"Valacyclovir": malangizo ntchito, ndemanga. Analogs "valaciclovir"

matenda tizilombo dikirani kwa munthu aliyense sitepe ya moyo wake mofulumira. Ndi ena a iwo, chitetezo cha munthu wathanzi akhoza kusamalira okha. Ndipo kuthana ndi munthu amafuna antivirals wapadera. makampani Modern ali chitukuko ndi kupanga mankhwala - makampani mankhwala - zachitika ndipo ndi wokonzeka kupereka odwala ake ndi ogwira ntchito zaumoyo mndandanda wa mankhwala amenewo. Mmodzi wa iwo ndi mankhwala "Valacyclovir."

Mfundo ntchito medicament ndi

Waukulu yogwira thunthu "valaciclovir" - valaciclovir hydrochloride (556 mg wa pa piritsi). Koyera valacyclovir - 500 mg. chigawo ichi kumabwezera mmbuyo kaphatikizidwe wa mavairasi DNA kuchititsa nsungu kumabwezera mmbuyo njira kugawanika (retards kapena kwathunthu kumabwezera mmbuyo ndondomeko anawaonjezera kuwirikiza kawiri DNA mamolekyulu).

Pambuyo medicament alowa m'thupi, chimandiswa mu acyclovir ndi L-valine. Ndiye, kudzera phosphorylation wa acyclovir triphosphate anapanga Ndipo zimenezi, kumabwezera mmbuyo nsungu HIV DNA kaphatikizidwe, sapereka iwo (DNA) awiri. Mwina ndiye chifukwa acyclovir ndi inalowa mu dongosolo la tizilombo DNA. Tikhoza kunena kuti "Valacyclovir" kwambiri kusankha pankhani zimakhala anakhudzidwa ndi HIV.

Dera la chikoka "valaciclovir"

Ambiri, "Valacyclovir" malangizo okhudza kugwiritsa ntchito malamulo (zachipatala - zoika kulandira) kwa anthu odwala matenda a nembanemba wa mucous ndi khungu, chikwiyire ndi HIV Herpeszoster. Tiyeni kulandira mankhwala zolinga njira. Komanso, akatswiri akhoza tisonyezeni "Valacyclovir" chifukwa kupewa matenda cytomegalovirus, amene angayambe m'kati mwa nthawi postoperative zokhudza chiwalo kupatsidwa zina. Kugwiritsa mankhwala chifuniro matailosi prolechivanii.

Contraindications ndi zofooka kulandira

"Valacyclovir" ali contraindicated mu anthu ndi tilinazo mkulu waukulu yogwira zikuluzikulu za mankhwala. Asamve ntchito mankhwala pa kupatsidwa zina mwa kupatsa impso ndi mafupa. Komanso si udindo "Valaciclovir" wodwala ali ndi HIV (ngati mlingo wa lymphocytes CD ₄ sudzatha mzere wa 100 mg / L). Pali contraindications kulandira mankhwala ana ndi achinyamata pansi ndi zaka 18. Kupatula Pankhaniyi angakhale ana omwe anali kuziika ziwalo. odwala amenewa saloledwa kuchiritsa "valaciclovir" ndi zaka 12 zakubadwa.

Pankhani malamulo, chifukwa "Valacyclovir" - mankhwala ndithu aukali, pali zoletsa zina pa ntchito yake ndi amayi apakati ndi amayi unamwino. Zapadera zasayansi kafukufuku pa nkhani imeneyi zinachitikadi.

Ngati mkazi akukonza pakati ndi mwana, ndipo mu thupi lili matalala nsungu HIV, ayenera kudziwa dokotala. Pakuti mwana wosabadwa mwana exacerbation la matenda nsungu ikhoza kukhala yoopsa. Nthawi yobereka palinso Mwina matenda a mwana mayi. Ufulu kukhala pa nkhani ya mimba anakonza kukumana kudzifufuza kuyambirira pamaso mu thupi la mtundu wachiwiri nsungu. Komanso, adokotala akhoza mankhwala ena macheke chizolowezi pa chizindikiritso zotheka kwa nsungu HIV.

Mulimonsemo, pamaso poika mankhwala mu gulu la odwala ntchito za umoyo ndi kuyerekeza mmene sikhala mankhwala chifukwa ngozi za thanzi la mayi wa m'tsogolo kapena kale anabadwa mwana. Pali zambiri kuti acyclovir aime ndi mkaka wa m'mawere mu woipa amene kangapo kuposa ndende zake plasma ndi (kwa nthawi 0,6 kwa 4.1).

chingachitike mbali

Pa tsiku lokonzekera "Valacyclovir" malangizo ntchito monga zonena medicament zomwe zingachititse mndandanda wa zinthu chowawa. Popeza mankhwala wadutsa mayesero onse ovutika ndi maphunziro taona (gulu la odwala ndi nsungu zoster, nsungu ndi chimodzi mwa iye, koma limodzi ndi immunodeficiency), tsopano anapeza zotsatira pafupifupi onse zotheka mbali.

Anthu GIT angayankhe ntchito ya kusapeza medicament mu epigastrium lapansi. Kodi kukhala zinthu monga anorexia, nseru, kusanza, kutsekula m'mimba, matenda a chiwindi, okwera chiwindi michere.

Pa mbali ya chapakati mantha dongosolo kungakhale anachita kwa "Valacyclovir" (wodwala umboni - umboni) mu mawonekedwe a chizungulire ndi mutu, maganizo, kuyerekezera zinthu m'maganizo, mkhutu chikumbumtima (yosowa kwambiri). Ngati odwala ndi kuvutika mu impso ntchito kapena zinthu zina zinanso - mwina isanayambike chikomokere. Nthawi angamvele ndi zimene dongosolo mtima monga tachycardia (mlingo kuchuluka mtima), kapena kuthamanga kwa magazi.

Nthawi zambiri pali thupi lawo siligwirizana chilengedwe: kuyabwa zidzolo, urticaria, anaphylaxis, angioedema ndi angioedema. Mwa zochitika zina zoipa kulandira medicament "Valaciclovir" (analogs kupangira kwenikweni anachita chimodzimodzi kapena ofanana kwambiri) angathe dyspnea, photosensitivity, kuchepa madzi m'thupi (madzi m'thupi), thrombocytopenia (utachepa chiwerengero cha othandiza magazi kuundana, amene anatsagana ndi mavuto magazi asiye kutuluka, ndi kuzikonzanso magazi). Komanso, madokotala kunena za kuonekera mwina nasopharyngitis, aplastic magazi m'thupi, vasculitis.

njira A kulandira yopereka mode

"Valaciclovir" (mapiritsi) anatengedwa pakamwa popanda chakudya. phwando mode ndi mlingo zosiyanasiyana malinga matenda ndi zovuta alili.

Nthawi zambiri mankhwala zotchulidwa zochizira nsungu HIV. Mu milandu mlingo tsiku 1000 mg (mapiritsi 2). Ndi bwino kutenga Mlingo awiri, limodzi m'mawa ndi madzulo. mankhwala akhoza osiyanasiyana monga masiku 5 mpaka 10 (aakulu njira ya matenda). Ali wopanikizika, ndi mlingo wofanana wa mankhwala amatengedwa ngati muyeso njira.

Matailosi "Valacyclovir" malangizo Buku amalimbikitsa kutenga njira yosiyana. Apa ndi mlingo wa 1000 mg - ntchito. Landirani mumalowedwe - katatu patsiku (ie mapiritsi 6 patsiku, katatu ndi zidutswa 2 ...). The njira ya mankhwala zambiri kumatenga masiku 7. Mwamsanga pambuyo isanayambike matenda a wodwalayo pitani kuchipatala, ubwino chikwaniritsidwa mofulumira.

Kwa odwala matenda kuvutika mu ntchito impso amafuna mlingo kusintha.

Ena mbali ya ntchito "valaciclovir"

Kwa anthu ndi impso kulephera kugwiritsa ntchito mankhwala kumachititsa kukhala mavuto osokoneza bongo kapena mtundu choopsa cha matenda. Odwala cha ukalamba ayenera kukhala m'kati mwa mankhwala kuwonjezera kadyedwe madzimadzi. Tiyenera kusamala kuti anthu odwala matenda chiwindi.

Ngati mankhwala amasankhidwa pa mankhwala a matenda, monga nsungu maliseche, "Valacyclovir" sadzatha kuteteza matenda a mnzake. Choncho, m'kati mwa mankhwala ayenera atapewa kugonana.

Ngati wodwalayo impso kumuika kapena mafupa, Yehova anasonyeza matenda chithunzi kachilombo ka HIV, pali mkhalidwe immunodeficiency kwambiri, kugwiritsa ntchito "valaciclovir" kungachititse kuti sizingasinthe, zotsatirapo zake zingakhale zoopsa. Mwina chitukuko cha thrombocytopenic purpura: kusintha pathological mu zigawo chimodzi kapena zingapo hemostasis, m'kukoma kukha magazi melkopyatnistyh capillary pakhungu, pansi pa khungu kapena nembanemba mucous. Palinso Mwina uremic syndrome (kutha kwa ntchito impso, mkodzo asiye njira). Onse zinthu izi (purpura ndi uremia) ndi Mwina mkulu zingachititse kuti imfa.

Musati adzaika "Valacyclovir" ana osaposera zaka 18, ngati palibe zinachitikira matenda ndi odwala amenewa.

Ngati mu njira ya mankhwala wodwala akufotokozera khunyu, mukubwadamuka, kuyerekezera zinthu m'maganizo, kuona zilubwelubwe, chisokonezo - kugwiritsa ntchito mankhwala ayenera anasiya ndi kukaonana ndi katswiri.

Mogwirizana ndi mankhwala ena

Aliyense kukomoka kwambiri mawonetseredwe mogwirizana "valaciclovir" ndi mankhwala ena si okhazikika. Komabe, waukulu yogwira chigawo chiphunzitso ndi linanena bungwe kudzera impso ndi katulutsidwe tubular. Choncho, mankhwala aliwonse kwa chimodzimodzi njira excretion, kutengeramo yomweyi, adzakhala kusokoneza ndondomeko ndi kuwonjezera madzi a m'magazi ndende ya valacyclovir. Choyamba onse ogwira ntchito zaumoyo ayenera kulabadira cimetidine ndi ofanana mankhwala kuti ndigwire tubular katulutsidwe limagwirira.

Anthu ambiri acyclovir mu madzi ndi chinawonjezeka ndi pamene kulandira "valaciclovir" ndi "Mycophenolate". Kufanana kulandira asatayike, complicating kapena n'kusokoneza ndi impso ( "Tacrolimus", "Cyclosporin" ndipo m. P.), Kodi kumapangitsanso katundu pa ziwalo zimenezi.

mankhwala ofanana

Mndandanda wa mankhwala mavairasi oyambitsa lero lonse zokwanira. Chigoba malamulo ATC 4 mlingo wa mankhwala zambiri, koma medicament wapafupi "Valacyclovir" "Valtrex", "Vayora", "Valogard", "Valtsikon", "Valavir", "Valvira", "Vatsireks". Pamndandanda uwu si wathunthu ndithu, n'zotheka kupitiriza.

The linafalitsidwa kwambiri ogula kufunika kwa analogues onse amasangalala lero "Valtrex". analogi izi kunja, ndi chinthu chomwecho yogwira. Mwachangu lokonzekera ndi pafupipafupi zizindikiro chowawa, zochita mbali zofanana "valaciclovir". kusiyana alipo yekha mu mtengo, "Valtrex" zambiri zodula. Choncho, odwala ambiri amachita chidwi ndi funso "Valacyclovir" kapena "Valtrex" - umene uli bwino. Yankho ndi - mankhwala onse ogwira zokwanira.

Opinion odwala ndi chisamaliro chaumoyo akatswiri a mankhwala

odwala ambiri kuyankha medicament m'njira zabwino. Anasonyeza digiri yapamwamba ya dzuwa "Valacyclovir" (ndemanga za azaumoyo ndi odwala chimodzimodzi) pa matenda a nsungu HIV. Kutupa amaziralira mwamsanga ndipo kwa nthawi mokwanira yaitali sichidzachitikanso. Nthawi zambiri, pamodzi ndi mapilisi anthu ntchito munali mankhwala valaciclovir mafuta (mtundu wina wa kumasulidwa mankhwala). Zikatero, mankhwala dzuwa ndi bwino, chifukwa zabwino zimatheka mu nthawi yaifupi nthawi. Komabe, odwala ayenera adzanyamula kukumbukira kuti pali pano palibe mankhwala omwe akhoza kuchotsa thupi la nsungu HIV, si koma otukuka. Pali mankhwala okha mankhwala symptomatic.

Komabe, kwa gulu osiyana odwala akhoza kumva chiwonetsero cha zochita chowawa. Nthawi zambiri ndi kupatuka kapepala kakuti m'mimba: nseru, kusanza, dyspepsia. ogula ambiri wokhutitsidwa ndi mtengo wochepa pa mapiritsi kapena mankhwala odzola "Valacyclovir." analogues ake, monga ulamuliro, ndi zambiri zodula, ndi mphamvu ya chimodzimodzi zochita chowawa komanso zofanana.

ogwira ntchito zachipatala komanso kutsimikizira mphamvu ya mankhwala mavairasi oyambitsa zochizira matenda ambiri a chikhalidwe ichi.

"Valacyclovir" - mankhwala nambala 1?

"Valaciclovir" malangizo Buku pamalo monga kwambiri ogwira mavairasi oyambitsa mankhwala. Matenda chiyambi tizilombo akhoza kukhala bwinobwino ndipo sadzadwalanso kuwononga moyo wa munthu. Komabe limathetseratu vuto lina lililonse, tiyerekeze ndi matenda nsungu silinakwaniritsidwe anatulukira. Inde, ndi matenda aliwonse tizilombo abwerere patapita nthawi zina za nthawi. Yankho kudziletsa cholinga ndi ntchito ya "valaciclovir" popanda kufunsa dokotala ana amakumana ndi mavuto aakulu. The osachepera kuti tingayembekezere - wangokhala kusowa kwa zotsatira zabwino. Ngati pali mavuto aakulu mu thupi zokhudzana ndi kufufuta impso kupatsidwa zina chomwecho impso ndi mafupa kudzikonda "valaciclovir" akhoza ndi chiyani ndi imfa. Ndipo mavuto ambiri.

Ngati mankhwala ndi kuikidwa ndi dokotala nawo, amenenso anayamba kulandira dera ndipo anasankha mlingo Mwachangu "valaciclovir" mankhwalawa matenda adzakhala pazipita pa osachepera mosavuta zochitika chowawa ndi matenda kulandira medicament.