Mankhwala "Atokor": Buku malangizo, analogue ndi ndemanga

Mkulu mafuta misinkhu mu madzi ndi limathandiza kuti chitukuko cha atherosclerosis ndi matenda a mtima ndondomeko.

Zogwiritsa zamadzimadzi kutsitsa mankhwala ntchito njira yapadera, mmodzi amene ndi mankhwala "Atokor". Malangizo pa mankhwala umu udindo wake hypocholesterolemic ndi gipotriglitseridemicheskuyu kuchepetsa ambiri zoipa mafuta m'thupi ndi mafuta ena mu thupi.

makhalidwe General

mankhwala ananena kuti zoletsa 3-methylglutaryl-3-hydroxy-CoA reductase. "Laboratories Dr. Reddy a" amapangidwa ndi kampani Indian.

Pokonzekera "Atokor" mlingo mwina 0,020 ndi 0,010 ga

Fomu kumasulidwa

Yopangidwa wothandizila mu mawonekedwe piritsi TACHIMATA ndi woyera filimu. Mapiritsi extruded mu kansalu mawonekedwe ndi pamalo biconvex pa limodzi mwa kalata "A" umagwiritsidwa, ndipo winayo ikhale mlingo wa "10" kapena "20".

kapangidwe

The yogwira pophika mankhwala ndi atorvastatin, woimiridwa ndi micronized kashiamu trihydrate. Mankhwala "Atokor" mlingo ndi zikuchokera kachulukidwe pophika yogwira yosiyaniranapo. Lililonse 0,01084 kapena 0,02168 ga atorvastatin kashiamu trihydrate lofanana 0.01 kapena 0,02 ga atorvastatin koyera.

Mkaka shuga, calcium carbonate, croscarmellose sodium, polysorbate 80, hydroxypropyl mapadi, lactose Deuteronomo, magnesium stearate phale anapanga dongosolo.

The casing filimu anapangidwa kuchokera hypromellose cps 15, propylene glycol, woyeretsedwa talc, titaniyamu woipa.

Chimodzimodzi kwa onse mlingo amatanthauza "Atokor" zikuchokera, ndi kutsogolera okwana awo.

Mapiritsi a 0.01 kapena 0,02 ga zidutswa 10 amapangidwa mu chithuza mmatumba mukatoni.

limagwirira kanthu

Mankhwala malangizo ntchito ikugwilizirana ndi kusankha, retarders mpikisano 3-methylglutaryl-3-hydroxy-kofermentaA reductase. Ndi puloteni zofunika kwa kutembenuka kwa pawiri 3-hydroxy-3-metilglyutarilkoenzima A kuti mevalonic asidi lomwe lili m'mbuyo styrenes ndi mafuta.

Ngati odwala wa hypercholesterolemia, homozygous heterozygous banja ndipo sanali banja mtundu, kuphatikizapo dyslipidemia, zakudya mankhwala "Atokor" kumathandiza kuchepetsa okwana mafuta, mafuta particles mu lipoproteins wa otsika ndi otsika kachulukidwe, triglycerides ndi apolipoprotein B.

Medicament "Atokor" ikulongosola za mankhwala likusonyeza lingathe mapiritsi wosakhazikika zothandiza kuonjezera mlingo wa sterol mu lipoproteins ndi osalimba mkulu.

Maselo chiwindi, ndi triglycerides holesterolovye mamolekyulu kukhala mbali yofunika ya lipoprotein zinthu ndi amphamvu otsika kachulukidwe. Iwo wotumidwa kwa plasma, amene kudutsa mu minofu zotumphukira. Mankhwala awa anapanga lipoprotein ndi otsika machulukitsidwe akhoza catalyzed anachita ndi mkulu kuyandikana cholandilira mtundu formations. Zonse zinthu zimenezi kungachititse kuti anthu chitukuko cha matenda atherosclerotic.

Action Atorvastatin amakhala ndi Amowabu ndi kulimbikira kuwonjezeka kwa dzuwa la LDL-cholandilira maofesi, kuchepetsa mafuta m'thupi woipa zoipa pa okwera hypercholesterolemia a mtundu homozygous cholowa.

Amatanthauza "Atokor" malangizo zikusonyeza mphamvu yake kuchepetsa plasma mafuta misinkhu ndi lipoprotein ndi inhibiting HMG-CoA reductase enzyme. Ndi kubweza mapangidwe mafuta maselo a chiwindi, kumawonjezera chiwerengero cha cholandilira dongosolo la lipoproteins ndi machulukitsidwe otsika mu nembanemba cha ndende. Izi timapitiriza adani ndi catabolism wa mafuta ku mamolekyulu lipoprotein ndende otsika.

Kodi ntchito

Medicament "Atokor" wogwiritsa Phunziro pankhaniyi limalangiza pakumwa mapiritsi pa zizindikiro chachikulu cha kuchuluka cholesterolemia heterozygous mtundu, m'dera ndipo sanali m'dera kuwonjezeka mafuta ndende, geterlipidemii wosanganiza, kuchuluka kuchuluka kwa tinthu plasma triglyceride.

Iwo kutumikiridwa mu osakaniza zakudya malangizo kutsitsa mkulu mafuta mlingo mu lipoproteins ndi machulukitsidwe otsika, apolipoprotein B ndi mankhwala triglyceride.

Mapiritsi kuchepetsa madzi ambiri mafuta mu LDL cholesterolemia pa kukwezeka mtundu homozygous banja, pamene zakudya chakudya ndi njira zina sanali pharmacological operewera.

Kodi kutenga

Medicament "Atokor" malangizo ntchito amalimbikitsa kumwa pambuyo poika muyezo hypocholesterolemic zakudya odwala munthu, amene ayenera kugwiritsidwa ntchito pa mankhwala. N'zimene wayikidwa padera kwa wodwala aliyense, amene masamu pa mlingo woyambilira wa mafuta mu lipoproteins ndi machulukitsidwe otsika. Nkofunika kuganizira ntchito anafuna, mphamvu ya mankhwala ndi "umboni Atokor.

Childs, mlingo woyambilira Matanthawuzo 0.010 ga nthawi imodzi patsiku. Ntchito mapiritsi sadalira nthawi ya tsiku ndi chakudya mowa.

Mlingo wa njira tsiku ndi tsiku 0,010 kuti 0,080 ga amusankha kuchokera koyamba zizindikiro mlandu wa mafuta zoipa, malo chandamale ndi mogwira munthu. Mu koyamba gawo la ntchito ndi kuwonjezera ndende ya mankhwala ayenera kukhala theka mwezi onani mlingo wa madzi mafuta, ndi kusintha mlingo kutero.

Pulayimale hypercholesterolemia ndi ophatikizana hyperlipidemia khalidwe ankachitira mlingo masiku 0,010 ga

Ntchito achire amapezeka mkati mwa masiku 14, ndipo dzuwa pazipita n'zotheka mwezi umodzi. ntchito yaitali limachititsa kukhala zotsatira achire.

Mankhwala "Atokor" mu bukhuli Russian kakunena pa terapiigiperholesterinemii a mtundu homozygous banja. Childs, Kwalamulidwa tsiku mlingo mu 0.080 ga Mu ntchito iyi ndi kuchepa LDL mfundo mafuta mpaka 40%.

Features mankhwala

Miyala "malangizo Atokor 'ntchito mpofunikila musanayambe kugwiritsa ntchito mankhwala ayenera kupeza chifukwa cha kuwonjezereka yachiwiri ya makhalidwe mafuta. zinthu izi monga a shuga, mankhwala osauka a shuga, hypothyroidism, nephrotic kusintha ndondomeko disproteinemicheskih, matenda obstructive chiwindi. Izi zikhoza monga mankhwala nanu mankhwala ena komanso mumapezeka mowa. Pokhapokha ndiyotani pakuchotsa zifukwa pamwamba, ndinu okonzeka ntchito piritsi "Atokor".

Ngakhale pamaso mankhwala amachitidwa mtima wa zamadzimadzi bwino pakati pa mafuta okwana LDL mafuta mu HDL mafuta ndi triglycerides.

Palibe deta pa ntchito mankhwala alionse Dokotala, kotero mapiritsi awa sali anasonyeza ana.

Mankhwalawa kwa wodwala okalamba, amene m'badwo zaka zoposa 60, akuwonjezeka milingo plasma wa chigawo yogwira wothandizira 40%.

Ngati kuphwanya kugwira ntchito aimpso Sikuti kusintha mlingo, monga chikhalidwe ichi si bwanji atorvastatinovoe okhutitsidwa m'magazi ndi mphamvu ya kutsitsa mafuta zoipa.

Pali umboni kuti ntchito za gulu ili la mankhwala chifukwa chitukuko rabdomioliznoy myopathy ndi impso ntchito osakwanira mu mawonekedwe pachimake. Mu matenda amenewa ndi mankhwala ayenera kuchotsedwa pa nthawi.

Kukonzekera pamaziko a atorvastatin ayenera kumwedwa mosamala kuti anthu amene amamwa mowa mwauchidakwa kapena matenda chiwindi m'mbuyomu.

Zimene zoletsa wa HMG-CoA reductase enzyme mwina kusintha zizindikiro amuzolengedwa wa ntchito chiwindi. Pakuti unsembe yake ya kuyan'anila ngati muyenera kuchita aziona ntchito kwa chiwindi, kenako miyezi 3 pambuyo kutenga mankhwala agwire cheke isanafike mankhwala.

Mankhwala "Atokor" malangizo Russian zikuphatikizapo zokhudza kuwonjezeka zikusintha plasma mfundo za pophika mwakhama odwala matenda a chiwindi, amene amadwala uchidakwa. Zosakhalitsa kapena wolephera mankhwala akubwerera chiwindi transaminase ntchito chimango pachiyambi. odwala ambiri sanathetse ntchito mankhwala pa mlingo kakang'ono, ndipo palibe zosiyanasiyana chokhwima chikanachitika.

Mankhwalawa angaone chizungulire, kukhala kusinza, choncho pa nthawi ya ntchito odwala mapiritsi akuletsedwa kulamulira zoyendera ndi zipangizo zina zovuta.

Omwe saloledwa

Pa medicament "Atokor" contraindications m'nyimbozo tilinazo chodziwa kuti aliyense pophika medicament lapansi.

Iye sadatenga nkhani ya matenda pachimake chiwindi ndi mkulu kutsegula kwa transaminase seramu michere pamene ntchito yawo ndi 3 zina kuposa malire chapamwamba mfundo yachibadwa.

mankhwala si Kwalamulidwa kwa akazi a zaka ubereki amene si kugwiritsa ntchito njira zolera chokwanira. Contraindication ndi chikhalidwe wobereka ndi yoyamwitsa.

Medicine Kodi Musanyoze ndi ana osaposera zaka 18 zakubadwa.

Chifukwa kukhalapo kwa mkaka mu zikuchokera miyala 'Atokor "shuga malangizo ntchito imaletsa kuzigwiritsa ntchito mu tsankho cholowa kuti zamoyo galactose, ndi wopanda lactase ndi shuga-galactose malabsortsii.

analogs

Pali ambiri mankhwala pamaziko a atorvastatin. Mafuta-kutsitsa ntchito mankhwala kuti "Atokor" malangizo Buku. Analogs amathanso mlingo wa mafuta zoipa magazi m'munsi.

mankhwala china mankhwala kwa Chisiloveniya "Atoris" imene ili amapanga olowa katundu kampani "Krka, Novo mesto." Izo zinabala mu mawonekedwe a miyala ndi yogwira pophika zili 0.010 ga, 0.020 ga, 0.040 ga

mankhwala cholinga kuthetsa chikhalidwe hyperlipidemic, momwe magawo zofunika kuchepetsa okwana mafuta m'thupi, lipoprotein mafuta mu mankhwala ndi machulukitsidwe otsika kuchuluka kwa apolipoprotein ndi tinthu wa triglyceride mu mtsempha wa magazi.

Mankhwala azichitira anthu ndi hypercholesterolemia polygenic heterozygous homozygous mtundu banja.

Mothandizidwa "Atoris" mankhwala kumawonjezera ndende ya mafuta mu lipoproteins ndi machulukitsidwe mkulu.

Wina Slovene analogue ankaona mankhwala "Tulip," womwe wapangidwa tsopano "Lek mankhwala Company". Pali Mlingo atatu filimu TACHIMATA mapiritsi: 0.01 ga, 0,02 ga ndi 0,04 ga

mankhwala akusonyeza kuti kuwonongedwa kwa mitundu yaikulu ya hypercholesterolemic ndi ophatikizana chikhalidwe hyperlipidemic, zochizira mafuta okwera amayamikira heterozygous ndi mtundu homozygous banja.

Mofananamo, njira ankaona Indian mankhwala "Astin" omwe amapangidwa ndi ogwira "yaying'ono Labs Limited". Ilipo mu Mlingo awiri: pa 0,010 ga ndi 0,020 ga atorvastatin.

mankhwala Kwalamulidwa pa kochulukira zili zamadzimadzi pamene mwaonapo zotsatira zabwino zochitika zakudya ndi zina.

Indian zotsimikizira ndi medicament "Storvas" zochokera kashiamu mchere wa atorvastatin. Chopangidwa ndi "Ranbaxy Laboratories Limited" mu mawonekedwe a piritsi TACHIMATA ndi m'chimake mu Mlingo awiri: pa 0,010 ga ndi 0,020 ga

Mankhwala "Storvas" kuchepetsa zili mkulu wa okwana mafuta m'thupi, LDL mafuta mamolekyulu, ndipo anthu ambiri mankhwala apolipoprotein triglyceride ku pulayimale, ndipo nonmarried heterozygous banja chikhalidwe hypercholesterolemic, komanso wosakaniza matenda hyperlipidemic.

Mankhwala amachepetsa kuthekera m'mnyewa wamtima infarction m'mnyewa wamtima boma zidzasintha a minofu, sitiroko ndi kusintha otaya oziziritsa magazi. Mapiritsi amachepetsa mphamvu ya matenda inatsekeratu atherosclerotic.

American mnzake ndi mankhwala "Lipitor" amapangidwa ndi "Pfizer". Izo zinabala mu mawonekedwe a miyala ndi chithope chipolopolo mu Mlingo atatu: pa 0.010 ga, 0.020 ga, 0.040 ga The mankhwala amagwiritsidwanso ntchito kuthetsa limati hypercholesterolemic a mitundu yosiyanasiyana ya chiyambi.

Reviews

Medicine "Atokor" wogwiritsa Phunziro pankhaniyi limanena kuti amatanthauza ndi mkulu efficacy kutsimikiziridwa. odwala ambiri ndi woipa okwera plasma wa mafuta zoipa, pambuyo moyo ntchito akupeza bwino. Khalidwe okwana mafuta ndi LDL mafuta ndi kuchepetsedwa pa mlingo wabwinobwino, omwe amachepetsa mwayi kukhala atherosclerosis, ndi zinthu ischemic.

Mankhwala wa atolankhani ndi tolerability wabwino, koma odwala ena chifukwa angayambitse akuchedwa chopondapo, bloating, kupweteka pamimba, nseru, kudzimbidwa. Pali mutu, kusokoneza tulo. Angathe jerky, asthenic ndi chikhalidwe myalgic.

Nthawi zina, mavuto ali owonetseredwa myositis, myopathy, paresthesia, neuropathy zotumphukira, kapamba, matenda a chiwindi, cholestatic matenda a chikasu ndiyo.

Mapiritsi zingachititse anorexia, kusanza, hepatotoxicity mawonetseredwe, alopecia, mawonetseredwe pruritic wa totupa, kusabala, ng'ala, hyper- kapena hypoglycemia.