Asayansi analandira zotsatira zabwino mayeso a mankhwala atsopano kwa khansa

Asayansi anatha kulenga mankhwala khansa ya m'magazi, amene kamodzinso analidi. M'mayesero matenda anasonyeza kuti chotupa mu 71% ya odwala akayakaya khansa utachepa kapena ngakhale kwambiri.

gulu yayenda

Phunziro amene zotsatira zinasindikizidwa mu Journal wa chipatala Oncology, anachititsa ndi nawo odwala 24 ndi aakulu lymphocytic khansa amene mankhwala ena sinathe. The zaka odwala ranged kwa zaka 40 kuti 73. Komanso, mbali pa phunziroli aliyense analandira avareji mitundu isanu osiyana mankhwala, kuphatikizapo chithandizo cha "Ibrutinib" - ndi chimagwiritsidwa ntchito mankhwala ndi mtundu wa khansa. Izi ophunzira pa chiopsezo ndi ndalama kupulumuka otsika.

mayesero matenda

Akatswiri a Research Center Freda Hatchinsona Cancer ntchito mankhwala oyambirira otchedwa immunotherapy timoralnogo cholandilira (galimoto). Ndi mtundu uwu wa mankhwala wodwala maselo yekha T yotengedwa magazi, ndipo anasintha zinthu zasayansi. Pankhaniyi, akhala kusinthidwa kuzindikira CD19 - Antigen padziko maselo a khansa.

Kenako maselo amenewa kusinthidwa ndi jekeseni kumbuyo mu mtima, kuwachititsa kuti amenyane khansa, ndi kufuna kuchulukitsa maselo a khansa kwa Antigen CD19. Ofufuzawa amanena kuti pasanathe miyezi sikisi ndi theka 17 24 odwala chotupa utachepa kapena kwathunthu mbisoweka.

"Poyamba sizinkadziwika ngati n'zotheka ntchito immunotherapy timoralnogo cholandilira T maselo zochizira odwala ndi aakulu lymphocytic khansa, amenenso m'gulu la yayenda - anati wolemba kuphunzira ndi kutsogolera Dr. Cameron Kamba, immunotherapy kafukufuku pa Fred Hutchinson Center. - phunziro lathu limasonyeza kuti maselo galimoto T ndi chithandizo zingamuthandize kwambiri kwa odwala ndi CLL amene yosayenera chithandizo "Ibrutinib."

CLL ndi chiyani?

Matenda lymphocytic khansa - matenda imene imayamba mu mafupa a anthu (ku minofu zofewa mwa mafupa kumene maselo magazi anapanga). Odwala ndi CLL, ndi mafupa umabala lymphocytes ambiri nthenda (mtundu nthenda ya maselo oyera).

Monga matenda ili m'kati, maselo amenewa nthenda angathe kuikidwa m'magulu pamodzi ndi kukula mu lymph mfundo, ndulu ndi chiwindi. Kukula za "zotupa lymphoid" angathe kuyeza ntchito zosiyanasiyana chindodo.

Healthy maselo - ndi maselo chitetezo ya thupi othandiza kulimbana ndi matenda, koma odwala ndi CLL, iwo sizikugwira ntchito bwino ndiponso chifukwa chisokonezo. Malinga ndi American Cancer Society, aakulu lymphocytic khansa mu 2017 chidzakhala chifukwa cha imfa 4660. Komanso ayenera kukhala za 20.110 amapezeka matendawa.

zotsatira zoyipazi

mankhwala atsopano mavuto kwambiri mbali, ngakhale ambiri a iwo kusintha. Kuphunzira pafupifupi 83% odwala anayesedwa cytokine kumasulidwa syndrome, ndi wamba Vuto mankhwala T-maselo ndi zizindikiro monga malungo, nseru, kuzizira, ndi kuthamanga abnormally otsika magazi. Mwatsoka, awiri odwala anali m'chipatala ndipo anafa pa chithandizo.

masabata anayi pambuyo chithandizo ofufuza kusanthula mafupa zitsanzo odwala 12, amene chifukwa chithandizo anali chikhululukiro, kuti awone ngati anakhalabe boma nditamaliza mankhwala. Awa, asanu ndi awiri palibe zilonda maselo a khansa.

kuphunzira ndi itangoyamba oyambirira, koma kale chiyembekezo ndithu. Zotsatira zake zoyipa Ndithu vuto, koma zingakhale zothandiza kwambiri upambana zawo.