Mankhwala ochepetsa: mndandanda ndi umboni. Kwambiri yogwira ma ARV mankhwala

HIV si chigamulo lero. Odwala akhoza bwinobwino moyo ndi matenda, ntchito, kuyamba banja. Zonse muyenera kuchita - ndi kulandira mankhwala zonse ndi wothandizila ma ARV chemotherapeutic. maofesi awa onse magulu atatu: zoletsa protease HIV, nucleoside ndipo sanali nucleoside HIV zoletsa n'zosiyana transcriptase.

M'pofunikanso kukumbukira kuti mankhwala ochepetsa sangathe kwathunthu kudzachiritsidwa AIDS. Kutsimikiza ndi matenda amadziwikanso bwino. Mankhwala yekha ziletsa chulutsa mavairasi, kuthandiza kusintha alili. Pansipa adzakhala anafotokoza mankhwala a ARV kwambiri anapempha.

"Lamivudine"

Mtumiki amatanthauza gulu la nucleoside zoletsa n'zosiyana transcriptase HIV. Mavairasi oyambitsa wothandizila likulowerera ku maselo zimapukusidwa kumeneko, potero kupangitsa chopinga wa tizilombo ta tizilombo. Njira ya chithandizo cha HIV kachilomboka ntchito mankhwala "Lamivudine" akusonyeza Mwachangu mkulu. Chida ndi yogwira motsutsana a chiwindi B. The mankhwala mofulumira odzipereka mokwanira kuchokera thirakiti m'mimba. Ola limodzi pambuyo ingestion bioavailability mu madzi a m'magazi umalandira chizindikiro 80%. Communication plasma mapuloteni ndi 30%. Ziyenera adzanyamula kukumbukira kuti mbali yogwira mosavuta mitanda chotchinga placental.

Mankhwala "Lamivudine" ntchito zochizira HIV akuluakulu ndi ana. Nthawi zambiri mankhwala ntchito monga mbali ya mankhwala osakaniza (mutha kugwiritsa ntchito atumiki mavairasi oyambitsa kwa mankhwala a HIV). Komanso mankhwala angathe kuperekedwa mu aakulu tizilombo chiwindi B. The mankhwala si contraindicated pa mimba ndi mkaka wa m'mawere. pamalowo angagwiritsidwe ntchito pa matenda a makanda. Lekani ntchito ndalama mankhwala okha kukachitika kuti pali mwai kulingalira ku zigawo zikuluzikulu.

Mwanjira mankhwala

Olowa phwando amatanthauza "Lamivudine" ndi "Zimavudin" zotheka. Ndi zothandiza kuti bioavailability mankhwala kwambiri yafupika. Iwo ali osavomerezeka ntchito mankhwala onse, amene kapangidwe kake ndi didanosine kapena sulfanilamin. Kunyalanyaza kutero kungachititse kuti aggravation a kapamba. N'zochititsa chidwi kumaonjezera ndende ya yogwira - lamivudine - magazi mankhwala "TMP".

Therapy wochititsidwa yekha mankhwala. Kukopedwa pa mankhwala akhoza kukhala mankhwala "Lamivudine" popanda dotolo. Mtengo wa mankhwala ndi 3,500 rubles. Mlingo ndi chithandizo waika kamwedwe katswiri, potengera makhalidwe munthu wodwala, ndi maonekedwe a matenda.

mankhwala ayenera kugwiritsidwa ntchito mosamala kwambiri ndi ntchito mkhutu aimpso. medicament The awerenge munthu waluso pa mlingo osachepera mlingo ngati QA ndi zosakwana 50 ml ya / min. Angagwiritse ya kamwedwe chithandizo, dokotala ayenera kuganizira kuti chigawo yogwira limapezeka makamaka impso. Anthu ndi mkhutu chiwindi ntchito mlingo kusintha chofunika. Pamene inu muwona zizindikiro ngati kochititsa mantha kupweteka m'mimba, nseru, kusanza, amatanthauza "Lamivudine" ayenera zimafika. The katswiri amachititsa mosamala mtima. Therapy akhoza anayambiranso yekha pamene matenda wolamulira "pachimake kapamba".

Kugwiritsa mankhwalawa matenda HIV ndi "Lamivudine". Mtengo wa mankhwala ndi wotsika. M'pofunikanso kukumbukira kuti palibe mankhwala simungathe kuteteza motsutsana matenda kudzera m'magazi kapena kukhudzana kugonana. mankhwala sangathe ntchito ngati prophylactic a.

"DdI"

Mankhwala mavairasi oyambitsa akugwira kwambiri ndi HIV. Akatswiri kawirikawiri amatanthauza "Didanosine." Guide anafotokoza njira ntchito, zizindikiro ndi mlingo. Mankhwala akupezeka mu mawonekedwe a miyala, miyala chewable, makapisozi. Ndi thandizo lawo, n'zothekanso kuti akonze slurry. Yogwira chigawo ndi didanosine. Komanso, zinthu zina amagwiritsidwa ntchito, monga aspartame, hydroxide magnesium, titaniyamu dioxide, sorbitol, calcium carbonate, magnesium stearate, ndi gelegedeya kununkhira. Njira amapangidwa mu mlingo wa 100, 125, 200 ndi 400 mg.

Didanosine ndi kupanga nucleoside analogue dioksiadenozina limaleka ayankhe HIV maselo a thupi. The bioavailability wa pophika yogwira ukufika 60% ola limodzi pambuyo kutenga mankhwala mkati. Aluso mankhwala chifuniro, ngati ntchito kwa ola limodzi asanadye kapena mawola 2 pambuyo chakudya. Ntchito limodzi ndi chakudya kumachepetsa bioavailability wa pophika mwakhama 50%. Anasonyeza mankhwala ndi chiwindi ndi impso. Kagayidwe didanosine zimadalira mlingo wa ntchito aimpso.

medicament akhoza kugwiritsidwa ntchito limodzi ndi mankhwala ena mavairasi oyambitsa kuchiza matenda HIV. medicament amaloledwa anaika akazi pa gestation ndi mkaka wa m'mawere. Osati contraindicated amatanthauza "ddI" ndipo ana. Kusankha mankhwala ana okha kwa zaka zitatu. Kuletsa mankhwala n'kofunika kukachitika kuti pali kochulukira kudziwa chigawo chimodzi chachikulu. Anthu ndi makutu chiwindi ntchito medicament ayenera kugwiritsidwa ntchito mosamala.

Kodi makhwalawa?

Sing'anga amakhazikitsa mlingo malingana ndi kuopsa kwa nthenda, ndi makhalidwe munthu wodwala. mankhwala ochepetsa mphamvu angathe kuchitidwa monga malangizo zafotokozeredwa malangizo. Mlingo tsiku zimadalira thupi. Anthu miyeso si upambana makilogalamu 60, ayenera zosaposa 250 mg wa mankhwala patsiku. Kwa odwala yolemera makilogalamu oposa 60, mlingo akhoza kufika 400 mg. Kapisozi anatengedwa kamodzi pa tsiku. Iwo sangakhoze kutafuna. Iwo ayenera kumwedwa ndi madzi ambiri. Ndi bwino kuti mankhwala m'mawa, pa chopanda kanthu m'mimba.

Mapiritsi Angagwiritsidwenso ntchito kuti akonze slurry. Onse inu muyenera kuchita ndi kuchepetsa nthumwi pang'ono madzi owiritsa. Onse mlingo tsiku akhoza kugawidwa mu masitepe awiri. Kukonzekera kuyimitsidwa sangathe kusungidwa zoposa ola. Madzulo, njira ayenera kumwedwa asanagone pa maola 2 pambuyo chakudya. Ana osaposa zaka 5 mankhwala Amasankhidwa kokha mu mawonekedwe a kuyimitsidwa a.

Odwala patapita zaka 70 anachita kusintha mlingo. Ichi ndi chifukwa chakuti mu ukalamba kusokonezedwa ntchito aimpso. Standard mlingo tsiku kungachititse kuti mavuto monga kapamba, neuropathy zotumphukira, lactic acidosis. Pa mbali pa mundawo m'mimba angathe zochitika zosasangalatsa monga pakamwa youma, anorexia, nseru, kusanza. Ngati kuwonongeka kwa thanzi mtima tikulimbikitsidwa kuti ndilembe kukambirana ndi katswiri. Mwina mankhwala adzakhala zimafika. Doctor mankhwala khalidwe wogwirizira ( "Thymidine" kapena analogs a "Thymidine", "ABC", "Lamivudine").

"Videx"

Yogwira zikuluzikulu za mankhwala ndi didanosine. mankhwala ochepetsa ku gulu ankagwiritsa ntchito pa matenda a HIV. Mfundo zabwino ndi mankhwala angagwiritsidwe ntchito makanda ndi ana aang'ono. Wamng'ono odwala wothandizila "Videx" akapatsidwa mu mawonekedwe a ufa kuyimitsidwa. Mlingo kuchita masamu payekha malinga ndi mlingo wa matenda, ndi makhalidwe munthu wodwala. Musagwiritse ntchito mankhwala pokhapokha ngati osauka hypersensitivity kuti didanosine.

mankhwala ochepetsa mphamvu ikuchitika yomweyo pambuyo kudziwika kwa matenda a AIDS. Monga mankhwala otetezera si ntchito. Mankhwala ali pafupifupi palibe contraindications. Mapiritsi kapena ufa "Videx" musati kuyambitsa zotsatira zoyipa, ngati bwino anasankha mlingo chakudya. Kuletsa mankhwala ayenera kukhala ngati pali kukayikirana pa chitukuko cha kapamba.

"AZT"

Mankhwala mavairasi oyambitsa akugwira kwambiri ndi HIV. Yogwira chigawo ndi zidovudine. Malangizo ntchito limafotokoza ndi auxiliaries. Zikuphatikizapo pregelatinized wowuma, mankhwala enaake a stearate, microcrystalline mapadi. ❖ kuyanika filimu kumaphatikizapo titaniyamu dioxide, polydextrose, glyceryl kaprilokaprata. A mankhwala ntchito monga mbali ya mankhwala osakaniza, monga HIV-1. Woyembekezera, mankhwala angagwiritsidwe ntchito ngati kupewa perinatal kufala kwa HIV kuchokera kwa mayi kupita kwa mwana wosabadwayo.

mankhwala angapo a contraindications. Miyala "AZT" si kutumikiridwa kwa ana ndi odwala wamkulu yolemera makilogalamu zosakwana 30. Nthawi zina, mwina kukhala hypersensitivity ku chigawo yogwira. Analandira mankhwala mkati, kaya chakudya. Amene anagula mankhwala "Zidovudine 300", muyenera kugwiritsira ntchito mapiritsi awiri pa tsiku. Ngati wodwala akulemera makilogalamu oposa 60, m'pofunika kutenga 20 mg wa mankhwala kawiri pa tsiku.

Zimatanthauza gulu la mankhwala apamwamba wogulira, "AZT". Mtengo wa paketi imodzi ya mapiritsi 60 oposa 10 000 rubles.

"Abacavir"

The yogwira zikuluzikulu za mapiritsi ndi abacavir sulphate. mankhwala chimagwiritsidwa ntchito mankhwala mavairasi oyambitsa wa HIV. Komanso, mapiritsi chikuphatikizapo zigawo izi: microcrystalline mapadi, chitsulo okusayidi chikasu, Polysorbate, titaniyamu woipa, magnesium stearate, Opadry Yellow, triacetin. Mankhwala akhoza kugwiritsidwa ngati gawo la mankhwala osakaniza. Sanagaŵiridwe mankhwala "ABC" vuto la hypersensitivity ku chigawo chachikulu. Mankhwala contraindicated odwala wamng'ono miyeso si upambana makilogalamu 14. CHENJEZO kodi mankhwala a odwala ndi insufficiency aimpso.

Mlingo wa mankhwala kuchita masamu payekha malinga ndi mawonekedwe a matenda a wodwalayo. Akuluakulu, ambiri kudya tsiku ndi 600 mg pa tsiku (anawagawa magawo atatu). Pogwiritsira ntchito mapiritsi a mu mlingo kuchuluka kungachititse kuti chitukuko cha thupi lawo siligwirizana.

Umatchedwanso njira yokwera mtengo wa "ABC". Mtengo wa paketi imodzi ya mapiritsi akhoza upambana 15 000 rubles.

"Ziagen"

Yogwira chigawo chimodzi, monga mmene zinalili m'mbuyomu, ndi abacavir sulphate. Kukonzekera ndi analogues ndipo akhoza m'malo mzake. Amatanthauza "Ziagen" mwaluso ntchito pa matenda a HIV. Mankhwalawa amathandiza kusintha alili, kubwerera ku moyo wabwinobwino. miyala ndi pafupifupi palibe contraindications. Si anatumizidwa mankhwala kokha odwala miyeso si upambana makilogalamu 14.

Mlingo tsiku la mankhwala anatsimikiza ndi dokotala. Pamafunika mumaganizira za mtundu wa matenda, komanso makhalidwe munthu wodwala (kulemera, m'badwo). Ana amene kulemera makilogalamu zosakwana 20, kutumikiridwa pa theka la piritsi kawiri pa tsiku. Daily mlingo kwa mtima wamkulu akhoza kufika mapiritsi atatu pa tsiku.

ntchito pachithunzichi mankhwala kungachititse kuti chitukuko mavuto. Iwo ayenera kupempha thandizo kwa dokotala ngati zizindikiro za matenda monga kutsekula m'mimba, kupweteka m'mimba, kunyansidwa ndi kusanza. zinthu zimenezi kungasonyeze kapamba. Komanso nthawi zambiri anati, thupi lawo siligwirizana mu mawonekedwe a zotupa ndi kuyabwa.

"Ziagen" mankhwala akhoza m'malo ndi njira "AZT". Mtengo wa mankhwala pafupifupi zofanana.

"Olitid"

Mankhwala mavairasi oyambitsa yogwira ndi HIV. Yogwira chigawo chimodzi - abacavir sulphate. Mankhwala akupezeka mu mawonekedwe a ufa kuyimitsidwa, ndi miyala. Amatanthauza "Olitid" zitha kukhala mbali ya mankhwala zovuta. Self-mankhwala sitikugwiritsa ntchito. Mlingo wa mankhwala anatsimikiza ndi dokotala. Kukonza piritsi mawonekedwe akhoza kugwiritsidwa ntchito kwa odwala amene kulemera kuposa makilogalamu 14. Chenjerani yoikika "Olitid" mapilitsi mu ukalamba. Ichi ndi chifukwa chiopsezo kukanika aimpso.

mankhwala ochepetsa, kuphatikizapo mankhwala "Olitid" ntchito pongofuna katswiri kuti cholinga. Kugula mankhwala mankhwala popanda mankhwala sangakhale.

"Retrovir"

mankhwala A chimagwiritsidwa ntchito mu mankhwala zovuta za HIV. Pambuyo wothandizila ingestion mofulumira odzipereka kwa mundawo m'mimba. Yogwira chigawo mosavuta likulowerera chotchinga placental. Izi n'komwe pamene osauka mankhwala regimens kwa amayi apakati. medicament angagwiritsidwe ntchito monga kupewa akatswiri HIV. Zimenezi n'zofunika kwambiri makamaka kwa ogwira ntchito choyezera amene kafukufuku zipangizo zimene zakhudzana.

Mlingo anatsimikiza aliyense payekha ndi dokotala nawo. Zolemba malire mlingo tsiku akuluakulu akhoza musalumphe 600 mg. Akatswiri amalangiza kuti muchigawane mu magawo atatu. A njira zambiri adzakhala ngati inu izo pa chopanda kanthu m'mimba. Pa zosayembekezereka ya zovuta zilizonse ayenera kuonana ndi dokotala.