"Azathioprine": malangizo Buku, ndemanga, mafotokozedwe, analogs

Imene imafuna mankhwala "Azathioprine"? Malangizo pa ntchito yanuyi ndi nthumwi adzakhala anafotokoza m'nkhani ino. Ifenso inu ngati pali contraindications ndi analogues ndi mankhwala, zomwe ndalama, zimene zidzachitike mu nkhani ya mankhwala osokoneza bongo, ndi zina zotero. D.

Zikuchokera, ma CD, mawonekedwe, malongosoledwe medicament

Mu mawonekedwe zimene zilipo mankhwala "Azathioprine"? Malangizo ntchito zikusonyeza kuti mankhwalawa ndi alembedwe piritsi. pophika awo yogwira amachita monga azathioprine. Komanso mu mankhwala ndi monga zosakaniza zina mwa mawonekedwe a mbatata wowuma, gelatin, lactose, ndi calcium stearate.

Mu phukusi anagulitsa mankhwala "Azathioprine"? Malangizo ntchito mankhwala ndi akachita mukatoni, amene anaika wotumbululuka chikasu Valium mapilitsi mu mapaketi chithuza zidutswa 50.

Pharmacological makhalidwe a medicament ndi

ndi mankhwalawa monga "Azathioprine" n'chiyani? Malangizo ntchito, akatswiri weniweni odziwa amanena kuti mankhwala funso ndi analogi "hypoxanthine", "Adenine" ndi "guanine", m'gulu kapangidwe ka zidulo mkati ndi kuonetsa Letsani zotsatira mwachibale kwa minofu kuchuluka ndi kugawikana selo.

"Azathioprine" - immunosuppressive wothandizira. Zimenezi umalimbana cytotoxicity ma.

Akuti mankhwala akhoza ziletsa zimene minofu zosagwirizana ndi bwanji kugawanika kwa chitetezo, koma Pamlingo yaing'ono. Poyerekeza ndi "mercaptopurine" yogwira mankhwala akusonyeza kwambiri kutchulidwa.

Pharmacokinetic mankhwala

Pambuyo mankhwala m'kamwa bwino odzipereka kwa mundawo m'mimba. Iwo ali chomangira otsika ndi mapuloteni plasma (pafupifupi 30%).

The biotransformation za kumasulidwa mankhwala kumachitika ndi asidi tioinozinovoy ndi mercaptopurine (i.e., yogwira metabolite). The ping'ono mankhwala mu minofu. Pankhaniyi, ndende ka mankhwala zimapedzeka ku ubongo.

Hafu ya moyo wa azathioprine, ndi metabolites ake yogwira ndi maola 6. Ndende apamwamba mankhwala magazi anaona pambuyo Mphindi 70-110.

Mankhwala pafupifupi kwathunthu akatulutsidwa pamodzi ndi ya ndulu, ndi% 1-2 kokha - ndi impsozo.

mapiritsi zikuonetsa

Kodi prescribers "Azathioprine" (malangizo ntchito mankhwala, analogs, ndemanga Adzaperekedwa ina)? kukonzekera kumaonekera bwino pamene kuvutika zotsatirazi:

• psoriasis;
• nyamakazi;
• wofiira zokhudza zonse lupus erythematosus ;
• anam'peza matenda a m'matumbo;
• dermatomyositis;
• myasthenia gravis;
• Pemphigus olaula;
• periarteritis nodosa;
• matenda amene amatupitsa ;
• glomerulonephritis, autoimmune;
• aakulu yogwira chiwindi;
• syndrome Reiter ndi ;
• purpura idiopathic thrombocytopenic.

Iwo ayenera kukumbukira kuti mankhwala izi kawirikawiri analamula kuti kupewa kumuika kukanidwa. Koma mu nkhani iyi amatengedwa limodzi ndi mankhwala ena.

Contraindications ntchito mankhwala

Malangizo ntchito mankhwala "Azathioprine" imatiuza odwala za contraindications zotsatirazi:

• kwa chiwindi kulephera ;
• hypersensitivity kuti yogwira kapena wothandiza zigawo mankhwala;
• pa mimba;
• mkhalidwe wa hematopoiesis oponderezedwa;
• zaka ana;
• yoyamwitsa.

Medicament "Azathioprine": Mlingo ndi yoyendetsa

Tengani "azathioprine" mapiritsi ayenera kuperekedwa pakamwa. Pa mayesero onsewa, mlingo wa mankhwala anatsimikiza payekha, malinga ndi umboni umene ulipo, komanso kukula kwa matendawa ndi mankhwala concomitant.

Pakuti kupewa mankhwala kumezanitsa kukana Kwalamulidwa osakaniza "cyclosporin" ndi corticosteroids. Kumayambiriro kwa kumwa mankhwala mankhwala mu Mumakonda mlingo kuti ndi 5 mg pa kilogalamu (pa miyezi iwiri). Kenako kumwa mankhwala ntchito yokonza mlingo (1-4 mg wa pa makilogalamu pa mlingo 3). Childs, zimenezi ikupitirira kwa nthawi yaitali. Ngati inu adzafafaniza mankhwala mlingo wa mankhwala adatchithisira pang'onopang'ono.

Pa zosayembekezereka zizindikiro loyamba kukana kuziika chiwalo chofunika kuonjezera mlingo tsiku la medicament kachiwiri mg wa 4 pa kg.

Zochizira matenda ena medicament bwinobwino kutumikiridwa mu mlingo tsiku la 1.5-2 mg wa pa makilogalamu kuti 4 Mlingo wogawanika. Ngati ndi kotheka, mwachindunji kuchuluka kwa mankhwala akhoza ziwonjezeke kwa 200-250 mg (ogaŵikana Mlingo 4). Kutalika kwa mankhwala ndi chida Izi payekha, katswiri wodziwa.

Kagwiritsidwe "Azathioprine" (mapiritsi) mu nyamakazi? Malangizo ntchito, mlingo (anafotokoza kukonzekera inali kuperekedwa pamwamba) limati zochizira matenda Kwalamulidwa 1-2.5 mg wa pa makilogalamu patsiku (ogaŵikana Mlingo 2). Nthawi mankhwala ayenera kukhala miyezi 3. Kuti muzilowa mtima amaperekedwa mlingo wa 0,5 mg wa pa makilogalamu (osakwatira mlingo).

Zochizira aakulu chiwindi B (yogwira) mankhwala mlingo tsiku la 1-1.5 mg wa pa kg.

Milandu mankhwala ambiri osokoneza bongo

Kodi zizindikiro cha mankhwala osokoneza bongo zidzachitika pa phwando cholakwika "Azathioprine" mankhwala? Malangizo ntchito kwenikweni madokotala odziwa amanena kuti mlingo wapamwamba mankhwala zikhoza boma zosiyanasiyana dyspeptic, pancytopenia, matenda a chiwindi ntchito ndi utithandize zotsatira zina mbali ya mankhwala.

Monga mankhwala a zochitika ngati ntchito mankhwala symptomatic. Ngati ndi kotheka, hemodialysis. Komabe, dziŵani kuti ndondomeko izi sizitanthauza kuwonongedwa kwathunthu kwa mankhwala yogwira thupi.

Mwanjira mankhwala

Ngati mankhwala ena zimakhudza mankhwala "Azathioprine"? Malangizo limati ntchito kuti Co-ka wothandizila ndi "Allopurinol" umathandiza zotsatira poizoni ya woyambayo, ndi molumikizana ndi "co-trimoxazole" umatsegulanso chinawonjezeka zotsatira myelotoxic.

Munthawi yomweyo chithandizo ndi zoletsa Ace kumaonjezera ngozi ya leukopenia kwambiri.

Mothandizana ndi immunosuppressants ena (mwachitsanzo, "Cyclosporins", glucocorticoids, odana CD3 chitetezo) nthawi osiyanasiyana neoplasms ndi matenda.

Ankaona kukonzekera akusonyeza zotsatira ankatsutsa kuti nedepolyarizuyushim relaxants minofu.

Iwo ayenera kukumbukira kuti katemera pa chithandizo "azathioprine" mosavuta ndithu zimalambira yimitsira ya ulimi wa chitetezo (mu nkhani ya katemera inactivated), komanso kuonjezera tizilombo ta tizilombo (ndi oyamba katemera moyo).

ayamikira yeniyeni

Zinthu kudziwa pamaso panu mankhwala "Azathioprine"? Malangizo ntchito kwenikweni (analogues mankhwala m'munsimu) amati miyezi iwiri yoyambirira ya mankhwala chofunika mlungu uliwonse kusunga chitsanzo cha magazi zotumphukira. Patapita nthawi izi, kuphunzira limasonyeza zigawo ndi pafupipafupi 1 iliyonse masiku 30.

M'pofunikanso kuwayang'anira mlingo wa bilirubin, phosphatase zamchere ndi michere chiwindi.

Pamaso pa kuvutika kwa impso kapena chiwindi, komanso phwando limodzi ndi "Allopurinol" medicament mlingo pansi kulingalira ayenera kuchepetsedwa kwa 1/4 gawo.

"Azathioprine" mosamala kwambiri anatumizidwa odwala anthu amene pali nsungu zoster, katsabola, xanthine oxidase akusowa, ndi pa cheza kapena cytotoxic mankhwala.

Analogues ndi mtengo mankhwala

Kodi m'malo "Azathioprine"? Malangizo ntchito (mtengo wa mankhwala amene ali m'munsi) limanena kuti takambiranazi mankhwala ali achinyamata ochepa. The ofanana kwambiri zo monga mankhwala zotsatirazi:

• "Alpha-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Monga mtengo, ndiye mankhwala si kwambiri. mapiritsi 50 "azathioprine" pafupifupi pafupifupi 230 Russian rubles.

Reviews a medicament

A ndemanga angapo a mankhwala "Azathioprine" amatanthauza losanganikirana. Anthu ena kumwa mankhwala chifukwa cha matenda ndi autoimmune, ali ndi kukhudzana yothandiza kwambiri ndi kupanda zotsatira aakulu mbali. Komabe, anthu ena odwala sadamve ndi chifukwa aliyense, choncho anaganiza zopatsa asankhira kuti njira zina.

Tikumbukenso kuti zizindikiro zonse ntchito mankhwala "Azathioprine" amanena za matenda m'malo oopsa amene mankhwala okwanira zitha kukhala odziwa akatswiri. Pa nkhani imeneyi, mu nkhani ya kukayikitsa pamaso pa matenda aliwonse pa mndandanda pamwamba, inu ayenera kukumana mwatsatanetsatane kuchipatala bwinobwino kuti kudziletsa medicate.