Mankhwala "valparin": malangizo ntchito, zikuchokera, ofanana matanthauzo, zofanana. Reviews kukonzekera

N'chifukwa chiyani ndikufunika mankhwala "valparin"? Malangizo ntchito, ofanana ndi zizindikiro za mankhwala zafotokozedwa m'nkhani ino.

The mawonekedwe ndi zikuchokera kwa

mawonekedwe Kodi chibadidwe mankhwala "valparin"? Piritsi - izo mu mawonekedwe a mankhwala funso lingathe kukopedwa pa mankhwala a. Iwo kuonetsa kanthu yaitali, wozungulira biconvex mawonekedwe, ndi yoyera mtundu ❖ kuyanika.

Gawo la mankhwala "valparin"? Guide imafotokoza kuti chida lili valproic acid ndi sodium wochuluka valproate. Mulinso ndi excipients zotsatirazi: glycerol, colloidal pakachitsulo dioxide, evdragit E-100, hydroxypropylmethylcellulose, polyethylene glycol 1500, ethylcellulose, ndi sodium saccharin, pakachitsulo woipa hydrate, evdragit OSATI-30D, titaniyamu woipa ndi talc.

Kugula mapiritsi angaonedwe mu n'kupanga zidutswa 10 mu makatoni mtolo motero.

mankhwala

Kodi mankhwala "valparin"? Malangizo ntchito (zikuchokera zikutanthauza wakhala tafotokozazi) limanena kuti ndi anticonvulsant mankhwala. Lili ndi sodium valproate zili utithandize GABA ku ubongo zomwe zimalimbikitsa kuwonjezeka zake manyuroni postsynaptic.

Tiyenera kuona kuti chigawo funso anakopa mayendedwe a ayoni potaziyamu kudutsa nembanemba okhudza mitsempha. Zimenezi limaleka chitukuko ndi kufala kwa malemeredwe khunyu mu ulusi mitsempha.

Tiyeneranso kuti ndi sodium valproate ali zimakhudzanso anticonvulsant mu zosiyanasiyana khunyu.

Mankhwala "valparin" alibe ndi sedative ndi zotsatira zachinyengo, ndipo si ogwetsa likulu la mpweya wa. Komanso, pophika ake yogwira alibe mavuto pa kugunda kwa mtima, thupi kutentha kwa wodwalayo, magazi ake ndi ntchito impso.

The kayendedwe katundu wa mankhwala

ndi makhalidwe pharmacokinetic mankhwala ali "valparin" n'chiyani? Guide amanena kuti pambuyo kutenga mankhwala mkati molamulirika amasulidwe mankhwala yogwira akuyamba yomweyo, ndipo pambuyo maola 2-8, kufika pazipita plasma mlingo.

Bioavailability njira ankaona 100%.

Zotsatira achire mankhwala imapezeka akafika pa valproic asidi ndende mu magazi, wofanana 45-100 mg / L. Adzakhululukidwa anazindikira kuti achire ndi pharmacological zochita za njira ankalamulira chigawo kumasulidwa pakati sikuti zimadalira woipa madzi a m'magazi.

Communication ankaona mankhwala kwa mapulotini plasma pafupifupi 85-90%. Iwo zimapukusidwa mu chiwindi ndi linanena bungwe pamodzi ndi mkodzo. Mu choyamba ichi-chiphaso kagayidwe zimawonedwa.

Theka moyo wa wothandizila ndi za 9-20 maola. Ana, nthawi imeneyi yafupika.

Zikuonetsa yopemphera

M'mikhalidwe zimene mankhwala yabwino kwambiri khalidwe "valparin"? Malangizo ntchito kwenikweni odziwa akatswiri amanena kuti anati medicament amapangidwa makamaka zochizira matenda a khunyu zowombetsa mkota, kuphatikizapo mitundu zotsatirazi kuukira:

• myoclonic;
• amajomba;
• atonic;
• zimandilimbikitsa-clonic.

Komanso, mankhwala Kwalamulidwa kwa tsankho khunyu, ndi zambiri mwachindunji, pa:

• sekondale zowombetsa mkota kukomoka;
• ophatikizana kapena khunyu yosavuta.

Komanso, mapiritsi amaona ntchito pamene syndromes yeniyeni (Lennox-Gastaut syndrome, West).

Ziletso ntchito mapiritsi

Iwo ali contraindications mankhwala osokoneza bongo "valparin"? Mogwirizana ndi malangizo a ku chida, pali zoletsa zambiri kugwiritsa ntchito:

• pa mimba;
• matenda aakulu mu kapamba;
• thrombocytopenia;
• chiwindi pachimake kapena aakulu;
• porphyria;
• Nthawi yogwira chiwindi (mankhwala chiyambi);
• Kuyamwitsa;
• m'badwo wa ana kwa zaka zitatu;
• hypersensitivity kuti mankhwala, kuphatikizapo asidi valproic.

Anticonvulsant "valparin": malangizo ntchito

Mlingo wa mankhwala amasankhidwa payekha, malingana ndi thupi ndi zaka za wodwalayo.

Childs, wamkulu poyambira mlingo ndi 600 mg wa mankhwala patsiku. Otsatirawa nambala iyi chinawonjezeka ndi 200 mg (masiku atatu kukwaniritsa chimene mukufuna).

Multiplicity Kulandira kutanthauza pansi pa kuganizira nthawi 1-2 pa tsiku. The pazipita analimbikitsa mlingo ndi 1-2 ga mankhwala patsiku.

Miyala "valparin", malangizo ntchito zimene takambirana mu pepala ayenera kuwameza lonse, kumwa pang'ono madzi ofunda.

Anthu okalamba dosing kamwedwe chida akufanana ndi dosing kamwedwe odwala wamkulu, koma anasankha anthu paokhapaokha.

Kwa ana yolemera makilogalamu 20 mlingo woyambilira wa medicament ndi 400mg patsiku. M'pofunika kuwonjezera kuchuluka pang'onopang'ono kukwaniritsa chimene mukufuna (za 20-30 mg / kg pa patsiku pa mlingo 1-2).

Mwana akulemera mpaka makilogalamu 20 perekani mankhwala anticonvulsant ndikoletsedwa.

Zochita ndi-khalidwe

ndi mavuto chifukwa "valparin" piritsi chiyani? Malangizo ntchito amatithandiza kuti zakudya za mankhwala odwala amatha kuona zotsatira osafunika:

• thupi lawo siligwirizana: Stevens-Johnson syndrome, zotupa pa khungu erythema multiforme, pruritus, khungu, photosensitivity.
• dongosolo m'mimba: nseru, chiwindi, kusanza, kudzimbidwa, m'mimba, kapamba.
• dongosolo ubereki: amenorrhea sekondale, osasamba kusamba.
• CNS: chikomokere, kenaka utentha mamba, ataxia, mkhutu kutsitsimuka.
• hemopoietic dongosolo: magazi, kupatsidwa zinthu za m'mwazi loitanirana chopinga, thrombocytopenia, leukopenia, neutropenia, utachepa fibrinogen.
• Other: kunenepa kwambiri, kuthothoka tsitsi, seramu creatinine, hyperammonemia.

ambiri osokoneza anticonvulsant

Kodi zizindikiro angayambe pamene mukumwa mlingo waukulu wa mankhwala "valparin"? Malangizo ntchito (mapiritsi lingathe kukopedwa pa mankhwala alionse pa mankhwala) ananena kuti tsiku cha mankhwala osokoneza bongo mwadala kapena mwangozi mankhwala pansi kulingalira anauzidwa kawirikawiri. Monga ulamuliro, ndi kuphwanya dosing wa mankhwala kumathandiza kuti maonekedwe a nseru, chizungulire, kusanza, kutsekula m'mimba, maganizo kupuma, chikomokere, ndi hyporeflexia.

Kuthetsa zinthu zimenezi wodwala Kwalamulidwa chapamimba lavage ndi adamulowetsa makala. Ngati ndi kotheka, mankhwala wodwala ikuchitika mu mawonekedwe a mankhwala symptomatic ndi hemodialysis.

Mogwirizana ndi mankhwala ena

Kaya adalowa mogwirizana ndi mankhwala ena mankhwala "valparin"? Malangizo ntchito imatiuza wodwalayo kuti valproate ndi sodium kuti azimveka zotsatira za antipsychotics, antidepressants ndi mankhwala antiepileptic.

Mosiyana ndi ena anticonvulsants , ankaona si mankhwala amalimbikitsa kwa chiwindi enzyme kupatsidwa ulemu, choncho sizichepetsa mphamvu ya kulera m'kamwa.

Mu phwando yomweyi "warfarin" ndi sodium wochuluka valproate utachepa kuchuluka lomanga zonsezo plasma choyamba.

Thunthu mankhwala yogwira imatengedwa amatha kusintha woipa plasma wa lamotrigine, ndi phenytoin. Pamene pamodzi ndi ena ofanana nawo a acetylsalicylic asidi anticoagulant ndi antiplatelet zotsatira kumatheka.

Ndi ntchito munthawi yomweyo "valparin" kuchokera Mowa ndi mankhwala ena kuti nkhawa CNS anatseka (mwachitsanzo, Mao zoletsa ndi antidepressants tricyclic, mankhwala antipsychotic) Mwina kumatheka CNS maganizo.

Mowa ndi mankhwala ena hepatotoxic azitaya kuwonongeka chiwindi.

Ankaona chiphunzitso kumawonjezera theka moyo "lamotrigine" ndi kubweza kagayidwe ake ndipo limaleka michere kwa chiwindi. Mogwirizana ndi uyu theka moyo wa mankhwala akhoza ziwonjezeke kwa maola 70 pa odwala wamkulu ndi maola 45 - ndi ana.

"Valparin" akhoza kuchepetsa chilolezo "zidovudine" pafupifupi 40%. Komanso ake theka moyo sasintha.

Mao zoletsa antidepressants, tricyclic ndi mankhwala antipsychotic (neuroleptics), komanso mankhwala ena kuti m'munsi kulanda pakhomo, ndithu kuchepetsa mphamvu ya medicament ankaona.

Kuyamwitsa ndi mimba

Malinga ndi akatswiri, kugwiritsa ntchito mankhwala "valparin" pa gestation ndi Zimatheka ngati ubwino anafuna amayi m'tsogolo kwambiri kuposa chiopsezo kuthekera kwa mwana.

Pamene kulandira mankhwala woyembekezera, onetsetsani kuti kuchititsa apadera akalandire chithandizo kuwunika mwana wosabadwayo.

Ntchito ya mankhwala pa mkaka wa m'mawere ali osavomerezeka.

tsatanetsatane

Musanayambe chithandizo cha ndalama, onetsetsani kukaonana ndi dokotala.

Mu ndondomeko ya kulandira mankhwala anticonvulsant amafuna polojekiti zonse bilirubin mu magazi, amylases ndi maselo othandiza magazi kuundana, komanso transaminases chiwindi (pa miyezi 3).

Malinga ndi akatswiri, asidi valproic amatha inhibiting kupatsidwa zinthu za m'mwazi loitanirana. Zimenezi kwambiri chiopsezo kuchuluka nthawi magazi coagulation kwa magazi. M'pofunika kuganizira mosavuta mavuto amene amagwirizana ndi magazi mu nthawi postoperative, anthu kulandira ndi sodium valproate.

Ngati yaitali chithandizo cha mankhwala mu odwala akhoza kuyamba mowiriza magazi ndi hematoma anapanga. Mu nkhani iyi, mankhwala ayenera kusiyidwa yomweyo.

Monga tanena, sodium valproate, mankhwala zimayambitsa kapamba, ndipo zimalimbikitsanso kusokoneza ntchito chiwindi (kawirikawiri mu miyezi 6 yoyambirira chithandizo). Pa nkhani imeneyi, pa chiyambi cha mankhwala n'kofunika kuti aziona udindo wa pancreatic khansa mtima, komanso nthawi zonse kuwunika chiwindi mayesero ntchito, ndi mlingo wa prothrombin.

Matenda a chiwindi ndi kwa chiwindi kulephera odwala kulandira ndi sodium valproate zingaoneke ana ndi khunyu matenda kagayidwe kachakudya ndi osachiritsika, retardation maganizo ndi organic ubongo minofu kudwala.

Mu ananena zizindikiro monga ulesi, amalembedwa kufooka, kutupa, ndi kusanza, matenda a chikasu ndiyo, mwamsanga kusiya ntchito medicament lapansi.

Mankhwalawa "valparin" wodwalayo ayenera kukhala osamala kwambiri pamene akugwira ntchito makina oopsa. Ichi ndi chifukwa chakuti medicament yogwira angathe kuchepetsa ndende.

Terms ndi zinthu yosungirako

Anticonvulsant mankhwala "valparin" choperekedwa mu pharmacies yekha mankhwala dokotala. Iwo ayenera kusungidwa mu patali ndi ana komanso wotetezeka ku chinyezi ndi pa kutentha osati kuposa 30 madigiri.

Alumali moyo wa mankhwala pansi kulingalira ndi zaka zitatu (kuchokera tsiku kupanga).

Medicament "valparin": analogues, ofanana matanthauzo

The mankhwala funso akhoza m'malo? Mau ofanana ndi analogues mu chida ichi, pali zambiri. Zikuphatikizapo mankhwala zotsatirazi: "Apilepsin" "Depakine," "Atsediprol" "Depakine Enterik" "Depakine Chronosphere" "Depakine Chrono", "Dipromal", "Konvulsofin", "Konvuleks", "Orphir" "Enkorat", "Everiden", "Enkorat Chrono".

Monga momwe zilili ndi "valparin" Ndalama zimenezi ayenera kumwedwa yekha pa malamulo dokotala, mu Mlingo analimbikitsa mosamalitsa.

Maganizo a ogula ndi akatswiri

Kodi madokotala kunena za mankhwala, monga "valparin"? Akatswiri alendo akusonyeza kuti mankhwala othandiza kwambiri ndipo imayenera, makamaka zowombetsa mkota ndi tsankho khunyu.

Koma ogula, ambiri a iwo amagwirizana ndi maganizo a dokotala. Odwala amati alandire izi zikutanthauza facilitates chitukuko mofulumira ndi kufalitsa kupondereza malemeredwe (khunyu) ndi manyuroni. Komabe, tisaiwale kuti ntchito za mankhwala nthawi zambiri amayambitsa zotsatira zina zoyipa. Malinga ndi maganizo kasitomala, kwambiri ambiri zikuchitika zosiyanasiyana chokhwima ndi: khungu ziwengo, nseru, kuchepa magazi, ndipo kunenepa. Ngati muli ndi zizindikiro zimenezi mwamsanga funsani dokotala.