mimba ndi yoyamwitsa.

Kukonzekera: eyedrops "Trusopt" okhala 1 ml ya 20 mg wa dorzolamide hydrochloride njira. Mbale - 5 ml. Chifukwa amapangidwa mu Netherlands ndi Merck akuthwa & Dohme.

Carbonic anhydrase zoletsa: Brinzolamide (brinzolamide)

Nzeru blocker wa anhydrase carbonic ndi luso pamene ntchito timitu kuti kuchepetsa kwambiri ndi ulamuliro IOP. Brinzolamide nazo mkulu selectivity kwa carbonic anhydrase II, ndi ambiri abwino thupi katundu mosavuta kudutsa mu diso. Poyerekeza ndi dorzolamide ndi atsetozolamidom inapeza kuti brinzolamide - kwambiri amphamvu mankhwala gulu la zoletsa carbonic anhydrase. Pali umboni kuti apakhungu kapena mtsempha ka brinzolamide kumabweretsa kusintha kwa litayamba chamawonedwe. Ndipo amachepetsa ndi pafupifupi 20% IOP. Zilibe ntchito carbonic anhydrase zoletsa onse. Limagwirira kanthu wapadera kwa brinzolamide.

Zizindikiro ndi mlingo

Zikuonetsa: ocular oopsa, otsegula ngodya khungu. Gwiritsani ntchito nthawi 2 tsiku kadontho.

Zotsatira zoyipa za mankhwalawa: kukoma kupotoza, kumverera thupi yachilendo, amaona masomphenya pa instillation (nthawi) ndi kugirigisha moto. Anasamutsa kwanuko kuposa dorzolamide.

Contraindications: kwambiri kudziwa mankhwala (kuti sulfonamides kuphatikizapo), ana a zaka, mimba ndi yoyamwitsa.

Kukonzekera: eyedrops "Azopt" okhala 1 ml ya kuyimitsidwa wa 10 mg brinzolamide. Mbale mphamvu 5 ml. Yopangidwa mu USA ndi Alcon.

Kodi aliyense ali carbonic anhydrase zoletsa?

opangidwa kuchokera prostaglandin

Latanoprost (latanoprost) - prostaglandin cholandilira kusankha agonist. Kumawonjezera outflow wa madzimadzi intraocular kudzera uvea, amene akutitsogolera kuti kutsitsa kuthamanga intraocular. Impact pa ulimi wa nthabwala amadzimadzi sikungakuthandizeni. Kodi kusintha kukula kwa mwana, koma pang'ono chabe. Pamene backfilling Chifalikira mu mawonekedwe a isopropyl efa kudzera diso ndi apo hydrolyzed kuti boma la asidi ndi biologically yogwira, sipangakhalenso akufotokozera woyamba maola 4 madzimadzi intraocular ndi madzi mu Ora loyamba. 0,16l / kg - buku la kugawa. maora awiri Kuwonjezera akwaniritsa ndende apamwamba mu nthabwala amadzimadzi, pambuyo umene anagawira chiyambi cha gawo kutsogolo, i.e. ndi zikope ndi conjunctiva, kenako alowa gawo zapambuyo (zochepa). The thupi lithe mu zimakhala wa diso pafupifupi osati zimapukusidwa, makamaka biotransformation chiwindi. Advantageously, metabolites ali excreted mu mkodzo. Tiyeni tione ena mwa carbonic zoletsa anhydrase.

Unoprostone (unoprostone)

Isopropyl unoprostone ndilochokera wa docosanoid mofulumira kuchepetsa kuthamanga intraocular (IOP) ntchito atsopano pharmacologic limagwirira. Popanda kusintha nthawi yopanga madzimadzi intraocular, facilitates outflow ake. Kafukufuku wasonyeza kuti, poyerekeza ndi 0.5% timolol maleate, isopropyl unoprostone kugwira ntchito zofanana kapena bwino kuchepetsa IOP. Mankhwala sikumangotikhudza malawi ndi sayambitsa kuchepetsa magazi ambiri, zimakhala ocular, miosis kapena mydriasis; corneal kusinthika kuchedwa komanso si wapezeka. Pambuyo apakhungu zikutsatiridwa isotropy unoprostone sanali wapezeka mu madzi.

carbonic zoletsa anhydrase kwa glaucoma sayenera mankhwala okha ndi dokotala, kudzikonda mankhwala sikuloledwa.