"Sumatriptan": malangizo ntchito, ndemanga. Mankhwala analogues "Sumatriptan"

Kodi zikutanthauzanji mankhwala "Sumatriptan"? Malangizo ntchito mankhwala zochita zake pharmacological, ndi mawonekedwe a zikuchokera Adzaperekedwa patsogolo pang'ono. Komanso, m'nkhani ino ife angakuuzeni zimene contra-zizindikiro ndi zotsatira zake zoyipa za mankhwala ali, chimene njira zake ntchito ndi mlingo, ngati iye anali analogues aliyense ndi zina zotero.

The zikuchokera mankhwala ndi kapangidwe kake

Panopa, mankhwala okha angapezeke mu pharmacies ndi mphuno utsi "Sumatriptan". Malangizo ntchito chida likunena zambiri kotheratu zikuchokera mankhwala. Bwino mudzatha tsopano.

A filimu TACHIMATA mapiritsi muli mankhwala yogwira monga sumatriptan succinate. Pankhani zinthu wothandiza, izi ndi izi: kashiamu wa phosphate wa hydrogen dihydrate, microcrystalline mapadi, giproloza (Klutsel kapena hydroxypropylcellulose LF), magnesium stearate, mannitol (kapena mannitol), croscarmellose ndi sodium (kapena primelloza).

The yogwira pophika m'mphuno utsi "Sumatriptan" muja sumatriptan. Koma zigawo wothandiza, iwo akhoza kusinthidwa malingana ndi mawonekedwe za kumasulidwa medicament. Tikumbukenso kuti kutsitsi ntchito pofuna kuchiza zochepa wamba kuposa miyala. Komabe, iwo ndi ogula wawo. Monga ulamuliro, izi ndi odwala amene sali omasuka kumwa mankhwalawa pakamwa.

Makhalidwe pharmacological mankhwala

mbali Kodi "Sumatriptan" miyala, zomwe amakambirana ife kuyang'ana zina?

Anati kukonzekera ndi protivomigrenoznoe zikutanthauza. Ndi yeniyeni ndi kusankha agonist 5-HT1-serotonin zolandilira, amene isanafalikire mu magazi zotengera za ubongo. Tikumbukenso kuti mankhwala alibe mphamvu pa subtypes zina za maselo 5-HT-serotonin.

Pambuyo kutenga mankhwala amachititsa vasoconstriction wachokera carotid wolumikizira bedi. Choncho, medicament "sumatriptan" (mapiritsi) amapereka magazi intracranial ndipo zimakhala extracranial. Tikumbukenso kuti meningeal vasodilatation ndi kutupa awo ndipo zimayambitsa migraine anthu.

Sitingathe kunena kuti pambuyo pa kukhazikitsidwa kwa chida ichi alibe zotsatira kwambiri (zoipa) pa otaya oziziritsa magazi. Mapiritsi yekha ziletsa cholandilira ntchito ulusi afferent (mathero awo) za mitsempha trigeminal, limene lili mu Dura lapansi. Izi zimachitika chifukwa cha kuchepa kwa chipangizo neuropeptide kumasulidwa.

Tiyeneranso kuti mankhwala "Sumatriptan" ndi "Sumatriptan Teva" kwathunthu kuthetsa photophobia ndi nseru, amene n'zogwirizana ndi kuukira migraine.

Mphamvu ya mankhwala

Kodi mwamsanga ubwino pambuyo kukhazikitsidwa kwa "Sumatriptan" mankhwala? Umboni wa medicament muli mudziwe kuti mankhwala akuyamba kuchita mphindi yokha pambuyo 30. Choncho wodwala sayenera kutenga muyezo wa 100 mg. Zodabwitsa ndizakuti, mu 50-70% odwala mwamsanga inathetsedwa kuukira migraine pambuyo ntchito 25-100 mg wa mankhwala. Masana pa 1/3 odwala muyambirenso, chimene chimafuna ntchito mobwerezabwereza mankhwala.

Pharmacokinetics

mankhwala "Sumatriptan" yaitali bwanji odzipereka? Yankho la funsoli anapezeka ku malangizo ntchito ndalama. Atalandira mankhwala mkati, pafupi nthawi yomweyo chosakanikirana kapepala kakuti m'mimba. Pambuyo mphindi 45 ndende ya mankhwala mu seramu magazi ukufika 70%.

Chifukwa mayamwidwe chosakwanira ndipo woyamba-chiphaso kagayidwe, ndi bioavailability mtheradi wa mankhwala pamene kutumikiridwa pafupifupi 14%. Ponena za kumanga zonsezo madzi a m'magazi, ndi otsika kwambiri (za 15-21%). Nthawi theka moyo 2-maola. Kukonzekera anachokera ambiri kudzera impso.

Absorbability mankhwala pa nkhani zosiyanasiyana matenda

Malinga ndi luso, kuukira migraine musati kwambiri bwanji absorbability wa sumatriptan yogwira wothandizila (by ingestion kapena makonzedwe intranasal).

Ngati wodwala anawawidwa chiwindi ntchito, ndiye pambuyo ntchito mankhwala akhoza kumva kuchuluka mlingo wa yogwira pophika mu madzi a. Izi zimachitika chifukwa cha kuchepetsa woyamba chikudutsa chilolezo.

Zikuonetsa ntchito mankhwala

Nthawi zina, prescribers "Sumatriptan"? Malangizo ntchito mankhwala limanena kuti ayenera kumwedwa yekha ndi maonekedwe a migraine (popanda aura kapena mkazi).

Contraindications ntchito

Ngati pali zolakwika ndi kutiletsa kumwa mankhwala "Sumatriptan" analogs za mankhwala? Ndikufuna kutsindika kuti pankhaniyi malangizo pali wambirimbiri zambiri. N'chifukwa chake asanadye mankhwala ndi izo, onetsetsani kuwerenga.

Choncho kodi contra-zikuonetsa yasonyeza mankhwala? Taonani mndandanda pakali pano:

• kuchuluka tilinazo wodwalayo miyambo ya chiphunzitso ndi;
• odwala Okalamba (zaka 65);
• basilar, kapena oftalmoplegicheskaya mawonekedwe hemiplegic migraine;
• munthawi yomweyo phwando la medicament ndi medicaments amene ali ergotamine ndi ena ofanana zosiyanasiyana komanso Mao zoletsa (akuletsedwa kuvomereza njira isanafike masiku 14 pambuyo achire wa anati mankhwala);
• inatsekeratu matenda a mtima, ndi amaganiziridwa izo;
• achinyamata ndiponso zaka ana (zaka 18);
• angina, kuphatikizapo Prinzmetal angina ;
• mimba ndi yoyamwitsa;
• m'mnyewa wamtima infarction, kuphatikizapo loyenda m'mbiri;
• oopsa (kusalankhula mtundu);
• oopsa (ankalamulira mtundu);
• occlusive zotumphukira matenda mtsempha wamagazi;
• khunyu, kuphatikizapo mavuto alionse pathological kugwirizana ndi otsika khunyu pakhomo;
• aimpso kapena kwa chiwindi kulephera;
• sitiroko kapena chosakhalitsa boma la otaya oziziritsa magazi, kuphatikizapo mbiri otaya.

Monga tanena mankhwala "Sumatriptan" ayenera kugwiritsidwa ntchito pa mimba. Koma ngati chiopsezo kwa mwana wosabadwayo ndi zosakwana phindu mayi, izo akadali Kwalamulidwa kwa amayi boma ndi unamwino amayi. Komabe, kuchita izi yekha katswiri wodziwa (mankhwala akutengedwa mosamalitsa moyang'aniridwa ake). Mwa njira, iwo ali osavomerezeka kuyamwitsa mwana wanu chifuwa mkati mwa tsiku atalandira mapiritsi anati.

Mankhwala "Sumatriptan": malangizo ntchito

Izi mankhwala anatengedwa pakamwa, kaya kudya chakudya. Mlingo mu nkhani iyi ayenera kukhala wolingana 50 mg (ngati pakufunika - 100 mg).

Ngati mwaganiza ntchito m'mphuno medicament "Sumatriptan" (kutsitsi), mlingo wake ndi 20 mg wa aliyense mphuno. Mobwerezabwereza utsogoleli wa mankhwala amaloledwa osati kale kuposa pambuyo 2 hr.

The pazipita tsiku Mlingo makonzedwe m'kamwa ndi 300 mg. Pamene ntchito intranasal chiphunzitso, ndi wofanana ndi mlingo awiri a 20 mg.

Features mankhwala

Tsopano inu mukudziwa momwe kupambana migraine. "Sumatriptan" (mapiritsi ndi kutsitsi) uzigwirizana bwino ntchitoyi. Komabe, tisaiwale kuti medicament sinafike kwa prophylaxis wa kupatuka anati.

Ntchito ya mankhwala n'chotheka mu choncho kumene matendawa ndi chipeneko. Pamaso poika mankhwala "Sumatriptan" odwala ndi atypical ndi kale anapezeka ndi migraine, dokotala ayenera kuonetsetsa kuti akatsimikizire mavuto ena a ubongo woopsawo. Tiyeneranso adzanyamula kukumbukira kuti odwala ndi matenda pambuyo pa kukhazikitsidwa miyala anati akhoza kukhala matenda cerebrovascular.

Pamaso pa kuvutika mu m'thupi (mu akulu kuposa zaka 40 ndi akazi postmenopausal) amafuna kufufuza kuyambirira kuti kukusalani kuvutika kwa ziwiya mtima ndi magazi.

Panopa pali nkhani pakutchulidwa wa kuyan'anila za mgwirizano, kufooka ndi hyperreflexia pambuyo kutenga mankhwala, "Sumatriptan" ndi mankhwala ena ku gulu la zoletsa kusankha.

Mpaka pa mankhwala ndi mankhwala anapereka amafuna zonse kudya chakudya, komanso kutsatira zakudya kwambiri. Motero, wodwalayo ayenera kuthetsa zakudya wanu zakudya zomwe zili tyramine mankhwala (chocolate, zipatso, koko, udzu winawake, mtedza, tchizi, nyemba, ndi tomato). Komanso, m'pofunika kusiya kumwa mowa, kuphatikizapo wofiira, wothwanima ndi youma vinyo, shampeni, mowa.

Khalani ndi kukhalabe moyo wathanzi ambiri (kuyenda, kusambira, kutsetsereka), komanso pamaso pa chizolowezi iliyonse amathandiza kuti zikamera maganizo abwino, amene kumathandiza chitukuko cha munthu wodwala anthu kuukira migraine.

Malangizo pa ntchito kutsitsi ndi m'mphuno

Trade dzina la kutsitsi ndi yogwira mankhwala sumatriptan zikumveka ngati "Imigran". Izi mankhwala ali ndi zigawo izi:

• achepetsa zala;
• achenjezo;
• buluu batani.

Tikumbukenso kuti batani buluu ndi adamulowetsa mofulumira kwambiri ndi kamodzi kokha. Pa nkhani imeneyi Ndi bwino osati kupitiriza mpaka nsonga ya analowa mu ndime m'mphuno. Apo ayi, mlingo zonse zidzatha pachabe.

Kugwiritsa ntchito kutsitsi m'mphuno, wodwala ayenera kutenga malo omasuka, kugona pansi, ataima kapena pansi. Mwa njira, pambuyo wodwalayo m'mphuno tikulimbikitsidwa kulitsuka ndi swabs thonje.

Kuchotsa chithuza paketi ndi kuchotsa mankhwala ntchito m'mphuno, mankhwala ayenera kulowa mu mphuno wina. Koma ena ndimeyi m'mphuno, ziyenera mbamuikha ndi chala kwa amphuno septum. Pankhaniyi, wodwala ayenera kupuma kupyolera pakamwa.

Amaika nsonga mu chiphunzitso mphuno m'mphuno akhale 1 centimeter. Mutu wa wodwalayo ayenera kusunga molunjika, kutaya kumbuyo kumbuyo. Pambuyo pake, wodwala ayenera kutseka pakamwa pake ndi kupanga phokoso ndi wosakwiya mpweya mu mphuno, ndi khama munthawi yomweyo alemba pa batani buluu ndi chala chanu. Pankhaniyi, munthu angaone kuti batani ndi zolimba kwambiri. Koma izi sizili choncho. Pa jekeseni wa mankhwala kuti patsekeke m'mphuno wodwalayo ayenera kumva kukomoka kuwonekera phokoso. Izi zikutanthauza kuti batani ali bwinobwino ntchito.

Pambuyo njirayi, wodwalayo ali wofunikila atsegule pakamwa pake, kupuma pang'onopang'ono mu izo. Mutu ayenera kusunga molunjika. Kenako, wodwala ayenera kupanga mpweya chete mwa m'mphuno, ndi chifukwa ndiye kutulutsa - kudzera (masekondi 10-20). Ndi bwino osati kupuma kwambiri.

Kamodzi ndondomeko udzatha jekeseni wa mankhwala, munthu akhoza kumverera kukhalapo kwa chinyontho mphuno, ndi kukhoza. zomverera Awa si owopsa thanzi ndi kudya pochitika zokha. Pambuyo ntchito limodzi la dispenser akhoza kuchotsedwa.

Akuchenjeza pamene ntchito

Mankhwala "Sumatriptan Teva", ndemanga zimene ziri zabwino mokulirapo, ayenera kumwedwa mosamala kwambiri kuti madalaivala a magalimoto, komanso anthu amene tikugwira ntchito woopsawo kuti zikuyenela chiwerengero cha anachita ndi chidwi.

zotsatira zoyipazi

Kodi zoyambitsa mavuto a mankhwala "Sumatriptan"? Kukonzekera kwa mtundu umenewu angathandize kuti chitukuko cha nambala mwachilungamo lalikulu la zochitika negative. Tiyeni tione iwo mwatsatanetsatane:

• anthu magazi dongosolo. Pa mbali ya chitetezo cha mu mtima kuthamanga otsika magazi akhoza anati, m'mnyewa wamtima infarction, kuthamanga yochepa kwambiri kwa magazi (zambiri chakachi ingestion), tachycardia, bradycardia, tachycardia, ndi zina, arrhythmia, spasms wa mitsempha inatsekeratu, chosakhalitsa kusintha ECG Raynaud ndi matenda.
• mantha dongosolo ndi ziwalo nzeru. Pambuyo kutenga mankhwala munthu, akhoza kufooka, chizungulire, kufooka ndi tulo. Nthawi zina, mankhwala amachititsa diplopia, khunyu, pakutchulidwa wa kukulowa ntchentche pamaso ake, nystagmus, utachepa zithunzi acuity, scotoma ndi tsankho imfa chosakhalitsa cha masomphenya.
• The m'mimba thirakiti. Ku chimbudzi mu mtima zimachitika kusanza, dysphagia, nseru, ndi kukula (zing'onozing'ono) ntchito michere chiwindi, kusapeza m'mimba ndi ischemic matenda a m'matumbo.
• Ziwengo. Pambuyo kutenga mankhwala ena odwala lipoti maonekedwe a pruritus, zidzolo, urticaria ndi erythema. Komanso, pali anaphylaxis, kumverera kutentha, kumva kulasalasa ndi kupweteka kwa mutu, kulemera, kuthamanga, ankatenthetsa, ndi myalgia. Intranasal utsogoleli wa mankhwala angayambe mawonekedwe a zochita m'dera m'mapapo chosakhalitsa kuyabwa kapena moto kumverera mu mmero ndi m'mphuno ndi magazi m'mphuno.

Mogwirizana ndi mankhwala ena

Kodi mankhwala ena pa mphamvu ndi mphamvu ya "Sumatriptan" mankhwala? Malangizo, ndemanga pa akatswiri pa nkhani imeneyi muli mfundo zotsatirazi. Ndi ntchito munthawi yomweyo mankhwala ndi medicament "Ergotamine" kutanthauza wodwala ergotaminsoderzhaschimi zotheka yaitali vasospasm. Mu nkhani imeneyi, imeneyi pakati Mlingo wa mankhwala ayenera kukhala maola osachepera 24.

Malinga ndi kafukufuku, pali zimachitika pakati mankhwala "sumatriptan" ndi Mao zoletsa. Choncho mlingo kagayidwe kachakudya yafupika woyamba, ndipo ndende ukuwonjezeka.

Ndi ntchito munthawi yomweyo anati mankhwala odana migraine, ndipo anali zoletsa kusankha serotonin reuptake, wodwala angathe kufooka, hyperreflexia ndi okhumudwa kugwirizana kayendedwe.

Ambiri osokoneza mankhwala (zizindikiro mankhwala)

Kodi chimachitika n'chiyani ngati mulibe kutsatira mlingo analimbikitsa ndi dokotala anu? Pamene ntchito yambiri pa ntchito yokonza "sumatriptan" odwala achuluke pamwamba zochita mbali. Pa nkhani imeneyi, chikhalidwe chawo amafuna kuonerera wapadera kwa maola 10.

Ngati ndi kotheka, ndi mtima ambiri osokoneza ndi anathandiza mu mawonekedwe a mankhwala symptomatic.

Mankhwala "Sumatriptan": analogues ndi mtengo mankhwala

Tatenga chida pa mankhwala aliwonse. Tikumbukenso kuti mtengo wa "Sumatriptan" mankhwala, ndi china, wotsika. Choncho pa 50 filimu TACHIMATA mapiritsi mwa inu kulipira 170-200 yekha Russian rubles. Koma m'mphuno zikutanthauza kuti mtengo wake ndi pafupi zofanana.

ngati Akhristu ndi mankhwala "Sumatriptan"? "Amigrenin" - mankhwala ambiri amangoti anapeza kuthetsa kuukira migraine ngati pamwamba zikutanthauza kutali mankhwala a. Kuwonjezera izo, analogues medicament "sumatriptan" zinthu yogwira ndi mankhwala zotsatirazi: "Sumarin" "Imigran", "Sumitran", "Migrepam", "Sumatriptan-Teva", "sumatriptan succinate", "sumatriptan Pfizer", "sumatriptan Adifarm "" Sumamigren "," Trimigren "ndi zina zotero.

Komanso, monga ofanana decongestants m'mphuno, akatswiri ena amalangiza ntchito kutsitsi "Imigran".

zinthu yosungirako ndi moyo alumali

Anapereka mankhwala ziyenera kusungidwa okha youma ndi kutetezedwa ku dzuwa malo. Kutentha mu chipinda sayenera madigiri oposa 25. Alumali moyo wa zachipatala maofesi ndi zaka 3. Itatha nthawi iyi, mankhwala ayenera kugwiritsidwa ntchito.