Zamadzimadzi-kutsitsa mankhwala "Rosuvastatin": malangizo ntchito

Medicine "Rosuvastatin" malangizo Buku limafotokoza hypolipidemic mankhwala a statins. The ntchito njira imeneyi kusankha ndi mpikisano chopinga wa HMG-CoA reductase. Kugwiritsa ntchito yokonza ndi "Rosuvastatin" (malangizo ntchito izo akutsimikiza) kangapo kuchuluka LDL catabolism, kuchuluka kwa ndalama ya maselo kwa chiwindi LDL ndi kuchuluka kwa VLDL yafupika. Pa katundu pharmacokinetic mankhwala zamadzimadzi-kutsitsa, ndi kutchulidwa achire zotsatira za phwando ake akupembedza masiku asanu ndi awiri pambuyo chiyambi cha mankhwala, kufika ake kumabweretsa zabwino mu masabata anayi.

Tengani mankhwala a "Rosuvastatin" wopanga akuonetsa kuti anthu akuvutika mawonekedwe a mitundu yosiyanasiyana a hypercholesterolemia (lembani IIb) hypercholesterolaemia kapena IIa (kuphatikizapo heterozygous) monga adjunct kuti zakudya.

Choncho dzuwa apamwamba hypolipidemic yogwira mankhwala zili choncho pamene mankhwala njira zina (zolimbitsa thupi, kuchepetsa thupi) sizitipatsa kupeza chifukwa choyenera achire. Komanso, ntchito kusankha nthumwi "Rosuvastatin" malangizo Buku akuonetsa ngati mankhwala othandiza pa mankhwala homozygous mtundu hypercholesterolemia banja.

Perekani mapiritsi izi kutiletsa ngati wodwala matenda aakulu chiwindi, myopathy kapena matenda m'kukoma impso ndi. Woyembekezera, komanso sayenera kumwa zamadzimadzi-kutsitsa mankhwala "Rosuvastatin." Mankhwalawa ndi contraindicated mu nyengo ya mkaka wa m'mawere. Komanso, ali osavomerezeka mapiritsi izi pamodzi ndi cyclosporine kapena hypersensitivity kwa zigawo zawo. Anthu amene alibe atapeza zaka khumi ndi zisanu ndi zitatu, ndipo si koyenera kuti asankhe wothandizila kusankha "Rosuvastatin." Malangizo ntchito si analangiza kuti achitenge icho pa nkhani ya uchidakwa anakhazikitsa aimpso kulephera kapena chiwindi matenda.

Mosamala kwambiri kugwiritsa ntchito mankhwala zamadzimadzi-kutsitsa akhale anthu kuvutika electrolyte, endocrine ndi kagayidwe kachakudya matenda, hypothyroidism kapena hypotension. Mu sepsis, kusalankhula khunyu, proteinuria, zoopsa zazikulu zikunena opaleshoni komanso ayenera kusiya kumwa mankhwala, "Rosuvastatin." Komanso, contraindications wachibale matenda otengera akulu ndi zaka wamkulu kuposa zaka makumi asanu ndi limodzi mphambu zisanu.

Pomaliza, tiyenera anati za zotheka zochita zoipa, pakutchulidwa amene akhoza zidzayambike ndi phwando amatanthauza "Rosuvastatin." Mwachitsanzo, odwala ambiri amadandaula kuwawa m'mimba, kudzimbidwa, chizungulire komanso nseru. Komanso, pali chiopsezo pang'ono za myopathy, proteinuria, asthenia , ndi myalgia.