"Nimesulide" mankhwala. Malangizo ntchito, Akhristu enieni

Ululu - ndi mtundu wa kuyesa za thupi kukopa chidwi cha munthu, kupempha thandizo. Olakwika chinachake "mu ufumu Chidanishi", ndi chuma cha thupi si zokwanira vutolo, tiyenera thandizo kuchokera kunja.

Kugula mankhwala msika la Chitaganya cha Russia anapereka mazana mankhwala kuthandiza anthu kuthana ndi ululu. Mankhwala onse osiyana zikuchokera, kukula ndi njira ya chikoka. Mmodzi wa yabwino kwambiri ndi mankhwala ochokera ku gulu la anthu omwe sanali steroidal mankhwala odana ndi yotupa. Pakati pawo ndi kuyimitsidwa ndi miyala "Nimesulide".

Kapangidwe ndi Kaonekedwe

mapiritsi Round ndi mawonekedwe lenticular. Mtundu kungakhale wotumbululuka chikasu kapena kungoti chikasu. Waukulu yogwira chigawo chimodzi - chinthu Nimesulide aliyense piritsi - 100 mg. Kuyambira angapo angatchedwe zina microcrystalline mapadi, wowuma (chimanga), sodium wowuma glycolate, colloidal pakachitsulo woipa.

Komanso, mankhwala amapatsidwa kwa ogula mu mawonekedwe a ufa kwa kuyimitsidwa "Nimesulide." Zikuchokera ndi chimodzimodzi kuti a mapiritsi, aliyense 100 mg sachet yaikulu yogwira chigawo.

pharmacodynamics

Nimesulide kusankha kumabwezera mmbuyo cyclooxygenase-2, cyclooxygenase-1, zotsatira zake ndi Pamlingo kwambiri wamng'ono. Mu nkhani imeneyi, chopinga wa prostaglandins kaphatikizidwe anati chikwiyire yotupa anachita. Komabe, mapangidwe prostaglandin-mtundu zolimbana nimesulide ochitachita zotsatira sadzachitanso amaonekera, chifukwa mu ina mawonetseredwe kochepa a dongosolo m'mimba.

Komanso, zochita za nimesulide akuwonetseredwa mu chopinga wa mapangidwe ankafuna kusintha zinthu mopitirira ufulu. Komabe, njira ya hemostasis ndi phagocytosis si akavutika ndi mankhwala. Limagwirira wa wotsutsa-yotupa tingati anagwira medicament ali danga ndithu ndi mphamvu yake kupondereza amasulidwe myeloperoxidase (matenda ambiri yotupa kungawononge minofu, ndi chimodzi mwa zizindikiro zolondola kwambiri matenda zimasonyeza chiopsezo angathe mtima kapena kachigawo).

Zikuonetsa ntchito

Lonse zokwanira kuchuluka kwa mankhwala "Nimesulide". Zimene zimapangitsa mankhwala? Chifukwa mankhwala ali pa zotsatira anthu ovuta - antioxidant, analgesic, antipyretic ndi odana - ndiye anatumizidwa ndi chiwerengero cha matenda yotupa. Kugwiritsa ntchito mankhwala osokoneza bongo ndi pamaso pa nyamakazi (matenda aakulu olowa mu malo oyamba waonongeka articular chichereŵechereŵe), tendinitis (kutupa tendon ndi minofu alibe), bursitis (kutupa zikwama mucous, umene uli malo).

zotsatira zabwino akutanthauza "nimesulide" mankhwalawa nyamakazi, owonjezera articular matenda enaake ophwanya. Bwinobwino kumenyana ndi matenda opatsirana amene anatsagana ndi njira yotupa. Nthawi zambiri, "Nimesulide" piritsi ntchito matenda achikazi, zochizira kuvulala chiyambi osiyana. Odwala kunena kuwonongedwa bwino ululu konzanso postoperative.

Contraindications "nimesulide"

Popeza medicament amatanthauza gulu lamakono la National Msonkhano Square, liri ndi mndandanda ndithu kwambiri contraindications. "Nimesulide" (zimene zimathandiza mankhwala - wakhala takambirana kale) sayenera kutenga anthu ndi hypersensitivity kwa chigawo chilichonse mu kapangidwe kake. Palibe mankhwala kutumikiridwa odwala amene ali ndi mbiri kuoneka zochita hepatotoxic ndi zochita hypersensitivity monga rhinitis, bronchospasm, urticaria (ndi aspirin kapena zina NSAIDs oimira gulu).

Contraindications ntchito medicament ndi kuti zotupa aliyense erosive-ulcerous a dongosolo m'mimba, amakonda kukhala magazi chiyambi iliyonse (T. E. chakuti kugwira ntchito clotting magazi).

Medicine "Nimesulide" malangizo limaletsa odwala ndi aimpso, kwa chiwindi, mtima insufficiency. Odwala "ndi aspirin" mphumu mowa, ndi kudalira mankhwala ndi Musawachite mankhwala.

Musati mankhwala mu zonsezi ngati wodwala kwambiri chifukwa thupi kutentha kapena zizindikiro zina za chimfine ali anaona. Komanso, ndi zosavomerezeka kutenga "Nimesulide" ana, pakati ndi akazi lactating.

Zotheka mbali zosiyanasiyana "nimesulide"

Kugwiritsa medicament ndi zingachititse angapo mavuto kuchokera ku ziwalo zosiyanasiyana ndi machitidwe a thupi.

Zimene ambiri analembedwa ndi dongosolo m'mimba, ndipo anaonetsa nseru, kusanza, kutsekula m'mimba, flatulence, ndi chitukuko cha gastritis. Pasanathe amayambira magazi m'mimba, zilonda mpaka perforation. Nthawi zina mungathe kumva za dyspepsia, stomatitis, kupweteka m'mimba.

Zingachititse "nimesulide" mbali kanthu mwa dongosolo hepatobiliary, nthawi zambiri akuwonetseredwa mu kuchuluka misinkhu chiwindi enzyme, osachepera - mu chitukuko cha matenda a chiwindi (kuphatikizapo fulminant ..), Cholestatic matenda a chikasu ndiyo.

Pa zimene dongosolo mtima akhoza kunena, ngati pali nyamuka azilandira magazi, odwala kawirikawiri nkhawa palpitations mtima, kukha mwazi ankatenthetsa, kuthamanga kwa magazi kudumpha.

dongosolo mkodzo angayankhe kuoneka edema (osati kawirikawiri), kawirikawiri - mkodzo posungira, hematuria, dysuria. kawirikawiri izo angathe kulephera aimpso, interstitial nephritis, oliguria.

zochita zotheka kwa CNS nthawi zambiri anaonetsa chizungulire, malaise, asthenia. Pasanathe zambiri angamvele za mutu, somnolence chitukuko (kufanana zachinyengo kugona), syndrome Reye a (encephalopathy), hypothermia (thupi kutentha kuchepa pansi pa chofunika kukhalabe kagayidwe zachilendo). Nthawi zina mungathe kumva za maganizo "Nimesulide", monga mantha, nkhawa, malubwelubwe.

Pankhani dongosolo lymphatic ndi dongosolo hematopoietic, "Nimesulide" (Malangizo, akuchipatala ndemanga amatsimikizira nkhani iyi) kawirikawiri imfayo magazi m'thupi, eosinophilia, komabe zochepa angayambe thrombocytopenia purpura pantsitopenicheskaya.

Kawirikawiri, koma mukhoza kumva za chisokonezo kagayidwe kachakudya (hyperkalemia), chitetezo (hypersensitivity, anaphylaxis), ziwalo masomphenya (kuona, clouding za m'minda), kupuma, mediastinum (dyspnea, bronchospasm, mphumu kuukira). Panali Zimene khungu ndi subcutaneous minofu (thukuta, kuyabwa, dermatitis, urticaria, erythema, kawirikawiri - poizoni epidermal necrolysis, Stevens-Johnson syndrome).

dosing ndi dera ntchito mode

odwala wamkulu mapiritsi "nimesulide" analangiza mmodzi pa nthawi (100 mg) kawiri pa tsiku. Ndi bwino kutero pambuyo chakudya ndi kumwa madzi ambiri kuti amuchiritse. Ngati ndi ufa kuyimitsidwa, ndiye nkhani za sachet imodzi ndiye kuti sitimadzipereka mu 100 ml ya madzi. Ana pa zaka 12 palibe kusintha mlingo, ndi ana mankhwala kulandira zoletsedwa. Pankhani ya chithandizo cha odwala achikulire banjali mlingo si anachita.

Pakuti anthu akuvutika insufficiency kwa chiwindi, creatine chilolezo mu osiyanasiyana 30-80 ml ya / min., The mlingo si zolondola. Ngati chizindikiro adatchithisira (30 ml ya / mphindi kapena zochepa.) - choletsedwa kulandira medicament.

Awa ndi malangizo chachikulu phwando mankhwala "Nimesulide". Mlingo amasankhidwa asang'ambe mwaluso, ndipo kwa nthawi yayifupi zotheka, umene tichepetse kutenga mavuto. Zolemba malire Inde mankhwala ntchito "Nimesulide" sadzakhala upambana masiku 15.

Kugwiritsa mlingo: Zizindikiro, Chithandizo

Kutenga mankhwala "Nimesulide", m'pofunika kutsatira Mlingo analimbikitsa malangizo kapena anasankhidwa ndi dokotala nawo. Self-ka medicament ndi (kapena) ntchito kusalankhula zingadzetse ambiri osokoneza. The kaŵirikaŵiri anati zizindikiro zotsatirazi: nseru, kusanza, magazi, m'mimba thirakiti, kugona, ulesi, matenda oopsa (kuthamanga magazi), chopinga wa ntchito kupuma, pachimake aimpso kulephera.

Chithandizo mu nkhani cha mankhwala osokoneza bongo symptomatic, wamugwira khalidwe. Adakalibe nimesulide panopa akusowa. Ngati kuyambira overdosing kapena kutenga mlingo mkulu wa medicament sichimaperekedwa maola oposa 4, wodwalayo chipatala chapamimba lavage analimbikitsa phwando absorbent (mwachitsanzo, adamulowetsa mpweya kuchuluka kwa 60-100 mg pa munthu wamkulu) ndi mitundu ina ya osmotic mankhwala ofewetsa tuvi tolimba mankhwala.

Pa nthawi yonse ya mankhwala ayenera kuyang'aniridwa ndi zachipatala ntchito chiwindi ndi impso. Information zokhuza kuthekera kuchotsa nimesulide m'thupi mwa hemodialysis palibe. Chifukwa cha digiri yapamwamba ya mankhwala kumanga zonsezo amakakamizidwa diuresis si zothandiza.

malangizo Special

"Nimesulide" kupeza mankhwala kuchokera pharmacies omwe safunika Komabe, ayenera kumwedwa mosamala. Pewani ntchito yomweyi medicament ndi wina aliyense sanali steroidal odana ndi yotupa wothandizira, analgesics mtumiki. Ndi chitukuko cha zizindikiro za odwala, kuwonongeka chiwindi khalidwe (nseru, kusanza, anorexia, mkodzo mdima) kapena kuwonjezera mlingo wa kwa chiwindi transaminases ntchito "nimesulide" ayenera adzasiyidwa. Ngati pali thupi kapena zizindikiro za chimfine, mankhwala ayenera anasiya pomwepo.

Kulingalira odwala ake ayenera kukhala kuti mu kufanana ndi "Nimesulide" kumwa mankhwala kuti azitaya zilonda m'mimba ndi magazi. CHENJEZO Kwalamulidwa mankhwala kwa anthu amene amadwala matenda a m'matumbo anam'peza kapena matenda amene amatupitsa, zilonda ndi mbiri odwala okalamba.

Anthu amene ayenera kutenga "Nimesulide" pamodzi ndi aspirin ndi pa mlingo mtima ayenera kupatsidwa kuphatikiza mankhwala ndi gastroprotectives.

Ntchito "Nimesulide" (kapena NSAID ina) lalikulu zedi ndipo pa nthawi yaitali kumabweretsa kuwonjezeka yaing'ono chiopsezo ngozi thromboembolic (sitiroko, m'mnyewa wamtima infarction, ndi zina zotero. N.).

Odwala ndi mtima mavuto "Nimesulide" dongosolo zosiyanasiyana Akhozanso kusankha yekha ngati phindu sikhala kuposa ngozi ya mavuto.

The medicament ali zimakhudzanso mlingo wa ntchito kupatsidwa zinthu za m'mwazi. Mfundozi n'kofunika kuti odwala matenda hemorrhagic diathesis. zotupa choopsa cha khungu zambiri kukhala pa ntchito nthawi yaitali "nimesulide". Kamodzi totupa pakhungu kuoneka, amakhala appreciable kuwonongeka kwa nembanemba mucous kapena mawonetseredwe ina lokhazikika la tsankho, mankhwala mankhwala ayenera anasiya.

The ntchito za amayi apakati "Nimesulide" lingachititse kutseka wolumikizira ritsa zisanafike chofunika, kuchepetsa buku la madzimadzi amniotic. Zotheka kuchuluka chiopsezo magazi intrauterine kufooka ntchito, maonekedwe a edema. Pazifukwa izi, amayi oyembekezera pa woyamba ndi trimesters chachiwiri cha mimba phwando "Nimesulide" ali osavomerezeka.

Izo ziyenera kukhala yankho la funso ngati sitingathe kutenga "Nimesulide" imodzi ndi mowa, n'zoonekeratu: ngati osakaniza sikuloledwa!

analogs

Pansi analogs "nimesulide" amatanthauza mankhwala magulu NSAID okhala ngati waukulu yogwira pophika nimesulide (mtengo iwo adzakhala oscillate pa pafupifupi osiyanasiyana yomweyo koma pang'ono m'munsi mwake). Kwambiri kudziwika ndi ambiri zotchulidwa zachipatala ndodo analogs monga mankhwala "Naiz" (gel osakaniza, piritsi, kuyimitsidwa), "Nimesil" (ufa) "Niemiec" (mapiritsi) 'nimulid "(gel osakaniza, mapiritsi, miyala kuyimitsidwa chifukwa woyamwa) .

analogs Pamoyo Mwachangu chokwanira ndipo apatsidwa kuthana ndi uthunthu wa lonse matenda, yotupa atavala khalidwe.

mtengo osiyanasiyana

Mitengo yekha "Nimesulide" ndi analogs ake pafupifupi chimodzimodzi, ngakhale takambirana mtengo mankhwala mosavuta osiyanasiyana ogula. Miyala "Nimesulide" (20 ma PC. Mu paketi a) ndalama 85-90 rubles pa paketi. The nambalayi a mapiritsi "Naiza" ndalama 110-140 rubles, "Niemiec" (komanso 20 ma PC.) - mu rubles 115-134. Kenaka "nimulid" 30 mapiritsi ndalama 180-220 rubles. Buku zili waukulu yogwira pophika (Nimesulide) mu analogs chomwecho - 100 mg.

M'malo mapiritsi "Nimesulide" (mtengo wotsikitsitsa) akhoza analandira Mwachitsanzo, slurry "Naiz" ndalama 200-300 rubles 60 ml ya kapena "nimulid" - 75-105 rubles kwa yofanana mankhwala. Likupezeka pa osiyanasiyana ogula lozenges "nimulid": 20 magawo pa mtengo 130-155 rubles pa paketi.

Mwina mtengo kwambiri mtundu wa kumasulidwa kwa mankhwala ndi nimesulide ndi mbali yaikulu - ufa 'Nimesil ". 30 matumba (phukusi) ndalama makasitomala kuchuluka kwa rubles kuchokera 560 mpaka 645.

Pakuti ntchito apakhungu ndi angakhale angelo ogwira ndi nimesulide. Motero, "Naiz" ndalama 120-145 rubles kwa chubu 20 ga kapena 215-275 rubles (50 g). Gel osakaniza "nimulid" pang'ono mtengo: 115-150 rubles pa chubu buku la '30

Pomaliza Ndikufuna kunena mfundo zotsatirazi. kusankha ntchito "nimesulide", analogue iliyonse kapena NSAIDs ina ayenera kumwedwa ndi dokotala nawo. Only za katswiri wa zachipatala angathe bwino ganizilani kuopsa kwa thanzi la odwala awo, kuganizira matenda onse ogwirizana, kusankha mankhwala mlingo kusankha ndipo ndinayamba kukhala ndi ndondomeko mankhwala kuti kuchepetsa mosavuta mavuto ndi kupeza zotsatira zabwino.