"Dopamine" - chimene chiri kuti? "Dopamine": malangizo, ntchito, mtengo

Mankhwala "Dopamine" amaoneka ngati crystalline ufa wa mtundu woyera ndi fungo sadzachitanso amaonekera wa acid amathiridwa. fomu iyi lili mu mawonekedwe a hydrochloride. "Dopamine" - chinthu sungunuka m'madzi ndi mowa. Zimakhudzidwira alkalis, wothandizila zosiyanasiyana oxidizing ndi salt chitsulo. Zizindikiro ndi contraindications kugwiritsa ntchito mankhwala "Dopamine", malangizo pa ntchito anayikidwa mu mabuku athu.

Amatanthauza chikalata ngati kulowetsedwa njira maganizo.

makhalidwe pharmacological

"Dopamine" - mankhwala, ndi mtundu. Pa katundu kagayidwe kachakudya wa dopamine ndi kalambulabwalo wa zikuwonjezereka masiku ano ndi noradrenaline. Mankhwala kumakhudzanso zolandilira lolingana, ndi woipa mkulu timapitiriza ntchito α- ndi β-adrenoceptors. "Dopamine" ntchito umalimbana:

• kuwongola wa zotumphukira mtima kukana;
• kuwonjezera kuthamanga systolic magazi;
• kukondoweza kwa kugunda kwa mtima;
• kuchuluka linanena bungwe mtima;
• zazing'ono kusintha kugunda kwa mtima;
• kwambiri mpweya okwanira.

"Dopamine" komanso timapitiriza magazi ziwiya ubongo, mtima, impso ndi matumbo. Kuchuluka mlingo glomerular kusefera ndi sodium wochuluka excretion ndi impso ndi.

"Dopamine" - kusala wotenga mankhwala. Patapita mphindi 5-10 pambuyo ine / g kulowetsedwa ntchito chimatha. Hafu ya moyo - pafupifupi maminiti awiri. Theka la thunthu interacts ndi mapuloteni mu madzi a m'magazi. Mankhwala akudutsa kagayidwe mofulumira ndondomeko mu impso, chiwindi ndi madzi a m'magazi chifukwa chikoka cha Mao ndi catechol-O-methyltransferase ku mkhalidwe metabolites anafooka ndipo mwachangu opangidwa ndi impso ndi. A kotala ya ntchito mlingo ndi kutembenukira ku norepinephrine mu adrenergic zikumera mitsempha. Chifukwa kuwonongedwa yogwira si kudzikundikira mankhwala mu thupi la munthu, ngakhale patapita nthawi yaitali phwando.

"Dopamine" ntchito

Zikuonetsa kuti alandire:

• zosiyanasiyanazo mantha, monga zoopsa, cardiogenic, postoperative, hypovolemic, endotoxin.
• Pachimake mtima ndi matenda a mtima.
• Low mtima linanena bungwe.

"Dopamine" ndi cardiogenic mantha mavuto apadera, izo kumawonjezera m'mnyewa wamtima contractile ntchito.

Mankhwala chikuyendetsedwera m'nsinga. 125 kapena 400 ml ya peresenti asanu njira ya sodium kolorayidi kapena shuga njira zofunika pa 25 kapena 200 mg motero. Choncho, 1 ml wa njira zopezera 200 kapena 500 .mu.g mankhwala. Ngati wodwala samatha kuperekedwa mabuku yaikulu ya madzimadzi akhoza kukhala njira wambiri moti 1 ml ya micrograms 800 anali "dopamine". Kuti tichite zimenezi, kutenga 200 mg pa 250 ml ya yothetsera. Mlingo wa oyamba ukufika 1-4 ug / kg pa mphindi kwa thupi avareji makilogalamu 70 (2 mpaka 11 madontho a 0,05% njira kapena ku madontho 1.5 kuti 6 a 0,08% njira). The achire mlingo - 5 mpaka 9 mg / kg pa min 1. Mlingo "Dopamine" 10-15 .mu.g / kg pa mphindi lipindulitsa pa vasodilation ndi hypotension. Mlingo makonzedwe akhoza ziwonjezeke kwa 18 .mu.g / kg pa mphindi. The kulowetsedwa chikuchitika mosalekeza komanso chimakwirira zapakati pa masiku maola 2-3 kwa 1-4 kapena kuposerapo. Mlingo patsiku osati choposa 800 mg. Ndi kumayambiriro "Dopamine" umachitika ECG polojekiti. Khama la mlingo ndi mlingo wa utsogoleli chiri monga kuthamanga wolumikizira, kugunda kwa mtima, linanena bungwe mtima, kugunda kwa mtima ndi diuresis. Ngati hypotension Kodi osadzuka, ndi utachepa mkodzo linanena bungwe, mlingo ayenera kuchepetsedwa.

contraindications

mankhwala ali contraindicated mu mwambo mavuto monga:

• arrhythmia;
• pheochromocytoma;
• Prostatic hypertrophy;
• kutsekedwa khungu.

zotsatira zoyipazi

The oyamba a mankhwala pa mlingo waukulu, mkulu mlingo wa "Dopamine" angathe kuyambitsa zotsatira zoyipa kuphatikizirapo:

• kugwedeza;
• tachycardia;
• vasospasm;
• arrhythmia;
• kuphwanya kayendedwe kupuma;
• anginal ndi mutu;
• psychomotor mukubwadamuka ;
• mawonetseredwe ena Adrenomimeticalkie kanthu.

Popeza Kupha "Dopamine" akugwira ntchito, zizindikiro pamwamba kutha ngati kuchepetsa mlingo kapena isiye utsogoleli wa mankhwala. Ngati mungoli wasweka, m'pofunika kugwiritsa ntchito mankhwala antiarrhythmic, kuphatikizapo "Verapamil", "lidocaine wa" ndi ena. Extravasation njira "Dopamine" zingachititse necrosis a subcutaneous adipose minofu ndi a khungu.

Kusamala

"Dopamine" pa mimba akhoza ziletso kokha pamene m'gulu la zinthu zofunika mankhwala kwa mayi, ndipo zotsatira achire ndi apamwamba kuposa chiopsezo kwa mwana wosabadwayo.

Mwatsopano njira ayenera kapangidwe chimaonekera ndipo alibe extraneous hue.

Munthawi yomweyo ndi mankhwala ena

mankhwala akhoza kumwedwa mu kufanana ndi glycosides mtima ndi okodzetsa (mwachitsanzo, furosemide ndi zina). Hypovolemic mantha liyenela kukhazikitsa "Dopamine" pamodzi ndi lonse magazi, madzi kapena madzi mmalo.

Musamalandire "Dopamine" nthawi yomweyo ndi "cyclopropane", Mao zoletsa ndi wothandizila kwa mankhwala ochititsa dzanzi ndi kampira ( "Halothane" ndi ena).

Mtondo chiphunzitso mix zosavomerezeka ndi njira zamchere mankhwala ena.

"Dopamine" - ndi mankhwala kuti ntchito yekha mankhwala. mtengo umadalira pa mlingo ndipo chiwerengero cha ampoules mu phukusi, kuyambira 80 rubles 300 pa paketi (5-10 ampoules).