Prokinetics - ndichiyani? mbadwo watsopano wa prokinetics: mndandanda

Prokinetics - ndichiyani? M'mayiko CIS, palibe kugwirizana za zimene mankhwala ali mgulu lino, kotero aliyense gastroenterologist yekha alinga kuti abweretse mndandanda, ndipo kodi si. Prokinetics - ndichiyani? Ndicho chimene ife tikuyesera kuti tipeze.

Tanthauzo ndi kufotokoza mwachidule

Prokinetics - ndichiyani? Izi gulu la mankhwala kuti Zimachititsa motility wa chubu m'mimba ndipo kumathandiza mafunde anastaltic.

matenda m'mimba nthawi zambiri limodzi ndi Reflux wa chyme kuchokera kunsi kwa chubu m'mimba mwa overlying, kuphwanya ndimeyi bolus kapena stagnation mu gawo intestine. Onse zizindikiro imakhudzana ndi makutu Kukwezeleza chyme ndi chubu m'mimba, ndiye kuchotsa zizindikiro kungakhale, okhudza chidule cha minofu yosalala mu mpanda wake. Ndicho chimene prokinetics. mmene achire ndi chifukwa kutsekereza wa limagwirira ion kutengerapo (dopamine, 5-HT4 zolandilira, kuphatikiza) kapena mphamvu pa kagayidwe wa acetylcholine. Kukwaniritsa zotsatira matenda ndi chifukwa kuchuluka kuchuluka kwa acetylcholine mu mphanga synaptic kapena amveke katundu cholinesterase amene timapitiriza kuwonongeka kwa Ach, mankhwala kuchepetsa Ach mitsempha mathero.

Zotsatira Physiologically kwa mankhwala kuoneka kuonjezera mtima esophageal sphincter kamvekedwe, achoke ya nkhani m'mimba, ndi kugwirizana pakati pa antrum ndi duodenum, zipatso intestine peristalsis.

Gulu loyamba la mankhwala

Prokinetics - mankhwala kuti ndigwire dopamine D2-zolandilira, potero zolimbikitsa ntchito minofu ndi kupereka ulusi m'mimba zotsatira antiemetic. Mankhwalawa monga: "metoclopramide" (m'badwo woyamba oimira - "Reglan" ndi "Raglan"), "bromopride", "Domperidone" (m'badwo wachiwiri), "Dimetpramid", "Itopride".

mankhwala Prokinetic, ntchito mankhwala a matenda gastroezofagialnoreflyuksnoy (GERD), YAZHDPK, dyspepsia zinchito chikhalidwe, kuchepetsa wa kholingo pambuyo choipa ndi chifukwa cha adhesions, postoperative paresis alowererepo m'mimba, chosokoneza cha outflow wa ya ndulu, flatulence.

Komanso prokinetics - mankhwala angagwiritsidwe ntchito kunyansidwa ndi kusanza chifukwa cha chiphe kapena kuphwanya malamulo chakudya, matenda a etiology tizilombo toyambitsa matenda, mimba mu trimester, pachimake inatsekeratu insufficiency, zoopsa mutu, mankhwala, cheza ndi mankhwala amphamvu. Osamveka kusanza chiyambi vestibular, monga zilibe bwanji khutu pakati ndi medulla oblongata.

Antipsychotics kuthandiza ndi kusanza

"Sulpiride" ndi "Levosulpirid" ndi neuroleptic ndi njira zofanana pa ntchito, iwonso zabwino odana emetic tingati choncho angagwiritsidwe ntchito kumapeto gastroenterological.

"Metoclopramide" (prokinetics): malangizo ntchito

"Metoclopramide" - ndi stimulator mwachindunji minofu yosalala ndipo ali ndi katundu chotheka kuti iyende kukomoka kwambiri, koma chifukwa cha permeability zopinga gematogistologicheskie ayenera kugwiritsidwa ntchito mosamala. chingachitike mbali monga kuphipha a minofu nkhope, ndi chizindikiro cha "Mapazi khwangwala a", rhythmic protrusion lilime, matenda bulbar, spasms ekrtraokulyarnyh minofu, torticollis spasmodic, amaika kamvekedwe ka minofu extensor, Parkinson matenda, somnolence, kufooka, tinnitus, litsipa, nkhawa, chisokonezo.

Nthawi zina, zofunika kutenga prokinetiki? Malangizo ntchito anati osafunika ntchito milandu hypersensitivity mankhwala, chotupa wa kotekisi adrenal, matumbo kutsekeka, perforation wa matumbo ndi chifukwa iwo magazi, prolaktinozavisimoy zotupa, khunyu ndipo matenda extrapyramidal, mpaka masabata 16 a gestation mwanayo, pa mkaka wa m'mawere, ana osaposa zaka 5. CHENJEZO ayenera mankhwala pa wotsikirapo chilolezo cha creatinine, kuchuluka magazi, mphumu, zaka zaka 14.

Kumeza mankhwala theka la ola pamaso chakudya, pa cholembapo 9:00, 12:00, 15:00 ndi 18:00. Nthawi chithandizo - masabata anayi ndi zisanu ndi chimodzi, nthawi zina angathe mpaka miyezi isanu ndi umodzi.

Ngati kumasulidwa mawonekedwe - madzi, ndi kutumikiridwa intramuscularly kapena kudzera m'mitsempha. Kwa akulu ndi ana oposa zaka 14 - 10 mg. Zolemba malire pa nthawi imodzi - 20 mg wa tsiku mlingo - 60 mg. Nkhani za ampoule akhoza sitimadzipereka mu saline isotonic kapena 5% shuga njira.

"Domperidone": malangizo ntchito

"Domperidone" ndi zina kusankha dopamine cholandilira blocker, kuwonjezera umalowa mu BBB Koma pamene phwando si kukhala mavuto tafotokozazi. Komabe, kuwonjezera katulutsidwe wa prolactin, izo akapsa gynecomastia, galactorrhea, ndiponso kusapezeka kwa menses. Komanso, odwala lipoti zotupa pa khungu pakamwa youma, kutsegula m'mimba ndi mutu.

Osavomerezeka ntchito kwa anthu ndi thupi lawo siligwirizana ndi zigawo zikuluzikulu za mankhwala, magazi kuchokera thirakiti m'mimba, kutsekeka m'matumbo, prolactinoma, mkaka wa m'mawere, zaka mpaka zaka 5 ukalamba ndi masekeli mpaka makilogalamu 20. CHENJEZO kutenga woyembekezera, aimpso ndi / kapena kwa chiwindi insufficiency.

Kumwa kwa mphindi makumi awiri musanadye chakudya 10 mg, ngati akufunikira, ndipo akhoza kumwa asanagone. Mlingo pazipita patsiku - 80 mg. Ngati alipo mankhwala a Mankhwalawa ayenera kumwedwa, kuchepetsa katulutsidwe wa madzi chapamimba, iwo ayenera kukhala wolekana ndi kumwa domperidone, kugawana kudya chakudya.

"Itopride": malangizo ntchito

"Itopride" Chili katundu wa dopamine cholandilira antagonist ndi blocker wa acetylcholinesterase. Mphamvu pa dongosolo hypothalamic-pituitary-adrenal, kuwonjezeka magawanidwe a somatostatin ndi kuchepetsa adrenocorticotropic timadzi. A zoyipa chimaonetsera leukopenia, thrombocytopenia, zochita hypersensitivity, hyperprolactinemia, nseru, kugwedeza, matenda a chikasu ndiyo. Pa phwando, m'pofunika kuti aziona boma la magazi zotumphukira, ndi kuonetsetsa pali zotsatira palibe mbali.

Osavomerezeka chifukwa anthu ndi hypersensitivity wa yomweyo kapena kuchedwa mtundu, mbiri m'mimba magazi, obturating wa lumen m'mimba kapena psinjika za thupi yachilendo yopanda, pansi zaka sikisitini, mimba, yoyamwitsa.

Mankhwala akutengedwa pakamwa pamaso chakudya 50 mg katatu patsiku.

Muzikangana "Acetylcholine"

gulu Izi zikuphatikizapo:

• "Aceclidine" (M-cholinomimetic);
• "Fiziostigmin" "Galantamine" "Tegaserod" "Prucalopride" (kusintha cholinesterase woletsa)

Mankhwalawa a pang'ono kokha kampani ya prokinetics chifukwa cha zotsatira zawo mbali: mmene nzeru ayoni potassium ndi chifukwa, kutalikitsa QT imeneyi, imbaenda zipolowe za mungoli mtima. chiwerengero cha mankhwala akhala achoka msika pharmacological pachifukwa ichi.

"Aceclidine": malangizo ntchito

Prokinetics - ndichiyani, ndiponso mmene angadzigwiritsire ntchito izo? Mulimonsemo, onetsetsani kukaonana ndi dokotala ndiponso kuphunzira tcheru ndi malangizo ntchito.

"Aceclidine" ntchito kupewa imfa ya kamvekedwe ka thirakiti m'mimba ndi chikhodzodzo pambuyo opaleshoni, kuchepetsa kuthamanga intraocular, Choncho ntchito mu pochiza matenda a maso. Mankhwala Fomu - jekeseni, jekeseni subcutaneously ndi 2.1 ml ya munthu njira 0.2%. Max pa nthawi - 0.004 ga, tsiku ndi zosaposa 0.012, mavuto - ptyalism, thukuta ndi kutsekula m'mimba.

Contraindications ntchito ndi CHD, okwera HDL, bronchial mphumu, ndi zina hyperkinesias parkinsonism, mimba, magazi kuchokera zonse m'mimba.

"Fiziostigmin" ntchito kwenikweni kuchita ophthalmic, koma nthawi zina ntchito mu gastroenterology pa za paresis matumbo. Mankhwala jekeseni pansi pakhungu wa 0,5 - 1 ml ya yankho 0.1%. The pazipita kuchuluka kwa mankhwala patsiku sayenera upambana 0,001 ga

Zotsatira zake zoyipa ndi kulimbitsa salivation, bronchospasm, matumbo kuphipha minofu, kusintha kugunda kwa mtima, kupweteka.

Contra-zikuonetsa: angina, khunyu, mphumu, makina kutsekeka m'matumbo, peritonitis, sepsis, mimba.

"Galantamine": malangizo ntchito

"Galantamine" nkhani zina zapadera ntchito monga antagonist kwa relaxants minofu mu nthawi postoperative ndi kuchepa minofu kamvekedwe ka mu matumbo ndi chikhodzodzo. Contraindications ntchito ndi hypersensitivity, khunyu, mphumu, kuthamanga kwa magazi pamwamba 139/99 mmHg, COPD, makina occlusion wa ritsa matumbo, aimpso ntchito kuwonongeka, zaka 9. Okha cholinga cha mimba milandu kumene mopweteka angathe kuposa ubwino. Pa mkaka wa m'mawere, zikhoza zimafalitsidwa kwa mwanayo kudzera mu mkaka wa.

Zotsatira zoyipa za mankhwalawa: kuchepetsa mlingo mtima, TTP, AV anatseka misewu, arrythmia, nseru, kusanza, kutsekula m'mimba, dyspepsia, spasms minofu, incontinence mkodzo, haematuria, kugwedeza.

Mwina kutumikiridwa subcutaneously, intramuscularly, m'nsinga, transdermally, pakamwa. Mlingo kusintha payekha, potengera mbiri ya matenda, ayenera kudzudzulidwa ndi dokotala nawo. Wapakati tsiku mlingo akuluakulu - 10 40 mg, ogaŵikana Mlingo awiri kapena anayi.

A mbadwo watsopano wa prokinetics

Pamaziko a lero Itopride kubala mankhwala monga "Ganaton", "Itomed", "Pramer". Mmodzi wa zatsopano zothandiza kwambiri ndi amene prokinetiki latsopano m'badwo monga "koordinaks" ndi "Prepulsid". Ngakhale angathe kuyambitsa zotsatira zina zoyipa mu mtima.

Wotchuka kwambiri pakati gastroenterologists amakhalabe "Motilium" (yogwira pophika - domperidone), chomwe chili ndi khalidwe la metoclopramide, koma alibe zotsatira zake zoipa.

ndi pprokinetiki yabwino kwambiri chiyani? Mndandanda wa mankhwala tsopano zikuphatikizapo:

1. "Itopride" (yogwira pophika) - "Ganaton", "Itomed", "phunziroli" (dzina malonda).
2. "Metoclopramide" - "Raglan" "Reglan".
3. "Cisapride" - "koordinaks", "Prepulsid".
4. "Domperidone" - "Motilium", "Motilak", "Motinorm", "Passazhiks".

Ife tikudziwa tsopano kuti prokinetic amenewa. Lembani ngati inu mukuona, ndi yayikulu kwambiri. Koma kumbukirani, musanagwiritse ntchito mankhwala aliwonse ayenera kuonana ndi dokotala! Khalani wathanzi!