"Capecitabine": malangizo ntchito, Akhristu enieni, mawonekedwe kumasulidwa, Mlengi. "Capecitabine-TL" mawu

Capecitabine (. Latin Capecitabinum) - mankhwala kuti ndi fluoropyrimidine carbamate otumphukira. Adzaupereka kwa gulu la antimetabolites - mankhwala enieni akhoza ziletsa kukula zotupa zilonda. The chidwi mu zinthu zina unachokera mu 1960 g. Zotsatira woyamba zosangalatsa akamagwira maphunziro mbewa. Patapita nthawi, anatulukira nchito zake pa matenda a matenda ena khansa anthu.

Lero, anticancer mankhwala ambiri munali yogwira mankhwala capecitabine. Reviews odwala ambiri akunena za kupambana kwa ntchito zinthu zimenezi mu mankhwala anticancer.

Achire ndi katundu

Chilinganizo capecitabine - 5'-deoxy-5-fluoro-N - [(pentyloxy) carbonyl] cytidine. Antimetabolites gulu mankhwala ukufanizidwa ndi chiwerengero cha zinthu ofanana m'chilengedwe katundu wa kagayidwe (kagayidwe) anthu. Iwo amatha kuchita zosiyanasiyana kagayidwe kachakudya, ndi kusintha iwo m'mbuyo zina amuzolengedwa. Choncho pali wonongeka maselo yofunika chotupa ndi chopinga kukula awo ntchito kukonzekera zochokera mankhwala capecitabine. Reviews a anthu akukambirana kuchepetsa kukula kwa zotupa. limagwirira Izi kanthu amatchedwa cytostatic.

katundu izi kulola kugwiritsa ntchito zinthu antimetabolitnyh iwo mu mankhwala anticancer. efficacy awo kutsimikiziridwa ndi zotupa zilonda wa kapepalako m'mimba ndi zopangitsa mammary. Pankhaniyi, zotsatira zabwino amapereka zonse monotherapy ndi kuphatikiza ndi atumiki. Pakali pano, pa maziko a odana metabolites analenga oposa 800 mankhwala, koma akupitirizabe kufufuza magulu atsopano a mankhwala.

limagwirira kanthu

Capecitabine kutsegula akupezeka zimakhala chotupa, ndipo kenako zimayamba khama zotsatira zake poizoni pa maselo (cytotoxic limagwirira). mankhwala kumatanthauza kagayidwe zotani ndi kumabweretsa mfundo yakuti athanzi ndi maselo chotupa mtima mu analogs cytotoxic. Choncho pali kuphwanya ikuyambitsa mankhwala koyenera kuti DNA kaphatikizidwe ndipo, chotero, ndondomeko magawano.

Popeza maselo Kusiya kuonjezera chiwerengero chawo. Mu chitsanzo china, pali "M'MALO" ya mankhwala wina, umene kaphatikizidwe mapuloteni ndi kutanganidwa pamene mukumwa mankhwala pogwiritsa capecitabine pawiri. Guide mwatsatanetsatane ndondomeko imeneyi.

Limagwirira cha kusintha minimizes kuthekera kuwonongeka kwa maselo wathanzi. Capecitabine ndi kuikapo maganizo kwambiri mu chotupa lokha, kuposa zimakhala ozungulira. Chotero mbali si zoipa kwa thupi pamene munthu akulandira mankhwala mankhwala zochokera pa capecitabine mankhwala. Malangizo ntchito amalimbikitsa kulandira ndalama pa mlingo mosamalitsa kumatanthauza kuti ofunitsitsa ndi dokotala nawo.

Khalani mankhwala mu thupi

Atalandira capecitabine ndi mayamwidwe ake mofulumira thirakiti m'mimba. Ngati kudya pa nthawi iyi, njira pang'onopang'ono. Choncho, potengera phwando mankhwala antimetabolite ikuchitika pambuyo ingestion. kusinthika Komanso akupezeka mankhwala chiwindi, wina kuchuluka kwa capecitabine ndi metabolites ake kumumanga kuti mapuloteni (mwachitsanzo, albumin). Kuchuluka pachimake seramu atapeza pambuyo 1.5 -3 maola pambuyo ntchito mankhwala osokoneza bongo. Limalankhula kwa mankhwala "Capecitabine" malangizo. Analogs ndi pharmacokinetics ofanana.

Ambiri mwa thunthu ndi excreted mu mkodzo, m'munsi - ndi chimbudzi. Komanso, osati umatuluka m'thupi capecitabine zikutsatiridwa (pafupifupi 3%), koma ena ofanana. Ena zimapukusidwa kuti mankhwala layamba. The zogona komanso kusintha kwa capecitabine mu thupi si anakhudzidwa ndi jenda, zaka, mtundu.

Pamene kutumikiridwa?

Capecitabine mu formulations zosiyanasiyana kutumikiridwa odwala khansa, kuphatikizapo siteji metastatic. Pankhaniyi, chuma ntchito chimango yekha, kapena amaphatikiza mankhwala ndi contraindications kapena kusowa efficacy mankhwala amphamvu. Nthawi zambiri, capecitabine pamodzi docetaxel.

Amagwiritsidwanso Kwalamulidwa kwa odwala khansa ya m'matumbo, kum'mero, m'mimba, kapamba, khansa colorectal, onse kufalitsa m'dera la bwalolo, ndi pa metastasis. Mankhwalawa khansa ya m'matumbo waperekedwanso "capecitabine". Malangizo ntchito amatsatira mlingo analimbikitsa ndi kutsatira malangizo a dokotala nawo.

Mogwirizana ndi mankhwala ena

Ngati mankhwala amphamvu anatsimikizira osamveka, ndi Oncology katswiri mwina mankhwala osakaniza mankhwala, zomwe zigwiritsidwe ntchito "capecitabine". Malangizo ntchito amatipatsa mndandanda wa zinthu, zomwe n'zotheka bwinobwino kusakaniza.

Mwachitsanzo, ndi "docetaxel" - mankhwala cytotoxic kanthu mtundu kukhala chiyambi masamba. Iwo akhoza angakhale kwa nthawi yaitali maselo woipa mkulu. Komabe, osakaniza wothandizira ali contraindicated anthu ndi kuchuluka kwa maselo othandiza magazi kuundana ndi neutrophils 100,000 / up ndi 1500 / l, motero. Komanso "Docetaxel" siligwira ntchito kwa odwala ndi kuchuluka kwa ndalama ya bilirubin. Mu nkhani iyi, angawagwere zotsatira. Ngati "Docetaxel" kwa ena chifukwa "kugwa" wa mankhwala chakudya, kupitiriza mankhwala "capecitabine", koma pa mlingo wotsikirapo.

Mu chochitika cha zochita hypersensitivity chithandizo "capecitabine" ndi "docetaxel" amasiya ndi kuthetsa zizindikiro chifukwa. Chiwembu ophatikizana supplementation akufotokozera waluso oncologist aluso. chiwembu Izi kusintha mu mwambo zotsatira poizoni.

"Capecitabine" ndi osankhidwa nthawi yomweyo "Sorivudinom" - ndi wothandizila mavairasi oyambitsa. kuphatikiza akhoza kuonjezera kawopsedwe wa mankhwala oyamba. The ntchito ophatikizana a antiepileptic mankhwala "phenytoin" kumaonjezera ndende ya yotsirizira mu madzi a m'magazi. N'zothekanso magazi chisokonezo mu ntchito anticoagulants coumarin ndi njira, kumene chigawo chachikulu - capecitabine. Malangizo ntchito kuchenjeza zingachitike, kotero muyenera choyamba mutidziwe bwino izo.

Amene contraindicated?

Chifukwa chakuti ali contraindicated kapena okha kuti mankhwala akhoza kukhala:

• Mkulu osiyanasiyana (hypersensitivity anachita).
• Pamaso pa aakulu insufficiency aimpso kapena kwa chiwindi.
• zosiyanasiyana mimba (mankhwala zimakhudza chipatso), kupatulapo nthawi imene moyo wa mayi anaika patsogolo;
• Kudyetsa kudya akhanda.

Komanso kulandira capecitabine malire anthu ndi matenda a mitima (CHD), pamene boma la kuchuluka ndende ya bilirubin mu magazi, matenda a chiwindi metastatic kuti kuphwanya ntchito zake zazikulu. palibe kukonzekera akulimbikitsidwa ana ndi okalamba. Izi zikugwirizana ndi mankhwala "Capecitabine" malangizo. Umboni kulankhula za zosiyanasiyana zotsatira zoyipa ndi zotsatira poizoni mankhwala. Choncho, capecitabine mankhwala kumachitika kuyang'aniridwa okhwima ndi oncologist katswiri.

Kodi pali zovuta zilizonse?

Pambuyo kutenga mankhwala akhoza kukhala mutu, boma la kutopa, ulesi, kufooka. Kusowa tulo kumachitika, kapena mosinthanitsa - tulo. Nthawi zina - imfa ya kugwirizana ndi kusamala chisokonezo.

Zotsatira zake zoyipa pa dongosolo mtima ndi magazi m'thupi (magazi). Pamlingo wamng'ono chifukwa angayambitse angina, m'mnyewa wamtima ischemia, sitiroko, kulephera mtima ndi ena. Ngati ndondomeko ziwalo kupuma zokhudza pangakhale kufupika kwa mpweya, zilonda zapakhosi, chifuwa. kawirikawiri - embolism m'mapapo mwanga, m'mapapo spasms.

Pamene ntchito zikuchokera yekha kapena amaphatikiza chithandizo zotheka mavuto obwera pa dongosolo minofu ndi mafupa. Izo kumaonekera ululu mu miyendo ndipo m'chiuno, uka hypertonus minofu (myalgia), molumikizana mafupa (arthralgia).

Khungu Angagwiritsidwenso anakhudzidwa. Zikhoza dermatitis, erythema, amaika dryness wa khungu, redness, kumva kulasalasa, dzanzi, ukuchoka, kuyabwa, kuchuluka mtundu, kuwonongeka amakhudza misomali. Nthawi zina pali ming'alu khungu, hypersensitivity kuti ultraviolet poizoniyu, ukuchoka ndi kuchuluka fragility mbale misomali.

Pa zochitika zina chokhwima kumachitika njira opatsirana chifukwa chitetezo cha mthupi kuchepetsa. Pambuyo mankhwala zimayambitsa kuchepa othandiza magazi kuundana magazi ndi maselo oyera. mawonetseredwe monga akufotokoza medicament "Capecitabine" malangizo Buku. Analogues kupereka zotsatira chomwecho.

mankhwala

"Capecitabine" oyenera okha ntchito mkati. Kawirikawiri kusamba pansi ndi madzi pambuyo theka la ola pambuyo chakudya, koma pambuyo pake. The tsiku mlingo anatsimikiza ndi oncologist nawo, malingana ndi kukula kwa zotupa, siteji chitukuko komanso okwana m'dera thupi pamwamba. Ndi zofunika kuti katswiri kale anali ndi luso la kugwira ntchito ndi mankhwala. Kwambiri kawirikawiri Kwalamulidwa kawiri tsiku - m'mawa ndi madzulo. Pankhaniyi, njira yonse kumatenga masabata awiri, ndiyeno - yopuma kwa masiku asanu ndi awiri, kenako mankhwala kubwereza.

Kwa odwala ndi insufficiency aimpso, ndi Mlingo tsiku yafupika. Ndi kuchepetsa chiwerengero cha leukocytes (leucopenia) ndi neutrophils (neutropenia) m'mwazi pitirizani kumwa mankhwala. Choncho akuonetsa njira "Capecitabine" malangizo Buku. Mau ofanana kapena analogues kutumikiridwa pa kuyamba kwa dokotala nawo.

kawopsedwe

Pali madigiri angapo, chimene osauka zotsatira poizoni wa mankhwala "capecitabine" (Malangizo Ntchito). Reviews anthu ambiri amanena kuti iyi ndi njira payekha.

Pali madigiri angapo kawopsedwe:

• 1 digiri. Pali zotsatira angapo mbali.
• 2 digiri. The m'mimba kwambiri (maulendo 4 tsiku) akutsatiridwa ndi nthambi kutupa, redness, ntchito matenda, kuwonjezereka lakuthwa mu bilirubin. Pa nthawi imeneyi, phwando usokoneze capecitabine mpaka zizindikiro za kawopsedwe wa gawo 1.
• 3 digiri. M'mimba amafulumizitsa maulendo 9 patsiku. Zimachitika malabsorption (sprue). Pamene unkachitika khungu amphamvu ukuchoka, redness, matuza ndi zironda. Pali ululu lakuthwa mu malekezero, utachepa ntchito. Bilirubin ndi chinawonjezeka ndi 3 zina. Apa wa chithandizocho anasiya, ndi chiwonetsero cha kawopsedwe wa digirii 1 kupitiriza kulandira kudzera mu mlingo m'munsi.
• 4 digiri. Pafupipafupi m'mimba - maulendo 10 pa tsiku. Chopondapo ndi magazi. Pali kufunika kumayambiriro mankhwala, anyalanyaza thirakiti m'mimba. Ngati zizindikiro za digiri izi mankhwala ayenera kusiyidwa ndi konse anayambiranso.

Kodi miyeso ayenera kusunga chitetezo?

The njira ya mankhwala ayenera kutenga malo moyang'aniridwa pafupi zachipatala. The katswiri ayenera yake kudziwa mawonetseredwe poizoni -. Kaya nseru, m'mimba, etc. Pa kudziwika mwa zizindikiro zimenezi, mankhwala kusintha. Ngati ndi kotheka, kuthetsa zizindikiro, kuchepetsa mlingo tsiku, kupanga yopuma. Chithandizo ayenera anapitiriza ngati zizindikiro za kawopsedwe musati loopsa moyo.

Kwa anthu ndi inatsekeratu matenda a mtima katswiri anaziika akhale makamaka mokwanira. Pankhaniyi, muyenera nthawi kuwulula kungasokoneze dongosolo mtima ndi nthawi kuti makonzedwe kutero.

Akatswiri kupewa kugwiritsa ntchito mankhwala mu mchitidwe Dokotala. Mphamvu ya ntchito chake osati akhazikitsidwa ana. Ngati mankhwala a pansi mkazi wa msinkhu wobereka, iye ayenera analangiza pa zotsatira za capecitabine pa mwana wosabadwayo. Pa nthawi ya mankhwala, iye ayenera kugwiritsa ntchito kulera odalirika.

Kukonzekera ndi analogues

Pali mankhwala angapo pamaziko a capecitabine. Mu msika Russian pali 7 malonda dzina la mankhwala, opangidwa ndi makampani akuluakulu zoweta ndi achilendo. Mwachitsanzo:

• "Capecitabine".
• "Capecitabine-TL".
• "Tutabin".
• "Xeloda".
• "Kabetsin".
• "Kapetsitover".
• "Kapametin FS".

Chikhazikitsireni maziko a njira zonse izi mmodzi ndi yemweyo yogwira pophika - capecitabine, chifukwa malangizo awo adzakhala ofanana. Kawirikawiri limasonyeza tebulo kuwerengetsa mlingo anapatsa thupi ndi mankhwala dera chilango chizindikiro cha amakhala osiyana a kawopsedwe.

Nkofunika kudziwa kuti chinthu choyamba kuliwerenga, pamene anaikidwa Mwachitsanzo, "Capecitabine TL" - malangizo. mfundo m'menemo si oyenera zida kudziletsa makonzedwe! kuwerengetsera zonse zokhudzana ndi mlingo ndi mankhwala chakudya, chimabala dokotala - oncologist ndi wokhoza wokwanira pa nkhani imeneyi. Self-ka wothandizila anticancer mavuto mpaka kalekale kwa thupi.

Tiyeni tione ena mwa mankhwalawa.

Kufotokozera za kukonzekera

• "Capecitabine - TL" zimapangitsa Russian kampani OOO "Technology mankhwala." A chigawo kiyi - capecitabine. Malangizo ntchito, amasulidwe mawonekedwe chidwi ambiri. Taganizirani tsatanetsatane. Izi piritsi, filimu TACHIMATA. Okhutira ndi zinthu yogwira - 150 kapena 500 mg. Wothandiza zigawo: mapadi, lactose, croscarmellose sodium, hypromellose, magnesium stearate. phukusi wina akhoza kukhala 60 kapena 120 mapiritsi, malingana ndi mlingo wa mankhwala "Capecitabine - TL". Malangizo ayenera muli mumve zambiri zokhudza ntchito ya ndalama.
• "Capecitabine" - zoweta mankhwala ndi chimodzimodzi yogwira pophika. Mafotokozedwe a Iye ndi ofanana ndi njira tatchulazi. mawonekedwe amasulidwe mankhwala "Capecitabine" - mapiritsi. Malangizo ntchito amagwiritsidwa unazunguliridwa mu phukusi.
• "Kabetsin" - anticancer wothandizira wa Russian kupanga ( "Company" Deco "). Mankhwala mawonekedwe - mapiritsi filimu TACHIMATA ndi 150 kapena 500 mg wa mankhwala yogwira. zosakaniza Secondary: microcrystalline mapadi, crospovidone, wowuma, magnesium stearate. Nyamukani ku pharmacies yekha ndi mankhwala.
• "Kapetsitover" - mankhwala a Russian kampani OJSC "Veropharm". wothandizila Izi anticancer zilipo mapiritsi a 150 kapena 500 mg 60 - 120 zidutswa. Kuwonjezera capecitabine pokonzekera kumaphatikizapo lactose, mapadi, croscarmellose ndi sodium, sodium stearate, ndi hypromellose.
• "Kapametin FS" - umatulutsa Russian kampani "Nativ" - ndi ophunzira yogwira mu ndondomeko inatha m'malo mankhwala. "Kapametin FS" kumasula mlingo 150 - 500 mg yogwira wothandizila - capecitabine. Malangizo ntchito (komanso sewerolo Khazikitsani mmenemo) angakuuzeni mmene miyala ambiri pa paketi - 60 kapena 120.
• "Tutabin" - mankhwala achilendo pamaziko a capecitabine. Amalima ndi Argentine kampani Laboratorio VARIFARMA SA, amenenso nthumwi kaundula. "Tutabin" amapangidwa mu mawonekedwe a miyala ndi yogwira pophika zili 500 mg. Kenaka - katoni ndi malangizo amaperekedwa.
• "Xeloda" - ndi wothandizila antitumor. Opangidwa ku Switzerland ndi "ndi F. Hoffman La Roche" ndi bulanchi ake ndi maudindo nthumwi m'mayiko ena - Mexico ndi United States. Mu msika Russian pali 5 mankhwala ndi dzina malonda. Mankhwala mawonekedwe - mapiritsi (150 - 500 mg) pa zidutswa 60 kapena 120. mu phukusi limodzi.

Reviews

Reviews ntchito pa maziko a zosiyanasiyana mankhwala capecitabine. Ambiri mwa iwo ndi abwino, koma palinso ndemanga negative. Komabe, sikuti zimaonetsa ndalama izi ndi zabwino kapena zoipa, chifukwa nthawi zonse muyenera kuganizira payekha thupi la munthu aliyense. Kulandira njira yomweyo ya anthu osiyana osataya zotsatira chomwecho. Chofunika kwambiri n'chakuti thupi kunagwa neoplasm ndi motalika bwanji momwe izo zinali kuchitika.

Anthu amene anatenga mankhwala, ananena amphamvu poizoni zotsatira pambuyo pa masiku angapo chikuonetseratu. Komabe, ambiri lipoti kusintha kwambiri chikhalidwe chawo ndipo ngakhale yolowera chikhululukiro. chikhalidwe zofunika kuti mankhwala ntchito komanso zotheka kwa munthu mmodzi, ndi oncologist kufunsira ndi mosamalitsa ndondomeko malangizo ake okhudza mankhwala.