M'badwo atsopano NSAIDs: ndemanga, mndandanda mitengo

A zambiri za kusintha pathological zimene zimachitika mu thupi limodzi ndi ululu. Pofuna zizindikiro chotero anayamba NSAIDs kapena osakhala steroidal odana ndi yotupa wothandizira. Iwo bwino zamizidwa ndi kusakhala, kutupa m'malo olumikizirana mafupa, kuchepetsa kutupa. Komabe, mankhwala ambiri ndi mavuto. Izi zimasokoneza n'zotheka ntchito zawo kuti ena odwala. Modern mankhwala zachitika m'badwo atsopano NSAIDs. mankhwala ndi zambiri zokayikitsa chifukwa zochita wosasangalala, koma kukhala mankhwala polimbana ndi ululu.

mmene mfundo za

Kodi ndi chifukwa zotsatira za NSAIDs pa thupi? Amachita cyclooxygenase lapansi. Cox ali isoforms awiri. Aliyense wa iwo akuchita ntchito zake. enzyme yotero (Cox) zimapangitsa mankhwala anachita chifukwa cha asidi arachidonic akudutsa mu prostaglandins, thromboxanes ndi leukotrienes.

Cox-1 ndi udindo kwa kupanga prostaglandins. Iwo kuteteza m'mimba chifukwa zosasangalatsa zimakhudza kugwira ntchito othandiza magazi kuundana ndi zotsatira za kusintha otaya aimpso magazi.

Cox-2 atakhala kwina ndi yeniyeni enzyme kutupa apanga kudzera cytotoxins, komanso nkhoswe ina.

Kuchita zimenezo wa NSAIDs monga chopinga a Cox-1, amanyamula kuchuluka kwa mbali-zotsatira.

zinthu zatsopano

Si chinsinsi kuti kukonzekera kwa m'badwo woyamba wa NSAIDs zimakhudzanso chowawa pa mucosa muzituluka. Choncho, asayansi ndi cholinga - kuchepetsa zotsatira osafunika. watsopano kumasulidwa mawonekedwe anayamba kupanga. Mu formulations amenewa pophika yogwira ali mu envelopu wapadera. kapisozi chinali zomangira kuti musakhale kupasuka mu malo acidic m'mimba. Iwo anayamba kugwa kokha pamene kugunda m'matumbo. N'zotheka kuchepetsa zotsatira akutivutitsa pa mucosa muzituluka. Komabe, limagwirira kuvulazidwa zosasangalatsa makoma thirakiti m'mimba akadali anapulumutsidwa.

Zimenezi zinapangitsa akatswiri apanga pawiri zatsopano. mankhwala mbuyo mwapadera limagwirira ntchito mwakhama. mbadwo watsopano wa NSAIDs yodziwika ndi zotsatira kusankha pa Cox-2, komanso chopinga kupanga prostaglandin. Zimenezi zimathandiza kuti akafike zotsatira zonse zofunikira - analgesic, antipyretic, odana ndi yotupa. Pankhaniyi, m'badwo atsopano NSAIDs kuchepetsa yaikulu coagulation magazi, kupatsidwa zinthu za m'mwazi ntchito chapamimba mucosa.

Anti-yotupa tingati chifukwa permeability m'munsi mwa makoma mtima, komanso kuchepa kupoletsa zosiyanasiyana owayimira yotupa. Chifukwa kukhudzana izi sanamvere mkwiyo wa zolandilira kupweteka kwa mitsempha. Impact pa malo ena thermoregulatory mu ubongo, lolani m'badwo atsopano NSAIDs kwambiri kuchepetsa kutentha wonse.

zikuonetsa

Ambiri zotsatira za NSAIDs kudziwika. Zotsatira za mankhwala umalimbana kuteteza kapena kuchepetsa yotupa ndondomeko. Mankhwalawa kupereka kwambiri antipyretic tingati. Zotsatira awo pa thupi angayerekezedwe ndi zotsatira za analgesics chomwa mankhwalawa. Komanso, kupereka analgesic, zotsatira odana ndi yotupa. NSAIDs amakwaniritsa lonse lonse mu malo matenda ndi tsiku ndi tsiku. Lero ndi imodzi mwa mankhwala wotchuka kwambiri mankhwala.

Impact zabwino amatchuka zifukwa zotsatirazi:

1. Matenda a dongosolo minofu ndi mafupa. Pa sprains zosiyanasiyana, kusupuka, deta nyamakazi mankhwala kungoti irreplaceable. NSAIDs ntchito osteochondrosis, yotupa arthropathy, nyamakazi. Mankhwala mavuto odana ndi yotupa mu kupindika msana, zimbale herniated.
2. ululu. Kukonzekera ndithu bwinobwino ntchito mu colic biliary, matenda achikazi matenda. Iwo kuthetsa mutu, ngakhale kupweteka kwa mutu, impso nkhawa. NSAIDs bwinobwino ntchito odwala mu nthawi postoperative.
3. Mkulu kutentha. zotsatira Antipyretic amalola ntchito mankhwala mu matenda osiyanasiyana chikhalidwe cha akulu ndi ana omwe. Mankhwalawa zimathandiza ngakhale pa malungo.
4. Thrombus mapangidwe. NSAIDs mankhwala antiplatelet. Zimenezi zimawathandiza kuti ntchito ischemia. Iwo ndi njira muyeso ndi vuto la mtima ndiponso sitiroko.

Gawo

Zaka pafupifupi 25 zapitazo, udaikidwa magulu 8 yokha ya NSAIDs. Lero, chiwerengerocho chawonjezeka mpaka 15. Komabe, yeniyeni chithunzi ngakhale kutchedwa madokotala Sadadzipangire. Kuwonekera pa msika, mwamsanga anapambana anthu ambiri NSAIDs. Kukonzekera atathamangitsidwa analgesics opioid. Chifukwa iwo, mosiyana ndi kale, sanali imfayo maganizo kupuma.

Gulu la NSAIDs kumafuna kugawikana m'magulu awiri:

1. mankhwala Akale (m'badwo woyamba). gulu Izi zikuphatikizapo mankhwala odziwika, "Tsitramon", "ndi aspirin", "Ibuprofen", "naproxen", "Nurofen", "Voltaren", "Diklak", "diclofenac", "indomethacin", "Movimed", "Phenylbutazone" .
2. NSAIDs watsopano (m'badwo wachiwiri). Pa zaka 15-20 zapitazi, mankhwala zachitika mankhwala kwambiri, monga "Movalis", "Nimesil", "Nise", "Celebrex" "Arcoxia."

Komabe, si gulu chabe la NSAIDs. mankhwala mbadwo watsopano anawagawa zotumphukira sanali acid ndi zidulo. Poyamba, tiyeni tikambirane gulu yamasika:

1. Salicylates. gulu ili lili mankhwala NSAID, "ndi aspirin", "diflunisal," "Lizinmonoatsetilsalitsilat".
2. Pyrazolidine. Oimira gulu la mankhwala ndi "phenylbutazone", "azapropazone", "oxyphenbutazone."
3. Oxicams. Awa ndi nzeru mbadwo watsopano wa NSAIDs. Mndandanda wa mankhwala: "piroxicam" "Meloxicam", "Lornoxicam", "tenoxicam". Mankhwala si wotsika mtengo koma mmene pa thupi limapitirira kwambiri kuposa NSAIDs ena.
4. Phenylacetic opangidwa kuchokera acid. gulu limeneli la NSAIDs zikuphatikizapo amatanthauza "diclofenac", "tolmetin," "Indomethacin", "Etodolac", "Sulindac," "Atseklofenak".
5. Formulations asidi anthranilic. Nthumwi yaikulu ya mankhwala "Mefenaminat".
6. Njira asidi propionic. gulu ili lili NSAIDs ambiri okongola. Mndandanda wa mankhwala: "Ibuprofen" "ketoprofen" "benoxaprofen", "fenbufen," "fenoprofen," "asidi tiaprofenic", "naproxen", "Flurbiprofen", "pirprofen," "nabumetone".
7. Isonicotinic opangidwa kuchokera acid. Main mankhwala "Amizon".
8. pyrazolone mankhwala. Kwa gulu ili kuti njira odziwika bwino, "Analgin".

Ndi sanali asidi ofanana nawo monga sulfonamides. gulu Izi zikuphatikizapo mankhwala, "Rofecoxib" "Celecoxib", "Nimesulide".

zotsatira zoyipazi

mbadwo watsopano wa NSAIDs tatchulazi, osiyana ogwira chikoka pa thupi. Komabe, iwo sikungawononge kugwira ntchito pa mundawo m'mimba. Chimasiyanitsa mankhwala awa ndi mfundo ina zabwino: mbadwo watsopano wa NSAIDs mulibe mavuto aakulu pa chichereŵechereŵe minofu.

Komabe, ngakhale njira wogwira mtima angathe n'zothandiza zingapo zotsatira osafunika. Iwo ayenera kudziwa, makamaka ngati mankhwala ntchito kwa nthawi yaitali.

Zotsatira waukulu mbali ingakhale monga iyi:

• chizungulire;
• kusinza;
• mutu;
• kutopa;
• palpitations mtima;
• amayamba kuthamanga;
• ndi kufupika pang'ono mpweya;
• youma chifuwa;
• matenda m'mimba;
• mapuloteni mu mkodzo;
• okwera chiwindi michere;
• ziwengo (mfundo);
• madzimadzi posungira;
• ziwengo.

Mu nkhani iyi, chapamimba mucosa chionongeko mwaonapo mu kuvomera NSAIDs latsopano. mankhwala alibe chifukwa exacerbation zilonda magazi.

Ayamikira ntchito

Odana ndi yotupa mankhwala abwino ndi phenylacetic asidi, salicylates, pirazolidony, oxicams, alkanones, mankhwala asidi propionic ndi sulfonamide.

Kuyambira molumikizana mafupa bwino kwambiri kuthetsa mankhwala "Indomethacin", "diclofenac", "Ketoprofen", "Flurbiprofen". Izi ndi NSAID bwino mu osteochondrosis. The mankhwala pamwamba zina kuposa "ketoprofen" kukonzekera Adzalandira kutchulidwa odana ndi yotupa kwenikweni. amatanthauza "piroxicam" kugwa mu gulu ili.

analgesics ogwira mtima "Ketorolac" mankhwala "Ketoprofen", "Indomethacin" "Diclofenac".

Mtsogoleri pakati pa mbadwo atsopano NSAIDs anali mankhwala "Movalis". chida ichi amaloledwa kugwiritsa ntchito nthawi yaitali. mankhwala Anti-yotupa ogwira analogs mankhwala "Movasin", "Mirloks", "Lem", "Artrozan", "Melox", "Melbek", "Mesipol" ndi "Amelotex".

Mankhwala "Movalis"

Izi mankhwala chikupezeka monga miyala, suppositories ndi njira thumbo kwa makonzedwe mu mnofu. Mtumiki amatanthauza opangidwa kuchokera enolovoy acid. Yodziwika kwambiri mankhwala analgesic ndi katundu antipyretic. Anapeza kuti mu njira pafupifupi onse yotupa mankhwala kumabweretsa zimakhala zolimbikitsa kwambiri.

Zikuonetsa ntchito mankhwala ndi nyamakazi, ankylosing spondylitis, nyamakazi.

Komabe, dziŵani kuti pali contraindications kuti wothandizila amalandira:

• hypersensitivity kwa chigawo chilichonse cha mankhwala;
• ulcerous matenda siteji pachimake;
• aakulu aimpso kuwonongeka;
• chilonda magazi;
• aakulu kwa chiwindi kulephera;
• pregnancy, kuyamwitsa;
• woopsa matenda a mtima.

Sititenga ana mankhwala kwa zaka 12.

odwala wamkulu amene amapezeka nyamakazi, tikulimbikitsidwa tsiku ndi 7.5 mg. Ngati ndi kotheka, mankhwalawa akhoza chinawonjezeka ndi nthawi 2.

Mu nyamakazi ndi ankylosing spondylitis tsiku wakudziko ndi 15 mg.

mosamala kwambiri ayenera kutenga mankhwala kwa odwala amene sachedwa zikamera mavuto. Anthu amene anasonyeza insufficiency aimpso ndi amene ali pa hemodialysis, ayenera zosaposa 7.5 mg wa pa tsiku.

Mtengo wa mankhwala "Movalis" mapiritsi a 7.5 mg, № 20 502 Podutsira rubles.

Ogula maganizo mankhwala

Ndemanga za anthu ambiri amene imvera ululu, kusonyeza kuti mankhwala "Movalis" - chida bwino ntchito nthawi yaitali. Ndi bwino analekerera ndi odwala. Komanso, kukhalapo yake yaitali mu thupi limachititsa mlingo umodzi wa mankhwala. Chinthu chofunika kwambiri, malinga ambiri ogula, ndi kuteteza chichereŵechereŵe, chifukwa mankhwala alibe kungasokoneze iwo. Nkofunika kwa odwala amene amagwiritsa ntchito njira mu osteochondrosis, arthrosis.

Komanso, mankhwala kwambiri amawapulumutsa ku zowawa zosiyanasiyana - dzino, mutu. Kupereka ulemu wapadera kwa odwala pa mndandanda chidwi mavuto. Ngakhale kulandira ndi NSAID chithandizo ngakhale lochenjeza Mlengi, kumva zotsatira zoipa.

Mankhwala "Celecoxib"

The kanthu chida umalimbana kuchepetsa mkhalidwe wa mtima ndi osteochondrosis ndi arthrosis. Mankhwala mwangwiro kumatha ululu, mogwira relieves ndondomeko yotupa. mavuto pa dongosolo m'mimba akhala sakudziwika.

Zikuonetsa ntchito kuperekedwa mu bukhuli ndi:

• psoriatic nyamakazi ;
• nyamakazi;
• nyamakazi;
• ankylosing spondylitis.

ameneŵa ali angapo contraindications. Komanso, mankhwala ali sananenedwe kwa ana osaposera zaka 18. Makamaka kusamala chiyenera kuchitika kwa anthu amene ali ndi mtima kulephera matenda monga njira kuwonjezeka chiwopsezo kuti posungira madzimadzi.

Mtengo wa mankhwala imasiyana malingana phukusi, m'dera la 500-800 rubles.

ogula maganizo

ndemanga ndithu zotsutsana za mankhwalawa. Odwala ena chifukwa a malo akhoza kuwina molumikizana mafupa. odwala ena amanena kuti mankhwala sizinathandize. Choncho, njira iyi si nthawi zonse zothandiza.

Komanso sitiyenera kutenga mankhwala okha. M'mayiko ena a ku Ulaya mankhwalawa ndikoletsedwa chifukwa zotsatira za cardiotoxicity, amene Kumkwanira mtima zikuwononga.

Mankhwala "Nimesulide"

Mankhwala si odana ndi yotupa ndi antipain kwenikweni. Njira ali antioxidant katundu kuti ziletsa mankhwala zinthu kuwononga chichereŵechereŵe ndi kolajeni ulusi.

Ntchito yothetsera:

• nyamakazi;
• nyamakazi;
• nyamakazi;
• myalgia;
• arthralgia;
• bursitis;
• malungo;
• ululu zosiyanasiyana syndromes.

Pankhaniyi, zotsatira analgesic mankhwala amapereka mofulumira. Childs, wodwala akumva mpumulo mwa Mphindi 20 pambuyo ingestion. Ndicho chifukwa chida ichi ndi othandiza kwambiri pachimake ululu paroxysmal.

Pafupifupi nthawi zonse, mankhwala bwino analekerera ndi odwala. Koma nthawi zina, mungachite mavuto monga chizungulire, tulo, mutu, nseru, kutentha, hematuria, oliguria, urticaria.

Chida sikuloledwa kulandira akazi apakati ndi ana kwa zaka 12. kusamalidwa ayenera kutenga mankhwala "Nimesulide" anthu amene aona oopsa, impso ntchito mkhutu, masomphenya kapena mtima.

mankhwala Price pafupifupi 76,9 rubles.

kuchita ogula chiyani?

Reviews kukonzekera ndi pafupifupi nthawi zonse zabwino. Popeza mankhwala mwangwiro relieves ululu ndipo kumachepetsa kutentha kwa thupi, ndewu kwambiri kutupa.

odwala ambiri amanena kuti zizindikiro mpumulo amapezeka mofulumira zokwanira, ndi nthawi ya ntchito zake ndi pafupi eyiti maola.

Kwambiri chida mwangwiro kumatha dzino, zoopsa, nyamakazi ululu. Mankhwala kungathandize kusapeza chifukwa cha entrapment mitsempha.

Mankhwala "Ksefokam"

Izi mankhwala m'gulu la oxicams gulu. Gulu la NSAID yosiyana kuchuluka theka moyo, chifukwa mu kukhudzana yaitali mankhwala. Ndi kwambiri yafupika pafupipafupi kulandira medicament. Choncho chiopsezo mavuto yafupika.

Mankhwala "Ksefokam" ndi wa mphamvu apamwamba kupulumutsa ululu. Zotsatira zake analgesic pa mphamvu mawonetseredwe ofanana morphine. Komabe, mosiyana ndi yamasika, chida si osokoneza ndi sikumangotikhudza chapakati mantha dongosolo.

Pa kuyezetsa, izo unkachitika kuti mankhwala relieves ululu kwa maola 12.

Mtengo wa mankhwala piritsi mawonekedwe (8 mg) № atanyamula 10 ndi 205 rubles.

Mankhwala "Rofecoxib"

Mankhwala ali wotsutsa-yotupa analgesic, antipyretic ndi zotsatira odana edematous. Anatumizidwa njira kwa matenda otsatirawa:

• periarthritis aakulu;
• nyamakazi;
• tendonitis;
• bursitis;
• kuvulala tendon wa Mitsemphayi, minofu.

Ndi okwanira bwino kuthetsa mankhwala "Rofecoxib" zizindikiro zosiyanasiyana chopweteka chifukwa cha neuralgia, osteochondrosis, guwa. Zikutanthauza mwangwiro relieves lumbago, dzino, radicular syndrome.

Mankhwala sayenera kukhala pansi kulandiridwa ndi odwala mphumu, pambuyo akuvutika mtima, sitiroko. Sikuti ntchito, ndi anthu matenda oncological, matenda oopsa ndipo atherosclerosis. mankhwala ndikoletsedwa ana osaposera zaka 12. Komanso, musanamwe m'pofunika kuti kuganizira zotsatira zotheka mbali.

Mankhwala "Parecoxib"

Izi ndi njira zabwino imene kuchepetsa ayankhe yotupa ndi zimathandiza kuti kuchepetsa tilinazo zolandilira ululu. Mankhwala zikufunika odwala likufa opaleshoni.

Iwo kumatha ululu syndromes wa zolimbitsa kuti mwamphamvu kwambiri. Kutumikiridwa pambuyo okwana m'chiuno ndipo bondo m'malo, hysterectomy, inatsekeratu mtsempha wamagazi kulambalala opaleshoni, ntchito mano ntchito.

Mlingo kusintha ndi mwangwiro payekha. Izo zimatengera zinthu matenda ndi umboni. Ana osaposera zaka 18 wa mankhwala sinafike.

Mankhwala "Arcoxia"

Mankhwalawa ali dzina lina - "Etorikoksib". njira amakhala ndi antiinflammatory, katundu mkulu analgesic. lokonzekera amalimbikitsa chopinga ululu mtima.

Odwala matenda a dongosolo minofu ndi mafupa mothandizidwa ndi chida kuchotsa m'mawa stiffness. Iwo akweza olowa zoyendayenda, amachepetsa mphamvu ya kutupa ndi, mwangwiro adathandizapo ndi ululu. Atalandira zotsatira achire amapezeka mkati mphindi makumi awiri mphambu anai. Thunthu mankhwala yogwira bwino chosakanikirana ndi m'magazi. lokonzekera amakhala ndi bioavailability mkulu. index Izi 100%.

Mlingo wa mankhwala akhoza mankhwala okha ndi dokotala. Nthawi zambiri ranges ku 60 mg kwa 120 mg pa masiku.

mankhwala sinafike ntchito za amayi apakati ndi ana kwa zaka 16.

Pomaliza

Modern mankhwala si chilili. Development wa watsopano, NSAIDs aluso. List of ena kuposa mbadwo watsopano wa mankhwala, pamwamba, limakupatsani kusankha chida yabwino pathologies iliyonse. Komabe, dziŵani kuti mankhwala sangathe kuchiza matenda. Ali yekha odana ndi yotupa ndi analgesic zotsatira.