Asidi Zoledronic: pharmacological zotsatira ndipo analogues

Amadziwika kuti bisphosphonates amakonda ziletsa chitukuko cha fupa metastasis ndi kupewa imfa fupa. Mmodzi wa mankhwala zabwino cha gulu ili - asidi zoledronic. Komanso, pali umboni kuti mankhwala ali angioneogenesis chopinga, kuwukira chotupa guluu wolimba maselo chotupa mu minofu fupa, induces aputosisi, ndipo pali synergy ndi mankhwala amphamvu.

Chiphunzitso 1 mbale

Zoledronic asidi monohydrate - 4,26 mg wa Excipients - sodium citrate, D-mannitol.

mankhwala

An woletsa fupa resorption. asidi Zoledronic limabweretsa latsopano kalasi ya kalasi mkulu wa bisphosphonates. Iwo ali zotsatira kusankha pa fupa. Amachepetsa ntchito osteoclasts, popanda kuchititsa zoyipa pa mapangidwe ndi makhalidwe ena a minofu fupa. Mmene bisphosphonates pa fupa zachokera kufanana mkulu mineralized fupa, koma limagwirira yeniyeni mamolekyulu amene amapereka inhibiting ntchito ya osteoclasts, lero akadali sichinayambe kuphunzira. Komanso ali mwachindunji odana ndi chotupa katundu, kuonetsetsa Mwachangu mu fupa metastasis.

Mu m'galasi anapeza kuti asidi zoledronic, induces aputosisi ndi inhibiting kuchuluka kwa maselo ali ndi antitumor kwenikweni mwachindunji myeloma, komanso maselo a khansa ya m'mawere, pamene kuchepetsa chiopsezo metastasis. Komanso, asidi zoledronic ali ndi chuma cha kuchepetsa ndende kashiamu mu hypercalcemia seramu, amene amayamba ndi chotupa.

zikuonetsa

• zotupa Osteolytic mu foci angapo myeloma.
• Osteoblastic, osteolytic wosanganiza fupa metastasis a zotupa zazikulu.
• Hypercalcemia, amene amayamba ndi chotupa chija.

contraindications

• Mimba ndi kuyamwitsa.
• Aimpso insufficiency.
• Ndi ana (ntchito chitetezo sichinayambe anakhazikitsa).
• Hypersensitivity kuti bisphosphonates acid zoledronic.
• CHENJEZO: aimpso kukanika, bronchial mphumu kwa chiwindi kulephera.

zotsatira zoyipazi

Magazi m'thupi, thrombocytopenia, mutu, chizungulire, conjunctivitis, nseru, anorexia, kusanza, kutsekula m'mimba, kupweteka mafupa, arthralgia, hypophosphatemia, hypocalcemia, malungo, matenda chimfine, kutopa, kunenepa. Mankhwalawa odwala ndi asidi zoledronic nthawi zina ankaona chitukuko cha osteonecrosis cha pachibwano (zambiri pambuyo alowererepo mano opaleshoni).

dosing

Mtsempha kukapanda kuleka, ndipo pasanathe mphindi 15, koma mochepa. Metastases wa myeloma angapo analimbikitsa mlingo wa 4 mg ndi kamodzi pamwezi. Pamene hypercalcemia, amene amayambitsidwa ndi chotupa zilonda, mlingo wa 4 mg ndi kamodzi tsiku lililonse.

Kusamala

Pamene mankhwala kutumikiridwa, m'pofunika kulamulira ndende ya magnesium, phosphorous, creatinine ndi calcium mu seramu magazi. Ngati n'kotheka, tikulimbikitsidwa kupewa opaleshoni mano.

asidi Zoledronic. analogs

Mankhwala "Actonel", "Aneldronat", "Areda lyophilisate", "Bonviva", "Bondronat", "Bonefos", "Klobir", "ksidifon", "Lindron", "Ostalon", "Ostealen", "Osterepar" "Pamidronate", "Pomegara", "Rizendros", "Strongos", "Tevanat", "Foroza" "Fosamax", "Fosfoteh", "Rizarteva".

asidi Zoledronic. mtengo

Childs, malo nawo kameredwe mankhwala malamulo, amasonyeza mitengo katundu wawo. Koma, oddly mokwanira, mtengo wa asidi zoledronic nthawi anasonyeza pafupifupi. Koma kuyandikira kufunika kwake ukufika 14 zikwi rubles pa botolo. Chogulitsidwa pharmacies ndi mankhwala okha.

The zambiri pamwamba cholinga dziŵani ogwira ntchito zachipatala. Nkhaniyi ndi za asidi zoledronic si m'malo malangizo oyenera a dokotala, ndipo sangapereke chitsimikizo cha ubwino kugwiritsa ntchito mankhwala.