"Azathioprine": analogues, mtengo, ndi Chiongoko ndi ndemanga

matenda Autoimmune - gulu la zinthu pathological limene pali kuchuluka ntchito chitetezo cha m'thupi thupi lake. Pofuna kuchepetsa ayankhe m'thupi, Kwalamulidwa mankhwala kubisa chitetezo cha m'thupi. Gulu la mankhwala ndi chofunika mu kupatsidwa zina kuteteza kumezanitsa kukanidwa. Tiyeni tione ngati mankhwala, monga "Azathioprine" analogs mankhwala ndi malangizo ntchito mbali yake.

pharmacological mapangidwe

Mu gawo lake la mankhwala "Azathioprine" lili yogwira pophika dzina chomwecho. Izi pawiri mankhwala ndilochokera zinthu zofunika kwa kaphatikizidwe wa DNA ndi RNA. Mu thupi, azathioprine amapereka DNA kaphatikizidwe ndipo, chotero, kumabwezera mmbuyo njira magawano khungu mu zimakhala. Kuchepetsa ntchito ya chitetezo cha m'thupi chifukwa cha mphamvu ya mankhwala "Azathioprine" mu minofu lymphoid.

Choncho pali chopinga njira magawano selo ndi ma ayankhe m'thupi. Pambuyo kumayambiriro "Azathioprine 'kukonzekeratu thupi nthenda kuchepetsa chiwerengero cha phagocytes ndi kuchepetsedwa immunoglobulin kaphatikizidwe. Tiyeni ife mopitirira mwakuya za mfundo zosiyanasiyana: Kodi ndi makhalidwe a "Azathioprine" analogues mankhwala, mtengo, malangizo ntchito.

Pharmacokinetics

Mankhwala ndi bwino kwambiri odzipereka mu makope zokhudza zonse, ndi ndende wake pazipita anati pambuyo maola 2 pokhapokha makonzedwe m'kamwa. Mankhwala si makamaka Mathotho zonsezo plasma: kumanga ake kuti 30%. Pakuti azathioprine khalidwe zotsatira kagayidwe kachakudya yaikulu kapena ziyambe kudutsa chiwindi.

Kudutsa hepatocytes ndi, mankhwala ndi zimapukusidwa kuti pawiri yogwira - mercaptopurine, ndipo amene ali zotsatira pharmacodynamic. Chiphunzitso pafupifupi mwathunthu excreted ndi ya ndulu. The mkodzo excreted ndi zosaposa 2% ya medicament.

zikuonetsa

Kukonzekera "Azathioprine" analogues ndi chinthu chomwecho yogwira ali anasonyeza ntchito kupatsidwa zina kuteteza kumezanitsa kukana anachita.

Komanso, mankhwala ndi bwino ntchito mchitidwe rheumatological kuchiza nyamakazi ndi matenda autoimmune monga chiwindi, zokhudza zonse lupus erythematosus, psoriasis, thrombocytopenic purpura, pemphigus, ndi ena ambiri.

contraindications

Mankhwala "Azathioprine" ali contraindicated odwala ndi hypersensitivity ku chigawo mankhwala. Chifukwa chakuti mankhwala kumabwezera mmbuyo majeremusi onse magazi, "Azathioprine" ali contraindicated mu matenda a magazi (magazi m'thupi leykotsito- ndi lymphopenia, thrombocytopenia), komanso pakati ndi unamwino.

Ntchito pa mimba ndi kuyamwitsa

Thunthu yogwira akudutsa mu mkaka wa m'mawere ndi mwa chotchinga gematoplatsentarny. Pa nkhani imeneyi, ntchito si tikuyivomereza mu mimba ndi kuyamwitsa. Ngati ndi kotheka, poika mankhwala kapena analogues ake mu gulu ili la anthu n'kofunika kuti aone chiopsezo ku ntchito ya ntchito mankhwala ndi mavuto kuthekera kwa mayi ndi mwana wosabadwayo. Pamene kugawa wothandizila pa yoyamwitsa posachedwapa kuletsa.

Features ya ntchito

The mankhwala ndi analogs ake ayenera kugwiritsidwa ntchito mosamala kwambiri odwala matenda katsabola, ndi odwala amene ali ndi vuto la xanthine oxidase.

zotsatira zoyipazi

Gulu lalikulu la mavuto kugwirizana ndi chopinga a mafupa ntchito, udindo yopanga maselo ofiira. Kutsatira analogs munali azathioprine, kuchuluka kwa kukula kwa maselo magazi, kuchepetsa leucocyte chizengerezo; kupatsidwa zinthu za m'mwazi chizengerezo; magazi m'thupi.

Pakuti gawo la kapepala m'mimba zotsatira ambiri mbali monga: utachepa kudya, matenda chopondapo, mkhutu kwa chiwindi ntchito, zotupa anam'peza pa mundawo m'mimba. imfa mwina hepatocytes, kenako kuwonjezeka bilirubin kapena zina mayesero chiwindi ntchito. Odwala likufa opaleshoni chifukwa kuziika ziwalo ndi minofu angathe kapamba, anam'peza zotupa m'mimba, matumbo, chitukuko za matenda oopsa.

thupi lawo siligwirizana zimachitika kawirikawiri pamene kutumikiridwa mankhwala "Azathioprine" analogs ofotokoza (mwachitsanzo, "Azathioprine"). Mawonetseredwe si anasonyeza, makamaka chifukwa zotupa pa khungu kapena limati thupi.

Mwa zotsatira zina mbali tisaiwale chitukuko cha njira yachiwiri matenda m'thupi, maonekedwe akulu ndi olowa ululu, pachimake aimpso zinchito insufficiency. Nthawi zina kwambiri, mankhwala "Azathioprine" analogues ndi chinthu chomwecho yogwira zingachititse hemolytic magazi m'thupi, kupereka zizindikiro kwa chapakati mantha dongosolo. Azathioprine monga pharmaceutically yogwira mankhwala, gawo la dzina mankhwala chomwecho ndi analogues ake, ali ndi chikoka kutchulidwa pa mwana wosabadwayo (teratogenic ndi mutagenic zotsatira) ndipo amatha n'zothandiza maonekedwe a njira chotupa ndi chotupa chija anayamba. Choncho, m'pofunika kufufuza Kusankhidwa kwa mankhwala "Azathioprine" (mapiritsi) ndemanga, mafotokozedwe, analogues mankhwala ndi kusankha machenjerero bwino. Poganizira, tiona kuti ngati yogwira pophika azathioprine ochitachita phindu pa njira ya matenda, malinga ndi zizindikiro. Tikutero osati madokotala komanso odwala okha.

"Azathioprine" - ofanana matanthauzo, analogs

Azathioprine - wapadera njira yake chinthu ali ndi kanthu immunosuppressive. Polingalira msika mankhwala si kwambiri kukonzekera bwino ankaimira munali azathioprine. Analogs "azathioprine" angathe kuperekedwa ngati mankhwala, monga "Azathioprine".

Mankhwala akupezeka piritsi mawonekedwe ndi ofanana zili azathioprine. The nuance yekha ndi mtengo wa "Azathioprine" mankhwala, zomwe mungathe nthawi 4-5 mtengo wa "azathioprine" kupanga Russian.

Poyizoni ndipo ambiri osokoneza

Mankhwala ambiri osokoneza "Azathioprine" ndi mnzake ake "Azathioprine" akuwonetseredwa matenda pa mundawo m'mimba, yimitsira a mafupa ntchito, komanso kuchuluka chiwindi mayesero ntchito. poyizoni mankhwala mankhwala palokha ndipo analogues ake ndi symptomatic, Cholinga chake ndi kuthetsa othamanga wa mankhwala m'thupi. No adakalibe yeniyeni. njira Dialysis detoxification ogwira chakuti thunthu yogwira mwa iwo excreted bwinobwino.

Kusamala

The mankhwala ndi analogs ake osavomerezeka ntchito nthawi yaitali. Kumayambiriro kwa chithandizo amafuna polojekiti zonse maselo a magazi zotumphukira, komanso kuwunika michere chiwindi.

M'tsogolo, ulamuliro tsiku la tchuthi, maphunziro polojekiti kamodzi kapena kawiri pa mwezi.

Pomaliza

The mankhwala ndi analogs zake tisonyezeni yekha katswiri wodziwa. Tisanayambe njira zofunika chokuchititsani kufufuza zonse ndipo mwina kuchititsa yokonza mankhwala. Kuti mudziwe zambiri, umathandiza poika "Azathioprine" kukonzekera malangizo ntchito. Price, analogues chida mbali ya funde la odwala. Choncho mtengo osachepera mapiritsi 50 ndi m'dera la 250-300 rubles, ndi za analogues tatchulazi. Tisanayambe muyenera kufufuza "ubwino" ndi "kuipa" ndipo anayamba mankhwala.