Mankhwala "Prosulpin": Buku malangizo, ndemanga ndi analogues

Medicine "malangizo Prosulpin 'ntchito ali pabwino monga mankhwala osokoneza bongo antipsychotic kuti ntchito mankhwala a matenda osiyanasiyana ya ubongo, komanso matenda ena. Zambiri za kukonzekera pamwamba werenganibe.

mafotokozedwe Short lokonzekera

mankhwala ili gulu la mmalo -benzenamine. Mu njira ina, tinganene kuti ndi mmene antipsychotic mankhwala "Prosulpin". Akatswiri alendo amanena kuti kanthu ake umalimbana kutsekereza dopamine maselo (D2i D3). Chifukwa zatchulidwazi antipsychotic mankhwala umabala zotsatira achire.

50 kapena 200 mg wa piritsi limodzi lili sulpiride "Prosulpin" kukonzekera.

Zotsatira zake zoyipa pamene mukumwa mankhwala, ndithudi, zimachitika zina. Choncho, mtima m'kati mwa mankhwala pamwamba antipsychotic akhale moyang'aniridwa okhwima zachipatala.

mankhwalawa ali ndi njira zosiyanasiyana. Ndi alembedwe chathabwa ndipo mu mawonekedwe a makapisozi, ndi njira yothetsera makonzedwe mu mnofu ndi zakumwa kwa ingestion.

Mankhwala ziyenera kusungidwa pa yachibadwa firiji koma osati kuposa 25 digiri Celsius. malo ayenera bwino kutetezedwa ku kuwala ndi chinyezi. Pafupifupi zaka ziwiri za alumali moyo "Prosulpin" mankhwala. Analogues si kovuta. Mankhwala pa msika osiyanasiyana okhala m'malo mwa mankhwala tatchulawa.

The kanthu pharmacological wa zatchulidwazi achire wothandizila

Medicine "Prosulpin" amene chithunzi amaperekedwa pansipa, ndi wothandizila antipsychotic kuti ndi neuroleptic. sulpiride mankhwala chifukwa kutsekereza ya maselo dopamine mu dera tuberoinfudibulyarnoy amalimbikitsa kuwonjezeka kwambiri misinkhu prolactin. Tikumbukenso kuti mu osiyanasiyana digiri 60-80% imasiyana kutsekereza dopamine zolandilira.

Yotsirizira amasiyana mokwanira mkulu kufanana kwa benzamide, ndilo khalidwe la mawonekedwe monga zotsatira bifazicheskoe pa dongosolo mtundu dopamine. Komanso, sakuchitira kuwonjezeka synaptic dopamine kaphatikizidwe dera, i.e. antagonize presynaptic galimoto cholandilira D2 D3.

Tikumbukenso kuti chiphunzitso pamwamba ndi amtengo neuroleptic ntchito. iwowa ali pamodzi timoanalepticheskim wina ndi zolimbikitsa zimene chida.

Mankhwala pamwamba zotsatirazi zotsatira pharmacological:

• antiemetics (dopamine cholandilira anatseka misewu imagwiridwa choyambitsa kusanza zone malo);
• antidepressant;
• antipsychotic.

Sulpiride ikutiphunzitsa antidepressant pa mlingo mpaka 600 mg. Pamwamba makonzedwe kale anati zotsatira antipsychotic za mankhwala m'thupi.

Komanso, mankhwala "Prosulpin" malangizo limasonyeza amabala ndi zotsatira kusankha pa ubongo imene imalamulira kutentha, ndi zizindikiro za chilonda muzituluka ndi gastroduodenitis. Choncho kuletsedwa malo okwezeka malemeredwe wa mantha dongosolo wachifundo bwino kotunga magazi m'mimba, inapita kuchuluka kwa granulation minofu, njira ya ntchofu katulutsidwe mmimba, aumbike kusinthidwa epithelium, kuchuluka kwa capillaries bwino minofu.

Amene ayenera kutenga mankhwala izi?

Kodi mankhwala "Prosulpin" zikuonetsa ntchito? Zolinga achire, mankhwala pamwamba ntchito matenda:

• matenda obwera chifukwa choganiza kwambiri;
• nkhawa zilonda za m'mimba thirakiti;
• zilonda symptomatic;
• gastroduodenitis;
• mmimba chilonda;
• kukwiya matumbo (m'matumbo);
• zilonda mankhwala;
• nonspecific anam'peza matenda a m'matumbo;
• Depression osiyana etymology;
• neuroses;
• zotakasika maganizo;
• dysphoric matenda;
• akuchita misala;
• aakulu mavuto a m'maganizo ;
• migraine;
• matenda a m'maganizo pachimake;
• vertigo etymology osiyana (vestibular neuritis, vertebrobasilar insufficiency, basilar, matenda Meniere a, otitis TV).

Mankhwala "Prosulpin" malangizo ntchito amapereka ntchito zochizira matenda khalidwe ndi psychoses odwala, ana mwachitsanzo. Izi matenda monga kudzichekacheka, mukubwadamuka, olakwika. Komanso mankhwala "Prosulpin" malangizo ntchito mosalekeza limalangiza kugwiritsa ntchito mbali ya njira ya mankhwala a satha kulankhula bwinobwino infantile. chida ichi amagwiritsidwa ntchito pofuna kuchiza odwala wamng'ono zaka 6.

Contraindications ntchito mankhwala zatchulidwazi

Mankhwala "malangizo Prosulpin 'ntchito bwino osati ngati wodwalayo ali ndi zizindikiro za matenda otsatirawa:

• hypersensitivity kuti mankhwala;
• hyperprolactinemia;
• prolaktinzavisimye zotupa (khansa ya m'mawere pituitary prolactinoma);
• matenda a maganizo;
• zakumwa poyizoni pachimake kuti muli mowa;
• kupulupudza;
• pheochromocytoma;
• Pachimake poyizoni ndi mankhwala kapena mankhwala ogonetsa;
• wosangalala monyanyira maganizo.

limati zonsezi contraindications kwambiri. Komanso mankhwala "Prosulpin" malangizo ntchito kuwaletsa kupereka kwa akazi amene amayamwitsa kudyetsa mwana wawo, ana osakwana zaka 18 (kwa 200 mg mapiritsi), achinyamata amene akudwala kwa zaka 6 (50 mg mapiritsi).

Komanso, tiyenera kukumbukira, ndi osafunika kugwiritsa ntchito mankhwala "Prosulpin" kobadwa nako akusowa cha lactose, shuga-galactose malabsorption, lactose tsankho. Contraindications ntchito ya wothandizila pamwamba achire zimagwilanso nchito kwa amayi apakati. Ntchito odwala otere analolera ngati ubwino ankayembekezera mankhwala adzakhala ambiri apamwamba kuposa chiopsezo kuthekera kwa mwana wosabadwayo kwa iye.

zotsatira zoyipazi

Pamene kulandira "Prosulpin" kukonzekera (Buku limauza), mungachite zotsatira zina zoyipa za mankhwalawa:

• pa mbali ya dongosolo endocrine - galactorrhea, dysmenorrhea, amenorrhea, frigidity, kusabala;
• kwa mitsempha - sedation, kenaka utentha mamba, chizungulire, dyskinesia oyambirira, syndrome extrapyramidal, somnolence, akinesia ndi akulu hypertonicity, akathisia, galimoto malemeredwe;
• kuwonjezera pa ntchito ya michere (ku chimbudzi ndi);
• hemolytic magazi m'thupi, leukocytosis, aplastic magazi m'thupi, granulocytosis, purpura, thrombocytopenic zimachitika pa mlingo waukulu "Prosulpin" kukonzekera (by zochita za magazi ndi lymph kachitidwe);
• tachycardia, orthostatic hypotension, utachepa kapena kuthamanga magazi, kutalikitsa ndi imeneyi QT, zina chitukuko cha matenda oopsa monga torsade des pointes syndrome (a mtima ndi njira zake).

Komanso amayambitsa zotsatira zina mbali mankhwala. Mankhwala "Prosulpin" (malangizo ayankhe madokotala ndi odwala mayankho umboni izi) kungakhale zochitika ngati zosasangalatsa monga dyskinesia tardive, amene amakhala ndi magulu musanaganizire rhythmic a nkhope kapena lilime (ndi yaitali achire Inde neuroleptics magulu onse), hyperthermia. Akatswiri kuchenjeza kuti Zikatero n'kofunika kwambiri makamaka nthawi kuletsa njira pamwamba, kuyambira kuwuka kutentha mwina zimasonyeza matenda owopsa monga syndrome neuroleptic zilonda.

kunenepa, kuchuluka thukuta, zotupa pa khungu ndi kuyabwa - zonse mwa zotsatirapo zimenezi zikhoza kuyambitsa mankhwala "Prosulpin". Malangizo, ndemanga akatswiri amalangiza mu Zikatero kusiya kutenga mankhwala pamwamba ndi kufunafuna mwamsanga dokotala thandizo ndi malangizo.

Ntchito pa mimba pamwamba nthumwi achire

Teratogenicity mankhwala sizinapezekebe chifukwa cha zatsopano nyama. Amayi ena amene amagwiritsa ntchito mankhwala pa mimba pako, ndipo sanali kusunga zotsatira tatchulawa. Koma odwala awa alandira otsika mlingo Spirit "Prosulpin". Malangizo ntchito, akatswiri enieni mulibe tsatanetsatane ponena za kugwiritsa ntchito ndalama apamwamba ndi zinthu monga sulpiride. Palinso palibe deta pa zotsatira za chiphunzitso zatchulidwazi pa chitukuko cha ubongo yoopsa.

Monga kukonzekereratu Akatswiri musati amalangiza ntchito mankhwala kwa akazi mu chikhalidwe. Ngakhale nthawi zina, komabe analola mankhwala kukonzekera tatchulawa odwala, iwo amayembekezera mwana, koma bukuli Mlingo kochepa.

Akatswiri dziwani kuti ngati mayi kulandira neuroleptics mankhwala yaitali nthawi, zinyenyeswazi wakhanda anali ndi mavuto ndi m'mimba thirakiti ntchito (mwachitsanzo bloating).

Ngati mkazi amagwiritsa mankhwala panthawi isanafike yobereka, ulamuliro pa thupi lake ndi chitukuko cha mwana wosabadwayo ndi dokotala ndi kuvomerezedwa.

Tiyeneranso kukumbukira kuti akudutsa mu mkaka wa m'mawere mankhwala "Prosulpin". Malangizo ntchito, akatswiri enieni musati amalangiza cholanda pa mkaka wa m'mawere.

Kodi kutenga mankhwala "Prosulpin"?

Guide amapereka odwala ntchito pamwamba antipsychotic mawola 8 pa piritsi limodzi. Ali osavomerezeka makhwalawa pambuyo 16,00, monga ntchito mwakhama kwambiri kumawonjezera pa nthawi ino. Tikumbukenso kuti ntchito kaya chakudya, nasamba pansi ndi okwanira kuchuluka kwa yokonzekera madzi "Prosulpin".

Miyala kuti muli 200 mg wa sulpiride, mwalandiridwa pa zizindikiro wokonda akuchita misala, delirious psychosis ndi maganizo. mankhwala akhoza amwedwa osiyanasiyana. tsiku pazipita ake mlingo ndi 100 mg kapena za 5 mapiritsi.

Mapiritsi, monga 50 mg wa sulpiride, amapereka malangizo kwa nditenge, ngati wodwalayo zizindikiro za gwero lachisokonezo, nkhawa. Patangotha masabata 4, odwalawo ayenera kudya osachepera limodzi ndi munthu pazipita mapiritsi 3 pa tsiku.

Komanso, mankhwala awa angathe kumwedwa ana ndi mavuto aakulu khalidwe. The zaka odwala ayenera nthawi zonse zaka kuposa 6. The pazipita tsiku mlingo odwala mu gulu ili ndi 5 mpaka 10 mg pa 10 makilogalamu thupi.

ambiri osokoneza

Buku zikusonyeza kuti ambiri osokoneza sulpiride nkhani yochepa. zizindikiro zotsatirazi akhoza anati mu chikhalidwe ichi mu mtima:

• lilime protrusion;
• dyskinesia ndi torticollis spasmodic;
• amaona masomphenya;
• youma pakamwa;
• zotheka chitukuko cha NSAs;
• Zizindikiro extrapyramidal;
• kuchuluka thukuta;
• nseru;
• sedation;
• gynecomastia;
• matenda Parkinson;
• kuwonjezera magazi.

Chithandizo cha boma pamwamba wodwalayo ikuchitika motere:

• anatsuka m'mimba mwa wodwalayo;
• zoikidwa ndi mpweya adamulowetsa;
• ndi mankhwala mwadongosolo.

Ngati ndi kotheka, mu Zikavuta, dokotala angakupatseni mpheto zina, monga njira diuresis kulowetsedwa ntchito soda kapena polojekiti zofunika m'thupi.

Tikumbukenso kuti kukonzekera izi lachokera mwina mu hemodialysis.

Magawo ena odwala ayenera kusamalitsa wapadera ntchito "Prosulpin" mankhwala. Izi likukhudza kwambiri choyamba kubadwa kwa akazi ndi nthawi osasamba, odwala hypotension kwambiri ndi matenda oopsa.

M'pofunikanso odwala khunyu kuyambirira electrophysiological zoona matenda. Tiyenera kukumbukira kuti mankhwala "Prosulpin" Sachita pakhomo pa ntchito kudwala.

Komanso, pamene galimoto zoyendera amafuna kusamalidwa pa ndi mankhwala pamwamba. M'pofunikanso kuchepetsa zochita zimene amafuna zosiyanasiyana mofulumira psychomotor ndi mkulu ndende.

Mogwirizana ndi atumiki achire

Malangizo ndi osati akuonetsa kuti tatchulawa mankhwala ophatikizana mankhwala ndi levodopa. Zinthu ziwiri yogwira ali muzikangana. Ngati wodwala yemwe amadwala matenda Parkinson, amatenga levodopa, dokotala ndi wothandizila ayenera anasankha kuti ali kochepa zotsatira extrapyramidal.

Arrhythmias monga torsades de A pointes ingayambe ndi osakaniza "Prosulpin" mankhwala ndi:

• mankhwala antiarrhythmic, amene ali a kalasi Ia (mankhwala "Dizopiramid" "quinidine");
• mankhwala "pimozide," "Haloperidol", "thioridazine" "Cisapride", "Pentamidine" imipraminovymi antidepressants;
• mankhwala antiarrhythmic kuti ali m'gulu la kalasi lachitatu (kutanthauza "Sotalol", "Kakamiodaron");
• mankhwala amene amayambitsa zizindikiro za matenda monga bradycardia (beta-blockers, calcium njira blockers);
• mankhwala zimene zimachititsa maonekedwe a zizindikiro za hypokalemia (Mankhwalawa amene stimulatory, hypokalemic okodzetsa, tetracosactide, glucocorticoids);
• dopamine muzikangana (antiparkinson): "apomorphine", "Amantadine" "Lisuride", "Ropinirole", "Entacapone" "Bromocriptine", "selegiline" "Pramipexole" "Piribedil");
• antipsychotic mankhwala kuti angathe kuyambitsa zizindikiro za torsades de A pointes ( "Chlorpromazine" "Amisulpride," "Tsiamemazin" "pimozide," "Droperidol" "levomepromazina" "tiapride," "Sertindole" "Veraliprid" "Sulpiride") ;
• mankhwala okhala lifiyamu (yotsirizira kwambiri kumaonjezera ngozi ya matenda extrapyramidal).

Komanso, Mulimonsemo, mankhwala "Prosulpin" sayenera kugwiritsidwa ntchito molumikizana ndi mowa. Last potentiates zotsatira sedative wa neuroleptics.

Komanso, ngati ife tatchulawa mankhwala osakaniza pakati zolimbikitsa zinthu (wotsutsa-asthmatics, anorectics), wodwala akhoza kuona zizindikiro za malemeredwe amphamvu, mantha, nkhawa, nkhawa.

Tiyenera kukumbukira kuti mankhwala antipsychotic Sachita mlingo wa mphamvu ya ropinirole.

Mmalo "Prosulpin" wothandizila achire

Analogs wa antipsychotic pamwamba:

• "Betamak T100";
• "Vero Sulpiride";
• "Betamax T50";
• "Depral";
• "Betamax";
• "The chiphunzitso cha";
• "Betamax T200";
• "Sulpiride";
• "Eglonil";
• "Sulpiril";
• "Eglek".

Koma anasintha popanda kufunsa titani dokotala si bwino "Prosulpin" malangizo Buku. analogues ake komanso kusokoneza awo mbali. Iwo akhoza kubweretsa mavuto aakulu kwa thanzi wodwalayo.

The mayankho njira zachipatala "Prosulpin"

Reviews wa mankhwala pamwamba makamaka positive. A ambiri odwala mukuwaphunzitsa limati maganizo. Iwo amati chida zimenezi zimathandiza kuthetsa zizindikiro za matenda ndi pafupifupi 100%.

Komanso, ambiri odwala okwanira mayankho, imene matenda monga akuchita misala, enterocolitis, matenda a m'matumbo, psychosis, enteritis, matenda anam'peza, azitsegula anatenga mankhwala "Prosulpin". Reviews a amasonyeza kuti m'zochitika zonse, chida imatulutsa zosaneneka machiritso zotsatira. Komanso, odwala amanena kuti mavuto zimachitika kawirikawiri.

Mankhwala pamwamba zotsatira zina zoyipa, kotero ntchito popanda kukambirana titani dokotala ndi koletsedwa.