Kufotokozera thiamine mankhwala. Malangizo ntchito

mankhwala Thiamine ndi alembedwe kapisozi kapena njira mu mnofu. Dzina lachiwiri la mankhwala - aneurine (achikale.). Ndi vitamini kuti dissolves m'madzi. thunthu alibe mtundu. Pamene yophika - waonongeka. Thiamine si sungunuka mowa. Nanga ali ndi makhalidwe zinchito za thiamine? Malangizo ntchito mwatsatanetsatane cholinga cha mankhwala.

Ntchito ya thiamine

Vitamini Thiamine amatchedwanso vitamini B1. Ndi nthawi kagayidwe thupi mafuta ndi chakudya, ziziyenda kukula ndi chitukuko, kusintha Mwachangu wa mtima, m'mimba ndi machitidwe mantha. Popeza wina wa katundu - ndi madzi sungunuka, mavitamini si waikamo mwa thupi ndipo alibe kuwola ndinso ya poizoni.

Zikamera wa Thiamine

Nkhani limayamba pamene wasayansi Christiaan Eijkman woyamba anatulukira zinthu monga mavitamini. Chifukwa cha zimene anatulukira mankhwala anakhala Nobel. wasayansi wina Casimir Funk, vitamini kudziwika monga pawiri ndi asafe mpunga chinangwa. Vitamini m'mwamba limodzi potsiriza anakwanitsa kufika mu 1926.

maonekedwe ndi mankhwala

Pafupifupi solubility mu madzi. Asidi njira amadzimadzi kutentha sikumangotikhudza thunthu. Thunthu soda pamene usavutike olumala. Molekyulu tichipeza pyrimidine ndi thiazole mphete popangidwa ndi methylene Mgwirizano.

Kufalitsa mu thupi

Taganizirani mmene anagawira mu thiamine thupi. The malangizo pofotokoza pharmacokinetics mankhwala. Pambuyo kudutsa thirakiti m'mimba mankhwala imatsala ndi unagwa m'mimba michere. Ndiye, mu mphindi 15, chimatilowetsa magazi kale mu mawonekedwe unbound. Theka la ola patapita ndi anagawira mu zimakhala zosiyanasiyana. Mu mawonekedwe woyera, thiamine chili mwa plasma, komanso mankwala esters - mu leukocytes ndi erythrocytes.

Monga kuchuluka 50% thiamine ali minofu striated, ziwalo chathandiza kuti 40% ya vitamini lapansi. Mitsempha minofu ndi chiwindi muli thiamine zokwanira.

Tiamindifosfata - yogwira phosphoric Ester, amene ali thiamine. Malangizo ntchito limasonyeza kuti Ester ndi amagwira ntchito njira kagayidwe kachakudya mafuta ndi chakudya. Linanena bungwe m'thupi kumachitika kudzera impso ndi matumbo.

ntchito

Kuyamba mankhwala kuperekedwa intramuscularly kapena pang'onopang'ono m'nsinga 1 nthawi patsiku. Standard Mlingo akuluakulu - kuchokera 25 mpaka 50 mg. Mankhwalawa nthawi akhoza osiyanasiyana monga masiku 10 kuti mwezi umodzi.

Komanso mu mankhwala aakulu hypovitaminosis akutengedwa pakamwa 10-25 mg. The tsiku mlingo - disposable kapena magulu.

Nthawi zina, mankhwala adakula thiamine mlingo? Malangizo ntchito pansi hypovitaminosis aakulu zimasiyanasiyana mlingo tsiku la 300 mg.

umboni

Chilolezo mwapatsidwa ntchito pa mimba ndi mkaka wa m'mawere. Mlingo monga anawalamulira dokotala.

zotsatira zoyipazi

Thiamine zingachititse angapo kukwiya zochita, pruritus, urticaria, angioedema, nthawi zina anaphylactic mantha angayambe. Mwa zotsatira zochepa wamba - tachycardia ndi diaphoresis.

contraindications

Panopa contraindications zonyozeka. The yokonza ntchito thiamine Buku imaletsa ntchito milandu hypersensitivity, pamene kusintha wamkazi, pamene encephalopathy.

malangizo zina

Pali ndondomeko ya ntchito njira thiamine. Malangizo ntchito osavomerezeka ntchito mankhwala m'malo zakudya, kokha pamene kwathunthu zakudya mankhwala. Ngati ingestion amachititsa kukana mankhwala (kusanza bongo, nseru, posachedwapa opareshoni) amaloledwa makonzedwe parenteral. Ngati anapeza encephalopathy Wernicke ayenera kupatsidwa dextrose asanadye mankhwala.