Fibrinogen - wakudziko ndi kudwala

Mu kuphunzira dongosolo magazi clotting, index izi anatsimikiza kwenikweni. Nkofunika kuti zinthu zosiyanasiyana. Pamaso opaleshoni, pokonzekera pobereka, matenda a mtima ndi yotupa mwazi nthawi zonse kudziwa fibrinogen. Norma sanali chimodzimodzi kwa akulu ndi ana. Kwa amayi oyembekezera, chapamwamba malire a apamwamba ake kwambiri. Koma kuganizira mfundo ina pang'ono. Choyamba, tiyeni tikambirane zimene ambirife akuimira fibrinogen.

Malinga ndi kapangidwe awo mankhwala, ndi - mapuloteni. Limatchedwanso zinthu zambiri clotting I. kumatanthauza chomaliza clotting magazi, ndicho - mu mapangidwe magazi aumirira. Mu fibrinogen wathanzi anthu mu magazi alipo mu chikhalidwe kusungunuka.

Pankhani ya kutsegula kwa coagulation pa mbali yake yoyamba pansi zochita za zinthu zina clotting thrombin anapanga.

Mu gawo lachiwiri mchikakamizo cha fibrinogen clotting ndi thrombin lamamatira n'kukhala Ulimbo insoluble, imene imagwiritsidwa maziko a magazi aumirira, ndi thrombus. Kumafuna wotseka magazi. Choncho amakhala tanthauzo bwino kuti thupi lili ndi fibrinogen. Ponseponse izi chenicheni kwa munthu wamkulu wathanzi munthu limafanana 2-4 g / L. Makanda obadwa kumene, mlingo wochepa - 1,25-3 g / L. Koma limatuluka pa mimba kwa 6 g / l. Izi ndi zomveka. Ndipotu m'thupi la mayi amakonzekera pobereka, zomwe nthawi zonse kugwirizana ndi magazi. Choncho, likukhalira, mlingo wa fibrinogen magazi si chimodzimodzi kwa onse. ndi apamwamba kwambiri kwa amayi apakati.

"Inde, koma kodi zinachokera kuti?" - mupempha. Iwo likukhalira kuti chinthu ichi clotting amapangidwa mu chiwindi ndi maselo a dongosolo reticuloendothelial. Choncho, matenda a chiwindi, monga chiwindi kapena matenda enaake katundu fibrinogen amene ponseponse - osachepera 2 g / L, nthawi zina kusanduka manambala ochepa. Zimenezi zingachititse kuti zosiyanasiyana magazi, magazi pakhungu ndipo zimagwira ntchito zosiyanasiyana mucous. Kumwa mankhwala ena (androgens, anabolic mankhwala) Mwina kuchepetsa mlingo wake. Nthawi zina, pali chathu chofuna zolakwa za maphunziro chinthu I. limeneli limatchedwa afibrinogenemia kapena hypofibrinogenemia.

The kuchepa zakuthwa fibrinogen zimawonedwa mu wachiwiri ndi wachitatu gawo dessiminirovannogo syndrome intravascular coagulation. Waukulu pathological chikhalidwe, kawirikawiri mpaka kukha mwazi mvula chifukwa mapangidwe ziwiya yaing'ono anamwazikana Ulimbo kuundana. Awo ndi mwakuti fibrinogen akuwononganso m'matangadza. Pachimake fibrinolysis, ndondomeko zimene zimagwiritsa kulimbitsa ya kuvunda kwa Ulimbo, komanso limodzi ndi kuchepa kwa fibrinogen. Iwo amachepetsa ndi aakulu myeloid khansa, ndi akusowa vitamini B12 pa thupi ndi S.

Mu matenda ena M'malo mwake, pali ndi fibrinogen kuchuluka. Wakudziko waukulu mtengo wa coagulating Chinthu ndi wofanana 4 g / L. Koma enaake ophwanya, matenda opatsirana, njira yotupa, khansa, thrombosis ndi infarctions chinthu Ine kuchulutsa akhoza chinawonjezeka ndi nthawi 1.5-2.5. Fibrinogen amatchedwanso pachimake gawo mapuloteni, kuyambira kuwonjezeka ake limodzi ndi yotupa matenda pachimake. Mlingo zomanga thupi ndi kuvulala, ntchito ya kulera m'kamwa ndi esitirojeni pambuyo opaleshoni.

Pali umboni kuti okwera milingo fibrinogen mwina patsogolo maonekedwe a sitiroko ndi matenda a mtima. ubale pakati pa matenda amenewa ndi okwera mlingo wake m'mbuyomu anapezeka kafukufuku.

Pofuna kudziwa mlingo wa fibrinogen, muyenera pochitika chopanda kanthu m'mimba magazi kuchokera mu mtsempha wa. magazi akutengedwa mu mayeso chubu ndi anticoagulant lapansi.