"Indomethacin" (mapiritsi): malangizo ntchito kwenikweni

Mmodzi wa akuluakulu a gulu la nonsteroidal mankhwala odana ndi yotupa ndi mankhwala "Indomethacin" (mapiritsi). Chifukwa odana ndi yotupa ake, analgesic ndi zotsatira antipyretic wa ntchito zochizira matenda yotupa, kupweteka, kuchepetsa kutupa ndi kubwezeretsa olowa kuyenda.

Kufotokozera lokonzekera

Waukulu yogwira pophika mankhwala ndi indomethacin, yomwe ikukhudzana bwanji ndi indole opangidwa kuchokera ku asidi acetic. Mkati ma CD medicament "Indomethacin" limafotokoza zinthu mapiritsi Chiongoko ndi zoteteza enteric ❖ kuyanika amene amalola woukitsa kumasulidwa ku intestine ndi, anyalanyaza m'mimba. The mawonekedwe a mapiritsi yozungulira biconvex, pamwamba yokutidwa ndi kuwala bulauni chipolopolo.

Mapiritsi ndi Mlingo angapo: 25 mg, 50 mg ndi 100 mg wa indomethacin. Akupezeka mu zidutswa 10 kapena 40 pa paketi.

mitundu yonse mlingo

Komanso mapiritsi, pali njira zina "Indomethacin" pokonzekera ntchito m'kamwa, mwachitsanzo chosunga kumasulidwa kapisozi mlingo wa 75 mg. Pakuti makonzedwe thumbo, suppositories ntchito ndi mlingo wa 50 mg. Ntchito panja analenga mafuta 5% ndipo 10% ndi 3% gel osakaniza.

limagwirira kanthu

The medicament ndi nonsteroidal antiinflammatory wothandizila zokhudza zonse kanthu, amene ali antiinflammatory, decongestant, analgesic ndi zotsatira antipyretic. Mayina mankhwala "Indomethacin" (mapiritsi) Chiongoko limagwirira limapangidwa ikulongosola za ntchito zake yogwira pophika kugwirizana ndi kuchepa mu ntchito cyclooxygenase a mtundu 1 ndi 2. Nayenso enzyme kuli ndi phindu kochepa pa asidi arachidonic omwe amachepetsa kutembenuka ake prostaglandin. zinthu izi chifukwa kutupa ndi ululu.

zinaonetsedwa pa chionetserocho Indomethacin antiplatelet tingati kuchepetsa kupatsidwa zinthu za m'mwazi clumping maselo magazi. Mankhwala attenuates ululu pa molumikizana mafupa mu mkhalidwe bata ndi mafoni, kuchepetsa m'mawa stiffness ndi kutupa, kumaonjezera osiyanasiyana apaulendo. Action indomethacin umalimbana kuchepetsa kutupa. Zotsatira pazipita zapatsidwa kwa tsiku lachisanu ndi chiwiri la mankhwala, miyala mankhwala.

kuti amachitira

Potengera limagwirira kanthu, "Indomethacin" piritsi malangizo Buku akuonetsa ntchito zokhudza zonse chithandizo cha:

• articular syndrome;
• matenda yotupa a dongosolo minofu ndi mafupa chifukwa cha rheumatoid, psoriatic, rheumatoid, zaumbanda nyamakazi, phewa mazira, ankylosing spondylitis, matenda olowa mu deforming osteitis ndi uretrookulosinovialnom syndrome;
• matenda osachiritsika a dongosolo minofu ndi mafupa chifukwa cha osteochondrosis ndi radicular syndrome, osteoarthrosis zimfundo, kupatula m'chiuno ndipo intervertebral arthrosis;
• akakufunsani matenda, kuphimba minofu connective;
• la misempha;
• suppurative yotupa zotupa matumba periarticular ndi tendons;
• Zizindikiro pachimake kupweteka m'munsi mmbuyo ndi zina mbali msana pamene sciatic neuralgia ndi misempha zina, kutupa minofu;
• zoopsa kutupa mu zimakhala zofewa kapena mafupa.

Angakuthandizeni kupirira mutu, kusamba, dzino, TB.

Ngati wothandizira wothandiza kwa matenda opatsirana ndi yotupa monga pharyngitis, zilonda zapakhosi, otitis amagwiritsa medicament "Indomethacin" (mapiritsi). Zikuonetsa monga mankhwala a cystitis, adnexitis, prostatitis.

Mankhwala othandiza kuti kuchotsa febrile matenda okhudzana ndi matenda Hodgkin a, lymphoma, metastatic zotupa, pamene asakuchita paracetamol ndi acetyl salicylic acid.

Kodi kutenga

"Indomethacin" mankhwala a mapiritsi ndi kutumikiridwa kwa wodwala mu mlingo makamaka zochokera mlingo wa matenda. Nthawi zambiri, akuluakulu kuyamba ndi kulandira mlingo wa 25 mg katatu tsiku mukatha kudya.

Ngati zotsatira za mankhwala osakwanira kutchulidwa awiri mlingo kuti 50 mg 3 nthawi patsiku. Zolemba malire kololeka mlingo sayenera upambana 200 mg indomethacin. Patapita kusintha kwambiri chifukwa cha mankhwala, mankhwala ayenera kusiyidwa masabata pambuyo 4 ntchito nthawi yapita kapena yafupika mlingo. Ngati odwala kumwa mankhwala kwa nthawi yaitali "Indomethacin" malangizo Buku akuonetsa mlingo wa 75 mg wa yogwira pophika patsiku.

chithandizo cha ana

Mwana tsiku mlingo masamu ndi kuchulukitsa 2.5 kapena 3 mg wa pa thupi lake misa, amatengedwa nthawi 3-4. Pakuti aliyense msinkhu anapereka ntchito koyamba mlingo tsiku ndi tsiku:

• ana 3 zaka 7 kutumikiridwa kwa 50 mg 75 mg, Chofanana mapiritsi 2 kapena 3;
• ana 7 mpaka zaka 12: 75 mg kuchokera kwa 100 mg womwe ndi miyala 3 kapena 4;
• Ana a zaka 12 Kwalamulidwa kwa 100 mg kwa 125 mg womwe ndi mapiritsi 4 kapena 5.

Mu masiku oyambirira angapo, muyenera kudziwa mmene mankhwala pa thupi la mwanayo, kotero ntchito mlingo ka mankhwala. Kutalika kwa mankhwala ndi "Indomethacin" (mapiritsi) malangizo anam'patsa monga nthawi kuchokera masiku 6 mpaka 7.

Features phwando

Pa nkhani imeneyi, pali kuthekera kwa mavuto pa kulandira amatanthauza "Indomethacin" mapiritsi, ndi bwino kugwiritsa ntchito zochizira enaake ophwanya malungo pachimake ana. Wotuluka mu mkaka wa m'mawere, zosakaniza yogwira limalowera mu magazi a mwanayo, kumaonjezera matenda a chikasu ndiyo thupi mu khanda ndi kugonjetsedwa kwa maselo chiwindi. Popewa izi, kuletsa yoyamwitsa.

Okalamba, odwala ndi chiwindi matenda, impso thirakiti m'mimba, zizindikiro dyspeptic, matenda oopsa, congestive kulephera mtima pambuyo opaleshoni, matenda Parkinson, khunyu, pakati pa ine ndi II trimester pamene kupatsa Indomethacin chithandizo chofunika kuwayang'anira udindo wa chamoyo. M'pofunika kuchepetsa ntchito ya ziwalo mabvuto, kamodzi pa masiku 7 kufufuza magazi zotumphukira.

Ngati m'mbuyomu matupi awo sagwirizana ndi sanali steroidal mankhwala odana ndi yotupa, mankhwala "Indomethacin" (mapiritsi) amasankhidwa milandu kwambiri.

Sitikudziwa amalangiza kugwira ntchito woopsawo mankhwala, monga kutanganidwa chidwi ndi psychomotor ntchito.

Pamene inu simungatenge

Pali matenda imene mankhwala contraindicated "Indomethacin" (mapiritsi). ntchito zake sizingatheke:

• hypersensitivity kuti indomethacin;
• pamaso pa erosive ndi zotupa anam'peza a dongosolo m'mimba mu gawo pachimake;
• pamene "ndi aspirin wa ku", yodziwika ndi tsankho kwa asidi acetylsalicylic, ndi tizilombo ting'onoting'ono m'mphuno ndi bronchial mphumu;
• pa hemodyscrasia;
• pamene kutchulidwa kusintha kwa chiwindi ndi impso;
• pa akuchedwa salt ndi zakumwa ndi zotheka edema zotumphukira;
• mu aakulu aakulu kulephera khalidwe la myocardium ya;
• pa kuthamanga okwera;
• bronchial mphumu;
• mu kutupa kapamba;
• mu III trimester wa gestation wa mwanayo;
• Kuyamwitsa;
• ana osakwana zaka 3.

zosiyanasiyana chokhwima

The mankhwala "Indomethacin" (mapiritsi) likhoza kulumikizidwa ndi zochitika chowawa zoipa zokhudza chikhalidwe cha thupi. Pakuti zochita wamba chowawa monga nseru, anorexia, kupweteka pamimba, bloating, kudzimbidwa, kudzimbidwa.

Nthawi zina, mavuto angayambe erosive ndi zotupa anam'peza, magazi ndi perforation za m'mimba ndi makoma matumbo; applasticheskoy kapena hemolytic magazi m'thupi, leukopenia, thrombocytopenia, agranulocytosis, zidzolo, tsitsi imfa, khungu kuyabwa, khunyu, angioedema, bronchospasm.

Zizindikiro za poizoni epidermal necrolysis, kawirikawiri anati anaphylactic mantha, erythema nodosum.

Pa mankhwala akhoza kusokoneza ntchito ya aimpso excretory ndi chiwindi, amene kumawonjezera chiwerengero cha bilirubin, kwa chiwindi transaminases.

Yaitali ntchito mankhwala "Indomethacin" (mapiritsi) alibe kukusalani zosiyanasiyana chokhwima kugwirizana ndi chisokonezo tulo, chizungulire, neuropathy zotumphukira, mutu, mukubwadamuka, irritability, kutopa. Iwo yodziwika ndi clouding wa diso, conjunctivitis, kumva kuwonongeka, tinnitus, matenda oopsa, edema.

Reviews

Nkofunika kuti adzatsatira malamulo onse a mankhwala, nadzatonza contraindications onse.

Ali osokonezeka pa kuvomera "Indomethacin" ndemanga mankhwala. Mapiritsi ndi zotsatira zoyipa zambiri kusiyana mitundu mlingo ntchito kunja. Komanso, yogwira mankhwala chikukhudza zoletsa wa cyclo-oxygenase 1 ndi 2, zimene ankaona kuti sakhala ogwira ndi chifukwa chiwerengero cha zochita oipa thirakiti gastro-m'mimba.

Rheumatologists ndi odwala awo, madokotala amakonda kulemba mankhwala atsopano ku gulu la oxicams. Iwo ziletsa cyclooxygenase mtundu 2 yekha, popanda okhudza enzyme mtundu 1, amene amaonetsetsa yopanga prostaglandins kuti kuteteza dongosolo m'mimba. N'chifukwa chake oxicams kuchita zoipa zochepa m'mimba kuposa kuchiza "Indomethacin" (mapiritsi). Malangizo maganizo olakwika zikuphatikizapo ikulongosola za zotsatira zoyipa, koma izi sizitanthauza kuti chithandizo ayenera wasonyeza. Zonse zimadalira makhalidwe a chamoyo.

odwala ambiri, izi zikutanthauza tikusunga ululu kumbuyo, myalgia, intercostal neuralgia, pamene mankhwala ena sititenga. A mavuto pafupifupi musati chichokera mankhwalawa "Indomethacin" mankhwala. Reviews miyala anachira odwala opangidwa positive. Ngakhale chiopsezo ndi zopezeka, ndi kokha adokotala akhoza mankhwala phwando ngati mankhwala oopsa.

analogs

Mapiritsi yogwira mankhwala Indomethacin amapangidwa ndi makampani ambiri achilendo ndi zoweta, monga kampani "Sopharma", "Ludwig Mekle" "Nycomed", "Farmahim", "Berlin Chemie Menarini," "Altfarm". Only lililonse mankhwala malonda dzina lake, kapangidwe kake wothandiza zigawo zikuluzikulu. Onse akamaphunzira ndi zizindikiro zomwezo ntchito, mavuto, contraindications.

Mankhwala otchuka "Indomethacin Sofarma" (mapiritsi). Yopangidwa mu mlingo wa 50 ndi 100 mg ndi "Sofarma" (Bulgaria). Zimatanthauza sanali steroidal mankhwala odana ndi yotupa.

Peyala yina ya osachepera analogues wa kudziwika - mankhwala "Indomethacin 50 mg wa Berlin-Chemie" ndi "Indomethacin 100 mg wa Berlin-Chemie". Yopangidwa mu Mlingo awiri (50 100 mg) ndi kampani Chitaliyana "Berlin-Chemie Menarini".

Pokonzekera "Indomethacin" (mapiritsi) ndi analogues ndi kupanga Russian. Zilipo zosiyanasiyana mlingo. ndi Anzawo chachikulu:

• "Indomethacin okwana" Mankhwala-mankhwala zomera JSC "Akrikhin";
• "Indomethacin-Altfarm", LLC "Altfarm";
• "Indomethacin-Biosynthesis", JSC "Biosynthesis";
• "Vero Indomethacin", OJSC "Veropharm".