Medicine ndi ojambula. okwera androstenedione

Androstenedione amatanthauza timadzi chiwalo chachimuna. androgen Izi testosterone kalambulabwalo. Anthu amene ankapanga kumachitika makamaka testes lapansi. Mu akazi, 60% ya androstenedione chifukwa cha kusintha zotumphukira, 40% kamapangikira zopangitsa kwa adrenal ndi thumba losunga mazira. Pa mlingo fairer kugonana mapangidwe ndi katulutsidwe wa timadzi izi kuposa testosterone, ndi zayamba yaitali anasonyeza extraadrenal kutembenuka yake testosterone.

androstenedione mlingo anatsimikiza mu zovuta DHEA-S ndi DHEA. Izi ndi zofunika kuti zolinga matenda ndipo ingatithandize kuzindikira zotsatira achire mu zikhalidwe hyperandrogenic.

Okwera androstenedione mu kusanthula magazi ndi khalidwe la odwala adrenal kotekisi hyperplasia kobadwa nako chikhalidwe. Komanso, pamene mkulu mlingo wa wapezeka syndrome Cushing, hyperplasia kapena neoplasm testicular stroma mu n'kuwasanganiza, komanso ngati ectopic ACTH katulutsidwe.

Anakwezedwa androstenedione anawona odwala ndi hirsutism ndi mazira polycystic.

Mu yochizira matenda, ndi woipa seramu wa timadzi wa chimagwiritsidwa ntchito kwa polojekiti mphamvu ya zikunena achire ntchito glucocorticoids mu kobadwa nako adrenal hyperplasia, monga amaona molondola kwambiri muyeso kuposa androgens ena.

Palibe kuchuluka androstenedione, ndi mosemphanitsa, kuchepetsa wokhutira limasonyeza kukhalapo kwa magazi m'thupi chikwakwa-selo. Kudwala akufotokozera motsutsa likhale insufficiency yamchiberekero ndi adrenal.

Androstenedione. Pamene anayesedwa?

Zikuonetsa kuphunzira ndi:

- kuwunika mankhwala ndi matenda a zinthu hyperandrogenic;

- matenda ubereki pa maziko a m'thupi kulephera;

- mankhwala ndi glucocorticoids.

chidwi linaperekedwa androstenedione anthu nawo ojambula akatswiri. Akukhulupirira kuti kukonzekera timadzi ndipo nkhani zake kulimbikitsa kukula minofu. Komabe, izi sizichitika nthawi zonse.

Androstenedione ndi timadzi waukulu zopangitsa kwa adrenal ndipo zikhoza kusinthidwa kapena testosterone kapena esitirojeni. Mbali yoyamba ndi analimbikitsa ndi puloteni kutembenuka yeniyeni. Tikumbukenso kuti unyolo wa masinthidwe a androstenedione steroid kuti testosterone ndi kwambiri kuposa DHEA. Zimenezi zimathandiza munthu wamkulu umatha usinthe. Chotero, kutembenuka chotsatira cha androstenedione kuti testosterone maziko mchikakamizo cha enzyme wina apite dihydrotestosterone. Zimenezi, limathandiza kuti chitukuko cha mavuto ambiri kwabasi. Dihydrotestosterone kumapangitsa ndi balding mutu, ndi kukulitsa malire a prostate, komanso kwambiri kukula tsitsi pa thupi ndi nkhope. Komanso, anabolic katundu alibe Komabe alibe mphamvu pa minofu misa. Choncho, pamene androstenedione kuchuluka, pali kuthekera kuwonjezeka magawanidwe a dihydrotestosterone.

Kuwonjezera zotsatira, pali vuto lina - gynecomastia. Kumapangitsa kukula kwa chifuwa kutembenuka kwa testosterone kuti estradiol (aromatization).

Ngakhale malonjezo a otsatsa kuti kuchuluka androstenedione kwambiri zotsatira kukula minofu akamwedwa molondola, mahomoni "mpheto" sizimadziwika ndi zovuta ndondomeko. Komanso kuganizira mfundo kuwonjezeka mu milingo testosterone ntchito mankhwala m'thupi, kumene, zimakhudza dongosolo limene akulamulira kupanga mankhwala kugonana.

Lero, androstenedione ndi zotsatira zake pa anthu bwinobwino. Ndiponso, kulandira anthu kapena kukonzekera zina m'thupi ayenera kuganizira mbali iliyonse chamoyo. Mwachitsanzo, ena kuwonjezeka mu ndende ya androstenedione zotsatira opindulitsa pa kukula kwa thupi, pamene ena amayambitsa mavuto aakulu.