Mankhwala "Sulpiride": ndemanga, zizindikiro, analogs

Psychosis wa kusinthasintha mwamphamvu limodzi umunthu konse. Kwa zaka zambiri ankakhulupirira kuti ziwanda ndi mdierekezi mwa munthu wodwala, choncho "mankhwala" vutoli wakhala yoyenera. Isanafike chilengedwe cha neuroleptic mpumulo mankhwala matenda a m'maganizo umatulutsa mankhwala azitsamba anayamba pamaziko a ndi belladonna, henbane, opiates. Ankachita monga mankhwala ndi kashiamu (mtsempha) ndi kumiza wodwala mu kugona mankhwala.

Woyambirira antipsychotic chlorpromazine angatchedwe, umene mwachangu ntchito zochizira odwala matenda a maganizo kuyambira 1953. Panopa mndandanda wa mankhwala antipsychotic, antipsychotics kwambiri kukodzedwa. Mmodzi wa mankhwala chimagwiritsidwa ntchito ya gulu limeneli ndi "Sulpiride". Umboni kufotokoza iye monga antipsychotic kwambiri atypical.

pharmacodynamics mankhwala

Neuroleptic zotsatira "sulpiride" antidofaminergicheskim kugwirizana ndi zochita, m. E. Mu chapakati midadada mantha dongosolo mankhwala makamaka dopaminergic zolandilira. Dopamine ndi zofunika chigawo chimodzi cha "dongosolo mphotho" ubongo - kumapangitsa zosangalatsa kutengeka wokhutiritsa kuposa Zikatero, amakhudza njira yophunzitsira ndi angalimbikitsire. Mu mlingo waukulu zokwanira, lopangidwa mu ndondomeko ya chochitika chilichonse zabwino (pa maganizo zotengera malingaliridwe a munthu) - phwando la chakudya zokoma, kugonana, palibe kosangalatsa zomverera thupi. Ndi kuchuluka kuchuluka kwa dopamine mu chapakati mantha dongosolo ndi bwino chitonthozo maganizo, ndi kuchepa ndi - zizindikiro za matenda a maganizo.

Action "sulpiride" pa mlingo choposa 600 mg (tsiku kuchuluka kwa mankhwala) ndi chikhalidwe antipsychotic. Ngati Mlingo wa zosakwana 600 mg - zambiri zofala stimulant ndi zotsatira antidepressant. Komabe serotonicheskie, histamine, adrenergic zolandilira mankhwala kwenikweni.

Mankhwala - analogues

The medicament "Sulpiride" - atypical neuroleptic, cha gulu la benzamides mmalo - ali ndi chiwerengero mokwanira lalikulu la mankhwala ofanana mu kapangidwe ali gwero. Pali mankhwala ofanana malamulo ATC 4 mlingo. Izi ndi njira "Betamax", "tiaprid", "Eglonil". Kupatula izi, chachikulu ogula ankafuna "Prosulpin", "Eglek" "lokhazika mtima pansi" "Vero Sulpiride", "Sulpiride Belupo." Reviews mankhwala onse ndi ogula akhoza nazo zonse zabwino malangizo ndi zoipa. Izi zidalira pa zovuta boma wodwalayo wathanzi, tilinazo wake waukulu yogwira pophika - sulpiride, ndi mlingo wa mankhwala anatumizidwa kulandira dokotala.

Zikuonetsa kuti alandire mankhwala othandiza

Sam neuroleptic "Sulpiride", analogs ake ndi dera zinthu zambiri za chikoka ndi awerenge kulandira matenda mokwanira kwambiri. Tengani izo pamaso pa akuchita misala mu magawo pachimake, ndipo pamene aakulu. Sulpiridsoderzhaschih wolungama ntchito antipsychotics pa siteji pachimake cha chitukuko cha kuona zilubwelubwe (matenda okhudza ubongo wa chilengedwe limodzi ndi chisokonezo cha chikumbumtima kuyambira chizungulire ndipo ngakhale chikomokere). Nthawi zambiri mankhwala Kwalamulidwa kwa matenda osiyanasiyana neurotic ndi maganizo, kaya anachokera.

Pamene vertigo chiyambi osiyana amalimbikitsa kutenga "Sulpiride" malangizo Buku. Reviews odwala ndi ogwira ntchito kuchipatala bwino yodziwika medicament pochiza vestibular neuritis, pamene kulephera vertebrobasilar-basilar mtundu ndi atolankhani otitis ndi mabvuto cranial, ndi matenda Meniere a (kukweza wa madzimadzi mu M'mimbamo mkati khutu, amene amaika kukakamiza maselo udindo kukhalabe mgwirizano thupi ndi lathu mu mlengalenga).

Monga "Sulpiride" mbali ya mankhwala mwatsatanetsatane angagwiritsidwe ntchito zinthu achire kwa zilonda matenda chilonda ndi azitsegula.

Amene sayenera kumwa mankhwala antipsychotic pamaziko a sulpiride?

Neuroleptics "Sulpiride" analogues mankhwala a yaikulu yogwira pophika ali ndi mndandanda enieni contraindications. Musamalandire kuti anthu ndi hypersensitivity kuti sulpiridu ndipo akuvutika hyperprolactinemia (kwambiri kukwezeka Kuchuluka kwa timadzi prolactin m'magazi). Choncho, mankhwala si anatumizidwa ndi zotupa prolactin amadalira (khansa ya m'mawere prolactinoma pituitary England , etc.).

Komanso, "Sulpiride" (zikuonetsa tafotokozazi) limaletsa malangizo pheochromocytoma (hormonally yogwira chromaffin zotupa khungu), amakhala wosangalala monyanyira psychosis ndi osiyanasiyana matenda affective ndi khalidwe mokwiya khunyu. Musagwiritse ntchito mankhwala sulpiridsoderzhaschih motsutsa likhale kuledzera pachimake mowa, chiphe ndi mankhwala zachinyengo mankhwala ndi analgesics chomwa mankhwalawa.

Sitingachisonyeze ndi ntchito neuroleptic "Sulpiride" odwala zaka osaposera zaka 18 ndi akazi pa mkaka wa m'mawere.

chingachitike mbali ya

zochita Kulanga kwa neuroleptic yekha ndi analogues "sulpiride" umboni mtima ndiponso akatswiri zimaonetsa ngati mokwanira kwambiri, kwambiri akuchuluka chikhalidwe cha anthu odwala. Pali kuthekera kwa hyperprolactinemia mu zosiyanasiyana (gynecomastia, dysmenorrhea, frigidity, yafupika potency, galactorrhea, kuwonjezeka mu thupi).

Komanso nkotheka chiwonetsero cha matenda extrapyramidal, amene anaonetsa matenda pathological cha kuchuluka ndi khalidwe la gululo mowiriza opangidwa ndi minofu chigoba kusintha mu minofu kamvekedwe. Komabe, ziwalo si chizindikiro kuti akutsimikiza mfundo za matenda extrapyramidal.

Monga zochita mbali "Sulpiride" analogs neuroleptic, angagwe kugwedeza, akathisia (kulephera kukhala pa mpumulo), dyskinesia tulo, kugona, nkhawa mkulu excitability, irritability. Angasonyeze zizindikiro za neuroleptic zilonda matenda, yodziwika ndi kuvutika autonomic, wotumbululuka khungu, hyperthermia.

Zotsatira zake zoyipa kwa mundawo m'mimba angakhale Timatha dryness mkamwa, chitukuko cha kutentha, nseru maonekedwe, retching, kudzimbidwa. N'zotheka kutsegula kwa transaminases kwa chiwindi ndi zamchere phosphatase.

Zamtima dongosolo ntchito "sulpiride" akhoza kuwonjezeka mu magazi (kawirikawiri - kuchepa magazi, chizungulire), kuchulukitsidwa kugunda kwa mtima, kuchuluka QT-imeneyi. kawirikawiri, koma mukhoza kumva kuti "Sulpiride" Poyankha mankhwala kwa asing'anga amasonyeza chitukuko torsadedepointes mtundu wa arrhythmia.

mawonetseredwe awo sagwirizana monga zotupa pa khungu pruritus, zotupa eczematous. Nthawi zina mungathe kumva za kuphwanya acuity zithunzi.

dosing ndi dera ntchito mode

Malinga ndi malangizo ntchito medicament ndi, odwala ambiri wamkulu malingana ndi matenda Kwalamulidwa mlingo wa 100-300 mg ndi patsiku (ogaŵikana Mlingo 2-3). Oral njira kutumikiridwa mu mlingo wosiyana: 100-800 mg wa pa tsiku makonzedwe mu mnofu (pamaso ntchito kwenikweni kugwedeza). The pazipita analekerera mlingo munthu wamkulu ndi 1.6 ga

Ngati zitavuta Ndinapereka "sulpiride" ana osaposera zaka 18, mlingo ayenera kuchita masamu kutenga nkhani kulemera pamaziko a 5 mg pa kilogalamu ya kulemera kwa thupi.

Ngati wodwala ali ndi vuto la psychosis mu gawo pachimake kapena aakulu, mankhwala ambiri akuyamba ndi makonzedwe mu mnofu (400-800 mg ndi tsiku). Nthawi zambiri, nthawi ya mankhwala masabata osachepera 2. Mwamsanga pamene thanzi la wodwalayo, ndi jekeseni mu mnofu kunditumiza ku phwando "sulpiride" mkati mapiritsi a. Neuroleptic "Sulpiride" ndemanga mtima kufotokoza monga mankhwala ntchito. Nthawi njira ya mankhwala zingadziŵike ndi kusinthidwa ngati ndi dokotala nawo.

Mlingo Kugwiritsa

Aliyense zizindikiro zenizeni zikusonyeza mfundo kwambiri kuposa pazipita chovomerezeka Mlingo pamwamba, palibe. Kawirikawiri awa, pali kuthamanga magazi, amaona masomphenya. Mwina chitukuko cha sedation (yimitsira chikugwirabe chikwiyire ndi mankhwala, kumukhazika mtima, pamene apamwamba Mlingo - zachinyengo). Nthawi zambiri, zotsatira za mankhwala "Sulpiride" umboni mtima amasonyeza maonekedwe a nseru, pakamwa youma, kuchuluka thukuta, kusanza. Nthawi zina kukhala ndi zizindikiro extrapyramidal, gynecomastia angayambe odwala wamwamuna (chifuwa kukulitsa). kawirikawiri kulankhula za parkinsonism kutchulidwa, chikomokere.

Monga kusankha yabwino yothetsera "sulpiride" olumikizidwa ku makina, mankhwala symptomatic bwino, malinga ndi mmene wodwalayo. Nthawi zina, ntchito holinoblokatory kanthu chapakati.

Pa zimene kulabadira?

Mwamtheradi mankhwala onse antipsychotic gulu (kuphatikizapo sulpiridsoderzhatsie "Betamax", "Vero Sulpiride", "Prosulpin", "Sulperid Belupo", "Eglonil", "Sulpiride") amakambirana akatswiri ndi malangizo opaleshoni ndipo amaletsa maziko a zakumwa mowa. Kwa odwala ndi khunyu tikulimbikitsidwa kuti maphunziro a matenda ndi electrophysiological akhala sulpiride izo Sachita pakhomo pa ntchito kudwala. Ngati mankhwala ntchito concomitantly ndi mankhwala azitaya arrhythmias yamitsempha yamagazi, odwala amenewa amafuna polojekiti zonse electrocardiogram lapansi. Kuchuluka QT-imeneyi zimadalira mlingo.

Ngati pa chithandizo, "sulpiride" anali zizindikiro za hyperthermia (a chakuti limanena za chitukuko cha matenda neuroleptic zilonda), mwa ntchito mankhwala ayenera anasiya.

Mwadzidzidzi kutha kwa mankhwala "sulpiride" kungakhale mavuto obwera. Maltitol chili mwa mankhwala kukhala kosatheka ntchito ndi anthu akuvutika fructose tsankho.

Pa nthawi chithandizo lonse kukhala osamala magalimoto ndi kukhazikitsa ntchito kasamalidwe zofuna mofulumira Poyankha psychomotor ndi mkulu ndende.

Sulpiridsoderzhaschie mankhwala ndi mimba

Akazi pa mimba "Sulpiride 'ndemanga anachoka mu njira zambiri zabwino. Zolemba malire kololeka mlingo amayi apakati ndi 200 mg pa tsiku sanali imfayo zotsatira teratogenic (kuchimwa chitukuko embryonic). Mlingo wamankhwala ndi lalikulu la mankhwala kwa amayi apakati No zomwe amapeza. Komanso, palibe deta pa ikhudzire wa mankhwala-antipsychotics pa ubongo chitukuko cha mwana.

Ambiri, a zaumoyo amakonda kugwiritsa ntchito "Sulpiride" zochizira amayi apakati, kupatula pa nthawi imene ndi ubwino kwa akazi chimapambana pa chiopsezo kuthekera kwa mwana wosabadwayo. Zikatero, "Sulpiride" malangizo (ndemanga akuchipatala anatsimikizira) amalimbikitsa kutumikiridwa mu Mlingo wotsikitsitsa zotheka ndipo ngati ndi kotheka kuchepetsa nthawi ya mankhwala.

Mu Ana amai pa mimba sulpiridsoderzhaschie mankhwala zina anati zizindikiro m'mimba (bloating, ndi zina zotero. N.) Zosonyeza atropinopodobnye chikoka neuroleptics. Nthawi zina mungathe kumva za matenda extrapyramidal. Pa yoyamwitsa olandiridwa "sulpiride" contraindicated.

Opinion odwala "sulpiride"

Zambiri za odwala pa mankhwala "Sulpiride" ndemanga masamba malangizo abwino. Neuroleptic mokwanira bwino ndipo wolungama makhalidwe ananena. Anthu wochotsa "Sulpiride" kapena analogues ake zizindikiro maganizo pa chilonda chapamimba kapena mmatumbo chilonda inanena kuchepa mphamvu ya ululu m'mimba ndi kusintha chikhalidwe ambiri.

Small mabuku a medicament (mg 50 300 tsiku) Kawirikawiri Kwalamulidwa kwa odwala kulandira pa madandaulo a chizungulire pafupipafupi akuwuka zifukwa zosiyanasiyana. Mtokoma wa odwalawo anali okhutitsidwa ndi zotsatira za mankhwala.

Mlingo Large "sulpiride" (zoposa 600 mg pa tsiku), mu maganizo a anthu ogwira ntchito zachipatala kupereka ogwira antipsychotic zotsatira pa odwala. Mlingo zosakwana 600 mg, ndi mu maganizo a madokotala ndi odwala, yotengekatengeka zolimbikitsa ndi zotsatira antidepressant.

Pali gulu la odwala amene anasiya "sulpiride" m'njira negative. Kodi anthu kukhala nseru, chisangalalo, giddiness. zizindikiro zoipa mbisoweka pambuyo discontinuation za "sulpiride".