Mankhwala "Captopril" ku chiyani? Ntchito, ndemanga, mtengo

Kodi mankhwala "Captopril", kumene izo ntchito ndi katundu? Mayankho a mafunso onsewa angapezeke mu zipangizo za nkhaniyi. Komanso, tidzakhala kukuuzani mmene kutenga mankhwala ndi mavuto ndi contraindications zimene kugwiritsa ntchito iwo ali.

General zokhudza mankhwala mankhwala

Mankhwala "Captopril" mu Latin zikumveka ngati "Captopril". Izi mankhwala ndi woletsa kupanga a angiotensin-akatembenuka enzyme (Ace kapena chidule). Iye chimagwiritsidwa ntchito yochizira matenda, kuti mofulumira kuchepetsa magazi.

The zikuchokera ndi maonekedwe za kumasulidwa mankhwala

Medicament "captopril" - kumene chida ulipo kuti? Childs, madokotala mankhwala kwa anthu amene amangokhalira akudwala matenda oopsa. Anapereka mankhwala amagulitsidwa kokha mu mawonekedwe a miyala ndi spigot kuti anayikidwa mu katoni. The yogwira pophika mankhwala ndi captopril. wokhutira aliyense piritsi ndi 25 kapena 50 mg. phukusi wina akhoza kukhala ndi 100, 50, 40, 30, 20 kapena 10 zidutswa.

The kanthu pharmacological mankhwala

Monga kudafotokozedwa pamwamba, "Captopril" mapiritsi malangizo amene zinapeza malo okhala katoni, ndi woletsa wa angiotensin-akatembenuka enzyme (Ace i.e.).

Tikumbukenso kuti katundu antihypertensive mankhwala zokhudza chopinga mpikisano wa Ace ntchito, zikubweretsa chidwi kuchepa mlingo kutembenuka kwa angiotensin 1 angiotensin 2, lomwe ndi mwachilungamo zimene vasoconstrictive chigawo.

Pambuyo kuchepa kwambiri mu ndende ya angiotensin 2 ndi kuwonjezeka mobwerezabwereza mu plasma renin ntchito ndi kuthetsa maganizo olakwika pamene anamasulidwa kuchepetsa mwachindunji kupanga aldosterone. Komanso, medicament "Captopril", analogs amene anapereka hereinafter, kumakhudza dongosolo kallikrein-kinin, potero popewa kuwonongedwa kwa bradykinin.

Chifukwa vasodilating zotsatira za mankhwala kwambiri amachepetsa okwana mtima kukana (zotumphukira), capillary mphero kuthamanga ndi m'mapapo mwanga mtima kukana mu iwo. Komanso akhoza kuonjezera mphindi buku la minofu mtima ndi kusankha kulolerana.

Ngati mankhwala "Captopril", ndemanga zimene ziri zabwino kwambiri, kutenga nthawi yaitali kwambiri, kumathandiza chitukuko cha matenda a mtima, kuchepetsa zovuta m'mnyewa wamtima hypertrophy wa ventricle kumanzere, komanso wodekha pansi kupitirira wa dilation.

Komanso, medicament ndi kuteteza kupitirira kwa matenda ashuga nephropathy, kutsitsa kamvekedwe efferent arterioles aimpso, ndi glomeruli kwambiri kusintha hemodynamics intraglomerular.

Pharmacokinetics mankhwala

Pambuyo kutenga mankhwala mkati mwamsanga odzipereka. Kuchita medicament lidzayamba pambuyo pa 40-60 Mphindi. Ndende pazipita zimatheka mu thupi la munthu pambuyo Ora loyamba.

Tikumbukenso kuti munthawi yomweyo kudya chakudya ndi mankhwala pano kumachepetsa absorbability ake 30-40%. Ichi ndi chifukwa mapiritsi akulangizidwa pitiliza 1 ora pamaso chakudya kapena pambuyo maola 1-1.5 nthawi yaitali.

Nthawi kanthu pambuyo ntchito medicament (kuti magazi kuchepetsa) zimadalira multiplicity wa phwando ake ndi mlingo. Pa chitukuko cha mphamvu zonse achire wodwala kungafune masabata angapo a mankhwala.

Makhalidwe ndi katundu wa mankhwala "Captopril"

Tsopano inu mukudziwa kuti ndi mankhwala "Captopril", imene imagwiritsidwa ntchito ndi momwe angachitire poyerekezera ndi thupi la munthu. Koma kumvetsa chifukwa mankhwala ndi wotchuka kwambiri, muyenera kuganizira katundu wake.

Thunthu yogwira zomwe ndi mbali ya "Captopril" kukonzekera nazo vasodilating, antihypertensive ndi katundu cardioprotective.

Izi mankhwala angathe kuwonjezera amasulidwe zinthu biologically yogwira ntchito ndi zotsatira natriuretic. Chifukwa chuma ichi kwambiri bwino otaya magazi kwa impso. Komanso, medicament "Captopril" wa zoipazi amachepetsa okwana pambuyo preload mtima, ndipo ukuwonjezeka mu linanena bungwe mtima.

Zikuonetsa ntchito mankhwala

Anapereka mankhwala anasonyeza zochizira ndi kuvutika zotsatirazi:

• Wolumikizira oopsa ndi renovascular. Thiabendazole angagwiritsidwe ntchito osakaniza kapena monotherapy.
• Matenda a ventricle kumanzere. Childs, mankhwala ntchito ndi anthu amene anali ndi vuto la mtima, ndipo tsopano mu chikhalidwe kukomoka khola.
• Ashuga nephropathy. Anawatumiza kwa anthu okhawo amene ali ndi matenda a shuga yoyamba, mwachitsanzo insulin amadalira anthu.
• Cardiomyopathy.

Mankhwala "captopril" - zimene aliyense akapatsidwa mankhwalawa? Monga amadziwika, mankhwala akhoza kuperekedwa ndi ntchito mankhwala zovuta chifukwa chakuti mtima (congestive).

Contraindications ntchito medicament ndi

Malinga ndi malangizo, mankhwala "Captopril" ndi kutiletsa kutenga milandu zotsatirazi:

• Mu nkhani ya hypersensitivity kwa pophika yogwira - captopril. Iwo ayenera kukumbukira kuti mankhwala yogwira ali osavomerezeka chifukwa anthu amene ali ndi tsankho pali gulu bwino mankhwala, amene zoletsa wa angiotensin-akatembenuka enzyme (i.e., odwala amene anayambitsa angionefrotichesky kutupa pa mankhwala ena Ace woletsa).
• Pamene asonyeza anthu chiwindi ntchito.
• Mu mantha cardiogenic.
• Pamene m'mimba thirakiti matenda.
• Pamene asonyeza anthu chikhalidwe impso ntchito pambuyo kupatsidwa zina za limba, amgwirizano stenosis wa mitsempha, azotemia, hyperkalemia, ndi hyperaldosteronism chachikulu.
• Ngati hypotension.
• Mu matenda immunological.
• Mitral stenosis ndi kung'ambika stenosis.

Komanso, mankhwala "Captopril" analogues wa mankhwala ali osavomerezeka kwa amayi apakati, ana osaposa zaka 18, komanso amayi unamwino.

Mankhwala "Captopril": malangizo, mtengo wa mankhwala

Malinga ndi malangizo Ufumuyo, mankhwala ayenera kumwedwa 1 ora pamaso chakudya. Kutalika kwa mankhwala ndi mlingo kamwedwe ka mankhwala anapereka ayenera kumatanthauza dokotala yekha anthu paokhapaokha, malingana ndi mtundu ndi nthenda ya matenda wogwila.

Choncho mmene kutenga mankhwala "Captopril"? Mlingo (koyamba) wa medicament ku matenda a matenda oopsa ndi 12,5 mg wa kawiri pa tsiku. Wosowa pachimake pa nthawi ina angagwiritsidwe ntchito yokonza mapiritsi 2 a 25 mg. Koma mu nkhani iyi phwando zabwino kwa kugawidwa mu nthawi 3. The pazipita tsiku mlingo umenewu medicament ndi 150 mg.

Ngati dokotala wanu wadzikakamiza yokonza mankhwala kwa nthawi yaitali, mankhwala "Captopril", amene anapereka umboni takambirana pamwamba chabe, ayenera piritsi loyamba (25 mg) katatu kapena kawiri pa tsiku.

Pamene renovascular oopsa ndi aimpso koyamba mlingo wa medicament ndi 6,25 mg wa katatu patsiku. mankhwala wothandiza pazikhalanso piritsi 1 chiphunzitso (25 mg) katatu patsiku.

Ngati inu amapezeka ndi kulephera aakulu mtima ndipo pali monyanyira mu impso, mlingo woyambilira akhale 12,5 kapena 6,25 mg wa katatu patsiku. Choncho aliyense masabata 2-3 ayenera anabweretsa yokonza mlingo wake wa 25-50 mg, ndi pafupipafupi chomwecho. The postinfarction nthawi alandire njira medicament ofanana.

Ace gulu la mankhwala okalamba amapatsidwa yekha kuti madokotala a. Pankhaniyi, mankhwala ayenera payekha payekha. Anaulandira "Captopril" Anthu awa akhale mlingo osachepera. Komanso, ali osavomerezeka kuonjezera mu mankhwala. Ngati kuli koyenera kutero mungathe Komanso ntchito kuzungulira diuretic.

Monga mtengo, ndiye kuti mapiritsi 40 mankhwala muyenera kulipira pafupi 50-60 Russian rubles. Monga mukuonera, amatanthauza "Captopril" ndi zimakhalanso zotsika mtengo mankhwala bwino m'munsi magazi mu njira wathanzi.

Anatengedwa ndi kusamala kwambiri

mankhwala anapereka ayenera kumwedwa mosamala kwambiri pamene:

• chopinga a mafupa a magazi;
• aakulu autoimmune matenda;
• shuga;
• ischemia oziziritsa ;
• inatsekeratu matenda a mtima.

zotsatira zoyipazi

Malinga ndi malangizo, pambuyo mankhwala "Captopril" kumachitika odwala zotsatirazi zochita mbali:

• bronchospasm, chifuwa, kufupika kwa mpweya, youma wosabereka chifuwa;
• CNS maganizo, kupweteka kwa mutu, khunyu, ataxia, chizungulire, kumva kulasalasa ku malekezero chapamwamba ndipo m'munsi, komanso kumverera chosokonezeka, chisokonezo, zipolowe wa fungo ndi masomphenya, kutopa, kuvutika;
• exfoliative dermatitis, kuyabwa, zotupa pa khungu photodermatitis, pemphigus, angioedema, urticaria, anaphylactic mantha, poizoni epidermal necrolysis, alopecia;
• mtima mungoli zipolowe, angina pectoris, orthostatic hypotension, m'mnyewa wamtima infarction, tachycardia;
• kukoma chisokonezo, flatulence, kusafuna kudya, stomatitis, nseru, kudzimbidwa, glossitis, anam'peza zotupa za mucosa muzituluka ndi pakamwa, kutsekula m'mimba, kusanza, xerostomia, kupweteka m'mimba;
• paresthesia, nyamakazi, neuropathy zotumphukira;
• neutropenia, hyperkalemia, thrombocytopenia, agranulocytosis, eosinophilia;
• oliguria, proteinuria, chakhungu impso ntchito;
• cholestatic chiwindi, kapamba, cholestasis, hepatocellular necrosis.

Malinga ndi machitidwe kusiya ogula la mankhwala, mavuto kumachitika kwambiri ngati, pamene kumwa mankhwala kutsatira mchere wochepa kapena mchere-free zakudya.

Mankhwala "Captopril" ambiri osokoneza

Mu deta ambiri osokoneza zikutanthauza odwala angasonyeze mavuto monga infarction m'mnyewa wamtima, ndipo anasonyeza mwa dontho mofulumira magazi, pachimake chisokonezo cha kufalitsidwa oziziritsa ndi mavuto thromboembolic.

kusamala

Akatswiri amanena kuti ali osavomerezeka kutenga mankhwala ndi okodzetsa potaziyamu-yosalekerera, ndi mankhwala ena kuti kwambiri pa ndende ya potaziyamu mu madzi a m'magazi. Ngati tinyalanyaza Council iyi, pali chiopsezo chachikulu cha hyperkalemia.

Komanso, mankhwala "Captopril" ayenera kugwiritsidwa ntchito mosamala kwambiri ndi phwando munthawi yomweyo amatanthauza "Procainamide", "" allopurinol "," Azathioprine "kapena immunosuppressants ena, makamaka matenda a ntchito aimpso.

Mu matenda akakufunsani connective minofu, komanso kulephera aakulu mtima, mankhwala Tiyenera kumwedwa moyang'aniridwa pafupi zachipatala.

Iwo ayenera kukumbukira kuti, malinga ndi odwala kuchipatala ndi ndemanga, zotsatira hypotensive wa medicament ndi kumachepetsa mankhwala "Indomethacin" ndi estrogens.

zinthu yosungirako

Mankhwala "Captopril" amatanthauza mankhwala List B. mankhwala Izi anamasulidwa mu unyolo mankhwala yekha mankhwala dokotala. alumali moyo wake ndi zaka 3 kuchokera tsiku kupanga. njira imeneyi akupanga makamaka mdima ndi youma, pa kutentha osati choposa 25 ° C.

analogues mankhwala

Malinga ndi pophika yogwira ali zotsatirazi analogs structural wa mankhwala:

• "Captopril Verein";
• "Angiopril 25";
• "Captopril ekala";
• "Alkadiene";
• "Captopril Sandoz";
• "Vero Captopril";
• "Captopril UBF";
• "Blokordil";
• "Captopril Akos";
• "Captopril hexane";
• "Capoten";
• "Captopril FPO";
• "Captopril akuti sar";
• "Katopil";
• "Aegis Captopril";
• "Epsitron";
• "Captopril opatsirana pogonana."

Monga mukuonera, anagonjera mankhwala ali angapo wapadera. Choncho, odwala zambiri akafunsa kuti, kodi ndi bwino - mankhwala "Captopril" kapena "Capoten". Kusiyana chachikulu pakati pawo. Amasiyana mzake kokha mwa Mlengi. Pachifukwa ichi, amatanthauza "Capoten" ndi ofunika nthawi 3.5 zodula mankhwala "Captopril".

Reviews kukonzekera

Ngakhale mtengo wochepa, ndi medicament "Captopril" mwaluso Sachita magazi. Odwala amene mobwerezabwereza ntchito mankhwala kuti zotsatira zake zimaonekera mwa maola 1-3 pambuyo ingestion.

Munthu matupi awo sagwirizana zochita pambuyo ntchito wothandizila pa zimachitika za 5-8% ya anthu. Ambiri amati mankhwala amachititsa kutupa kwambiri. N'chifukwa chake asanayambe ntchito, onetsetsani kukaonana ndi dokotala. Ngati njira ya "Captopril" ndi chimodzi mbali zotsatira, ndi zofunika kukana kwa izo ndipo kupita pa mankhwala kuthamanga kwa magazi kuchokera ku gulu lina.

Pali zambiri ndithu ndemanga kuti "Captopril" mankhwala "Capoten" ndi analogues zina za ndalama zimenezi moyenera kumathandiza kuchotsa matenda oopsa okalamba. Koma pamaso njira zoterozo, onetsetsani kukaonana ndi dokotala. Komanso, munthu wokalamba kuthetsa kuthamanga kwa magazi ndi matenda ena akulimbikitsidwa kugwiritsa ntchito kokha mlingo wotsikitsitsa mankhwala.

Kodi palibe chovuta kugwiritsa ntchito mankhwala?

Pamaziko a chipatala dera mu Rivne (Ukraine) mu 2010, kafukufuku kunachitidwa pafupipafupi mavuto sanaphe mankhwala "Captopril". Mu njirayi, anapezeka ndi anthu ofatsa ndi odziletsa wolumikizira oopsa. Chifukwa, wa anthu 500 anadandaula mavuto anthu 73 okha. Awa, 53 - kusiya kumwa mankhwala, ndi 20 otsala - anapitiriza, ngati iwo apeza kuti umabweretsa kwambiri wabwino kuposa zoipa thanzi.