Protamine sulphate: Kufotokozera ndi Wosuta

ndi mankhwala mankhwala monga protamine sulphate chiyani? malangizo ntchito zake, komanso mawonekedwe ndi umboni wa ndalama adzakhala ali m'munsiwa.

Zikuchokera, maonekedwe, mawonekedwe

Kodi protamine sulphate? njira m'chipatala monga chikasu kapena colorless madzi mandala anafuna makonzedwe mtsempha. Kukonzekera zochokera mankhwala ali dzina chomwecho, ndi zina limapangidwa madzi a jekeseni.

Mu kugulitsa "Protamine sulphate" umaperekedwa mu mbale kuti anayikidwa mu ndondomeko foni kuchokera polyvinyl mankhwala enaake film, amene ankanyamula mu makatoni. Komanso mu phukusi aikidwa malangizo ntchito ndi ampoule kutsegula.

kanthu mankhwala

Kodi protamine sulphate? Guide inanena kuti heparin antagonist (yeniyeni). 1 mg wa thunthu angathe neutralizing magazi wodwalayo pafupifupi 80-115 IU wa heparin.

Action malipoti zikutanthauza pambuyo mtsempha jekeseni akuyamba yomweyo zimatha kwa maola pafupifupi awiri. Complexation la mankhwala chifukwa cha kuchuluka kwa magulu cationic kuti kumumanga kwa heparin malo anionic.

Malinga ndi malangizo a protamine sulphate anthu ali complexed heparin-protamine, amene akuswa kumasula otsiriza.

Mu ambiri osokoneza izi zikutanthauza wodwala kwambiri yafupika magazi clotting, kuyambira ankaona yogwira wothandizila chiphunzitso akusonyeza mkulu anticoagulant ntchito.

Pharmacokinetics njira

Kodi katundu kayendedwe wa sulphate heparin protamine? Malinga ndi akatswiri, iwo ali pharmacokinetic katundu wa mankhwala sanali kuphunzira. Choncho iwo ankaimira mu bukhuli.

Zikuonetsa njira yothetsera

Nthawi zina, wodwalayo mtsempha njira "Protamine sulphate" awerenge? Ntchito njira imeneyi kukuonetsedwa:

• asanachite opareshoni anthu kutenga heparin zolinga achire;
• pa hyperheparinemia;
• kwa magazi zikuchitika chifukwa heparin ambiri osokoneza;
• pambuyo ntchito pa Mitsempha ndi mtima ndi makope extracorporeal.

Ziletsozi kumaloku njira

Mankhwala "Protamine sulphate" (mankhwala kugula ayenera mankhwala dokotala) ndi contraindicated milandu zotsatirazi:

• ndi thrombocytopenia;
• mkulu kudziwa miyambo ya mankhwala;
• aakulu hypotension;
• kobadwa nako kapena idiopathic hyperheparinemia (mu boma mankhwala ndi operewera, ndipo akhoza kwambiri kumapangitsanso magazi);
• utsogoleli wa insulin ndi mankhwala ena munali protamine sulphate;
• thupi lawo siligwirizana mankhwala nsomba, kuphatikizapo mbiri;
• adrenal insufficiency.

Sitingathe kunena kuti zinachitikira ntchito zachipatala chida ana yochepa.

Pa mimba ndi mkaka wa m'mawere "Protamine sulphate" angagwiritsidwe ntchito. Komabe, zimenezi ziyenera kuchitidwa Koma ngati, ngati zotsatira za mankhwala ndi apamwamba kwambiri kuposa ngozi mwina kwa mwana wosabadwayo, kapena mwana.

Kukonzekera "Protamine sulphate": malangizo ntchito

Ankaona njira ayenera kuperekedwa ndi wosakwiya IV kukapanda kuleka kapena bolus. Choncho mlingo wa utsogoleli sayenera upambana 5 mg pa mphindi. Mofulumira oyamba mankhwala chingachititse mtima anaphylactoid anachita.

Mlingo wa medicament chimadalira pa njira ya utsogoleli. Mlingo masamu ayenera zidzasungunuka mu 300-500 ml ya 0,9% mphamvu sodium kolorayidi njira. Izo kutiletsa kulowa oposa 150 mg wa mankhwala kwa mphindi 60.

• Ndi bolus jekeseni mlingo wa protamine sulphate yafupika malingana nthawi kuti wadutsa kuchokera ku ulamuliro wa heparin. Ichi ndi chifukwa chakuti yotsirizira ndi mosalekeza kuchotsedwa thupi.
• Ngati heparin chikuyendetsedwera mtsempha kukapanda kuleka, m'pofunika kuti asiye kulowetsedwa ndi ntchito za 20-30 mg wa protamine sulphate.
• Pamene subcutaneous jekeseni wa heparin mlingo wa protamine sulphate 1-1.5 mg wa 100 IU heparin. Choncho woyamba 25-50 mg wa ayenera pang'onopang'ono kutumikiridwa m'nsinga, ndi kuchuluka otsala - mtsempha kukapanda kuleka kwa maola 8-17. N'zothekanso likukulira makonzedwe, koma Pakufunika polojekiti okhwima APTT.
• Pamene alowererepo mwamsanga pa nkhani ya extracorporeal makope njira ankaona mlingo ndi 1.5 mg wa ku 100 INE heparin.

Kutalika pazipita mankhwala a ndalama ndi masiku 3.

Action mwa khalidwe

Kodi protamine sulphate kupangitsa zosiyanasiyana chokhwima? limati Manual kuti ambiri mankhwala awa ndi bwino analekerera ndi odwala. Komabe, mu zina, akhoza kuchititsa mavuto pa mbali ya chitetezo, zamtima ndi m'mimba kachitidwe, komanso khungu:

• bradycardia, kuchepetsa kuthamanga kwa magazi;
• kusanza, nseru;
• kuyabwa, zotupa pa khungu chitukuko cha zochita anaphylactoid;
• kumverera otentha, kumverera kochepa kwa mpweya, ndi ankatenthetsa wa khungu.

Overdoses ndipo mogwirizana ndi mankhwala ena

Ankaona njira anafuna makonzedwe mtsempha ndi yosemphana ndi penicillin ndi cephalosporins. Popeza kuti ndi antagonist, otsika maselo kulemera heparins, yogwira mankhwala achuluke nthawi ndi mphamvu ya zochita za relaxants sanali depolarizing minofu.

An ambiri osokoneza mankhwala akhoza kugwirizana ndi magazi. Ichi ndi chifukwa chakuti thunthu mu funso ali mkulu anticoagulant ntchito. Pankhaniyi, akuchita mankhwala symptomatic chofunika.

tsatanetsatane

Zimene muyenera kudziwa musanalowe mu njira monga protamine sulphate? Akatswiri amanena kuti ntchito za mankhwala ayenera kwambiri kuunikira dokotala amene anayenera kuyan'ana magazi clotting mtima.

Pamaso kumayambiriro mankhwala pofuna mtima okwanira a magazi buku. Ichi ndi chifukwa chakuti hypovolemia kwambiri kumaonjezera ngozi ya kugwa.

zinthu kusungiramo kotunga pharmacies, moyo alumali

Kaya momasuka chogulitsidwa pharmacies mankhwala "Protamine sulphate '? Chinsinsi mu chinenero Latin kapena Russian, onetsetsani kuti asonyeze pharmacist, mwinamwake mankhwala adzamasulidwa.

Kusunga njira ankaona n'zofunika patali ndi ana ndipo zimatetezedwa ku dzuwa kumene kutentha mpweya pakati pa 4 ndi 10 madigiri. Iwo ayenera kukumbukira kuti mtsempha njira "Protamine sulphate" Mulimonsemo sayenera zii.

Alumali moyo wa mankhwala ndi zaka 4 kuchokera tsiku kupanga. Musagwiritse ntchito zoposa atapita nthawi imeneyi.

analogues mankhwala ndi ndemanga za izo

Analogues mu zipangizo malipoti si ambiri kwambiri. Yankho mtsempha akhoza m'malo ndi mankhwala monga "Protamine" ndi "Protamine-Verein".

Pankhani ndemanga ogula pafupifupi zonse abwino. "Protamine sulphate" - ichi ndi kothandiza kwambiri komanso zothandiza njira kupezeka kwa aliyense. Iwo maganizo amagawidwa ndi ambiri odwala. Iwo amati mankhwala sapereka heparin kuti ziletsa ndondomeko ya clotting magazi, kuwongolera alili pa magazi lolemera.

Monga ku zoyenereza za mankhwala monga zotsatira zake mofulumira ndi yaitali. Komanso, kukwaniritsa zotsatira achire kwa wodwala kumafunika kuti tigwire chithandizo yaitali. Nthawi pazipita ntchito mankhwala awa ndi masiku atatu.