Mefenamic asidi

"Mefenamic asidi" - mankhwala chimagwiritsidwa ntchito arthrology, chithandizo cha matenda opatsirana a yotupa chikhalidwe, akuvutika zizindikiro za ubongo.

mankhwala ili gulu la zinthu pharmacological fenamates - zinthu ndi odana ndi yotupa kwenikweni. "Mefenamic asidi" wakhazikitsa yokha ngati antipyretic kwambiri ndi analgesic.

Mankhwala ali limagwirira zovuta kanthu kumafuna nawo mwachindunji zochita yotupa. "Mefenamic asidi" (yogwira mankhwala) amachepetsa kaphatikizidwe wa zinthu zenizeni (nkhoswe), yomwe ndi prostaglandins, kinin, serotonin. Komanso kwambiri kumachepetsa ntchito za lysosomal michere proteolytic, nawo mwachindunji mu magawo awiri oyambirira a kutupa: exudation, kuchulukana. Zotsatira zina za mankhwala monga: ndi olimba a nembanemba selo ndi ultrastructures mapuloteni, kuchepa mtima permeability ndi kutupa zimakhala akhudzidwa wowonjezera ntchito ya serotonin, kuchuluka kukaniza maselo, kukondoweza njira kusinthika. Analgesic zotsatira mankhwala ndi mmene mwachindunji limagwirira chapakati ululu tilinazo, komanso kanthu pachilumbachi cholinga yotupa. katundu Antipyretic imakhudzana ndi mwachindunji kutsekereza prostaglandin kaphatikizidwe, zotsatira pa malo thermoregulatory mu ubongo. Chinthu china ndi kupangidwa kwa interferon, amene mwachindunji timapitiriza katundu proliferative wa chinthu yogwira.

Mefenamic asidi ali mokwanira mkulu mayamwidwe koyefishienti. Ndende pazipita zimatheka pambuyo maola awiri kapena anayi pambuyo phwando. Mlingo wa mankhwala magazi nthawi zonse molingana ndi mlingo wake analandira. Transport mu m'magazi mankhwala kumachitika ndi kumanga kwa albumin. Hafu ya moyo wa chinthu yogwira ndi maola atatu. Pafupifupi makumi asanu peresenti excreted mu mkodzo mu mawonekedwe pafupifupi unaltered, twente-faifi - ndi chimbudzi.

"Mefenamic asidi" ali ndi sipekitiramu lonse mokwanira ntchito, yolongosoledwa ndi kuchuluka kwa zotsatira kuti imatembenuza woukitsa. matenda akuluakulu ndi zizindikiro zomwe mungathe kupirira bwino yogwira mankhwala ndi nonspecific nyamakazi, pachimake enaake ophwanya malungo, neuralgia, myalgia, arthralgia, matenda Bechterew ndi ozizira, periodontitis. medicament nazonso anafuna kugogoda mutu, mano kupweteka m'thupi kutentha khunyu, zizindikiro za matenda kusamba.

Pakuti "asidi mefenamic" Pali contraindications angapo, waukulu umene ali hypersensitivity pamaso pa mmatumbo matenda chilonda ndi m'mimba, m'mimba yotupa matenda a magazi, a impso. Woyembekezera, mkaka wa m'mawere muyenera kuchepetsa kugwiritsa ntchito mankhwala.

Mogwirizana ndi mankhwala ena magulu - mmodzi kwambiri mbali, amene amakhala asidi mefenamic. Guide to lokonzekera mwatsatanetsatane zonse zochita zotheka ndi zosokonezeka. Pamene zimavuta ndi "Analgin" ndi salicylates kumatheka odana ndi yotupa kwenikweni. The mankhwala kumawonjezera prothrombin nthawi pamene mukumwa anticoagulants.

Zotsatira yaikulu mbali, amene ali asidi mefenamic, ndi ku matenda m'mimba anaonetsa galimoto ndi zipolowe dyspeptic. Ndi ntchito yaitali mankhwala angathe hemolytic magazi m'thupi mtundu.